{
    "info": {
        "nct_id": "NCT06276491",
        "official_title": "A Phase 1, First-in-Human, Dose Escalation and Expansion Study to Evaluate the Safety and Tolerability of XmAb541 in Advanced Solid Tumors",
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        "exclusion_criteria": "* Prior exposure to a CLDN6 targeting product\n* Ovarian cancer that is platinum refractory, or has rapid progression on most recent prior ≥ second line systemic anticancer therapy\n* Have known active central nervous system metastases and/or carcinomatous meningitis. Patients with treated brain metastases may participate, provided they are radiologically stable.\n* Active known or suspected autoimmune disease\n* Has any condition requiring systemic treatment with corticosteroids, prednisone equivalents, or other immunosuppressive medications within 14 days prior to first dose of study drug\n* Clinically significant cardiovascular, pulmonary or gastrointestinal disease\n* Positive test for hepatitis C RNA\n* Positive test for hepatitis B surface antigen or hepatitis B core antibody (hBcAb)",
        "miscellaneous_criteria": "Key"
    },
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                                        "value": 0,
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                        "and_criteria": [
                            {
                                "exact_snippets": "Clinically significant ... gastrointestinal disease",
                                "criterion": "gastrointestinal disease",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "clinically significant"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Positive test for hepatitis C RNA",
                "criterions": [
                    {
                        "exact_snippets": "Positive test for hepatitis C RNA",
                        "criterion": "hepatitis C RNA",
                        "requirement": {
                            "requirement_type": "test result",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Positive test for hepatitis C RNA",
                    "criterion": "hepatitis C RNA",
                    "requirement": {
                        "requirement_type": "test result",
                        "expected_value": "positive"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Positive test for hepatitis B surface antigen or hepatitis B core antibody (hBcAb)",
                "criterions": [
                    {
                        "exact_snippets": "Positive test for hepatitis B surface antigen",
                        "criterion": "hepatitis B surface antigen",
                        "requirement": {
                            "requirement_type": "test result",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "Positive test for ... hepatitis B core antibody (hBcAb)",
                        "criterion": "hepatitis B core antibody (hBcAb)",
                        "requirement": {
                            "requirement_type": "test result",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Positive test for hepatitis B surface antigen",
                        "criterion": "hepatitis B surface antigen",
                        "requirement": {
                            "requirement_type": "test result",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "Positive test for ... hepatitis B core antibody (hBcAb)",
                        "criterion": "hepatitis B core antibody (hBcAb)",
                        "requirement": {
                            "requirement_type": "test result",
                            "expected_value": "positive"
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "Key",
                "criterions": [
                    {
                        "exact_snippets": "Key",
                        "criterion": "key",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Key",
                        "criterion": "key",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Active known or suspected autoimmune disease",
                "criterions": [
                    {
                        "exact_snippets": "Active known or suspected autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "Active known or suspected autoimmune disease",
                        "criterion": "autoimmune disease",
                        "requirement": {
                            "requirement_type": "certainty",
                            "expected_value": [
                                "known",
                                "suspected"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Active known or suspected autoimmune disease",
                                "criterion": "autoimmune disease",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "active"
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "Active known or suspected autoimmune disease",
                                        "criterion": "autoimmune disease",
                                        "requirement": {
                                            "requirement_type": "certainty",
                                            "expected_value": "known"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Active known or suspected autoimmune disease",
                                        "criterion": "autoimmune disease",
                                        "requirement": {
                                            "requirement_type": "certainty",
                                            "expected_value": "suspected"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}