{
    "info": {
        "nct_id": "NCT06076772",
        "official_title": "Palbociclib Induced Neutropenia; Risk Factors and Treatment Outcome in Metastatic Breast Cancer Patients",
        "inclusion_criteria": "* Histological pathological confirmation of primary breast cancer or metastatic disease.\n* Hormonal receptor-positive, HER2 negative.\n* Metastatic breast cancer at presentation (Den novo) or recurrent.\n* Patients did not receive any previous systemic therapy for metastatic disease.\n* Performance status (ECOG) 0-2.\nHealthy volunteers allowed",
        "exclusion_criteria": "* Patient with co-morbidity\n* Pregnant and breast lactating women",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Histological pathological confirmation of primary breast cancer or metastatic disease.",
                "criterions": [
                    {
                        "exact_snippets": "Histological pathological confirmation of primary breast cancer",
                        "criterion": "primary breast cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histological pathological"
                        }
                    },
                    {
                        "exact_snippets": "Histological pathological confirmation of ... metastatic disease",
                        "criterion": "metastatic disease",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histological pathological"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Histological pathological confirmation of primary breast cancer",
                        "criterion": "primary breast cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histological pathological"
                        }
                    },
                    {
                        "exact_snippets": "Histological pathological confirmation of ... metastatic disease",
                        "criterion": "metastatic disease",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histological pathological"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hormonal receptor-positive, HER2 negative.",
                "criterions": [
                    {
                        "exact_snippets": "Hormonal receptor-positive",
                        "criterion": "hormonal receptor status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "HER2 negative",
                        "criterion": "HER2 status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hormonal receptor-positive",
                        "criterion": "hormonal receptor status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "HER2 negative",
                        "criterion": "HER2 status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Metastatic breast cancer at presentation (Den novo) or recurrent.",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic breast cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "metastatic"
                        }
                    },
                    {
                        "exact_snippets": "recurrent",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Metastatic breast cancer",
                                "criterion": "breast cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "metastatic"
                                }
                            },
                            {
                                "exact_snippets": "Den novo",
                                "criterion": "presentation",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "Den novo"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "recurrent",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients did not receive any previous systemic therapy for metastatic disease.",
                "criterions": [
                    {
                        "exact_snippets": "Patients did not receive any previous systemic therapy for metastatic disease.",
                        "criterion": "previous systemic therapy for metastatic disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients did not receive any previous systemic therapy for metastatic disease.",
                        "criterion": "previous systemic therapy for metastatic disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Performance status (ECOG) 0-2.",
                "criterions": [
                    {
                        "exact_snippets": "Performance status (ECOG) 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "scale",
                            "expected_value": "ECOG"
                        }
                    },
                    {
                        "exact_snippets": "Performance status (ECOG) 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status (ECOG) 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "scale",
                            "expected_value": "ECOG"
                        }
                    },
                    {
                        "exact_snippets": "Performance status (ECOG) 0-2",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Patient with co-morbidity",
                "criterions": [
                    {
                        "exact_snippets": "co-morbidity",
                        "criterion": "co-morbidity",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "co-morbidity",
                    "criterion": "co-morbidity",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant and breast lactating women",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breast lactating",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breast lactating",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}