{
    "info": {
        "nct_id": "NCT02858804",
        "official_title": "EDOCH Alternating With DHAP Regimen Combined Rituximab or Not to Treat New Diagnosed Younger (Age≤65 Years) Mantle Cell Lymphoma in China: A Multicentre Phase III Trial",
        "inclusion_criteria": "* age≤65 years\n* diagnosis with mantle cell lymphoma\n* Ann Arbor stage II,III or IV\n* ECOG≤1 or if ECOG≥2 but recover after pretreatment.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 65 Years",
        "exclusion_criteria": "* with centre neural system involvement\n* serious complications such as uncontrolled diabetes, gastric ulcer or other serious angiocardiopathy determined by the physician\n* HIV positive or active HBV infection or other uncontrolled systematic infection\n* clinical central nervous dysfunction\n* serious surgery within 30 days\n* pregnancy or baby nursing period or un-contracepted child bearing period woman.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* age≤65 years",
            "criterions": [
                {
                    "exact_snippets": [
                        "age≤65 years"
                    ],
                    "criterion": "age",
                    "requirement_type": "N/A",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 65
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* diagnosis with mantle cell lymphoma",
            "criterions": [
                {
                    "exact_snippets": [
                        "diagnosis with mantle cell lymphoma"
                    ],
                    "criterion": "mantle cell lymphoma",
                    "requirement_type": "diagnosis",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Ann Arbor stage II,III or IV",
            "criterions": [
                {
                    "exact_snippets": [
                        "Ann Arbor stage II,III or IV"
                    ],
                    "criterion": "Ann Arbor stage",
                    "requirement_type": "stage",
                    "expected_value": [
                        "II",
                        "III",
                        "IV"
                    ]
                }
            ]
        },
        {
            "line": "* ECOG≤1 or if ECOG≥2 but recover after pretreatment.",
            "criterions": [
                {
                    "exact_snippets": [
                        "ECOG≤1"
                    ],
                    "criterion": "ECOG",
                    "requirement_type": "performance status",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 1
                            }
                        ]
                    }
                },
                {
                    "exact_snippets": [
                        "ECOG≥2",
                        "recover after pretreatment"
                    ],
                    "criterion": "ECOG",
                    "requirement_type": "performance status",
                    "expected_value": "recover after pretreatment"
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 65 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 65 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 65
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* with centre neural system involvement",
            "criterions": [
                {
                    "exact_snippets": [
                        "centre neural system involvement"
                    ],
                    "criterion": "central nervous system",
                    "requirement_type": "involvement",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* serious complications such as uncontrolled diabetes, gastric ulcer or other serious angiocardiopathy determined by the physician",
            "criterions": [
                {
                    "exact_snippets": [
                        "uncontrolled diabetes"
                    ],
                    "criterion": "diabetes",
                    "requirement_type": "control",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "gastric ulcer"
                    ],
                    "criterion": "gastric ulcer",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "serious angiocardiopathy"
                    ],
                    "criterion": "angiocardiopathy",
                    "requirement_type": "severity",
                    "expected_value": "serious"
                }
            ]
        },
        {
            "line": "* HIV positive or active HBV infection or other uncontrolled systematic infection",
            "criterions": [
                {
                    "exact_snippets": [
                        "HIV positive"
                    ],
                    "criterion": "HIV",
                    "requirement_type": "status",
                    "expected_value": "positive"
                },
                {
                    "exact_snippets": [
                        "active HBV infection"
                    ],
                    "criterion": "HBV infection",
                    "requirement_type": "activity",
                    "expected_value": "active"
                },
                {
                    "exact_snippets": [
                        "uncontrolled systematic infection"
                    ],
                    "criterion": "systematic infection",
                    "requirement_type": "control",
                    "expected_value": "uncontrolled"
                }
            ]
        },
        {
            "line": "* clinical central nervous dysfunction",
            "criterions": [
                {
                    "exact_snippets": [
                        "clinical central nervous dysfunction"
                    ],
                    "criterion": "central nervous system",
                    "requirement_type": "dysfunction",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* serious surgery within 30 days",
            "criterions": [
                {
                    "exact_snippets": [
                        "serious surgery within 30 days"
                    ],
                    "criterion": "serious surgery",
                    "requirement_type": "recency",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 30
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* pregnancy or baby nursing period or un-contracepted child bearing period woman.",
            "criterions": [
                {
                    "exact_snippets": [
                        "pregnancy"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "baby nursing period"
                    ],
                    "criterion": "baby nursing period",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "un-contracepted child bearing period woman"
                    ],
                    "criterion": "contraception",
                    "requirement_type": "usage",
                    "expected_value": false
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}