{
    "info": {
        "nct_id": "NCT06464380",
        "official_title": "Anti Cancer Potential of Saffron in Hepatocellular Carcinoma",
        "inclusion_criteria": "* Adult male and female patients above 18 years\n* Patients with end-stage HCC not candidate for curative, loco regional treatment and /or systemic chemotherapy\n* Patients with available baseline laboratory parameters and contrast- enhancing images after given written consent for research participation.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Patients who are candidate for curative and/or loco-regional or combination treatment for HCC\n* Patients with concomitant malignancies other than HCC",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Adult male and female patients above 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Adult male and female patients",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "above 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adult male and female patients",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "male",
                                "female"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "above 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with end-stage HCC not candidate for curative, loco regional treatment and /or systemic chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "end-stage HCC",
                        "criterion": "HCC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "end-stage"
                        }
                    },
                    {
                        "exact_snippets": "not candidate for curative, loco regional treatment",
                        "criterion": "treatment candidacy",
                        "requirement": {
                            "requirement_type": "candidacy",
                            "expected_value": [
                                "curative treatment",
                                "loco regional treatment"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "not candidate for ... systemic chemotherapy",
                        "criterion": "chemotherapy candidacy",
                        "requirement": {
                            "requirement_type": "candidacy",
                            "expected_value": "systemic chemotherapy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "end-stage HCC",
                                "criterion": "HCC stage",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "end-stage"
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "not candidate for curative, loco regional treatment",
                                    "criterion": "treatment candidacy",
                                    "requirement": {
                                        "requirement_type": "candidacy",
                                        "expected_value": [
                                            "curative treatment",
                                            "loco regional treatment"
                                        ]
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "not candidate for ... systemic chemotherapy",
                            "criterion": "chemotherapy candidacy",
                            "requirement": {
                                "requirement_type": "candidacy",
                                "expected_value": "systemic chemotherapy"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with available baseline laboratory parameters and contrast- enhancing images after given written consent for research participation.",
                "criterions": [
                    {
                        "exact_snippets": "available baseline laboratory parameters",
                        "criterion": "baseline laboratory parameters",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "contrast-enhancing images",
                        "criterion": "contrast-enhancing images",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "given written consent for research participation",
                        "criterion": "written consent for research participation",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "available baseline laboratory parameters",
                                "criterion": "baseline laboratory parameters",
                                "requirement": {
                                    "requirement_type": "availability",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "contrast-enhancing images",
                                "criterion": "contrast-enhancing images",
                                "requirement": {
                                    "requirement_type": "availability",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "given written consent for research participation",
                        "criterion": "written consent for research participation",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients with concomitant malignancies other than HCC",
                "criterions": [
                    {
                        "exact_snippets": "concomitant malignancies other than HCC",
                        "criterion": "concomitant malignancies",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": "HCC"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "concomitant malignancies other than HCC",
                        "criterion": "concomitant malignancies",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": "HCC"
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Patients who are candidate for curative and/or loco-regional or combination treatment for HCC",
                "criterions": [
                    {
                        "exact_snippets": "Patients who are candidate for curative and/or loco-regional or combination treatment for HCC",
                        "criterion": "treatment candidacy",
                        "requirement": {
                            "requirement_type": "treatment type",
                            "expected_value": [
                                "curative",
                                "loco-regional",
                                "combination"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "HCC",
                        "criterion": "condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "Patients who are candidate for curative and/or loco-regional or combination treatment for HCC",
                                        "criterion": "treatment candidacy",
                                        "requirement": {
                                            "requirement_type": "treatment type",
                                            "expected_value": "curative"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Patients who are candidate for curative and/or loco-regional or combination treatment for HCC",
                                        "criterion": "treatment candidacy",
                                        "requirement": {
                                            "requirement_type": "treatment type",
                                            "expected_value": "loco-regional"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Patients who are candidate for curative and/or loco-regional or combination treatment for HCC",
                                        "criterion": "treatment candidacy",
                                        "requirement": {
                                            "requirement_type": "treatment type",
                                            "expected_value": "combination"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "HCC",
                                "criterion": "condition",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}