Cluster 0: cypa strong inhibitors inducers cytochrome subfamily family polypeptide medications moderate Cluster 1: infection requiring systemic active therapy antibiotics antibiotic intravenous treatment days Cluster 2: transaminase serum aminotransferase glutamic oxaloacetic sgot sgpt upper normal pyruvate Cluster 3: bilirubin mg dl total syndrome gilberts gilbert serum direct unless Cluster 4: investigational participated study device participating currently agent weeks therapy dose Cluster 5: phase ii patients aim prior expansion cohort portion study treatment Cluster 6: creatinine clearance min ml serum mg dl estimated uln crcl Cluster 7: consent informed procedures study specific provide written prior signed ability Cluster 8: metastasis brain leptomeningeal known distant patients symptomatic suspected cns evidence Cluster 9: expectancy life weeks greater patients estimated years equal investigator year Cluster 10: women contraception men childbearing potential use adequate unwilling pregnant study Cluster 11: cardiac significant disease arrhythmia function history impaired arrhythmias requiring uncontrolled Cluster 12: hiv positive known immunodeficiency virus human infection patients cd aids Cluster 13: contraceptive use potential effective reproductive method study methods men agreed Cluster 14: qtc interval qt msec corrected prolongation ecg electrocardiogram prolonged milliseconds Cluster 15: males females years age older aged time consent old non Cluster 16: hemoglobin dl transfusion days mmol prior transfusions registration erythropoietin transfused Cluster 17: hgb hemoglobin dl transfusion achieve intervention acceptable days note use Cluster 18: hemoglobin dl mmol gm hb mg greater level weeks phase Cluster 19: platelets mm cells days anc prior transfusion registration obtained plt Cluster 20: received prior therapy patients treatment previously systemic days study weeks Cluster 21: heart angina myocardial infarction unstable congestive failure cardiac months uncontrolled Cluster 22: hepatitis virus immunodeficiency hiv human infection known active hcv hbv Cluster 23: cancer cell basal squamous adequately skin treated years situ malignancy Cluster 24: granulocyte colony stimulating csf factor count mm absolute factors macrophage Cluster 25: surgery prior patients weeks days radiation patient major treatment planned Cluster 26: breast cancer invasive diagnosis prior patients inflammatory metastatic carcinoma dcis Cluster 27: pregnancy lactation breastfeeding current test positive women testing time standards Cluster 28: neutrophil absolute count anc mm cells days registration prior support Cluster 29: signed informed consent written form dated patient guardian study document Cluster 30: ecog performance status appendix patients score scale equal adequate patient Cluster 31: feeding breast pregnant women females pregnancy female patients lactating planning Cluster 32: samples research provide purposes correlative blood willing tissue mandatory willingness Cluster 33: corticosteroids inhaled topical steroids systemic prednisone immunosuppressive mg doses daily Cluster 34: ps ecog performance eastern cooperative oncology group status score scale Cluster 35: bone marrow function adequate involvement cells blood biopsy patients prior Cluster 36: organ transplant history allogeneic solid allograft allografts corneal marrow bone Cluster 37: childbearing potential pregnancy test negative female serum females urine prior Cluster 38: illness compliance social requirements psychiatric intercurrent situations uncontrolled limit study Cluster 39: platelets ul plt ml microliter cells days transfusion registration prior Cluster 40: mcl platelets days initiation performed treatment registration prior transfusion obtained Cluster 41: bilirubin upper normal limit total uln institutional times gilberts syndrome Cluster 42: ul platelet count lymphocyte neutrophils transfusion independent days obtained prior Cluster 43: measurable disease evaluable lesion patients non defined cm lesions criteria Cluster 44: pregnant women excluded study patients planning currently female females patient Cluster 45: grade toxicity alopecia toxicities prior therapy related recovered resolved previous Cluster 46: platelet mm count days cells transfusion prior transfusions obtained independent Cluster 47: interstitial lung pneumonitis disease history evidence active infectious pulmonary ild Cluster 48: contraception methods intrauterine barrier device method use condom potential effective Cluster 49: therapy steroid immunosuppressive form systemic receiving immunodeficiency diagnosis dose days Cluster 50: therapies prior received number anti patients therapy cancer anticancer treatment Cluster 51: rituximab containing prior therapy treatment regimen refractory months received chemotherapy Cluster 52: effects recovered prior toxic therapy acute fully grade chemotherapy radiotherapy Cluster 53: pressure mmhg blood systolic diastolic hypertension bp uncontrolled controlled antihypertensive Cluster 54: pd programmed anti death ligand cell lymphocyte ctla antibody cytotoxic Cluster 55: bleeding diathesis active history disorder disorders gastrointestinal known significant evidence Cluster 56: hemorrhage intracranial stroke months history enrollment prior hemoptysis study dose Cluster 57: fraction ejection left ventricular lvef cardiac echocardiogram shortening lower normal Cluster 58: willingness understand sign ability written document informed consent subjects subject Cluster 59: aminotransferase ast alt aspartate alanine uln upper normal limit times Cluster 60: eastern cooperative oncology group ecog performance status karnofsky score scale Cluster 61: bowel gastrointestinal malabsorption resection vomiting absorption nausea small significantly disease Cluster 62: pneumonitis organizing fibrosis idiopathic pneumonia induced pulmonary history chest obliterans Cluster 63: transplant stem cell allogeneic autologous prior hematopoietic months received patients Cluster 64: inr normalized ratio international time uln prothrombin pt thromboplastin partial Cluster 65: days prior registration study therapy treatment dose radiotherapy enrollment growth Cluster 66: study pregnant inform suspect immediately agree contraception woman barrier duration Cluster 67: histologically confirmed cytologically adenocarcinoma diagnosis prostate metastatic cancer nsclc cell Cluster 68: compliance psychological safety condition protocol study conditions psychiatric medical procedures Cluster 69: staff medical regimens conduct history noncompliance compliance study planning non Cluster 70: concurrent therapy investigational agents chemotherapy cancer treatment use immunotherapy anti Cluster 71: ct pet tomography scan computed emission positron imaging mri disease Cluster 72: vaccines live attenuated influenza flu seasonal allowed inactivated intranasal vaccine Cluster 73: mcl neutrophil absolute count anc days initiation performed treatment registration Cluster 74: mm longest measured measurable accurately lesion dimension diameter ct recorded Cluster 75: bacterial fungal viral infection active uncontrolled infections systemic requiring antibiotics Cluster 76: patients eligible study excluded therapy prior treated treatment receiving receive Cluster 77: hodgkin lymphoma non nhl cell refractory relapsed classical autologous confirmed Cluster 78: english read speak speaking able understand write spanish ability language Cluster 79: imaging resonance magnetic mri ct tomography computed scan disease brain Cluster 80: inability comply procedures unwillingness follow protocol study swallow requirements pills Cluster 81: hepatitis positive virus hcv antibody hbv antigen surface infection test Cluster 82: ctcae grade nci neuropathy hemorrhage version event bleeding diarrhea alopecia Cluster 83: trial confound best abnormality results interfere participate laboratory duration current Cluster 84: vascular peripheral aortic disease aneurysm significant arterial repair thrombosis collagen Cluster 85: organ function adequate marrow defined hematologic end laboratory bone days Cluster 86: brain metastases known patients treated stable trial excluded clinical evidence Cluster 87: protein urine ratio mg hour serum light dl proteinuria chain Cluster 88: illness medical psychiatric interfere condition prevent opinion abnormality potentially likely Cluster 89: carcinoma cell skin basal squamous situ malignancy years cervix treated Cluster 90: expecting conceive trial projected screening children father visit breastfeeding duration Cluster 91: monoclonal antibody reaction hypersensitivity severe history antibodies reactions infusion mab Cluster 92: half lives shorter whichever investigational prior weeks days drug therapy Cluster 93: disease progression progressive patients evidence leptomeningeal therapy refractory treatment prior Cluster 94: participant research study received treatment therapy prior disease receiving investigator Cluster 95: sarcoma soft tissue ewing oncogene homolog tumor diagnosis confirmed rhabdomyosarcoma Cluster 96: albumin dl serum mg days initiation treatment performed gm registration Cluster 97: unable unwilling protocol comply follow requirements study consent patients abide Cluster 98: live vaccine days attenuated received prior dose study vaccination receipt Cluster 99: tissue tumor biopsy archival available sample slides obtained fresh paraffin Cluster 100: leukemia aml promyelocytic acute apl mds myeloid diagnosis myelodysplastic patients Cluster 101: immunodeficiency hiv virus human known positive infection history antibodies acquired Cluster 102: platinum based chemotherapy regimen disease progression therapy line prior resistant Cluster 103: contraindication contrast mri hypersensitivity known drugs allergy concomitant including gadolinium Cluster 104: surgically childbearing sterile potential abstain heterosexual activity sterilized study subjects Cluster 105: limits normal institutional bilirubin total upper creatinine serum potassium uln Cluster 106: chemotherapy prior received cytotoxic patients regimen treatment cancer regimens systemic Cluster 107: bilirubin uln total direct serum syndrome gilbert gilberts levels subjects Cluster 108: normal limit upper creatinine uln serum times institutional alt ast Cluster 109: lactating pregnant women females female patients breastfeeding study excluded subject Cluster 110: alcohol abuse drug history substance current known dependence active illicit Cluster 111: risk high intermediate ipss mds prognostic scoring international patients disease Cluster 112: healing wound fracture ulcer non bone presence major days active Cluster 113: diagnosed newly cancer malignancy patients years previously disease nonmelanoma residual Cluster 114: therapy prior anti chemotherapy systemic cancer hormonal treatment patients radiation Cluster 115: weeks earlier administered adverse events recovered agents prior entering study Cluster 116: recist measurable disease version criteria defined according lesion evaluable based Cluster 117: inhibitor prior treatment kinase therapy received parp mek cdk mtor Cluster 118: radiation therapy prior weeks chemotherapy treatment patients study received palliative Cluster 119: white wbc blood cell cells ul count mm mcl days Cluster 120: stage iv iii cancer disease ajcc melanoma ii breast nsclc Cluster 121: bmi mass index body kg obese overweight greater patients weight Cluster 122: function adequate liver renal marrow bone kidney defined hematological inadequate Cluster 123: tumor biopsy primary cm patients biopsies solid accessible size resection Cluster 124: aptt activated thromboplastin partial ptt anticoagulant intended anticoagulants time pt Cluster 125: receptor er ihc negative estrogen positive progesterone hybridization fish breast Cluster 126: tuberculosis tb bacillus active known history previous clinical diagnosis latent Cluster 127: inclusion criteria apply meet registration cohort patients additional specific protocol Cluster 128: infections active uncontrolled requiring antibiotics systemic illnesses opportunistic patients medical Cluster 129: cr remission complete induction response aml leukemia pr patients relapse Cluster 130: heparin low molecular weight warfarin anticoagulation therapeutic aspirin dose lmwh Cluster 131: concurrently investigational receiving agents study patients therapy treatment agent using Cluster 132: glioma world organization grade health glioblastoma diagnosis histologically confirmed iv Cluster 133: contraception use effective agree potential study childbearing male method female Cluster 134: drug study dose days administration prior weeks investigational therapy experimental Cluster 135: ischemic transient thrombosis attack cerebrovascular accident deep months embolism history Cluster 136: qt long syndrome congenital history family qtc interval msec corrected Cluster 137: cancer diagnosis lung ovarian small cell primary center patients non Cluster 138: pembrolizumab excipients hypersensitivity severe known grade epacadostat substance active history Cluster 139: months survival prior past expected enrollment study history treatment therapy Cluster 140: pulmonary obstructive disease chronic severe requiring copd antibiotics hospitalization history Cluster 141: common terminology adverse ctcae events grade criteria version institute national Cluster 142: hla donor matched leukocyte antigen unrelated drb related typing human Cluster 143: treatment prior previous study patients weeks therapy allowed dose anti Cluster 144: consent informed able sign understand willing written form document patient Cluster 145: fasting glucose mg dl mmol triglycerides cholesterol serum plasma diabetes Cluster 146: agents investigational receiving patients currently participants study anti eligible cancer Cluster 147: equal greater years age dl count platelets hemoglobin mm platelet Cluster 148: inhibitors prior kinase treatment tyrosine therapy mtor patients use pik Cluster 149: nervous central cns metastases active known untreated disease meningitis lymphoma Cluster 150: hepatitis active infection known chronic hiv history positive viral patients Cluster 151: step registration prior randomization days eligibility crossover criteria dl patients Cluster 152: pneumonitis infectious non history steroids required current evidence active known Cluster 153: egfr alk mutation tki exon kinase mutations epidermal receptor treatment Cluster 154: leukemia acute plasma chronic cell lymphoblastic myeloid myelogenous lymphoma cml Cluster 155: response criteria recist solid evaluation tumors measurable disease version evaluable Cluster 156: capacity forced predicted dlco carbon monoxide fev expiratory volume diffusing Cluster 157: test pregnancy negative urine serum positive female hours confirmed study Cluster 158: laboratory values parameters clinical following abnormalities study places clia range Cluster 159: fcbp agree contact sexual vasectomy condom latex successful potential lenalidomide Cluster 160: absorption gastrointestinal gi interfere disease alter oral malabsorption significantly disorders Cluster 161: diabetes mellitus type uncontrolled controlled poorly ac insulin hbac glucose Cluster 162: autoimmune disease active history systemic past requiring suspected vitiligo immunosuppressive Cluster 163: major surgery weeks prior study days recovered drug dose effects Cluster 164: hamster chinese ovary hypersensitivity recombinant products antibodies known human cell Cluster 165: stable dose decreasing corticosteroids prior days patients weeks corticosteroid enrollment Cluster 166: time pt prothrombin thromboplastin ptt partial inr uln normalized ratio Cluster 167: consent informed written voluntary sign guidelines nature legal accordance patients Cluster 168: month prior therapy study investigational treatment patients enrollment hemoptysis use Cluster 169: hormone releasing lhrh luteinizing therapy agonist thyroid androgen orchiectomy gnrh Cluster 170: investigational agent days treatment study prior weeks received drug receiving Cluster 171: hypersensitivity known excipients components history component drugs study formulation excipient Cluster 172: weeks prior radiotherapy therapy chemotherapy study treatment dose nitrosoureas mitomycin Cluster 173: illness pectoris social situations intercurrent arrhythmia uncontrolled compliance congestive limited Cluster 174: pugh child class score hepatic impairment cirrhosis liver severe classification Cluster 175: advanced locally metastatic unresectable disease histologically cancer confirmed solid recurrent Cluster 176: creatinine calculated clearance min ml serum measured uln crcl mg Cluster 177: allergy known hypersensitivity components history study excipients formulations drug formulation Cluster 178: score karnofsky lansky performance years age patients kps ambulatory wheelchair Cluster 179: bearing child potential pregnancy test women negative pregnant serum female Cluster 180: retinal rvo occlusion vein history evidence current retinopathy serous risk Cluster 181: following criteria meet patients treatment disease prior therapy defined progression Cluster 182: history primary immunodeficiency disease prior known hypertensive pancreatitis leptomeningeal patients Cluster 183: hepatitis reactive qualitative hbsag rna detected hcv ribonucleic surface acid Cluster 184: creatinine uln serum times institutional renal days registration obtained prior Cluster 185: lymph node nodes axillary sentinel cm biopsy dissection disease regional Cluster 186: significant clinically disease cardiac history uncontrolled pulmonary investigator active ecg Cluster 187: seizure disorder history patients seizures medication brain requiring uncontrolled controlled Cluster 188: adjuvant chemotherapy neoadjuvant therapy prior setting months metastatic neo treatment Cluster 189: hypertension uncontrolled diabetes controlled despite pulmonary poorly history medical hypertensive Cluster 190: pacemaker metal implanted clips implants mri metallic devices pacemakers aneurysm Cluster 191: age years time patients consent donor men old lansky women Cluster 192: liver uln disease metastases chronic cirrhosis alt ast hepatitis patients Cluster 193: inappropriate make judgment study investigator severe interfere patient entry increase Cluster 194: donor donors matched unrelated related blood cell infusion lymphocyte haploidentical Cluster 195: nursing pregnant women female patients females excluded lactating study mothers Cluster 196: mg dl creatinine serum years age maximum male calcium female Cluster 197: hepatic function adequate renal marrow bone defined hematological coagulation cardiac Cluster 198: breastfeeding pregnant women females female patients excluded patient subject study Cluster 199: return follow institution enrolling willing monitoring phase active mayo study Cluster 200: mri contrast undergo ct patients unable brain scan imaging contraindications Cluster 201: filtration glomerular rate min ml gfr creatinine estimated clearance renal Cluster 202: malignancy active years history concurrent treatment second prior requiring patients Cluster 203: carcinoma cell squamous small urothelial adenocarcinoma histologically clear histology renal Cluster 204: alkaline phosphatase uln limit normal upper liver alp times bone Cluster 205: pelvic radiation prior radiotherapy irradiation previous abdominal therapy history patients Cluster 206: hematologic function adequate renal hepatic inadequate coagulation liver defined toxicity Cluster 207: autoimmune requiring psoriasis vitiligo diabetes recur hypothyroidism trigger type mellitus Cluster 208: msec qtcf interval fridericia qt formula corrected ecg screening correction Cluster 209: disease inflammatory bowel colitis autoimmune ulcerative history arthritis systemic lupus Cluster 210: swallow capsules tablets able unable patients inability intact pills ability Cluster 211: cord spinal compression brain metastases leptomeningeal untreated symptomatic stable disease Cluster 212: expectancy life months greater estimated investigator opinion patients anticipated predicted Cluster 213: involvement nervous central cns known active lymphoma leukemia patients malignancy Cluster 214: creatinine institutional clearance normal levels min ml uln upper calculated Cluster 215: recovered therapy prior grade note molecule complications targeted administered adequately Cluster 216: neuropathy grade peripheral sensory pain motor greater existing higher patients Cluster 217: immediate reaction hypersensitivity idiosyncrasy chemically delayed drugs related dmso excipients Cluster 218: platelet count mcl days transfusion prior transfusions plt dl ml Cluster 219: board review irb approved institutional consent informed sign understand written Cluster 220: cancer skin non melanoma malignancy situ years carcinoma cervix invasive Cluster 221: infection active uncontrolled patients ongoing antibiotics eligible presence evidence systemic Cluster 222: composition compounds chemical similar attributed allergic reactions biologic history used Cluster 223: products hypersensitivity blood known murine investigational tobacco containing study allergy Cluster 224: contraception dose study agree male method adequate abstinence use starting Cluster 225: karnofsky performance status kps scale score lansky patients greater ecog Cluster 226: transaminase aminotransferase serum uln sgpt glutamic sgot alt oxaloacetic alanine Cluster 227: cll lymphocytic sll leukemia chronic iwcll diagnosis lymphoma transformation treatment Cluster 228: psa ng ml prostate rising progression value specific antigen prostatectomy Cluster 229: years older age male female aged patients subjects time consent Cluster 230: exclusion criteria registration apply cohort treatment specific patients tnbc pre Cluster 231: myeloma multiple diagnosis relapsed refractory imwg therapy criteria working prior Cluster 232: interfere results study interpretation condition medical investigator participation opinion evaluation Cluster 233: oxygen air room pulse oximetry saturation supplemental rest dyspnea pulmonary Cluster 234: cooperation substance abuse disorders interfere psychiatric requirements trial known study Cluster 235: rems program revlimid registered mandatory comply willing requirements mitigation able Cluster 236: myocardial infarction months angina unstable history prior coronary study stroke Cluster 237: uncontrolled medical severe disease active infection conditions seizures concurrent disorder Cluster 238: eligibility criteria medi phase cohort ii study cancer meet registration Cluster 239: altered prohibit understanding mental rendering dementia consent informed status psychiatric Cluster 240: oral medications able medication inability ability patients absorption gastrointestinal tolerate Cluster 241: standard therapy care advanced solid metastatic refractory available histologically confirmed Cluster 242: weight loss months hearing lbs body past pounds unintentional program Cluster 243: opinion condition investigator medical study subject compromise patient participation safety Cluster 244: comply visits procedures willing able study scheduled follow protocol ability Cluster 245: mg equivalent prednisone day dose corticosteroids daily corticosteroid systemic steroids Cluster 246: hcc hepatocellular diagnosis systemic carcinoma sorafenib prior fibrolamellar confirmed liver Cluster 247: treated situ cancer adequately carcinoma curatively years curative intent malignancy Cluster 248: antiretroviral combination hiv immunodeficiency positive ineligible virus human therapy patients Cluster 249: metformin taking hypersensitivity reason subjects insulin currently known patients doxycycline Cluster 250: muga fraction echocardiogram acquisition ejection scan gated left ventricular lvef Cluster 251: abdominal perforation fistula gastrointestinal abscess intra history months obstruction gi Cluster 252: women pregnancy test childbearing negative potential serum days prior urine Cluster 253: cns metastases nervous central patients disease stable symptomatic treated brain Cluster 254: lymphoma cell large follicular diffuse dlbcl mantle zone refractory marginal Cluster 255: longer whichever half lives investigational drug days study prior treatment Cluster 256: pd inhibitor ctla prior anti treatment therapy including durvalumab previous Cluster 257: blasts marrow bone leukemia aml blood mds peripheral refractory patients Cluster 258: cardiovascular significant disease clinically uncontrolled history including evidence pulmonary condition Cluster 259: traumatic injury major procedure significant surgical open biopsy days study Cluster 260: prostate cancer adenocarcinoma prior biopsy therapy diagnosis treatment prostatectomy chemotherapy Cluster 261: replacement systemic modifying thyroxine pituitary disease autoimmune insulin physiologic adrenal Cluster 262: surgical procedure resection major prior days study weeks biopsy patients Cluster 263: syndrome myelodysplastic history poems malabsorption organomegaly endocrinopathy polyneuropathy gilbert changes Cluster 264: severe infection immunodeficiency disease moderate pneumonia bacteremia hospitalization impairment complications Cluster 265: metastatic disease evidence patients distant prior chemotherapy therapy recurrent cancer Cluster 266: provide consent informed written able willing trial assent ability patients Cluster 267: host graft gvhd versus disease transplant active stem allogeneic acute Cluster 268: wort st phenytoin carbamazepine phenobarbital cypa rifampin johns inducers rifabutin Cluster 269: kg body weight area surface bsa cells cd weigh patients Cluster 270: ms qt interval corrected qtc qtcf fridericia mean correction ecg Cluster 271: use medications prohibited medication drugs taking current study prior concomitant Cluster 272: ventricular heart arrhythmias fibrillation uncontrolled history myocardial block infarction failure Cluster 273: zubrod performance status patients registration days prior step ps karnofsky Cluster 274: patient study subjects prior diagnosis participants subject clinical known blood Cluster 275: birth control potential effective use study method agree childbearing women Cluster 276: start treatment prior study weeks days trial investigational therapy radiotherapy Cluster 277: hcg chorionic gonadotropin beta human test pregnancy negative women potential Cluster 278: neck head radiation squamous carcinoma cancer cell prior therapy cavity Cluster 279: physical examination activity history registration compulsorily detained days prior exam Cluster 280: immunosuppressive systemic corticosteroids medications therapy treatment chronic use medication agents Cluster 281: creatinine gault cockcroft clearance min ml formula calculated using equation Cluster 282: access venous internet computer telephone central placement phone adequate sampling Cluster 283: bilateral hysterectomy oophorectomy potential consecutive postmenopausal months childbearing tubal undergone Cluster 284: leukocytes mcl ul mm microliter days registration obtained ml phase Cluster 285: swallow oral retain able medication ability pills medications orally bowels Cluster 286: finding metabolic reasonable suspicion contraindicates examination render dysfunction physical giving Cluster 287: testosterone ng dl castrate serum level nmol levels castration androgen Cluster 288: mother breastfeeding discontinued pregnant excluded women treated study agents potential Cluster 289: coagulopathy bleeding diathesis evidence history anticoagulation significant therapeutic absence disorder Cluster 290: requirements comply able study protocol adhere schedule visit monitoring safety Cluster 291: anti pd ctla antibody prior therapy received checkpoint targeting agent Cluster 292: ul neutrophil absolute count anc cells days peripheral registration prior Cluster 293: hg pressure mm blood systolic hypertension diastolic uncontrolled bp despite Cluster 294: lipase amylase uln serum pancreatitis radiologic normal clinical pancreatic evidence Cluster 295: allergic reactions reaction history anaphylactic severe hypersensitivity humanized proteins antibodies Cluster 296: transplantation allogeneic stem organ cell prior solid autologous hematopoietic marrow Cluster 297: warfarin anticoagulation vitamin antagonists therapeutic use patients receiving concomitant requires Cluster 298: pleural ascites effusion effusions pericardial requiring paracentesis drainage clinically thoracentesis Cluster 299: heart york association new failure class congestive nyha iv iii