{
    "info": {
        "nct_id": "NCT05690048",
        "official_title": "Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA)",
        "inclusion_criteria": "1. Age 18 years or older\n2. Confirmed imaging or histological diagnosis of unresectable HCC, BCLC stadium C\n3. ECOG performance status of 0-1\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Advanced liver cirrhosis (Child-Pugh Score C)\n2. Diagnosis of immunodeficiency (e.g. HIV, immunosuppressants)\n3. Usage of antibiotics within 2 weeks prior enrollment",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. Age 18 years or older",
                "criterions": [
                    {
                        "exact_snippets": "Age 18 years or older",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age 18 years or older",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Confirmed imaging or histological diagnosis of unresectable HCC, BCLC stadium C",
                "criterions": [
                    {
                        "exact_snippets": "Confirmed imaging or histological diagnosis of unresectable HCC",
                        "criterion": "unresectable HCC",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "confirmed imaging or histological"
                        }
                    },
                    {
                        "exact_snippets": "BCLC stadium C",
                        "criterion": "BCLC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "C"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Confirmed imaging or histological diagnosis of unresectable HCC",
                        "criterion": "unresectable HCC",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "confirmed imaging or histological"
                        }
                    },
                    {
                        "exact_snippets": "BCLC stadium C",
                        "criterion": "BCLC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "C"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. ECOG performance status of 0-1",
                "criterions": [
                    {
                        "exact_snippets": "ECOG performance status of 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG performance status of 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "1. Advanced liver cirrhosis (Child-Pugh Score C)",
                "criterions": [
                    {
                        "exact_snippets": "Advanced liver cirrhosis",
                        "criterion": "liver cirrhosis",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "Child-Pugh Score C",
                        "criterion": "Child-Pugh Score",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "C"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Advanced liver cirrhosis",
                        "criterion": "liver cirrhosis",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "Child-Pugh Score C",
                        "criterion": "Child-Pugh Score",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "C"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Diagnosis of immunodeficiency (e.g. HIV, immunosuppressants)",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of immunodeficiency (e.g. HIV, immunosuppressants)",
                        "criterion": "immunodeficiency",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosis of immunodeficiency (e.g. HIV, immunosuppressants)",
                        "criterion": "immunodeficiency",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Usage of antibiotics within 2 weeks prior enrollment",
                "criterions": [
                    {
                        "exact_snippets": "Usage of antibiotics within 2 weeks prior enrollment",
                        "criterion": "antibiotics usage",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Usage of antibiotics within 2 weeks prior enrollment",
                    "criterion": "antibiotics usage",
                    "requirement": {
                        "requirement_type": "time frame",
                        "expected_value": {
                            "operator": "<=",
                            "value": 2,
                            "unit": "weeks"
                        }
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}