{
    "info": {
        "nct_id": "NCT06242691",
        "official_title": "A Phase 1/2 Open-label Study to Evaluate the Safety and Efficacy of MK-1200 in Participants With Advanced Solid Tumors",
        "inclusion_criteria": "* Confirmed advanced (unresectable and/or metastatic) solid tumor: gastric cancer (including gastroesophageal junction cancer), esophageal cancer, biliary tract cancer, or pancreatic ductal adenocarcinoma\n* Participants who experienced Adverse Events (AEs) due to previous anticancer therapies must have recovered to < Grade 1 or baseline\n* Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on antiretroviral therapy\n* Hepatitis B surface antigen (HBsAg) positive participants are eligible if they have received Hepatitis B Virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV viral load\n* Participants with a history of Hepatitis C Virus (HCV) infection are eligible if HCV viral load is undetectable\n* Received and progressed on or after 1 or 2 prior lines of therapy\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Active severe digestive disease\n* History of acute myocardial infarction; unstable angina; stroke or transient ischemic attack within 6 months prior to the first dose of study intervention\n* Diabetes or hypertension that cannot be controlled by medication\n* HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease\n* Received prior systemic anticancer therapy including investigational agents within 4 weeks before study intervention\n* Received prior radiotherapy within 2 weeks of start of study intervention, or has radiation-related toxicities, requiring corticosteroids\n* Known additional malignancy that is progressing or has required active treatment within the past 2 years\n* Known active central nervous system (CNS) metastases and/or carcinomatous meningitis\n* Active infection requiring systemic therapy\n* Have not adequately recovered from major surgery or have ongoing surgical complications",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
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                "line": "* Confirmed advanced (unresectable and/or metastatic) solid tumor: gastric cancer (including gastroesophageal junction cancer), esophageal cancer, biliary tract cancer, or pancreatic ductal adenocarcinoma",
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                            "expected_value": true
                        }
                    },
                    {
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                        }
                    },
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                            "expected_value": true
                        }
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                        "criterion": "gastric cancer",
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                            "expected_value": true
                        }
                    },
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                            "expected_value": true
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                    },
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                        "requirement": {
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                            "expected_value": true
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                    },
                    {
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                        "criterion": "pancreatic ductal adenocarcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
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                    }
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                                }
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                                }
                            },
                            {
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                "line": "* Participants who experienced Adverse Events (AEs) due to previous anticancer therapies must have recovered to < Grade 1 or baseline",
                "criterions": [
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                        "criterion": "adverse events due to previous anticancer therapies",
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                            "expected_value": {
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                                "value": 1,
                                "unit": "Grade"
                            }
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                "criterions": [
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                        "exact_snippets": "Human immunodeficiency virus (HIV)-infected participants",
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                        }
                    },
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                        "criterion": "antiretroviral therapy",
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                        }
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                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Hepatitis B surface antigen (HBsAg) positive participants are eligible if they have received Hepatitis B Virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV viral load",
                "criterions": [
                    {
                        "exact_snippets": "Hepatitis B surface antigen (HBsAg) positive",
                        "criterion": "Hepatitis B surface antigen (HBsAg)",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
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                        "exact_snippets": "received Hepatitis B Virus (HBV) antiviral therapy for at least 4 weeks",
                        "criterion": "Hepatitis B Virus (HBV) antiviral therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
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                    },
                    {
                        "exact_snippets": "undetectable HBV viral load",
                        "criterion": "HBV viral load",
                        "requirement": {
                            "requirement_type": "detectability",
                            "expected_value": false
                        }
                    }
                ]
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                        }
                    }
                ]
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        },
        {
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                "criterions": [
                    {
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                        "criterion": "Hepatitis C Virus (HCV) infection history",
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                            "expected_value": true
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                    {
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                            "expected_value": false
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                            "requirement_type": "minimum",
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                                "value": 18,
                                "unit": "Years"
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                                "value": 18,
                                "unit": "Years"
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        {
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                        "criterion": "digestive disease",
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                    }
                ]
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        },
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                "criterions": [
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                        "exact_snippets": "History of acute myocardial infarction",
                        "criterion": "acute myocardial infarction",
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                                "value": 4,
                                "unit": "weeks"
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            "identified_line": {
                "line": "* Received prior radiotherapy within 2 weeks of start of study intervention, or has radiation-related toxicities, requiring corticosteroids",
                "criterions": [
                    {
                        "exact_snippets": "Received prior radiotherapy within 2 weeks of start of study intervention",
                        "criterion": "prior radiotherapy",
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                            "requirement_type": "time since last treatment",
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                                "operator": "<=",
                                "value": 2,
                                "unit": "weeks"
                            }
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                    },
                    {
                        "exact_snippets": "radiation-related toxicities",
                        "criterion": "radiation-related toxicities",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "requiring corticosteroids",
                        "criterion": "corticosteroid requirement",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Received prior radiotherapy within 2 weeks of start of study intervention",
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                        "and_criteria": [
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                                "exact_snippets": "radiation-related toxicities",
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                                "exact_snippets": "requiring corticosteroids",
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                        ]
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                ]
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        },
        {
            "identified_line": {
                "line": "* Known additional malignancy that is progressing or has required active treatment within the past 2 years",
                "criterions": [
                    {
                        "exact_snippets": "Known additional malignancy",
                        "criterion": "additional malignancy",
                        "requirement": {
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                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Known additional malignancy ... has required active treatment within the past 2 years",
                        "criterion": "additional malignancy",
                        "requirement": {
                            "requirement_type": "treatment requirement",
                            "expected_value": {
                                "operator": "<=",
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                                "unit": "years"
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            "logical_structure": {
                "or_criteria": [
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                        "and_criteria": [
                            {
                                "exact_snippets": "Known additional malignancy",
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                                    "requirement_type": "progression",
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                                }
                            },
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                                "exact_snippets": "Known additional malignancy ... has required active treatment within the past 2 years",
                                "criterion": "additional malignancy",
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                                    "requirement_type": "treatment requirement",
                                    "expected_value": {
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                                        "unit": "years"
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                        ]
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                ]
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        },
        {
            "identified_line": {
                "line": "* Known active central nervous system (CNS) metastases and/or carcinomatous meningitis",
                "criterions": [
                    {
                        "exact_snippets": "Known active central nervous system (CNS) metastases",
                        "criterion": "central nervous system (CNS) metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Known active central nervous system (CNS) metastases",
                        "criterion": "central nervous system (CNS) metastases",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "carcinomatous meningitis",
                        "criterion": "carcinomatous meningitis",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
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                        "and_criteria": [
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                                "exact_snippets": "Known active central nervous system (CNS) metastases",
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                                "requirement": {
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                                    "expected_value": true
                                }
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                                "exact_snippets": "Known active central nervous system (CNS) metastases",
                                "criterion": "central nervous system (CNS) metastases",
                                "requirement": {
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                                    "expected_value": "active"
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                            }
                        ]
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                    {
                        "exact_snippets": "carcinomatous meningitis",
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                        }
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active infection requiring systemic therapy",
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                    {
                        "exact_snippets": "Active infection requiring systemic therapy",
                        "criterion": "active infection",
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                            "requirement_type": "treatment",
                            "expected_value": "systemic therapy"
                        }
                    }
                ]
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                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Have not adequately recovered from major surgery or have ongoing surgical complications",
                "criterions": [
                    {
                        "exact_snippets": "Have not adequately recovered from major surgery",
                        "criterion": "recovery from major surgery",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "adequate"
                        }
                    },
                    {
                        "exact_snippets": "have ongoing surgical complications",
                        "criterion": "surgical complications",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
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                ]
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                    {
                        "exact_snippets": "have ongoing surgical complications",
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                        }
                    }
                ]
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        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}