{
    "info": {
        "nct_id": "NCT05401162",
        "official_title": "Conventional Dose Chemotherapy for Ovarian Cancer Supported by Autologous Haematopoietic Stem Cell Transfusion",
        "inclusion_criteria": "1）18-60 years old; 2)there are chemotherapy indicators for ovarian cancer;3)ovarian cancer diagnosed by histopathology;4)recurrent and metastatic ovarian cancer;5)the Eastern Cooperative Oncology Group (ECOG) performance status score≤1;6)the expected survival time was more than 3 months; 7)pre-menopausal women (post-menopausal women must have been postmenopausal for at least 12 months to be considered infertile), and the serum pregnancy test results are negative;8)all patients must agree to take effective contraceptive measures during the study period and within 6 months after stopping treatment;9)the subjects voluntarily participate in this clinical trial sign an informed consent form and are able to complete the study procedures and follow-up examinations;10)bone marrow function is good,ability to perform stem cell mobilisation and collection.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 60 Years",
        "exclusion_criteria": "1) patients with bone marrow disease;2)central nervous system or soft meningeal or bone or bone marrow metastases confirmed by imaging or pathology;3)patient has severe cardiac insufficiency;4)previous history of allogeneic stem cell transplantation or organ transplantation;5)patients with active bleeding and autoimmune thrombocytopenic purpura;6)patients with chemotherapy contraindications;7)positive for human immunodeficiency virus (HIV);8)acute or chronic active hepatitis B or hepatitis C infection.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 60 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 60 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 60,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 60 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 60,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "1) patients with bone marrow disease;2)central nervous system or soft meningeal or bone or bone marrow metastases confirmed by imaging or pathology;3)patient has severe cardiac insufficiency;4)previous history of allogeneic stem cell transplantation or organ transplantation;5)patients with active bleeding and autoimmune thrombocytopenic purpura;6)patients with chemotherapy contraindications;7)positive for human immunodeficiency virus (HIV);8)acute or chronic active hepatitis B or hepatitis C infection.",
                "criterions": [
                    {
                        "exact_snippets": "patients with bone marrow disease",
                        "criterion": "bone marrow disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "central nervous system or soft meningeal or bone or bone marrow metastases confirmed by imaging or pathology",
                        "criterion": "metastases",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "central nervous system",
                                "soft meningeal",
                                "bone",
                                "bone marrow"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "central nervous system or soft meningeal or bone or bone marrow metastases confirmed by imaging or pathology",
                        "criterion": "metastases",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": [
                                "imaging",
                                "pathology"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "patient has severe cardiac insufficiency",
                        "criterion": "cardiac insufficiency",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    },
                    {
                        "exact_snippets": "previous history of allogeneic stem cell transplantation or organ transplantation",
                        "criterion": "transplantation history",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "allogeneic stem cell",
                                "organ"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "patients with active bleeding and autoimmune thrombocytopenic purpura",
                        "criterion": "active bleeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients with active bleeding and autoimmune thrombocytopenic purpura",
                        "criterion": "autoimmune thrombocytopenic purpura",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients with chemotherapy contraindications",
                        "criterion": "chemotherapy contraindications",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "positive for human immunodeficiency virus (HIV)",
                        "criterion": "HIV",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "acute or chronic active hepatitis B or hepatitis C infection",
                        "criterion": "hepatitis infection",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "acute",
                                "chronic active"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "acute or chronic active hepatitis B or hepatitis C infection",
                        "criterion": "hepatitis infection",
                        "requirement": {
                            "requirement_type": "virus",
                            "expected_value": [
                                "hepatitis B",
                                "hepatitis C"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "central nervous system or soft meningeal or bone or bone marrow metastases confirmed by imaging or pathology",
                                "criterion": "metastases",
                                "requirement": {
                                    "requirement_type": "location",
                                    "expected_value": [
                                        "central nervous system",
                                        "soft meningeal",
                                        "bone",
                                        "bone marrow"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "central nervous system or soft meningeal or bone or bone marrow metastases confirmed by imaging or pathology",
                                "criterion": "metastases",
                                "requirement": {
                                    "requirement_type": "confirmation",
                                    "expected_value": [
                                        "imaging",
                                        "pathology"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "patients with bone marrow disease",
                        "criterion": "bone marrow disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patient has severe cardiac insufficiency",
                        "criterion": "cardiac insufficiency",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "severe"
                        }
                    },
                    {
                        "exact_snippets": "previous history of allogeneic stem cell transplantation or organ transplantation",
                        "criterion": "transplantation history",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "allogeneic stem cell",
                                "organ"
                            ]
                        }
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "patients with active bleeding and autoimmune thrombocytopenic purpura",
                                "criterion": "active bleeding",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "patients with active bleeding and autoimmune thrombocytopenic purpura",
                                "criterion": "autoimmune thrombocytopenic purpura",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "patients with chemotherapy contraindications",
                        "criterion": "chemotherapy contraindications",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "positive for human immunodeficiency virus (HIV)",
                        "criterion": "HIV",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "acute or chronic active hepatitis B or hepatitis C infection",
                                "criterion": "hepatitis infection",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": [
                                        "acute",
                                        "chronic active"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "acute or chronic active hepatitis B or hepatitis C infection",
                                "criterion": "hepatitis infection",
                                "requirement": {
                                    "requirement_type": "virus",
                                    "expected_value": [
                                        "hepatitis B",
                                        "hepatitis C"
                                    ]
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "1）18-60 years old; 2)there are chemotherapy indicators for ovarian cancer;3)ovarian cancer diagnosed by histopathology;4)recurrent and metastatic ovarian cancer;5)the Eastern Cooperative Oncology Group (ECOG) performance status score≤1;6)the expected survival time was more than 3 months; 7)pre-menopausal women (post-menopausal women must have been postmenopausal for at least 12 months to be considered infertile), and the serum pregnancy test results are negative;8)all patients must agree to take effective contraceptive measures during the study period and within 6 months after stopping treatment;9)the subjects voluntarily participate in this clinical trial sign an informed consent form and are able to complete the study procedures and follow-up examinations;10)bone marrow function is good,ability to perform stem cell mobilisation and collection.",
                "criterions": [
                    {
                        "exact_snippets": "18-60 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 60,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "chemotherapy indicators for ovarian cancer",
                        "criterion": "chemotherapy indicators for ovarian cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "ovarian cancer diagnosed by histopathology",
                        "criterion": "ovarian cancer diagnosis",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "histopathology"
                        }
                    },
                    {
                        "exact_snippets": "recurrent and metastatic ovarian cancer",
                        "criterion": "ovarian cancer",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "recurrent",
                                "metastatic"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status score≤1",
                        "criterion": "ECOG performance status score",
                        "requirement": {
                            "requirement_type": "score",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "expected survival time was more than 3 months",
                        "criterion": "expected survival time",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "pre-menopausal women",
                        "criterion": "menopausal status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "pre-menopausal"
                        }
                    },
                    {
                        "exact_snippets": "post-menopausal women must have been postmenopausal for at least 12 months",
                        "criterion": "post-menopausal duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "serum pregnancy test results are negative",
                        "criterion": "serum pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "all patients must agree to take effective contraceptive measures during the study period and within 6 months after stopping treatment",
                        "criterion": "contraceptive measures",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "subjects voluntarily participate in this clinical trial sign an informed consent form",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "able to complete the study procedures and follow-up examinations",
                        "criterion": "ability to complete study procedures",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "bone marrow function is good",
                        "criterion": "bone marrow function",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "good"
                        }
                    },
                    {
                        "exact_snippets": "ability to perform stem cell mobilisation and collection",
                        "criterion": "stem cell mobilisation and collection",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}