{
    "info": {
        "nct_id": "NCT06167460",
        "official_title": "Analysis of Circulating Tumor DNA Dynamics to Predict and Monitor Response to Tyrosine Kinase Inhibitors in Patients With Advanced Non-small Cell Lung Cancer",
        "inclusion_criteria": "* Patients are diagnosed with advanced non-small cell lung cancer and indicated for TKI (first or second line). TKI combined with chemotherapy is allowed.\n* FFPE/FNA sample is available.\n* Compliant with treatment protocol.\n* Patients consented to participate in the study.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Patients already started TKI before enrollment.\n* Patients already started chemotherapy before enrollment.\n* Medical or psychiatric conditions or occupational responsibilities that may preclude compliance with the protocol.\n* Patients did not agree to participate in the studies.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients are diagnosed with advanced non-small cell lung cancer and indicated for TKI (first or second line). TKI combined with chemotherapy is allowed.",
                "criterions": [
                    {
                        "exact_snippets": "diagnosed with advanced non-small cell lung cancer",
                        "criterion": "non-small cell lung cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "indicated for TKI (first or second line)",
                        "criterion": "TKI indication",
                        "requirement": {
                            "requirement_type": "line of therapy",
                            "expected_value": [
                                "first",
                                "second"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "diagnosed with advanced non-small cell lung cancer",
                                "criterion": "non-small cell lung cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "advanced"
                                }
                            },
                            {
                                "exact_snippets": "indicated for TKI (first or second line)",
                                "criterion": "TKI indication",
                                "requirement": {
                                    "requirement_type": "line of therapy",
                                    "expected_value": [
                                        "first",
                                        "second"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "indicated for TKI (first or second line)",
                                "criterion": "TKI indication",
                                "requirement": {
                                    "requirement_type": "line of therapy",
                                    "expected_value": [
                                        "first",
                                        "second"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "TKI combined with chemotherapy is allowed",
                                "criterion": "TKI combined with chemotherapy",
                                "requirement": {
                                    "requirement_type": "allowance",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* FFPE/FNA sample is available.",
                "criterions": [
                    {
                        "exact_snippets": "FFPE/FNA sample is available",
                        "criterion": "FFPE/FNA sample",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "FFPE/FNA sample is available",
                        "criterion": "FFPE/FNA sample",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Compliant with treatment protocol.",
                "criterions": [
                    {
                        "exact_snippets": "Compliant with treatment protocol",
                        "criterion": "treatment protocol compliance",
                        "requirement": {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Compliant with treatment protocol",
                        "criterion": "treatment protocol compliance",
                        "requirement": {
                            "requirement_type": "compliance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients consented to participate in the study.",
                "criterions": [
                    {
                        "exact_snippets": "Patients consented to participate in the study.",
                        "criterion": "consent to participate",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients consented to participate in the study.",
                        "criterion": "consent to participate",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 80 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients already started TKI before enrollment.",
                "criterions": [
                    {
                        "exact_snippets": "Patients already started TKI before enrollment.",
                        "criterion": "TKI treatment",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "started before enrollment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients already started TKI before enrollment.",
                        "criterion": "TKI treatment",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "started before enrollment"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients already started chemotherapy before enrollment.",
                "criterions": [
                    {
                        "exact_snippets": "Patients already started chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "started"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients already started chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "started"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients did not agree to participate in the studies.",
                "criterions": [
                    {
                        "exact_snippets": "Patients did not agree to participate",
                        "criterion": "agreement to participate",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patients did not agree to participate",
                    "criterion": "agreement to participate",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Medical or psychiatric conditions or occupational responsibilities that may preclude compliance with the protocol.",
                "criterions": [
                    {
                        "exact_snippets": "Medical or psychiatric conditions",
                        "criterion": "medical or psychiatric conditions",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "occupational responsibilities",
                        "criterion": "occupational responsibilities",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Medical or psychiatric conditions",
                        "criterion": "medical or psychiatric conditions",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "occupational responsibilities",
                        "criterion": "occupational responsibilities",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}