{
    "info": {
        "nct_id": "NCT02415257",
        "official_title": "Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function",
        "inclusion_criteria": "* Vestibular schwannoma advised to surgical treatment\n* No measurable remaining vestibular function\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* impaired decision making\n* neurofibromatosis\n* signs for central dysfunction\n* remaining vestibular function\n* Patients are advised not to participate in the gentamicin arm if\n* hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz) and speech discrimination better than 70%\n* the neurosurgeon aim at hearing preservation surgery and do not want to risk gentamicin associated hearing loss",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Vestibular schwannoma advised to surgical treatment",
            "criterions": [
                {
                    "exact_snippets": [
                        "Vestibular schwannoma"
                    ],
                    "criterion": "vestibular schwannoma",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "advised to surgical treatment"
                    ],
                    "criterion": "surgical treatment",
                    "requirement_type": "recommendation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* No measurable remaining vestibular function",
            "criterions": [
                {
                    "exact_snippets": [
                        "No measurable remaining vestibular function"
                    ],
                    "criterion": "vestibular function",
                    "requirement_type": "quantity",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "volunteer health status",
                    "requirement_type": "allowance",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* impaired decision making",
            "criterions": [
                {
                    "exact_snippets": [
                        "impaired decision making"
                    ],
                    "criterion": "decision making",
                    "requirement_type": "impairment",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* neurofibromatosis",
            "criterions": [
                {
                    "exact_snippets": [
                        "neurofibromatosis"
                    ],
                    "criterion": "neurofibromatosis",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* signs for central dysfunction",
            "criterions": [
                {
                    "exact_snippets": [
                        "signs for central dysfunction"
                    ],
                    "criterion": "central dysfunction",
                    "requirement_type": "signs",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* remaining vestibular function",
            "criterions": [
                {
                    "exact_snippets": [
                        "remaining vestibular function"
                    ],
                    "criterion": "vestibular function",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Patients are advised not to participate in the gentamicin arm if",
            "criterions": [
                {
                    "exact_snippets": [
                        "Patients are advised not to participate in the gentamicin arm"
                    ],
                    "criterion": "gentamicin arm participation",
                    "requirement_type": "advisability",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz) and speech discrimination better than 70%",
            "criterions": [
                {
                    "exact_snippets": [
                        "hearing is better than 30 deciBel (dB) in pure tone average (500, 1000, 2000, 3-4000 Hz)"
                    ],
                    "criterion": "hearing",
                    "requirement_type": "pure tone average",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">",
                                "value": 30
                            }
                        ]
                    }
                },
                {
                    "exact_snippets": [
                        "speech discrimination better than 70%"
                    ],
                    "criterion": "speech discrimination",
                    "requirement_type": "percentage",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">",
                                "value": 70
                            }
                        ]
                    }
                }
            ]
        },
        {
            "line": "* the neurosurgeon aim at hearing preservation surgery and do not want to risk gentamicin associated hearing loss",
            "criterions": [
                {
                    "exact_snippets": [
                        "hearing preservation surgery"
                    ],
                    "criterion": "hearing preservation surgery",
                    "requirement_type": "aim",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "gentamicin associated hearing loss"
                    ],
                    "criterion": "gentamicin associated hearing loss",
                    "requirement_type": "risk",
                    "expected_value": false
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}