{
    "info": {
        "nct_id": "NCT05314101",
        "official_title": "TAS-102 Combined With Bevacizumab and Tislelizumab Third-line or Above in the Treatment of Liver Metastasis in Colorectal Cancer : An Open-label 、Phase Ⅱ Clinical Trial",
        "inclusion_criteria": "* Patients who provided informed consent and voluntarily enrolled\n* Patients with liver metastasis of advanced colorectal adenocarcinoma with MSS confirmed by pathology;\n* 18-75 years old;\n* Measurable target lesions according to RECIST V1.1 assessment criteria;\n* Progression after standard second-line treatment (irinotecan, oxaliplatin, or fluorouracil);\n* 0 ~ 2 points according to ECOG quality of life score;\n* Drugs can be taken orally\n* Estimated survival ≥3 months;\n* Women of childbearing age should comply with contraceptive measures if pregnancy test is negative;\n* Ascites with no obvious symptoms and no clinical intervention;\n* Adequate organ and bone marrow functions, ecg, blood, biochemical and other basic tests are not contraindications of chemotherapy;\n* Adherence to scheduled visits, treatment plans, laboratory tests, and other study procedures Willingness and ability.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* Previous application of TAS-102;\n* Pregnant or lactating women;\n* No contraception during the reproductive period;\n* patients known to have a history of allergy to any study drug, similar drug or excipient;\n* Patients with risk of massive gastrointestinal bleeding or gastrointestinal obstruction;\n* Patients with a history of thromboembolism, except those caused by PICC;\n* Patients with active infection;\n* Patients with uncontrolled hypertension (systolic blood pressure ≥160 mmHg and diastolic blood pressure ≥90) MmHg);\n* Patients with brain metastases with clinical symptoms or imaging evidence;\n* Contraindications for treatment of other chronic diseases;\n* Previous immunotherapy-related myocarditis, pneumonia, colitis, hepatitis, kidney Inflammation and other conditions, the current AE is still ≥2;\n* According to THE NCI CTCAE 5.0 assessment criteria, there are all types of existing cases due to previous treatment Patients with grade ≥2 toxic reactions;\n* Other conditions that the investigator determines are not suitable for inclusion in the study.\n* Received any anti-tumor therapy and participated in other clinical studies within 4 weeks prior to enrollment.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients who provided informed consent and voluntarily enrolled",
                "criterions": [
                    {
                        "exact_snippets": "Patients who provided informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "voluntarily enrolled",
                        "criterion": "voluntary enrollment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients who provided informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "voluntarily enrolled",
                        "criterion": "voluntary enrollment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with liver metastasis of advanced colorectal adenocarcinoma with MSS confirmed by pathology;",
                "criterions": [
                    {
                        "exact_snippets": "liver metastasis",
                        "criterion": "liver metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "advanced colorectal adenocarcinoma",
                        "criterion": "advanced colorectal adenocarcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "MSS confirmed by pathology",
                        "criterion": "MSS (microsatellite stability)",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "pathology"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "liver metastasis",
                        "criterion": "liver metastasis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "advanced colorectal adenocarcinoma",
                        "criterion": "advanced colorectal adenocarcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "MSS confirmed by pathology",
                        "criterion": "MSS (microsatellite stability)",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "pathology"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 18-75 years old;",
                "criterions": [
                    {
                        "exact_snippets": "18-75 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "18-75 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable target lesions according to RECIST V1.1 assessment criteria;",
                "criterions": [
                    {
                        "exact_snippets": "Measurable target lesions according to RECIST V1.1 assessment criteria",
                        "criterion": "target lesions",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": "according to RECIST V1.1 assessment criteria"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Measurable target lesions according to RECIST V1.1 assessment criteria",
                        "criterion": "target lesions",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": "according to RECIST V1.1 assessment criteria"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Progression after standard second-line treatment (irinotecan, oxaliplatin, or fluorouracil);",
                "criterions": [
                    {
                        "exact_snippets": "Progression after standard second-line treatment (irinotecan, oxaliplatin, or fluorouracil)",
                        "criterion": "progression after second-line treatment",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "irinotecan",
                                "oxaliplatin",
                                "fluorouracil"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Progression after standard second-line treatment (irinotecan, oxaliplatin, or fluorouracil)",
                        "criterion": "progression after second-line treatment",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": [
                                "irinotecan",
                                "oxaliplatin",
                                "fluorouracil"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 0 ~ 2 points according to ECOG quality of life score;",
                "criterions": [
                    {
                        "exact_snippets": "0 ~ 2 points according to ECOG quality of life score",
                        "criterion": "ECOG quality of life score",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "points"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "points"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "0 ~ 2 points according to ECOG quality of life score",
                        "criterion": "ECOG quality of life score",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "points"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "points"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Drugs can be taken orally",
                "criterions": [
                    {
                        "exact_snippets": "Drugs can be taken orally",
                        "criterion": "drug administration route",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "oral"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Drugs can be taken orally",
                        "criterion": "drug administration route",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "oral"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Estimated survival ≥3 months;",
                "criterions": [
                    {
                        "exact_snippets": "Estimated survival ≥3 months",
                        "criterion": "estimated survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Estimated survival ≥3 months",
                        "criterion": "estimated survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Women of childbearing age should comply with contraceptive measures if pregnancy test is negative;",
                "criterions": [
                    {
                        "exact_snippets": "Women of childbearing age",
                        "criterion": "gender and reproductive status",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "Women of childbearing age",
                        "criterion": "gender and reproductive status",
                        "requirement": {
                            "requirement_type": "reproductive status",
                            "expected_value": "childbearing age"
                        }
                    },
                    {
                        "exact_snippets": "pregnancy test is negative",
                        "criterion": "pregnancy test result",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Women of childbearing age",
                                    "criterion": "gender and reproductive status",
                                    "requirement": {
                                        "requirement_type": "gender",
                                        "expected_value": "female"
                                    }
                                },
                                {
                                    "exact_snippets": "Women of childbearing age",
                                    "criterion": "gender and reproductive status",
                                    "requirement": {
                                        "requirement_type": "reproductive status",
                                        "expected_value": "childbearing age"
                                    }
                                }
                            ]
                        },
                        {
                            "exact_snippets": "pregnancy test is negative",
                            "criterion": "pregnancy test result",
                            "requirement": {
                                "requirement_type": "result",
                                "expected_value": "negative"
                            }
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": "Women of childbearing age should comply with contraceptive measures",
                    "criterion": "contraceptive measures compliance",
                    "requirement": {
                        "requirement_type": "compliance",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Ascites with no obvious symptoms and no clinical intervention;",
                "criterions": [
                    {
                        "exact_snippets": "Ascites",
                        "criterion": "ascites",
                        "requirement": {
                            "requirement_type": "symptoms",
                            "expected_value": "no obvious symptoms"
                        }
                    },
                    {
                        "exact_snippets": "Ascites",
                        "criterion": "ascites",
                        "requirement": {
                            "requirement_type": "clinical intervention",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Ascites",
                        "criterion": "ascites",
                        "requirement": {
                            "requirement_type": "symptoms",
                            "expected_value": "no obvious symptoms"
                        }
                    },
                    {
                        "exact_snippets": "Ascites",
                        "criterion": "ascites",
                        "requirement": {
                            "requirement_type": "clinical intervention",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adherence to scheduled visits, treatment plans, laboratory tests, and other study procedures Willingness and ability.",
                "criterions": [
                    {
                        "exact_snippets": "Adherence to scheduled visits",
                        "criterion": "adherence to scheduled visits",
                        "requirement": {
                            "requirement_type": "adherence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adherence to ... treatment plans",
                        "criterion": "adherence to treatment plans",
                        "requirement": {
                            "requirement_type": "adherence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adherence to ... laboratory tests",
                        "criterion": "adherence to laboratory tests",
                        "requirement": {
                            "requirement_type": "adherence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adherence to ... other study procedures",
                        "criterion": "adherence to other study procedures",
                        "requirement": {
                            "requirement_type": "adherence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability",
                        "criterion": "willingness and ability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "Adherence to scheduled visits",
                                                "criterion": "adherence to scheduled visits",
                                                "requirement": {
                                                    "requirement_type": "adherence",
                                                    "expected_value": true
                                                }
                                            },
                                            {
                                                "exact_snippets": "Adherence to ... treatment plans",
                                                "criterion": "adherence to treatment plans",
                                                "requirement": {
                                                    "requirement_type": "adherence",
                                                    "expected_value": true
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "Adherence to ... laboratory tests",
                                        "criterion": "adherence to laboratory tests",
                                        "requirement": {
                                            "requirement_type": "adherence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Adherence to ... other study procedures",
                                "criterion": "adherence to other study procedures",
                                "requirement": {
                                    "requirement_type": "adherence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Willingness and ability",
                        "criterion": "willingness and ability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 75 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Previous application of TAS-102;",
                "criterions": [
                    {
                        "exact_snippets": "Previous application of TAS-102",
                        "criterion": "TAS-102 application",
                        "requirement": {
                            "requirement_type": "previous application",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Previous application of TAS-102",
                        "criterion": "TAS-102 application",
                        "requirement": {
                            "requirement_type": "previous application",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant or lactating women;",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No contraception during the reproductive period;",
                "criterions": [
                    {
                        "exact_snippets": "No contraception during the reproductive period",
                        "criterion": "contraception",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No contraception during the reproductive period",
                    "criterion": "contraception",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* patients known to have a history of allergy to any study drug, similar drug or excipient;",
                "criterions": [
                    {
                        "exact_snippets": "patients known to have a history of allergy to any study drug",
                        "criterion": "allergy to study drug",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients known to have a history of allergy to any ... similar drug",
                        "criterion": "allergy to similar drug",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients known to have a history of allergy to any ... excipient",
                        "criterion": "allergy to excipient",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "patients known to have a history of allergy to any study drug",
                        "criterion": "allergy to study drug",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients known to have a history of allergy to any ... similar drug",
                        "criterion": "allergy to similar drug",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients known to have a history of allergy to any ... excipient",
                        "criterion": "allergy to excipient",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with a history of thromboembolism, except those caused by PICC;",
                "criterions": [
                    {
                        "exact_snippets": "history of thromboembolism",
                        "criterion": "thromboembolism",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except those caused by PICC",
                        "criterion": "thromboembolism caused by PICC",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "history of thromboembolism",
                    "criterion": "thromboembolism",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "not_criteria": {
                        "exact_snippets": "except those caused by PICC",
                        "criterion": "thromboembolism caused by PICC",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Patients with active infection;",
                "criterions": [
                    {
                        "exact_snippets": "Patients with active infection",
                        "criterion": "active infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patients with active infection",
                    "criterion": "active infection",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients with uncontrolled hypertension (systolic blood pressure ≥160 mmHg and diastolic blood pressure ≥90) MmHg);",
                "criterions": [
                    {
                        "exact_snippets": "uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "systolic blood pressure ≥160 mmHg",
                        "criterion": "systolic blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 160,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "diastolic blood pressure ≥90) MmHg",
                        "criterion": "diastolic blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 90,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "systolic blood pressure ≥160 mmHg",
                                "criterion": "systolic blood pressure",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 160,
                                        "unit": "mmHg"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "diastolic blood pressure ≥90) MmHg",
                                "criterion": "diastolic blood pressure",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 90,
                                        "unit": "mmHg"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Received any anti-tumor therapy and participated in other clinical studies within 4 weeks prior to enrollment.",
                "criterions": [
                    {
                        "exact_snippets": "Received any anti-tumor therapy",
                        "criterion": "anti-tumor therapy",
                        "requirement": {
                            "requirement_type": "receipt",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "participated in other clinical studies within 4 weeks prior to enrollment",
                        "criterion": "participation in other clinical studies",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Received any anti-tumor therapy",
                        "criterion": "anti-tumor therapy",
                        "requirement": {
                            "requirement_type": "receipt",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "participated in other clinical studies within 4 weeks prior to enrollment",
                        "criterion": "participation in other clinical studies",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Adequate organ and bone marrow functions, ecg, blood, biochemical and other basic tests are not contraindications of chemotherapy;",
                "criterions": [
                    {
                        "exact_snippets": "Adequate organ and bone marrow functions",
                        "criterion": "organ and bone marrow functions",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "ecg",
                        "criterion": "ECG",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "blood",
                        "criterion": "blood tests",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "biochemical",
                        "criterion": "biochemical tests",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "other basic tests",
                        "criterion": "other basic tests",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Adequate organ and bone marrow functions",
                                "criterion": "organ and bone marrow functions",
                                "requirement": {
                                    "requirement_type": "adequacy",
                                    "expected_value": true
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "ecg",
                                    "criterion": "ECG",
                                    "requirement": {
                                        "requirement_type": "contraindication",
                                        "expected_value": true
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "blood",
                            "criterion": "blood tests",
                            "requirement": {
                                "requirement_type": "contraindication",
                                "expected_value": true
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "biochemical",
                            "criterion": "biochemical tests",
                            "requirement": {
                                "requirement_type": "contraindication",
                                "expected_value": true
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "other basic tests",
                            "criterion": "other basic tests",
                            "requirement": {
                                "requirement_type": "contraindication",
                                "expected_value": true
                            }
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Patients with risk of massive gastrointestinal bleeding or gastrointestinal obstruction;",
                "criterions": [
                    {
                        "exact_snippets": "risk of massive gastrointestinal bleeding",
                        "criterion": "risk of massive gastrointestinal bleeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "risk of ... gastrointestinal obstruction",
                        "criterion": "risk of gastrointestinal obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "risk of massive gastrointestinal bleeding",
                        "criterion": "risk of massive gastrointestinal bleeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "risk of ... gastrointestinal obstruction",
                        "criterion": "risk of gastrointestinal obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with brain metastases with clinical symptoms or imaging evidence;",
                "criterions": [
                    {
                        "exact_snippets": "brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "clinical symptoms",
                        "criterion": "clinical symptoms",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "imaging evidence",
                        "criterion": "imaging evidence",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Contraindications for treatment of other chronic diseases;",
                "criterions": [
                    {
                        "exact_snippets": "Contraindications for treatment of other chronic diseases",
                        "criterion": "contraindications for treatment",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "other chronic diseases"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous immunotherapy-related myocarditis, pneumonia, colitis, hepatitis, kidney Inflammation and other conditions, the current AE is still ≥2;",
                "criterions": [
                    {
                        "exact_snippets": "Previous immunotherapy-related myocarditis",
                        "criterion": "immunotherapy-related myocarditis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Previous immunotherapy-related ... pneumonia",
                        "criterion": "immunotherapy-related pneumonia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Previous immunotherapy-related ... colitis",
                        "criterion": "immunotherapy-related colitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Previous immunotherapy-related ... hepatitis",
                        "criterion": "immunotherapy-related hepatitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Previous immunotherapy-related ... kidney Inflammation",
                        "criterion": "immunotherapy-related kidney inflammation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "the current AE is still ≥2",
                        "criterion": "current adverse event (AE) grade",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* According to THE NCI CTCAE 5.0 assessment criteria, there are all types of existing cases due to previous treatment Patients with grade ≥2 toxic reactions;",
                "criterions": [
                    {
                        "exact_snippets": "Patients with grade ≥2 toxic reactions",
                        "criterion": "toxic reactions",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Other conditions that the investigator determines are not suitable for inclusion in the study.",
                "criterions": [
                    {
                        "exact_snippets": "Other conditions that the investigator determines are not suitable for inclusion in the study.",
                        "criterion": "other conditions",
                        "requirement": {
                            "requirement_type": "suitability for inclusion",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_miscellaneous": []
}