{
    "info": {
        "nct_id": "NCT02481518",
        "official_title": "Preloading Magnesium Attenuate Cisplatin-induced Nephrotoxicity",
        "inclusion_criteria": "* Age > 18 years\n* Eastern Cooperative Oncology Group score 0-2\n* First Diagnosed Head and neck cancer and plan for treatment with cisplatin\n* Serum creatinine ≤1.5 mg/dl or eGFR≥60(ml/min/1.73 m2)\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Prior treatment with cisplatin before randomization\n* Uncontrolled concurrent disease\n* Pregnancy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Age > 18 years",
            "criterions": [
                {
                    "exact_snippets": [
                        "Age > 18 years"
                    ],
                    "criterion": "age",
                    "requirement_type": "N/A",
                    "expected_value": {
                        "operator": ">",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "* Eastern Cooperative Oncology Group score 0-2",
            "criterions": [
                {
                    "exact_snippets": [
                        "Eastern Cooperative Oncology Group score 0-2"
                    ],
                    "criterion": "Eastern Cooperative Oncology Group score",
                    "requirement_type": "range",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 0
                            },
                            {
                                "operator": "<=",
                                "value": 2
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* First Diagnosed Head and neck cancer and plan for treatment with cisplatin",
            "criterions": [
                {
                    "exact_snippets": [
                        "First Diagnosed Head and neck cancer"
                    ],
                    "criterion": "head and neck cancer",
                    "requirement_type": "diagnosis",
                    "expected_value": "first"
                },
                {
                    "exact_snippets": [
                        "plan for treatment with cisplatin"
                    ],
                    "criterion": "treatment plan",
                    "requirement_type": "medication",
                    "expected_value": "cisplatin"
                }
            ]
        },
        {
            "line": "* Serum creatinine ≤1.5 mg/dl or eGFR≥60(ml/min/1.73 m2)",
            "criterions": [
                {
                    "exact_snippets": [
                        "Serum creatinine ≤1.5 mg/dl"
                    ],
                    "criterion": "serum creatinine",
                    "requirement_type": "level",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": "<=",
                                "value": 1.5
                            }
                        ]
                    }
                },
                {
                    "exact_snippets": [
                        "eGFR≥60(ml/min/1.73 m2)"
                    ],
                    "criterion": "eGFR",
                    "requirement_type": "level",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 60
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "Must have maximum age of 80 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "maximum age of 80 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "maximum",
                    "expected_value": {
                        "operator": "<=",
                        "value": 80
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Prior treatment with cisplatin before randomization",
            "criterions": [
                {
                    "exact_snippets": [
                        "Prior treatment with cisplatin"
                    ],
                    "criterion": "cisplatin treatment",
                    "requirement_type": "prior",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Uncontrolled concurrent disease",
            "criterions": [
                {
                    "exact_snippets": [
                        "Uncontrolled concurrent disease"
                    ],
                    "criterion": "concurrent disease",
                    "requirement_type": "control status",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* Pregnancy",
            "criterions": [
                {
                    "exact_snippets": [
                        "Pregnancy"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}