{
    "info": {
        "nct_id": "NCT03495609",
        "official_title": "The Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers",
        "inclusion_criteria": "* premenopausal women\n* BRCA1 carrier\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 30 Years",
        "exclusion_criteria": "* History of allergic reaction to compounds of similar chemical or biologic composition to hCG\n* receiving medication that could interfere with the study protocol objectives (hormonal contraceptives, androgens, prednisone, thyroid hormones, insulin)\n* previous treatment with follicle stimulating hormone for assisted reproduction\n* uncontrolled intercurrent illness\n* Heart disease\n* Severe cognitive decline\n* Psychiatric desease\n* HIV positive\n* Hepatitis B or C infection",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* premenopausal women",
            "criterions": [
                {
                    "exact_snippets": [
                        "premenopausal women"
                    ],
                    "criterion": "menopausal status",
                    "requirement_type": "specific status",
                    "expected_value": "premenopausal"
                }
            ]
        },
        {
            "line": "* BRCA1 carrier",
            "criterions": [
                {
                    "exact_snippets": [
                        "BRCA1 carrier"
                    ],
                    "criterion": "BRCA1",
                    "requirement_type": "carrier status",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": [
                        "Must be FEMALE"
                    ],
                    "criterion": "gender",
                    "requirement_type": "specific value",
                    "expected_value": "female"
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 30 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 30 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 30
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* History of allergic reaction to compounds of similar chemical or biologic composition to hCG",
            "criterions": [
                {
                    "exact_snippets": [
                        "History of allergic reaction"
                    ],
                    "criterion": "allergic reaction",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "compounds of similar chemical or biologic composition to hCG"
                    ],
                    "criterion": "compounds",
                    "requirement_type": "composition",
                    "expected_value": "similar to hCG"
                }
            ]
        },
        {
            "line": "* receiving medication that could interfere with the study protocol objectives (hormonal contraceptives, androgens, prednisone, thyroid hormones, insulin)",
            "criterions": [
                {
                    "exact_snippets": [
                        "receiving medication that could interfere with the study protocol objectives"
                    ],
                    "criterion": "medication",
                    "requirement_type": "interference with study protocol",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "hormonal contraceptives"
                    ],
                    "criterion": "hormonal contraceptives",
                    "requirement_type": "usage",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "androgens"
                    ],
                    "criterion": "androgens",
                    "requirement_type": "usage",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "prednisone"
                    ],
                    "criterion": "prednisone",
                    "requirement_type": "usage",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "thyroid hormones"
                    ],
                    "criterion": "thyroid hormones",
                    "requirement_type": "usage",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "insulin"
                    ],
                    "criterion": "insulin",
                    "requirement_type": "usage",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* previous treatment with follicle stimulating hormone for assisted reproduction",
            "criterions": [
                {
                    "exact_snippets": [
                        "previous treatment with follicle stimulating hormone"
                    ],
                    "criterion": "follicle stimulating hormone treatment",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "assisted reproduction"
                    ],
                    "criterion": "assisted reproduction",
                    "requirement_type": "purpose",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* uncontrolled intercurrent illness",
            "criterions": [
                {
                    "exact_snippets": [
                        "uncontrolled intercurrent illness"
                    ],
                    "criterion": "intercurrent illness",
                    "requirement_type": "control status",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* Heart disease",
            "criterions": [
                {
                    "exact_snippets": [
                        "Heart disease"
                    ],
                    "criterion": "heart disease",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Severe cognitive decline",
            "criterions": [
                {
                    "exact_snippets": [
                        "Severe cognitive decline"
                    ],
                    "criterion": "cognitive decline",
                    "requirement_type": "severity",
                    "expected_value": "severe"
                }
            ]
        },
        {
            "line": "* Psychiatric desease",
            "criterions": [
                {
                    "exact_snippets": [
                        "Psychiatric desease"
                    ],
                    "criterion": "psychiatric disease",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* HIV positive",
            "criterions": [
                {
                    "exact_snippets": [
                        "HIV positive"
                    ],
                    "criterion": "HIV",
                    "requirement_type": "status",
                    "expected_value": "positive"
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* Hepatitis B or C infection",
            "criterions": [
                {
                    "exact_snippets": [
                        "Hepatitis B"
                    ],
                    "criterion": "Hepatitis B infection",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "Hepatitis C"
                    ],
                    "criterion": "Hepatitis C infection",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}