{
    "info": {
        "nct_id": "NCT02713087",
        "official_title": "Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors",
        "inclusion_criteria": "* Patients scheduled for supine-positioned elective craniotomy for supratentorial malignant and non-malignant brain tumors 3 cm or larger (measured as the largest diameter in any plane on MR images)\n* ASA (American Society of Anesthesiologist) status 1-3 (27)\n* Written informed consent from participating patients\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* Age younger than 18 yrs. or older than 75 yrs.\n* Pregnancy or nursing (negative pregnancy blood test)\n* History of allergic reactions to phenylephrine or ephedrine\n* eGFR < 60ml/min/1.73m2",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Patients scheduled for supine-positioned elective craniotomy for supratentorial malignant and non-malignant brain tumors 3 cm or larger (measured as the largest diameter in any plane on MR images)",
            "criterions": [
                {
                    "exact_snippets": [
                        "supine-positioned elective craniotomy"
                    ],
                    "criterion": "craniotomy",
                    "requirement_type": "position",
                    "expected_value": "supine"
                },
                {
                    "exact_snippets": [
                        "elective craniotomy"
                    ],
                    "criterion": "craniotomy",
                    "requirement_type": "type",
                    "expected_value": "elective"
                },
                {
                    "exact_snippets": [
                        "supratentorial malignant and non-malignant brain tumors"
                    ],
                    "criterion": "brain tumor",
                    "requirement_type": "location",
                    "expected_value": "supratentorial"
                },
                {
                    "exact_snippets": [
                        "malignant and non-malignant brain tumors"
                    ],
                    "criterion": "brain tumor",
                    "requirement_type": "malignancy",
                    "expected_value": [
                        "malignant",
                        "non-malignant"
                    ]
                },
                {
                    "exact_snippets": [
                        "brain tumors 3 cm or larger"
                    ],
                    "criterion": "brain tumor",
                    "requirement_type": "size",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 3
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* ASA (American Society of Anesthesiologist) status 1-3 (27)",
            "criterions": [
                {
                    "exact_snippets": [
                        "ASA (American Society of Anesthesiologist) status 1-3"
                    ],
                    "criterion": "ASA status",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 1
                            },
                            {
                                "operator": "<=",
                                "value": 3
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* Written informed consent from participating patients",
            "criterions": [
                {
                    "exact_snippets": [
                        "Written informed consent"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "form",
                    "expected_value": "written"
                },
                {
                    "exact_snippets": [
                        "participating patients"
                    ],
                    "criterion": "patient participation",
                    "requirement_type": "status",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 75 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 75 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 75
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Age younger than 18 yrs. or older than 75 yrs.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Age younger than 18 yrs."
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<",
                                "value": 18
                            }
                        ]
                    }
                },
                {
                    "exact_snippets": [
                        "older than 75 yrs."
                    ],
                    "criterion": "age",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">",
                                "value": 75
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* Pregnancy or nursing (negative pregnancy blood test)",
            "criterions": [
                {
                    "exact_snippets": [
                        "Pregnancy"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "presence",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "nursing"
                    ],
                    "criterion": "nursing",
                    "requirement_type": "presence",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "negative pregnancy blood test"
                    ],
                    "criterion": "pregnancy blood test",
                    "requirement_type": "result",
                    "expected_value": "negative"
                }
            ]
        },
        {
            "line": "* eGFR < 60ml/min/1.73m2",
            "criterions": [
                {
                    "exact_snippets": [
                        "eGFR < 60ml/min/1.73m2"
                    ],
                    "criterion": "eGFR",
                    "requirement_type": "quantity",
                    "expected_value": {
                        "operator": "<",
                        "value": 60
                    }
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "line": "* History of allergic reactions to phenylephrine or ephedrine",
            "criterions": [
                {
                    "exact_snippets": [
                        "History of allergic reactions to phenylephrine"
                    ],
                    "criterion": "allergic reactions",
                    "requirement_type": "history",
                    "expected_value": "phenylephrine"
                },
                {
                    "exact_snippets": [
                        "History of allergic reactions to ephedrine"
                    ],
                    "criterion": "allergic reactions",
                    "requirement_type": "history",
                    "expected_value": "ephedrine"
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}