{
    "info": {
        "nct_id": "NCT06726720",
        "official_title": "A Prospective, Observational, Real World Multi-cohort Study of Patients With Non-small Cell Lung Cancer (NSCLC) Initiating AstraZeneca (or Alliance Developed) Drugs",
        "inclusion_criteria": "* Adult patients (≥ 18 years old)\n* Patients with histologically or cytologically proven NSCLC\n* Patients initiated with approved drugs developed by AZ or as part of an AZ alliance at the time of the enrollment or within the previous three weeks.\n* Informed patients who consent to participate in the study as per local regulations.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Patients participating in an interventional clinical trial for NSCLC*\n\n  * with the exception on low-interventional studies (RIPH2) where the intervention does not involve the NSCLC treatment\n* Patients already enrolled in another module of the cohort in UMBREALUNG\n* Patients under safeguard of justice, curatorship or guardianship",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Adult patients (≥ 18 years old)",
                "criterions": [
                    {
                        "exact_snippets": "Adult patients (≥ 18 years old)",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adult patients (≥ 18 years old)",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with histologically or cytologically proven NSCLC",
                "criterions": [
                    {
                        "exact_snippets": "histologically or cytologically proven NSCLC",
                        "criterion": "NSCLC",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "histologically or cytologically proven NSCLC",
                        "criterion": "NSCLC",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Informed patients who consent to participate in the study as per local regulations.",
                "criterions": [
                    {
                        "exact_snippets": "Informed patients who consent to participate in the study",
                        "criterion": "consent to participate",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "as per local regulations",
                        "criterion": "compliance with local regulations",
                        "requirement": {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Informed patients who consent to participate in the study",
                        "criterion": "consent to participate",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "as per local regulations",
                        "criterion": "compliance with local regulations",
                        "requirement": {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients participating in an interventional clinical trial for NSCLC*",
                "criterions": [
                    {
                        "exact_snippets": "Patients participating in an interventional clinical trial",
                        "criterion": "participation in interventional clinical trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "NSCLC",
                        "criterion": "NSCLC",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients participating in an interventional clinical trial",
                                "criterion": "participation in interventional clinical trial",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "NSCLC",
                                "criterion": "NSCLC",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* with the exception on low-interventional studies (RIPH2) where the intervention does not involve the NSCLC treatment",
                "criterions": [
                    {
                        "exact_snippets": "low-interventional studies (RIPH2)",
                        "criterion": "study type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "low-interventional (RIPH2)"
                        }
                    },
                    {
                        "exact_snippets": "intervention does not involve the NSCLC treatment",
                        "criterion": "intervention involvement",
                        "requirement": {
                            "requirement_type": "involvement",
                            "expected_value": "does not involve NSCLC treatment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "low-interventional studies (RIPH2)",
                            "criterion": "study type",
                            "requirement": {
                                "requirement_type": "type",
                                "expected_value": "low-interventional (RIPH2)"
                            }
                        },
                        {
                            "exact_snippets": "intervention does not involve the NSCLC treatment",
                            "criterion": "intervention involvement",
                            "requirement": {
                                "requirement_type": "involvement",
                                "expected_value": "does not involve NSCLC treatment"
                            }
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": "low-interventional studies (RIPH2)",
                            "criterion": "study type",
                            "requirement": {
                                "requirement_type": "type",
                                "expected_value": "low-interventional (RIPH2)"
                            }
                        },
                        {
                            "exact_snippets": "intervention does not involve the NSCLC treatment",
                            "criterion": "intervention involvement",
                            "requirement": {
                                "requirement_type": "involvement",
                                "expected_value": "does not involve NSCLC treatment"
                            }
                        }
                    ]
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients already enrolled in another module of the cohort in UMBREALUNG",
                "criterions": [
                    {
                        "exact_snippets": "Patients already enrolled in another module of the cohort in UMBREALUNG",
                        "criterion": "enrollment in another module of the cohort",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patients already enrolled in another module of the cohort in UMBREALUNG",
                    "criterion": "enrollment in another module of the cohort",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients under safeguard of justice, curatorship or guardianship",
                "criterions": [
                    {
                        "exact_snippets": "Patients under safeguard of justice",
                        "criterion": "safeguard of justice",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "curatorship",
                        "criterion": "curatorship",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "guardianship",
                        "criterion": "guardianship",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Patients under safeguard of justice",
                        "criterion": "safeguard of justice",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "curatorship",
                        "criterion": "curatorship",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "guardianship",
                        "criterion": "guardianship",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Patients initiated with approved drugs developed by AZ or as part of an AZ alliance at the time of the enrollment or within the previous three weeks.",
                "criterions": [
                    {
                        "exact_snippets": "Patients initiated with approved drugs developed by AZ or as part of an AZ alliance",
                        "criterion": "drug initiation",
                        "requirement": {
                            "requirement_type": "developer",
                            "expected_value": [
                                "AZ",
                                "AZ alliance"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Patients initiated with approved drugs developed by AZ or as part of an AZ alliance",
                        "criterion": "drug initiation",
                        "requirement": {
                            "requirement_type": "approval_status",
                            "expected_value": "approved"
                        }
                    },
                    {
                        "exact_snippets": "at the time of the enrollment or within the previous three weeks",
                        "criterion": "drug initiation timing",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "at the time of the enrollment or within the previous three weeks"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients initiated with approved drugs developed by AZ or as part of an AZ alliance",
                                "criterion": "drug initiation",
                                "requirement": {
                                    "requirement_type": "developer",
                                    "expected_value": "AZ"
                                }
                            },
                            {
                                "exact_snippets": "Patients initiated with approved drugs developed by AZ or as part of an AZ alliance",
                                "criterion": "drug initiation",
                                "requirement": {
                                    "requirement_type": "developer",
                                    "expected_value": "AZ alliance"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Patients initiated with approved drugs developed by AZ or as part of an AZ alliance",
                        "criterion": "drug initiation",
                        "requirement": {
                            "requirement_type": "approval_status",
                            "expected_value": "approved"
                        }
                    },
                    {
                        "exact_snippets": "at the time of the enrollment or within the previous three weeks",
                        "criterion": "drug initiation timing",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "at the time of the enrollment or within the previous three weeks"
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}