{
    "info": {
        "nct_id": "NCT05763472",
        "official_title": "Molecular Landscape Involved in the Onset of Breast Cancer in Patients With Germline BRCA-1/2 Mutations, During or After Therapy With Platinum-based Agents and/or PARP-inhibitors for Ovarian Cancer",
        "inclusion_criteria": "* Written informed consent.\n* Age older than 18 years.\n* Germline BRCA1/2 mutation.\n* Histologically confirmed ovarian cancer treated with platinum-based chemotherapy and/or PARP inhibitors.\n* Histologically confirmed breast cancer occurred during or after therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer.\n* Availability of FFPE breast and ovarian tumor samples.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Other malignancies in the last 2 years.\n* Prior chemotherapy or radiation therapy for other malignancies.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Written informed consent.",
                "criterions": [
                    {
                        "exact_snippets": "Written informed consent.",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Written informed consent.",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age older than 18 years.",
                "criterions": [
                    {
                        "exact_snippets": "Age older than 18 years.",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age older than 18 years.",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Germline BRCA1/2 mutation.",
                "criterions": [
                    {
                        "exact_snippets": "Germline BRCA1/2 mutation",
                        "criterion": "germline BRCA1/2 mutation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Germline BRCA1/2 mutation",
                        "criterion": "germline BRCA1/2 mutation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically confirmed ovarian cancer treated with platinum-based chemotherapy and/or PARP inhibitors.",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "treated with platinum-based chemotherapy",
                        "criterion": "treatment",
                        "requirement": {
                            "requirement_type": "treatment type",
                            "expected_value": "platinum-based chemotherapy"
                        }
                    },
                    {
                        "exact_snippets": "treated with ... PARP inhibitors",
                        "criterion": "treatment",
                        "requirement": {
                            "requirement_type": "treatment type",
                            "expected_value": "PARP inhibitors"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "treated with platinum-based chemotherapy",
                                "criterion": "treatment",
                                "requirement": {
                                    "requirement_type": "treatment type",
                                    "expected_value": "platinum-based chemotherapy"
                                }
                            },
                            {
                                "exact_snippets": "treated with ... PARP inhibitors",
                                "criterion": "treatment",
                                "requirement": {
                                    "requirement_type": "treatment type",
                                    "expected_value": "PARP inhibitors"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Histologically confirmed ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically confirmed breast cancer occurred during or after therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer.",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed breast cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "occurred during or after therapy with platinum-based agents",
                        "criterion": "therapy with platinum-based agents",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "during or after"
                        }
                    },
                    {
                        "exact_snippets": "occurred during or after therapy with ... PARP-inhibitors",
                        "criterion": "therapy with PARP-inhibitors",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "during or after"
                        }
                    },
                    {
                        "exact_snippets": "therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "platinum-based agents",
                                "PARP-inhibitors"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Histologically confirmed breast cancer",
                                        "criterion": "breast cancer",
                                        "requirement": {
                                            "requirement_type": "confirmation method",
                                            "expected_value": "histologically confirmed"
                                        }
                                    },
                                    {
                                        "or_criteria": [
                                            {
                                                "exact_snippets": "occurred during or after therapy with platinum-based agents",
                                                "criterion": "therapy with platinum-based agents",
                                                "requirement": {
                                                    "requirement_type": "timing",
                                                    "expected_value": "during or after"
                                                }
                                            },
                                            {
                                                "exact_snippets": "occurred during or after therapy with ... PARP-inhibitors",
                                                "criterion": "therapy with PARP-inhibitors",
                                                "requirement": {
                                                    "requirement_type": "timing",
                                                    "expected_value": "during or after"
                                                }
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "therapy with platinum-based agents and/or PARP-inhibitors for ovarian cancer",
                                "criterion": "ovarian cancer",
                                "requirement": {
                                    "requirement_type": "treatment",
                                    "expected_value": [
                                        "platinum-based agents",
                                        "PARP-inhibitors"
                                    ]
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Availability of FFPE breast and ovarian tumor samples.",
                "criterions": [
                    {
                        "exact_snippets": "Availability of FFPE breast and ovarian tumor samples.",
                        "criterion": "FFPE breast tumor samples",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Availability of FFPE breast and ovarian tumor samples.",
                        "criterion": "FFPE ovarian tumor samples",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Availability of FFPE breast and ovarian tumor samples.",
                        "criterion": "FFPE breast tumor samples",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Availability of FFPE breast and ovarian tumor samples.",
                        "criterion": "FFPE ovarian tumor samples",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Other malignancies in the last 2 years.",
                "criterions": [
                    {
                        "exact_snippets": "Other malignancies in the last 2 years.",
                        "criterion": "other malignancies",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Other malignancies in the last 2 years.",
                    "criterion": "other malignancies",
                    "requirement": {
                        "requirement_type": "time frame",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 2,
                                    "unit": "years"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prior chemotherapy or radiation therapy for other malignancies.",
                "criterions": [
                    {
                        "exact_snippets": "Prior chemotherapy ... for other malignancies.",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Prior ... radiation therapy for other malignancies.",
                        "criterion": "prior radiation therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Prior chemotherapy ... for other malignancies.",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Prior ... radiation therapy for other malignancies.",
                        "criterion": "prior radiation therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}