Creatinine clearance of > 60 ml/min; creatinine clearance may be measured or calculated; if calculating, creatinine clearance, use the Cockroft-Gault formula =< 2 weeks prior to randomization

Serum creatinine ? 2.0 mg/dL or creatinine clearance ? 40 mL/min measured or calculated by Cockroft Gault equation.

Calculated serum creatinine clearance >= 60 mL/min/1.73 m^2, within 28 days prior to administration of study treatment

Adequate renal function determined within 6 weeks prior to randomization defined as the most recent serum creatinine =< ULN or measured or calculated creatinine clearance > 60 mL/min

STEP I: Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior to randomization)

Serum creatinine =< 1.5 times ULN OR calculated creatinine clearance >= 70 mL/min

Calculated creatinine clearance > 30 ml/min within 14 days prior to step 2 randomization

Serum creatinine =< 1.5 x mg/dL OR measured or calculated creatinine clearance >= 50 mL/min; creatinine measurements must be obtained within 28 days prior to registration

Creatinine =< 2.0 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance >= 30 mL/min

Creatinine =< 1.5 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance > 45 mL/min using the lean body mass formula only

Serum creatinine must be =< 2 x the institutional ULN OR creatinine clearance (either measured or calculated) must be > 30 mL/min; must be obtained within 28 days prior to registration

Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min, obtained within 28 days prior to step 2 registration

Creatinine =< upper limit of normal (ULN) or calculated creatinine clearance >= 60 mL/min

Within 14 days of registration: Calculated (calc.) creatinine clearance > 50 mL/min

Patients must have adequate renal function as documented by a calculated creatinine clearance >= 60 mL/min, within 28 days prior to registration

Creatinine =< 1.5 x upper limit of normal (ULN) mg/dL OR calculated (calc.) creatinine clearance >= 60 mL/min

Obtained within 28 days prior randomization: serum creatinine =< 1.5 x ULN for the lab or measured or calculated creatinine clearance >= 30 mL/min

Serum creatinine =< 1.5 x upper limit of normal (ULN) or calculated creatinine clearance (CrCl) >= 40 mL/min, within 4 weeks of randomization

Serum creatinine =< 1.5 ULN OR measured or calculated creatinine clearance >= 30 mL/min

Within 10 days of treatment initiation: Measured or calculated creatinine clearance >= 50 mL/min\r\n* Creatinine clearance should be calculated using modified Cockcroft-Gault equation (using ideal body mass [IBM] instead of mass). Direct measured creatinine clearance (i.e. 24h urine or other method) can be substituted if calculated creatinine clearance is thought to be inadequate per treating physician

Renal: serum creatinine within normal limits (WNL), defined as within 25% of the institution's stated reference range, or a calculated creatinine clearance >45 mL/min/1.73 m. sq. for patients with abnormal, increased, creatinine levels.

Serum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 mL/min

Serum creatinine =< 1.5 times ULN OR if serum creatinine >= 1.5 mg/dL, calculated creatinine clearance >= 30 mL/min

Or, if serum creatinine > 1.5 mg/dL: calculated creatinine clearance (ClCR) > 50 mL/min

Creatinine < 1.5 mg/dL and calculated creatinine clearance >= 60 cc/min

Or a calculated or measured creatinine clearance or radioisotope GFR >= 70ml/min/1.73m^2 obtained within 14 days prior to registration

Calculated creatinine clearance (Cr Cl) >= 50 ml/min; eligible for full dose methotrexate

Serum creatinine ? 1.5 x upper limit of normal (ULN) or calculated creatinine clearance ? 60 mL/minute

Calculated creatinine clearance at least 30 mL/min.

Calculated creatinine clearance (by Cockroft-Gault) >= 50 mL/min or serum creatinine below 2 g/dL

Calculated creatinine clearance >= 30 mL/min

Calculated creatinine clearance >= 30 mL/min

Serum creatinine =< 2.0 mg/dl or a calculated creatinine clearance of > 60 ml/min

Patients with severe renal impairment (creatinine clearance [CrCL] < 30 mL/min) are not eligible; a calculated CrCl is acceptable

Serum creatinine >= 1.5 times the upper normal limit or calculated/measured creatinine clearance =< 60 mL/min

Renal: serum creatinine ?1.5 x ULN or creatinine clearance (CrCl) ?60 mL/min as calculated by the Cockroft-Gault method

Creatinine clearance > 60 Ml/min/1.73 m2 for patients with creatinine levels above ULN calculated using Calvert formula

Calculated creatinine clearance > 60 ml/min.

Calculated creatinine clearance > 50 mL/min

PHASE II INCLUSION CRITERIA: Calculated creatinine clearance > 50 mL/min

Creatinine clearance < 50 mL/min calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation

Normal creatinine for age or a calculated creatinine clearance >= 60 mL/min/1.73 m^2

Estimated creatinine clearance >= 60 mL/min as calculated using the method standard for the institution

Creatinine within the institution's laboratory upper limit of normal (ULN) or calculated creatinine clearance >50 ml/min

Creatinine =< 1.5 mg/dL OR calculated (calc.) creatinine clearance >= 30 mL/min

Calculated creatinine clearance >= 50 mL/min

Calculated creatinine clearance by Modification of Diet in Renal Disease (MDRD) (CrCl) >= 60 ml/min/1.73 squared meter

Obtained =< 21 days prior to registration and confirmed prior to the first dose of study drug: Calculated creatinine clearance >= 30 mL/min

Have acceptable renal function defined as: Serum creatinine ? 1.5 × ULN, OR calculated creatinine clearance ? 45 mL/min for patients with creatinine levels above 1.5 mg/dL

Serum creatinine =< 2.5 mg/dL or a calculated creatinine clearance >= 50 mL/min

Serum creatinine < 2 mg/dL OR calculated creatinine clearance (CrCl) > 30 ml/min

Calculated creatinine clearance >50 mL/min;

creatinine ? 2.0 mg/dL, or calculated creatinine clearance ? 45 mL/min

Serum creatinine =< 1.5 x ULN or serum creatinine > 1.5 – 3 x ULN if calculated creatinine clearance (CrCl) is >= 30 mL/min using the Cockroft-Gault equation

Serum creatinine < 1.4 mg/dL or calculated creatinine clearance (CrCl) >= 30 mL/min

Renal: Creatinine clearance (CrCl) > 50 ml/min (measured or calculated/estimated).

Calculated or measured creatinine clearance >= 30 ml/min, obtained =< 14 days prior to registration

Calculated creatinine clearance >= 60 ml/min.

Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min

Renal: Creatinine clearance of ? 40 mL/min, estimated or calculated.

Calculated creatinine clearance of >= 50 mL/min

Serum creatinine =< 2 mg/dL or calculated creatinine clearance of >= 40 ml/min within 14 days of registration using Modification of Diet in Renal Disease (MDRD) formula

Creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min for subject with creatinine ? 1.5 x institutional ULN obtained =< 14 days prior to registration

Within 4 weeks before enrollment: Calculated creatinine clearance > 40 mL/min

Serum creatinine < 2 x upper limit of normal (ULN) or estimated creatinine clearance > 30 ml/min as calculated using the method standard for the institution

Calculated creatinine clearance >= 10 mL/min

Serum creatinine < 2.0 mg/dl OR measured or calculated creatinine clearance (GFR can also be used in place of creatinine or CrCl) ? 50 ml/mm within 10 days prior to “on study” status\r\n* Creatinine clearance should be calculated per institutional standard

Creatinine =< 2.0 mg/dL or calculated creatinine clearance >= 30 mL/min

Creatinine =< 1.5 ULN or calculated creatinine clearance >= 50 ml/min

Estimated creatinine clearance >= 30 ml/min (calculated according using Cockcroft–Gault formula)

Obtained =< 28 days prior to registration: Creatinine =< 1.0 x ULN OR measured or calculated creatinine clearance (per institutional standard) must be >= 60 ml/min

Serum creatinine clearance of >= 50 ml/min (calculated or measured)

Cockcroft calculated creatinine clearance of >= 45 ml/min or 1.5 x the upper limit of normal (ULN)

Pretreatment calculated or measured creatinine clearance (absolute value) of >= 60 mL/minute.

Creatinine > or = 2.0 x ULN or creatinine clearance < 50 mL/min (calculated).

Creatinine clearance > 30 mL/min (calculated according to institutional standards or using Cockcroft–Gault formula)

Obtained within 14 days prior to enrollment: calculated creatinine clearance > 30 ml/min

Creatinine =< 1.5 ULN OR creatinine clearance >= 60 Ml/min/1.73 m^2 for patients with creatinine levels above ULN calculated using Calvert formula

Serum creatinine =< 2 x upper limit of normal (ULN) or estimated creatinine clearance >= 15 mL/min as calculated using the method standard for the institution

Patients must have a calculated creatinine clearance of >= 35

Calculated or measured creatinine clearance >= 50 ml/min

Serum creatinine > 1.5 x upper limit of normal (ULN) or creatinine clearance < 40 mL/min (measured or calculated by Cockroft-Gault formula)

Creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min for subject with creatinine ? 1.5 x institutional ULN obtained =< 14 days prior to registration

Creatinine OR =< 1.5 x ULN; calculated creatinine clearance OR >= 50 mL/min; 24-hour urine creatinine clearance >= 50 mL/min

Creatinine =< 2.0 mg/dL; however, patients with a creatinine > 2.0 mg/dL but with a calculated creatinine clearance of > 30 ml/min, as measured by the Modification of Diet in Renal Disease (MDRD) equation, will be eligible

Serum creatinine =< 1.5 x ULN or a calculated creatinine clearance >= 60 ml/min/1.73 m^2 (Cockcroft-Gault method) for patients receiving combination of cisplatin and pemetrexed and >= 45 ml/min/1.73 m^2 for patients receiving pemetrexed; 24 hour urine for creatinine clearance is acceptable if the calculated creatinine clearance is insufficient

Obtained =< 14 days prior to registration: Calculated or measured creatinine clearance >= 30 ml/min

Calculated creatinine clearance must be >= 30 mL/minute

Serum creatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 ml/min/1.73 m^2)

Adequate renal function defined as: • Serum creatinine ? 1.5 x ULN (upper normal limit) or calculated creatinine clearance (determined by MDRD) > 50 mL/min/1.73m2.

Creatinine clearance (CrCl) >= 40 ml/min; CrCl will be calculated using the modification of diet in renal disease (MDRD) equation

Serum creatinine =< upper limit of normal (ULN) for the lab or a calculated creatinine clearance >= 60 mL/min

Creatinine >1.5 times ULN or creatinine clearance <50 mL/min (measured or calculated by Chronic Kidney Disease Epidemiology (CKD-EPI) Collaboration equation); confirmation of creatinine clearance is only required when creatinine is >1.5 times ULN.

Creatinine less than or equal to 1.5 x upper limit of normal (ULN) with calculated creatinine clearance greater than 30 ml/min

Creatinine clearance >= 40 ml/min (24 hour urine collection preferred; can be calculated if not available)

Calculated creatinine clearance >= 30 mL/min/1.73 m^2

Creatinine clearance >= 40 mL/min (measured or calculated per local practice)

Creatinine clearance (CrCl) >= 50 mL/min calculated by the Cockroft-Gault

Creatinine =< 2.0 mg/dL OR calculated creatinine clearance >= 50 mL/min (as calculated by the Cockcroft-Gault method)

Calculated creatinine clearance (CrCl) > 30 mL/min

Calculated or measured creatinine clearance (method determined by the prescribing physicians) < 50 ml/min

Creatinine clearance >= 40 mL/min, estimated or calculated

Serum creatinine < 2.0 times the upper limit of normal (ULN) (or a calculated creatinine clearance >= 60 mL/min)

Calculated or measured creatinine clearance (CrCl) > 30 ml/min

Serum creatinine >= ULN and/or calculated or measured creatinine clearance < 75% lower limit of normal (LLN)

Calculated creatinine clearance >= 50 mL/min

DONOR: Serum creatinine within normal limits or a minimum creatinine clearance (CrCl) value of >= 60 ml/min calculated using the Modification of Diet in Renal Disease (MDRD) study equation

Serum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 mL/min

Serum creatinine =< 1.5 x the ULN and calculated creatinine clearance > 30 ml/min

Estimated creatinine clearance >= 30 mL/min (calculated or measured by 24 hour urine collection)

Calculated creatinine clearance >= 45 mL/min

Calculated creatinine clearance >= 30 mL/min

Calculated creatinine clearance >= 50 mL/min/1.73 m^2

CERITINIB INCLUSION CRITERIA: Creatinine OR creatinine clearance < 1.5 mg/dL >= 30 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULN

REGORAFENIB INCLUSION CRITERIA: Creatinine OR creatinine clearance =< 1.5 x ULN; > 40 mL/min (calculated by Cockgraft-Gault) for patients with creatinine levels above ULN

Serum creatinine =< 1.5 mg/dL and/or calculated creatinine clearance >= 50 mL/min (via Cockroft and Gault)

Calculated creatinine clearance >= 30 mL/min

Serum creatinine =< 1.25 times upper limit of normal or calculated creatinine clearance >= 50 ml/min

Either a serum creatinine ? ULN for age, or calculated or measured GFR ? 70 mL/min/1.73 m2

Calculated creatinine clearance >= 30 mL/min

Serum creatinine > 1.5 x upper limit of normal (ULN) and calculated creatinine clearance, based on a 24-hour urine collection, < 30 mL/min--unless related to ALL/tumor lysis syndrome and able to be corrected

Creatinine =< 1.5 x upper limit of normal (ULN) for the laboratory or calculated or actual creatinine clearance >= 60 mL/min

Calculated creatinine clearance >= 30 mL/min or serum creatinine =< 1.5 mg/dl

Calculated creatinine clearance (by Cockroft-Gault) >= 50 ml/min or serum creatinine below 2 g/dL

Calculated creatinine clearance ? 30 mL/min

Calculated creatinine clearance >= 30 mL/min

Serum creatinine >1.5 x ULN and/or measured or calculated creatinine clearance <75% LLN

Creatinine clearance > 30 mL/min (calculated according to institutional standards or using Cockcroft–Gault formula; subjects with requirement of hemodialysis will be excluded)

Serum creatinine =< 1.5 x ULN OR a measured creatinine clearance or calculated creatinine clearance >= 50 mL/min

Creatinine clearance > 50 ml/min (calculated creatinine clearance is permitted)

Creatinine =< 1.5 x ULN 2 OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance >= 50 mL/min

Calculated creatinine clearance (absolute value) of >= 50 mL/minute or creatinine < 2.0 mg/dl or < 2 times upper limit of normal for the research participant's age group

If the research participant is to undergo leukapheresis, he/she must have a pretreatment calculated creatinine clearance of >= 50 mL/minute

Serum creatinine ? 2.5 mg/dL or calculated creatinine clearance (CrCl) ?25.0 mL/min.

Patients must have adequate renal function as evidenced by a serum creatinine ? 1.5 X ULN for the reference laboratory OR a calculated creatinine clearance of ? 60 mL/min by the Cockroft-Gault equation.

Creatinine < 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance of >= 50ml/min

Serum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 ml/min

Calculated or measured creatinine clearance >= 60 cc/min for cisplatin candidates, >= 30 cc/min for carboplatin candidates

Serum creatinine =< 1.2 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated)

Calculated creatinine clearance > 30 ml/min

Or, if > 1.5 mg/dL: calculated creatinine clearance (ClCR) >= 30 mL/min

Calculated creatinine clearance >= 40 ml/min or 24 hour urine

Calculated creatinine clearance >= 45 mL/min/1.73 m^2

Serum creatinine =< 1.5 x ULN or clearance >= 60 mL/min (measured or calculated)

Creatinine < 1.5 mg/dL or calculated creatinine clearance > 60 mL/min

Serum creatinine =< 1.2 mg/dL or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated)

Adequate renal function (creatinine =< 1.25 upper limit of institutional normal [ULIN] or calculated creatinine clearance > 50 ml/min)

Calculated creatinine clearance > 60 ml/min

Calculated creatinine clearance ?50 mL/min.

Calculated creatinine clearance of ? 50 ml/min.

Calculated Creatinine Clearance of 50 ml/min

Calculated creatinine clearance > 50 mL/min.

Calculated creatinine clearance >30ml/m

Calculated creatinine clearance of <60 mL/min in Stage 1 and <40 mL/min in Stage 2

Patients with moderate or severe renal impairment (calculated creatinine clearance of < 60 mL/min)

Adequate renal function documented by serum creatinine of 1.5 mg/dl or less, or calculated creatinine clearance > 50 ml/min.

ORAL CAVITY SQUAMOUS CELL CARCINOMA COHORT: Calculated creatinine clearance > 50 mL/min

HPV-ASSOCIATED OROPHARYNX SQUAMOUS CELL CARCINOMA: Calculated creatinine clearance > 50 mL/min

Creatinine clearance > 40 ml/min (calculated or measured)

Creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 50 mL/min for patients with creatinine levels > 1.5 x IULN

Calculated creatinine clearance >= 30 mL/min

Estimated creatinine clearance >= 60 ml/min as calculated using the method standard for the institution

Calculated creatinine clearance of > 60 mL/min/m^2, within 28 days prior to registration.

Calculated creatinine clearance must be > 60 mL and serum creatinine =< 2 mg/dL

Creatinine clearance (calculated or measured) > 30 mL/min

Calculated creatinine clearance >= 50 mL/min

Creatinine =< 1.5 mg/dL; however, patients with a creatinine > 1.5 mg/dL but with a calculated creatinine clearance of > 60 ml/min, as measured by the Modification of Diet in Renal Disease (MDRD) equation, will be eligible

Creatinine =< 1.5 x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance >= 30 mL/min

Calculated (calc.) creatinine clearance > 45 mL/min

Within 14 days prior to registration: Serum creatinine =< 1.5 x institution’s ULN or calculated 24-hour creatinine clearance >= 50 mL/min

Serum creatinine =< 2.0 mg/dL or calculated creatinine clearance >= 60 mL/min

Creatinine OR =< 1.5 mg/dl x upper limit of normal (ULN) OR calculated (calc.) creatinine clearance > 45 mL/min

Serum creatinine =< ULN for the lab and measured or calculated creatinine clearance > 60 mL/min within 28 days before randomization

Calculated creatinine clearance > 70 mL/min/1.73 m^2

Creatinine =< 1.5 x upper limit of normal (ULN) for the laboratory or calculated or actual creatinine clearance >= 60 mL/min

Serum creatinine normal for age or calculated creatinine clearance (CrCl) >= 70 ml/min/1.73 m^2

Serum creatinine < 2.0 mg/dl, creatinine clearance >= 50 ml/mm (can be calculated or measured)

Calculated creatinine clearance >= 50 cc/min

Creatinine =< 2.0 mg/dL, OR calculated creatinine clearance >= 30 mL/min (calculated by the Cockcroft and Gault method)

Patients must have serum creatinine =< 2 mg/dl with creatinine clearance >= 60 ml/min (either calculated or measured)

Serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min

Creatinine clearance >= 40 mL/minute (measured or calculated/estimated)

Patients must have a serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50 mL/min

Renal function: calculated or measured creatinine clearance >= 50 ml/min and/or serum creatinine =< 1.6 mg/dl

Creatinine =< 1.5 x upper limit of normal (ULN) for the laboratory or calculated or actual creatinine clearance > 45 mL/min

Measured or calculated creatinine clearance >= 30 mL/min

Serum creatinine =< 1.5 x ULN or calculated or directly measured creatinine clearance (CrCl) >= 50% LLN (lower limit of normal)

Calculated creatinine clearance >= 30 mL/min within 14 days of enrollment

Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min

Serum creatinine >= 1.5 times the upper normal limit or calculated/measured creatinine clearance =< 60 mL/min

Calculated or measured creatinine clearance >= 30 ml/min within 14 days prior to registration

Creatinine clearance (calculated or 24 hour) >= 30 ml/min

Calculated creatinine clearance >= 60 mL/min

Creatinine clearance (CrCL) (calculated creatinine clearance is permitted) > 40 mL/min

Obtained within 28 days prior to registration: Serum creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 60 mL/min

Calculated creatinine clearance ?60 mL/min/1.73m^2

Calculated creatinine clearance >= 40 mL/min using a serum creatinine or by 24-hour urine creatinine obtained within 28 days prior to registration

Calculated creatinine clearance >= 30 mL/min within four weeks prior to randomization

Serum creatinine ?1.5 × ULN or calculated creatinine clearance ?50 milliliters/minute.

Serum creatinine > 2.0 mg/dL or creatinine clearance < 40 mL/min measured or calculated by Cockroft-Gault equation.

Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min be obtained within 42 days prior to registration

Calculated creatinine clearance (CrCl) > 30 mL/min

CLINICAL/LABORATORY CRITERIA: Serum creatinine =< 1.5 x IULN OR measured or calculated creatinine clearance >= 40 mL/min; this result must have been obtained within 28 days prior to registration

Creatinine < 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance of >= 50 ml/min

Calculated creatinine clearance ? 30 mL/min

Calculated Creatinine clearance>/= 45ml/min

Calculated creatinine clearance >= 45 ml/min

Serum creatinine =< 2.0 x upper limit of normal (ULN) or calculated creatinine clearance (CrCl) >= 30 mL/min obtained within 28 days prior to registration

Renal: Serum Creatinine ? 1.5 x ULN or creatinine clearance (CrCl) ? 60 mL/min as calculated by the Cockroft-Gault method

Measured or calculated creatinine clearance >= 40 ml/min

AMKL PATIENTS: Creatinine < 1.5 x ULN or calculated creatinine clearance > 30 ml/min

MF PATIENTS: Creatinine < 1.5 x ULN or calculated creatinine clearance > 30 ml/min

Serum creatinine =< ULN within 14 days prior to registration OR calculated creatinine clearance > 50 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to registration

Calculated creatinine clearance > 60 mL/min

Adequate renal function as assessed by serum creatinine ? 2.0 mg/dL; or calculated or 24-hour urine creatinine clearance >40 mL/min.

Calculated or measured creatinine clearance ? 40 mL/min

An average calculated creatinine clearance > 30 mL/min/1.73 m^2

Renal: Serum Creatinine ? 1.5 x ULN or creatinine clearance (CrCl) ? 60 mL/min as calculated by the Cockroft-Gault method

Calculated creatinine clearance > 30 ml/min

Calculated creatinine clearance > 50 mL/min

Calculated creatinine clearance > 50 mL/minute (Appendix 4)

Serum creatinine =< 1.6 mg/dl or a calculated creatinine clearance >= 60 cc/min

Calculated creatinine clearance must be >= 30 mL/minute

Creatinine =< 1.5 mg/dL x upper limits of normal (ULN) OR calculated (calc.) creatinine clearance >= 30 mL/min

Calculated creatinine clearance > 60 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to Step 2 Randomization

Calculated creatinine clearance > 60 ml/min; the serum creatinine value used in the calculation must have been obtained within 14 days prior to Step 3 registration

Creatinine: =< 1.5 mg/dL, OR calculated creatinine clearance >= 40 mL/min (calculated by the modified Cockcroft and Gault method)

Serum creatinine =< 1.5 x upper limit of normal (ULN) for the lab, calculated creatinine clearance >= 60 mL/min or 24-hour creatinine clearance >= 50 mL/min

Calculated creatinine clearance >= 30 mL/min

Calculated creatinine clearance (CrCL) of ? 45 mL/min

Creatinine clearance of >= 40 mL/min, estimated or calculated

Participant has serum creatinine ? 1.5 x ULN. If serum creatinine > 1.5 x ULN the calculated creatinine clearance should be > 40 milliliters/minute (mL/min)

Have calculated creatinine clearance (CrCL) ?30 mL/minute or serum creatinine ?1.5 times below the upper limit of normal.

Serum creatinine ?1.5 times institutional ULN or calculated creatinine clearance >30 mL/min;

Serum creatinine ? 1.5 × ULN or calculated or measured creatinine clearance ? 50 mL/min/1.73 m2

Serum creatinine ? 1.5 x upper limit of normal (ULN) or calculated creatinine clearance ? 60 mL/minute

Serum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 ml/min

Creatinine =< ULN or a calculated creatinine clearance of >= 45 ml/min if creatinine is greater than the ULN

Creatinine =< 1.5 x ULN or creatinine clearance (CrCl) calculated CrCl >= 60 mL/min/1.73m^2

Serum creatinine =< 1.5 x IULN or a calculated or measured creatinine clearance >= 50 mL/min; these tests (including creatinine [mg/dl] if using calculated creatinine clearance) must be obtained within 14 days prior to registration

Calculated creatinine clearance (by Cockroft-Gault) of > 50 ml/min

Renal creatinine =< 1.5 X ULN OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance =< 1.5 X ULN

Calculated creatinine clearance >= 30 mL/min

Creatinine clearance (CrCl) >= 15 mL/minute, either measured or calculated

Calculated or measured creatinine clearance (CrCl) of ? 30 mL/min

Calculated creatinine clearance >= 30 mL/min

Serum creatinine =< 1.5 x ULN, or calculated creatinine clearance >= 60 ml/min

Serum creatinine performed within 4 weeks prior to study entry must be less than or equal to 1.25 x ULN or estimated creatinine clearance less than 60 mL/min (as calculated using the method standard for the institutions).

Patients must have adequate renal function, defined as serum creatinine ? 1.5 x ULN or creatinine clearance (calculated) ? 60 mL/min/1.73 m2 for patients with creatinine > 1.5 x ULN.

Creatinine =< 2.5 mg/dL OR calculated creatinine clearance >= 50 mL/min (as calculated by the Cockcroft-Gault method)

Calculated creatinine clearance >= 60 mL/min

Calculated creatinine clearance > 40 ml/min or 24 hour urine

Creatinine clearance > 30 mL/min (calculated according to institutional standards or using Cockcroft–Gault formula; subjects with requirement of hemodialysis will be excluded)

Serum creatinine > 2.0 x ULN; if creatinine 1.5 - 2.0 x ULN, creatinine clearance will be calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and patients with creatinine clearance < 30 mL/min should be excluded

Calculated creatinine clearance ? 30 milliliter per minute (mL/min).

Creatinine clearance; calculated creatinine clearance (CrCl) >= 30 mL/min and < 60 mL/min (Cockroft-Gault) unless the patient qualified based on hearing loss or neuropathy

Calculated creatinine clearance >= 45 mL/min

Calculated creatinine clearance > 30 ml/min

Calculated creatinine clearance of ? 45 mL/min

Serum creatinine =< 1.5 x the ULN or calculated creatinine clearance >= 60 ml/min

Creatinine clearance > 50 mL/minute within 30 days prior to cycle 1 day 1, either measured or calculated using a standard formula

Serum creatinine =< 2 mg/dL or calculated creatinine clearance of >= 40 ml/min within 14 days of registration using Modification of Diet in Renal Disease (MDRD) formula

Patient has a calculated or measured creatinine clearance of < 30 mL/minute

At least 4 weeks (28 days) prior to registration: Serum creatinine =< 1.5 x ULN or calculated or directly measured creatinine clearance (CrCl) >= 50% LLN (lower limit of normal)

Calculated creatinine clearance ? 60 mL/min.

Creatinine =< 1.8 mg/dL OR a calculated creatinine clearance >= 60 mL/hr within 4 weeks of enrollment

Serum creatinine ? 1.5 × age-adjusted upper limit of normal (ULN) OR calculated creatinine clearance > 30 mL/min

Calculated creatinine clearance > 30 ml/min

Serum creatinine =< 1.5 mg/dL OR measured or calculated creatinine clearance >= 50 mL/min

Serum creatinine =< 1.5 × the institutional ULN; if creatinine is above the ULN, the patient's measured or calculated creatinine clearance (CrCl) must be >= 50 mL/min

Serum creatinine of =< 1.5 mg/dl or calculated creatinine clearance of >= 60 mL/min

Calculated creatinine clearance (CRCL) > 60 mL/min

Adults: calculated creatinine clearance must be > 60 mL and serum creatinine =< 2 mg/dL

Children (< 18 years old): calculated creatinine clearance must be > 60 mL/min

Calculated creatinine (calc. creat.) clearance >= 60 ml/min

Creatinine =< 1.5 x institutional ULN or creatinine clearance (calculated or measured) > 60 ml/min

Serum creatinine =< 1.5 x upper limit of normal OR calculated creatinine clearance >= 50 ml/min

Renal: serum creatinine < 1.5 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 40 ml/min (measured or calculated/estimated)

Either serum creatinine >150 µmol/L (>1.7 mg/dL), or creatinine clearance <50 mL/min calculated by the Cockroft Gault method, eventually confirmed by measured creatinine clearance (or measured glomerular filtration rate (GFR) using plasma clearance methods, not gamma camera-based) <50 mL/min (the measured creatinine clearance / GFR is required only as confirmatory exam).

Serum creatinine =< 1.5 mg/dL or calculated creatinine clearance >= 60 mL/min

Creatinine clearance (calculated creatinine clearance is permitted) should be > 40 ml/min

If > 1.5 mg/dL, calculated creatinine clearance >= 50 mL/min

Serum creatinine =< 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance >= 40 mL/min

Patients with severe renal impairment (creatinine clearance [CrCl] < 30 mL/min); a calculated CrCl is acceptable

Creatinine clearance >= 50 ml/mm (can be calculated)

Serum creatinine =< 1.5 x upper limit of normal (ULN) or calculated creatinine clearance >= 50 mL/min

Serum creatinine =< 1.5 mg/dl or a calculated creatinine clearance >= 60 cc/min

Serum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min

Serum creatinine =< 1.5 x ULN or calculated creatinine clearance >= 60 mL/min

Serum creatinine =< 1.5 x the upper limit of normal or creatinine clearance >= 60 mL/min (measured or calculated)

Serum creatinine =< 1.5 x the upper limit of normal or calculated creatinine clearance >= 60 mL/min

Patient has a calculated or measured creatinine clearance of < 20 ml/minute within 14 days before enrollment

Calculated creatinine clearance (Cockroft-Gault) >= 30ml/min

Creatinine < 1.5 x ULN OR calculated creatinine clearance >= 50 mL/min

Serum creatinine ?1.5 x ULN or calculated 24-hour creatinine clearance ?60 mL/minute

Serum creatinine ?1.5 x upper limit of normal (ULN) or a calculated creatinine clearance >60 mL/min,

Creatinine =< 1.5 x ULN OR calculated creatinine clearance >= 60 ml/min

Calculated creatinine clearance > 30 mL/min/1.73 m^2

Calculated creatinine clearance >= 50ml/min; for adults this will be calculated per the Cockgroft-Gault formula and in pediatric cases this will be calculated per the Schwartz formula

Calculated creatinine clearance >= 45 ml/min

Creatinine < ULN OR calculated creatinine clearance >= 50 mL/min\r\n* Creatinine clearance should be calculated by Cockcroft and Gault method

Creatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 ml/min

Creatinine (Cr) =< 1.5 mg/dL x upper limit of normal (ULN), creatinine clearance (CrCl) >= 50 mL/min calculated by the Cockroft-Gault method

Subjects must have calculated creatinine clearance >= 30 ml/min

Serum creatinine > 2.0 mg/dL or calculated creatinine clearance < 30 ml/min

Calculated (method of Cockroft-Gault) creatinine clearance <60 mL/min.

Baseline serum-creatinine > 2.0 mg/dl and a calculated or measured creatinine clearance of < 50 ml/minute

Serum creatinine <1.5 x upper limit of normal (ULN) or estimated creatinine clearance 60 mL/min (as calculated using the standard method of the institution);

Adequate renal function defined as serum creatinine ? 1.5x upper limit of normal (ULN) for age. If the serum creatinine is above these values, the calculated creatinine clearance or radioisotope GFR must be ? 70 mL/min/1.73m2.

Creatinine of measured or calculated creatinine clearance of >= 50 cc/min

Renal: Serum creatinine ? 1.5 x ULN OR calculated creatinine clearance (CrCl) > 30 ml/min as calculated by the Cockcroft-Gault method

Calculated creatinine clearance >= 30 mL/min

Renal: Serum creatinine < 1.5 x ULN OR calculated creatinine clearance (CLcr) ? 60 ml/min

Renal: Serum creatinine < ULN OR calculated creatinine clearance (CLcr) of ? 60 ml/min

Serum creatinine > 1.5 x ULN and/or measured or calculated creatinine clearance < 75% LLN (lower limit of normal) Bone marrow function:

Creatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 mL/min (please use institutional formula)

Calculated creatinine clearance >= 30 mL/min

Serum creatinine < ULN OR calculated creatinine clearance (CrCl) of ? 60 ml/min

Calculated creatinine clearance >= 30 mL/min

Calculated creatinine clearance (CrCl) of greater than or equal to 50 or serum creatinine less than 2 x ULN; even if organ function abnormalities are considered due to tumor, the upper limit for creatinine is less than or equal to 2 mg/dL

Serum creatinine =< 1.5 x ULN or calculated creatinine clearance > 50 mL/min

Urothelial cancer patients should be ineligible for cisplatin based on one or more of the following:\r\n* Calculated creatinine clearance of < 60 mL/min (but >= 30 mL/min)\r\n* Solitary kidney\r\n* Karnofsky performance status < 80%

Serum creatinine < 2 or calculated creatinine clearance (CrCl) >= 30 mL/min

Serum creatinine =< 1.5 mg/dl or measured or calculated creatinine clearance >= 50 ml/min

Calculated or measured creatinine clearance (CrCl) >= 30 mL/min

Creatinine clearance > 30 mL/min (calculated according to institutional standards or using Cockcroft–Gault formula), +/- 7 days from date of ICF signing

Calculated creatinine clearance of ? 60 ml/min.

Creatinine =< 1.5 x laboratory upper limit of normal or calculated creatinine clearance of >= 50 ml/min

Serum creatinine =< 1.5 x upper limit of normal (ULN), or, calculated creatinine clearance (CrCl) >= 50 mL/min

Serum creatinine ? 2.0 mg/dL or calculated creatinine clearance of ? 60 mL/min

Serum Creatinine < 1.5 x ULN (upper limit of normal) or estimated creatinine clearance ? 60 mL/min, as calculated using method standard for the institution (Appendix 2).

Calculated creatinine clearance >= 40 ml/min or 24 hour urine

Creatinine clearance equal or > 50 ml/min (calculated)

Creatinine clearance < 50 ml/min (calculated)

Creatinine < 1.5 times the upper limit of normal (ULN) or creatinine clearance > 40 mL/min (as measured or calculated by Cockroft-Gault formula)

Serum creatinine ? 1.5 x upper limit of normal (ULN) or calculated creatinine clearance > 60 mL/min if the serum creatinine is > 1.5 x ULN

Serum creatinine ? 1.5 x ULN, or calculated creatinine clearance ? 40 mL/min (if renal impairment is suspected 24-hour urine collection for measurement is required).

Calculated or measured creatinine clearance >= 50 ml/min or serum creatinine =< 1.6 mg/dl

Serum creatinine >= 1.5 times the upper normal limit or calculated/measured creatinine clearance =< 60 mL/min

Creatinine ? 1.5 x ULN, or calculated or measured creatinine clearance ? 50 mL/min, or 24-hour measured urine creatinine clearance ? 50 mL/min.

Measured creatinine clearance or calculated creatinine clearance > 30 mL/minute. Note: If a calculated creatinine clearance is used, it should be calculated according to the Cockcroft-Gault formula.

Creatinine ? 1.5 × institutional ULN or Creatinine Clearance > 50 ml/min (as calculated by the Cockroft-Gault equation) within 14 days prior to randomization.

Patient must have a calculated creatinine clearance or radioisotope GFR > 60mL/min/1.73m2 or a normal serum creatinine based on age/gender

Serum creatinine <=1.2 mg/dL or calculated/measured creatinine clearance >=50 mL/minute

Calculated or measured creatinine clearance >= 45 mL/min

Creatinine >= 1.5 × ULN for the institution (or a calculated creatinine clearance < 60 mL/min/1.73 m2)

Serum creatinine =< 1.5 x ULN OR calculated creatinine clearance >= 50 mL/min

A calculated creatinine clearance (CrCl) that meets entry criteria for enrollment (ie, calculated CrCl either ? 90 or < 30 mL/min

Serum creatinine > 1.5× ULN (or a calculated creatinine clearance < 60 mL/min/1.73 m2)

Calculated creatinine clearance by Modification of Diet in Renal Disease (MDRD) (CrCL) > 50 ml/min/1.73 squared meter

Kidney disease with a calculated creatinine clearance <30% normal value.

Serum creatinine =< 1.5 x ULN or serum creatinine > 1.5-3 x ULN if calculated creatinine clearance (CrCl) is >= 30 mL/min using the Cockroft-Gault equation

Calculated creatinine clearance (CrCl) >= 50 mL/min (modification of diet in renal disease [MDRD] Formula)

Creatinine < 1.5 x the upper limit of normal (ULN) or calculated creatinine clearance >= 50 cc/min

Serum creatinine ? 2.0 mg/dL or calculated creatinine clearance ?60 mL/min

Calculated creatinine clearance >= 60 mL/min

Patient has a calculated or measured creatinine clearance of < 20 mL/minute within 14 days prior to treatment initiation

Calculated creatinine clearance > 30 ml/min (unless demonstrated Hodgkin lymphoma involvement of the kidney)

Patient has adequate renal function (calculated creatinine clearance of ?30 mL/min according to the Cockroft-Gault)

MDRD calculated or measured CrCl of ?30 mL/min

MDRD calculated or measured CrCl of ?30 mL/min

Calculated creatinine clearance >= 30 mL/min

Calculated creatinine clearance > 50 mL/min.

Serum creatinine =< 1.5 mg/dL or calculated creatinine clearance >= 60 mL/min

Calculated creatinine clearance > 50 mL/min.

Serum creatinine < 2mg/dl and calculated creatinine clearance >10ml/min.

Calculated creatinine clearance > 20 mL/min per institutional standard

Serum creatinine < 1.5 mg/dl and/or calculated or measured creatinine clearance (CrCl) >= 30 ml/min

Calculated or measured creatinine clearance >= 60 mL/min

Creatinine =< 2.0 mg/dL or calculated creatinine clearance >= 40

Calculated creatinine clearance >= 30 mL/min\r\n* For females, use 85% of calculated creatinine clearance (CrCl) value

Renal insufficiency (defined as calculated creatinine clearance < 30 mL/min)

Severe renal impairment (calculated creatinine clearance =< 29 cc/min)

Creatinine clearance (calculated or measured) of < 50 cc/minute

Calculated creatinine clearance < 30 ml/min; creatinine clearance will be calculated using the Modification of Diet in Renal Disease (MDRD) method

Renal: serum creatinine < 1.2 mg/dl or if serum creatinine is outside the normal range, then creatinine clearance (CrCl) > 50 ml/min (measured or calculated/estimated)

Patients must have a calculated creatinine clearance > 30 mL/min; the serum creatinine value used in the calculation must have been obtained within 28 days prior to registration

Calculated or measured creatinine clearance >= 30 mL/min

Creatinine clearance (24 hour or calculated) > 50 ml/min

Serum creatinine of < 1.5 mg/dl or calculated creatinine clearance > 50 ml/min

Renal disease, and we will use a calculated serum creatinine clearance over 30 ml/min at the screening appointment as an exclusion criteria

Patients with calculated creatinine clearance (Cockroft-Gault) less than 35 mL/min

Creatinine clearance calculated >= 50 mL/min

Creatinine ?2.0 mg/dL or calculated creatinine clearance ?50 mL/min

Creatinine clearance < 50 ml/min (calculated or measured)

Creatinine clearance < 50 mL/min (calculated or measured)

Calculated creatinine clearance ? 50 mL/min

Calculated creatinine clearance >= 30 mL/min

Serum creatinine < 1.5 x upper limit of normal (ULN) or a calculated creatinine clearance >= 60 mL/min

Creatinine =< 1.5 x ULN OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance >= 50 mL/min

Calculated creatinine clearance >= 30 mL/min using the Calvert Formula

Serum creatinine =< 4.0 x ULN or calculated or directly measured creatinine clearance (CrCl) >= 50% of LLN (lower limit of normal)

Have a calculated creatinine clearance >= 50 mL/min

NORMAL VOLUNTEERS: Have a calculated creatinine clearance >= 50 ml/min

Serum creatinine =< 2.0 mg/dl (calculated creatinine clearance > 45 ml/min)

Serum creatinine =< 1.5 x institutional ULN or calculated or measured 24-hour clearance >= 50 mL/min

Calculated creatinine clearance >= 30 mL/min

Have adequate renal function, defined as serum creatinine levels ?2.0 ULN or calculated creatinine clearance >45 mL/min.

Creatinine =< 1.5 X ULN OR calculated creatinine clearance >= 50 mL/min OR 24-hour urine creatinine clearance >= 50 mL/min

calculated creatinine clearance > 100 mL/min/1.73 m2

Adequate renal function (calculated creatinine clearance ? 30 mL/min)

Creatinine < 1.5 x ULN. If >1.5 x ULN, patient may still be eligible if calculated creatinine clearance >50 mL/min (0.83mL/s) as calculated by the Cockcroft-Gault method.

Calculated creatinine clearance >= 60 mL/min

Measured or calculated creatinine clearance (CrCl; GFR can also be used in place of CrCl) >= 30 mL/min