{
    "info": {
        "nct_id": "NCT02393287",
        "official_title": "Activity and Toxicity Profile of Eribulin Mesylate in Pretreated Metastatic Breast Cancer: an Observational Multicentric Retroprospective Study",
        "inclusion_criteria": "1. Age ≥ 18 years\n2. Patient with breast cancer, histologically proven, metastatic or locally advanced\n3. Patient treated by Eribulin between January and October 2014 (for the retrospective part) or between November 2014 and September 2015 (for the prospective part).\n4. Patient with at least an assessment of the response to Eribulin\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Presence of other neoplasia\n2. Man",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "1. Age ≥ 18 years",
            "criterions": [
                {
                    "exact_snippets": [
                        "Age ≥ 18 years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        },
        {
            "line": "2. Patient with breast cancer, histologically proven, metastatic or locally advanced",
            "criterions": [
                {
                    "exact_snippets": [
                        "Patient with breast cancer"
                    ],
                    "criterion": "breast cancer",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "histologically proven"
                    ],
                    "criterion": "histological proof",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "metastatic"
                    ],
                    "criterion": "cancer stage",
                    "requirement_type": "stage",
                    "expected_value": "metastatic"
                },
                {
                    "exact_snippets": [
                        "locally advanced"
                    ],
                    "criterion": "cancer stage",
                    "requirement_type": "stage",
                    "expected_value": "locally advanced"
                }
            ]
        },
        {
            "line": "3. Patient treated by Eribulin between January and October 2014 (for the retrospective part) or between November 2014 and September 2015 (for the prospective part).",
            "criterions": [
                {
                    "exact_snippets": [
                        "Patient treated by Eribulin"
                    ],
                    "criterion": "Eribulin treatment",
                    "requirement_type": "treatment period",
                    "expected_value": [
                        "January 2014 to October 2014",
                        "November 2014 to September 2015"
                    ]
                }
            ]
        },
        {
            "line": "4. Patient with at least an assessment of the response to Eribulin",
            "criterions": [
                {
                    "exact_snippets": [
                        "assessment of the response to Eribulin"
                    ],
                    "criterion": "response to Eribulin",
                    "requirement_type": "assessment",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": [
                        "Must be FEMALE"
                    ],
                    "criterion": "gender",
                    "requirement_type": "specific value",
                    "expected_value": "female"
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "1. Presence of other neoplasia",
            "criterions": [
                {
                    "exact_snippets": [
                        "Presence of other neoplasia"
                    ],
                    "criterion": "other neoplasia",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "2. Man",
            "criterions": [
                {
                    "exact_snippets": [
                        "Man"
                    ],
                    "criterion": "gender",
                    "requirement_type": "specificity",
                    "expected_value": "male"
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}