{
    "info": {
        "nct_id": "NCT02818816",
        "official_title": "A Prospective Study to Evaluate the Effect of Preoperative Topical Brimonidine Tartrate 0.2% (Allergan, Irvine, CA) on Intraocular Pressure (IOP) of Patients Undergoing Robot-assisted Laparoscopic Prostatectomy (RALP)",
        "inclusion_criteria": "* Males aged 18 years and above\n* Patients with a diagnosis of prostatic carcinoma requiring prostate surgery\nHealthy volunteers allowed\nMust be MALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Patients having had an ophthalmic surgical procedure within 6 months of the beginning of the study.\n* Patients with a diagnosis of glaucoma\n* Any abnormality of the cornea which may prevent reliable applanation tonometry\n* Known allergy/ hypersensitivity reaction to Brimonidine\n* Contra-indication to Brimonidine including patients on monoamine oxidase inhibitors (MOA)\n* Patients unwilling or unable to provide informed consent\n* Patients with anticipated difficult airway management (as this may require medications and/or airway manipulations resulting in increased IOP)",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Males aged 18 years and above",
            "criterions": [
                {
                    "exact_snippets": [
                        "Males"
                    ],
                    "criterion": "gender",
                    "requirement_type": "specificity",
                    "expected_value": "male"
                },
                {
                    "exact_snippets": [
                        "aged 18 years and above"
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 18
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* Patients with a diagnosis of prostatic carcinoma requiring prostate surgery",
            "criterions": [
                {
                    "exact_snippets": [
                        "diagnosis of prostatic carcinoma"
                    ],
                    "criterion": "prostatic carcinoma",
                    "requirement_type": "diagnosis",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "requiring prostate surgery"
                    ],
                    "criterion": "prostate surgery",
                    "requirement_type": "necessity",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must be MALE",
            "criterions": [
                {
                    "exact_snippets": [
                        "Must be MALE"
                    ],
                    "criterion": "gender",
                    "requirement_type": "specificity",
                    "expected_value": "male"
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Patients having had an ophthalmic surgical procedure within 6 months of the beginning of the study.",
            "criterions": [
                {
                    "exact_snippets": [
                        "ophthalmic surgical procedure"
                    ],
                    "criterion": "ophthalmic surgical procedure",
                    "requirement_type": "recency",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 6
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* Patients with a diagnosis of glaucoma",
            "criterions": [
                {
                    "exact_snippets": [
                        "diagnosis of glaucoma"
                    ],
                    "criterion": "glaucoma",
                    "requirement_type": "diagnosis",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Any abnormality of the cornea which may prevent reliable applanation tonometry",
            "criterions": [
                {
                    "exact_snippets": [
                        "abnormality of the cornea"
                    ],
                    "criterion": "cornea",
                    "requirement_type": "abnormality",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Known allergy/ hypersensitivity reaction to Brimonidine",
            "criterions": [
                {
                    "exact_snippets": [
                        "Known allergy/ hypersensitivity reaction to Brimonidine"
                    ],
                    "criterion": "allergy",
                    "requirement_type": "presence",
                    "expected_value": "Brimonidine"
                },
                {
                    "exact_snippets": [
                        "Known allergy/ hypersensitivity reaction to Brimonidine"
                    ],
                    "criterion": "hypersensitivity reaction",
                    "requirement_type": "presence",
                    "expected_value": "Brimonidine"
                }
            ]
        },
        {
            "line": "* Contra-indication to Brimonidine including patients on monoamine oxidase inhibitors (MOA)",
            "criterions": [
                {
                    "exact_snippets": [
                        "Contra-indication to Brimonidine"
                    ],
                    "criterion": "Brimonidine",
                    "requirement_type": "contra-indication",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "patients on monoamine oxidase inhibitors (MOA)"
                    ],
                    "criterion": "monoamine oxidase inhibitors (MOA)",
                    "requirement_type": "current medication",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Patients unwilling or unable to provide informed consent",
            "criterions": [
                {
                    "exact_snippets": [
                        "unwilling or unable to provide informed consent"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "ability to provide",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Patients with anticipated difficult airway management (as this may require medications and/or airway manipulations resulting in increased IOP)",
            "criterions": [
                {
                    "exact_snippets": [
                        "anticipated difficult airway management"
                    ],
                    "criterion": "airway management",
                    "requirement_type": "difficulty",
                    "expected_value": true
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}