{
    "info": {
        "nct_id": "NCT01236417",
        "official_title": "Exercise Intervention in Breast Cancer Patients With Treatment-Induced Arthralgia",
        "inclusion_criteria": "* Post menopausal women with a history of estrogen positive breast cancer who are receiving aromatase inhibitors for at least one month.\n* Patients must complain of mild to moderate arthralgia.\n* Ability to understand and sign informed consent.\n* Patients meet criteria for low to moderate risk for moderate exercise based oon the ACSM guidelines.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Inability to comply with study requirements.\n* Metastatic breast cancer.\n* Patients with orthopedic or neuromuscular disorders that preclude participation in exercise.\n* Rheumatoid arthritis.\n* History of MI, angina or congestive heart failure.\n* Pregnant or lactating females.\n* Patients that are high risk for moderate exercise based on ACSM risk classification.\n* Patients who exceed minimal physical activity recommendations from the US Surgeon General's Report: Accumulation of 30 minutes or more of moderate physical activity on most days of the week.\n* Morbidly obese with BMI ≥ 40",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Post menopausal women with a history of estrogen positive breast cancer who are receiving aromatase inhibitors for at least one month.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Post menopausal women"
                    ],
                    "criterion": "menopausal status",
                    "requirement_type": "specific status",
                    "expected_value": "postmenopausal"
                },
                {
                    "exact_snippets": [
                        "history of estrogen positive breast cancer"
                    ],
                    "criterion": "estrogen receptor status",
                    "requirement_type": "specific status",
                    "expected_value": "positive"
                },
                {
                    "exact_snippets": [
                        "history of estrogen positive breast cancer"
                    ],
                    "criterion": "breast cancer",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "receiving aromatase inhibitors"
                    ],
                    "criterion": "aromatase inhibitors",
                    "requirement_type": "current treatment",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "for at least one month"
                    ],
                    "criterion": "duration of aromatase inhibitor treatment",
                    "requirement_type": "minimum duration",
                    "expected_value": {
                        "operator": ">=",
                        "value": 1
                    }
                }
            ]
        },
        {
            "line": "* Patients must complain of mild to moderate arthralgia.",
            "criterions": [
                {
                    "exact_snippets": [
                        "mild to moderate arthralgia"
                    ],
                    "criterion": "arthralgia",
                    "requirement_type": "severity",
                    "expected_value": [
                        "mild",
                        "moderate"
                    ]
                }
            ]
        },
        {
            "line": "* Ability to understand and sign informed consent.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Ability to understand"
                    ],
                    "criterion": "understanding",
                    "requirement_type": "ability",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "sign informed consent"
                    ],
                    "criterion": "informed consent",
                    "requirement_type": "ability to sign",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": [
                        "Healthy volunteers allowed"
                    ],
                    "criterion": "healthy volunteers",
                    "requirement_type": "participation",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "Must be FEMALE",
            "criterions": [
                {
                    "exact_snippets": [
                        "Must be FEMALE"
                    ],
                    "criterion": "gender",
                    "requirement_type": "specific value",
                    "expected_value": "female"
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": [
                        "minimum age of 18 Years"
                    ],
                    "criterion": "age",
                    "requirement_type": "minimum",
                    "expected_value": {
                        "operator": ">=",
                        "value": 18
                    }
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Inability to comply with study requirements.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Inability to comply with study requirements"
                    ],
                    "criterion": "compliance with study requirements",
                    "requirement_type": "ability",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Metastatic breast cancer.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Metastatic breast cancer"
                    ],
                    "criterion": "breast cancer",
                    "requirement_type": "metastasis",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Patients with orthopedic or neuromuscular disorders that preclude participation in exercise.",
            "criterions": [
                {
                    "exact_snippets": [
                        "orthopedic or neuromuscular disorders"
                    ],
                    "criterion": "orthopedic disorders",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "orthopedic or neuromuscular disorders"
                    ],
                    "criterion": "neuromuscular disorders",
                    "requirement_type": "presence",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "preclude participation in exercise"
                    ],
                    "criterion": "ability to participate in exercise",
                    "requirement_type": "ability",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* Rheumatoid arthritis.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Rheumatoid arthritis"
                    ],
                    "criterion": "rheumatoid arthritis",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Pregnant or lactating females.",
            "criterions": [
                {
                    "exact_snippets": [
                        "Pregnant"
                    ],
                    "criterion": "pregnancy",
                    "requirement_type": "status",
                    "expected_value": false
                },
                {
                    "exact_snippets": [
                        "lactating"
                    ],
                    "criterion": "lactation",
                    "requirement_type": "status",
                    "expected_value": false
                }
            ]
        },
        {
            "line": "* Patients that are high risk for moderate exercise based on ACSM risk classification.",
            "criterions": [
                {
                    "exact_snippets": [
                        "high risk for moderate exercise"
                    ],
                    "criterion": "exercise risk",
                    "requirement_type": "severity",
                    "expected_value": "high"
                },
                {
                    "exact_snippets": [
                        "ACSM risk classification"
                    ],
                    "criterion": "ACSM risk classification",
                    "requirement_type": "presence",
                    "expected_value": true
                }
            ]
        },
        {
            "line": "* Patients who exceed minimal physical activity recommendations from the US Surgeon General's Report: Accumulation of 30 minutes or more of moderate physical activity on most days of the week.",
            "criterions": [
                {
                    "exact_snippets": [
                        "exceed minimal physical activity recommendations",
                        "30 minutes or more of moderate physical activity",
                        "most days of the week"
                    ],
                    "criterion": "physical activity",
                    "requirement_type": "quantity",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 30
                            }
                        ]
                    }
                },
                {
                    "exact_snippets": [
                        "most days of the week"
                    ],
                    "criterion": "physical activity",
                    "requirement_type": "frequency",
                    "expected_value": "most days of the week"
                }
            ]
        },
        {
            "line": "* Morbidly obese with BMI ≥ 40",
            "criterions": [
                {
                    "exact_snippets": [
                        "Morbidly obese"
                    ],
                    "criterion": "obesity",
                    "requirement_type": "severity",
                    "expected_value": "morbid"
                },
                {
                    "exact_snippets": [
                        "BMI ≥ 40"
                    ],
                    "criterion": "BMI",
                    "requirement_type": "value",
                    "expected_value": {
                        "comparisons": [
                            {
                                "operator": ">=",
                                "value": 40
                            }
                        ]
                    }
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "line": "* Patients meet criteria for low to moderate risk for moderate exercise based oon the ACSM guidelines.",
            "criterions": [
                {
                    "exact_snippets": [
                        "low to moderate risk for moderate exercise"
                    ],
                    "criterion": "risk for moderate exercise",
                    "requirement_type": "level",
                    "expected_value": [
                        "low",
                        "moderate"
                    ]
                },
                {
                    "exact_snippets": [
                        "based on the ACSM guidelines"
                    ],
                    "criterion": "guidelines",
                    "requirement_type": "source",
                    "expected_value": "ACSM"
                }
            ]
        }
    ],
    "failed_exclusion": [
        {
            "line": "* History of MI, angina or congestive heart failure.",
            "criterions": [
                {
                    "exact_snippets": [
                        "History of MI"
                    ],
                    "criterion": "myocardial infarction",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "History of angina"
                    ],
                    "criterion": "angina",
                    "requirement_type": "history",
                    "expected_value": true
                },
                {
                    "exact_snippets": [
                        "History of congestive heart failure"
                    ],
                    "criterion": "congestive heart failure",
                    "requirement_type": "history",
                    "expected_value": true
                }
            ]
        }
    ],
    "failed_miscellaneous": []
}