{
    "info": {
        "nct_id": "NCT05029882",
        "official_title": "A Phase 1 First in Human Study Evaluating Safety, Pharmacokinetics and Efficacy of ABBV-400 as Monotherapy and in Combination With Bevacizumab in Adult Subjects With Advanced Solid Tumors",
        "inclusion_criteria": "* Diagnosis of malignant solid tumor (World Health Organization [WHO] criteria).\n* Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.\n* For Part 1 only - advanced solid tumors including (but not limited to) non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), gastroesophagel junction adenocarcinoma (GEA), colorectal cancer (CRC), and renal cell carcinoma (RCC), who have progressed on all standard of care therapy and are not amenable to surgical resection or other approved therapeutic options that have demonstrated clinical benefit.\n* For Part 2 only - advanced non-squamous squamous Non-Small Cell Lung Cancer (NSCLC) that have progressed after treatment with at least:\n\n  * Platinum-based chemotherapy and an immune checkpoint inhibitor and/or appropriate targeted therapy for an actionable gene alteration, if applicable, for non-squamous wtEGFR NSCLC (Part 2i) and squamous NSCLC (Part 2iii).\n  * Platinum-based chemotherapy doublet and tyrosine kinase inhibitor(s) (TKI[s]) for non- squamous mutEGFR NSCLC (Part 2ii).\n  * Must have no more than 2 lines of prior cytotoxic chemotherapy excluding adjuvant therapy and must have advanced NSCLC that is not amenable to surgical resection or other approved therapeutic options that have demonstrated clinical benefit.\n* For Part 3 only - Participants with advanced GEA that has progressed after treatment with at least 1 prior cytotoxic chemotherapeutic regimen for locally advanced or metastatic disease and have not received more than 2 prior lines of cytotoxic chemotherapy regimens. Participants must have progressed on\n\n  * If applicable, an immune checkpoint inhibitor.\n  * If applicable, appropriate available therapies, including HER2-directed therapies.\n\nParticipants who are considered ineligible for or are intolerant of standard therapy per investigator are eligible.\n\n* For Part 4 only - Participants with history of advanced histopathologically or cytologically confirmed colorectal cancer (CRC) that does not harbor the BRAF V600E mutation and are not dMMR+/MSI-Hi with progression on:\n\n  * A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine).\n  * Oxaliplatin.\n  * Irinotecan.\n  * If applicable, anti-EGFR (including, but not limited to cetuximab or panitumumab).\n  * If applicable, anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept).\n  * If applicable, targeted therapy\n  * Participants who are considered ineligible for or are intolerant of standard therapy per investigator are eligible. Prior trifluridine/tipiracil (TAS-102) or Regorafenib treated participants are eligible.\n* For Part 5 only - participants with advanced histologically or cytologically confirmed solid tumors characterized by MET amplification who are not amenable to surgical resection and who have disease progression after at least one prior systemic therapy and/or who have no satisfactory alternative treatment options. Participants who are intolerant to standard treatment are eligible.\n\nFor Part 6 only - Participants with advanced histologically or cytologically confirmed solid tumors harboring MET mutations including: mutations in the tyrosine kinase domain, the juxtamembrane region and the extracellular domain (as locally determined by next-generation sequencing (NGS) or a validated qPCR on tissue), who are not amenable to surgical resection and who have disease progression after at least one prior systemic therapy and/or who have no satisfactory alternative treatment options.\n\n* Intolerant to the standard treatment are eligible\n* For Part 7 (CRC combination) only: Participants with history of advanced histopathologically or cytologically confirmed CRC that does not harbor the mutation and are not dMMR+/MSI-H with progression on:\n\n  * A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine)\n  * Oxaliplatin\n  * Irinotecan\n  * If applicable, anti-EGFR (including, but not limited to cetuximab or panitumumab)\n  * If applicable, anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept)\n  * If applicable, targeted therapy Participants who are considered ineligible for or are intolerant of standard therapy per investigator are eligible. Participants treated previously with TAS-102 or regorafenib are not eligible.\n* Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.\n* Laboratory values meeting the criteria outlined in the protocol.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, nor any evidence of active ILD or on screening chest CT scan..\n* History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis.\n* History of clinically significant, intercurrent lung-specific illnesses, as noted in the protocol.\n* For Part 7 only: Prior TAS-102 or regorafenib treated participants are not eligible.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Diagnosis of malignant solid tumor (World Health Organization [WHO] criteria).",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of malignant solid tumor (World Health Organization [WHO] criteria)",
                        "criterion": "malignant solid tumor",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosis of malignant solid tumor (World Health Organization [WHO] criteria)",
                        "criterion": "malignant solid tumor",
                        "requirement": {
                            "requirement_type": "criteria",
                            "expected_value": "World Health Organization [WHO]"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosis of malignant solid tumor (World Health Organization [WHO] criteria)",
                        "criterion": "malignant solid tumor",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosis of malignant solid tumor (World Health Organization [WHO] criteria)",
                        "criterion": "malignant solid tumor",
                        "requirement": {
                            "requirement_type": "criteria",
                            "expected_value": "World Health Organization [WHO]"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.",
                "criterions": [
                    {
                        "exact_snippets": "Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "evaluation criteria",
                            "expected_value": "Response Evaluation Criteria in Solid Tumors (RECIST) v1.1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "evaluation criteria",
                            "expected_value": "Response Evaluation Criteria in Solid Tumors (RECIST) v1.1"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* For Part 1 only - advanced solid tumors including (but not limited to) non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), gastroesophagel junction adenocarcinoma (GEA), colorectal cancer (CRC), and renal cell carcinoma (RCC), who have progressed on all standard of care therapy and are not amenable to surgical resection or other approved therapeutic options that have demonstrated clinical benefit.",
                "criterions": [
                    {
                        "exact_snippets": "advanced solid tumors including (but not limited to) non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), gastroesophagel junction adenocarcinoma (GEA), colorectal cancer (CRC), and renal cell carcinoma (RCC)",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "advanced solid tumors",
                                "non-small cell lung cancer (NSCLC)",
                                "head and neck squamous cell carcinoma (HNSCC)",
                                "gastroesophagel junction adenocarcinoma (GEA)",
                                "colorectal cancer (CRC)",
                                "renal cell carcinoma (RCC)"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "who have progressed on all standard of care therapy",
                        "criterion": "progression on standard of care therapy",
                        "requirement": {
                            "requirement_type": "progression",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "are not amenable to surgical resection or other approved therapeutic options that have demonstrated clinical benefit",
                        "criterion": "amenability to surgical resection or other approved therapeutic options",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "advanced solid tumors including (but not limited to) non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), gastroesophagel junction adenocarcinoma (GEA), colorectal cancer (CRC), and renal cell carcinoma (RCC)",
                                "criterion": "cancer type",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": [
                                        "advanced solid tumors",
                                        "non-small cell lung cancer (NSCLC)",
                                        "head and neck squamous cell carcinoma (HNSCC)",
                                        "gastroesophagel junction adenocarcinoma (GEA)",
                                        "colorectal cancer (CRC)",
                                        "renal cell carcinoma (RCC)"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "who have progressed on all standard of care therapy",
                                "criterion": "progression on standard of care therapy",
                                "requirement": {
                                    "requirement_type": "progression",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "are not amenable to surgical resection or other approved therapeutic options that have demonstrated clinical benefit",
                        "criterion": "amenability to surgical resection or other approved therapeutic options",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* For Part 2 only - advanced non-squamous squamous Non-Small Cell Lung Cancer (NSCLC) that have progressed after treatment with at least:",
                "criterions": [
                    {
                        "exact_snippets": "advanced non-squamous squamous Non-Small Cell Lung Cancer (NSCLC)",
                        "criterion": "Non-Small Cell Lung Cancer (NSCLC)",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "advanced",
                                "non-squamous",
                                "squamous"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "progressed after treatment",
                        "criterion": "disease progression",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "progressed"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "advanced non-squamous squamous Non-Small Cell Lung Cancer (NSCLC)",
                                "criterion": "Non-Small Cell Lung Cancer (NSCLC)",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": [
                                        "advanced",
                                        "non-squamous",
                                        "squamous"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "progressed after treatment",
                                "criterion": "disease progression",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "progressed"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "For Part 2 only",
                        "criterion": "trial part",
                        "requirement": {
                            "requirement_type": "participation",
                            "expected_value": "Part 2"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Must have no more than 2 lines of prior cytotoxic chemotherapy excluding adjuvant therapy and must have advanced NSCLC that is not amenable to surgical resection or other approved therapeutic options that have demonstrated clinical benefit.",
                "criterions": [
                    {
                        "exact_snippets": "no more than 2 lines of prior cytotoxic chemotherapy",
                        "criterion": "prior cytotoxic chemotherapy",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "lines"
                            }
                        }
                    },
                    {
                        "exact_snippets": "advanced NSCLC",
                        "criterion": "NSCLC",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "not amenable to surgical resection",
                        "criterion": "surgical resection",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not amenable to ... other approved therapeutic options that have demonstrated clinical benefit",
                        "criterion": "other approved therapeutic options",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "no more than 2 lines of prior cytotoxic chemotherapy",
                                "criterion": "prior cytotoxic chemotherapy",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "lines"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "advanced NSCLC",
                                "criterion": "NSCLC",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "advanced"
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "not amenable to surgical resection",
                                "criterion": "surgical resection",
                                "requirement": {
                                    "requirement_type": "amenability",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "not amenable to ... other approved therapeutic options that have demonstrated clinical benefit",
                                "criterion": "other approved therapeutic options",
                                "requirement": {
                                    "requirement_type": "amenability",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, an immune checkpoint inhibitor.",
                "criterions": [
                    {
                        "exact_snippets": "an immune checkpoint inhibitor",
                        "criterion": "immune checkpoint inhibitor",
                        "requirement": {
                            "requirement_type": "applicability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "an immune checkpoint inhibitor",
                    "criterion": "immune checkpoint inhibitor",
                    "requirement": {
                        "requirement_type": "applicability",
                        "expected_value": true
                    }
                },
                "then_criteria": null,
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, appropriate available therapies, including HER2-directed therapies.",
                "criterions": [
                    {
                        "exact_snippets": "appropriate available therapies, including HER2-directed therapies",
                        "criterion": "therapies",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "appropriate",
                                "available",
                                "HER2-directed"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "If applicable",
                    "criterion": "applicability",
                    "requirement": {
                        "requirement_type": "N/A",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "appropriate available therapies, including HER2-directed therapies",
                    "criterion": "therapies",
                    "requirement": {
                        "requirement_type": "type",
                        "expected_value": [
                            "appropriate",
                            "available",
                            "HER2-directed"
                        ]
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "Participants who are considered ineligible for or are intolerant of standard therapy per investigator are eligible.",
                "criterions": [
                    {
                        "exact_snippets": "considered ineligible for ... standard therapy",
                        "criterion": "eligibility for standard therapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "intolerant of standard therapy",
                        "criterion": "tolerance to standard therapy",
                        "requirement": {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "considered ineligible for ... standard therapy",
                        "criterion": "eligibility for standard therapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "intolerant of standard therapy",
                        "criterion": "tolerance to standard therapy",
                        "requirement": {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* For Part 4 only - Participants with history of advanced histopathologically or cytologically confirmed colorectal cancer (CRC) that does not harbor the BRAF V600E mutation and are not dMMR+/MSI-Hi with progression on:",
                "criterions": [
                    {
                        "exact_snippets": "history of advanced histopathologically or cytologically confirmed colorectal cancer (CRC)",
                        "criterion": "colorectal cancer (CRC)",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histopathologically or cytologically"
                        }
                    },
                    {
                        "exact_snippets": "history of advanced histopathologically or cytologically confirmed colorectal cancer (CRC)",
                        "criterion": "colorectal cancer (CRC)",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "does not harbor the BRAF V600E mutation",
                        "criterion": "BRAF V600E mutation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "are not dMMR+/MSI-Hi",
                        "criterion": "dMMR+/MSI-Hi",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "history of advanced histopathologically or cytologically confirmed colorectal cancer (CRC)",
                                                "criterion": "colorectal cancer (CRC)",
                                                "requirement": {
                                                    "requirement_type": "confirmation",
                                                    "expected_value": "histopathologically or cytologically"
                                                }
                                            },
                                            {
                                                "exact_snippets": "history of advanced histopathologically or cytologically confirmed colorectal cancer (CRC)",
                                                "criterion": "colorectal cancer (CRC)",
                                                "requirement": {
                                                    "requirement_type": "stage",
                                                    "expected_value": "advanced"
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "does not harbor the BRAF V600E mutation",
                                        "criterion": "BRAF V600E mutation",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "are not dMMR+/MSI-Hi",
                                "criterion": "dMMR+/MSI-Hi",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine).",
                "criterions": [
                    {
                        "exact_snippets": "A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine)",
                        "criterion": "fluoropyrimidine treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine)",
                        "criterion": "fluoropyrimidine treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Oxaliplatin.",
                "criterions": [
                    {
                        "exact_snippets": "Oxaliplatin.",
                        "criterion": "oxaliplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Oxaliplatin.",
                        "criterion": "oxaliplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Irinotecan.",
                "criterions": [
                    {
                        "exact_snippets": "Irinotecan.",
                        "criterion": "irinotecan",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Irinotecan.",
                        "criterion": "irinotecan",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, anti-EGFR (including, but not limited to cetuximab or panitumumab).",
                "criterions": [
                    {
                        "exact_snippets": "anti-EGFR (including, but not limited to cetuximab or panitumumab)",
                        "criterion": "anti-EGFR treatment",
                        "requirement": {
                            "requirement_type": "applicability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "anti-EGFR (including, but not limited to cetuximab or panitumumab)",
                    "criterion": "anti-EGFR treatment",
                    "requirement": {
                        "requirement_type": "applicability",
                        "expected_value": true
                    }
                },
                "then_criteria": null,
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept).",
                "criterions": [
                    {
                        "exact_snippets": "anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept)",
                        "criterion": "anti-VEGF monoclonal antibody",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "If applicable",
                    "criterion": "applicability",
                    "requirement": {
                        "requirement_type": "N/A",
                        "expected_value": "applicable"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept)",
                    "criterion": "anti-VEGF monoclonal antibody",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, targeted therapy",
                "criterions": [
                    {
                        "exact_snippets": "targeted therapy",
                        "criterion": "targeted therapy",
                        "requirement": {
                            "requirement_type": "applicability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "targeted therapy",
                    "criterion": "targeted therapy",
                    "requirement": {
                        "requirement_type": "applicability",
                        "expected_value": true
                    }
                },
                "then_criteria": null,
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Participants who are considered ineligible for or are intolerant of standard therapy per investigator are eligible. Prior trifluridine/tipiracil (TAS-102) or Regorafenib treated participants are eligible.",
                "criterions": [
                    {
                        "exact_snippets": "Participants who are considered ineligible for ... standard therapy",
                        "criterion": "eligibility for standard therapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Participants who are ... intolerant of standard therapy",
                        "criterion": "tolerance to standard therapy",
                        "requirement": {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Prior trifluridine/tipiracil (TAS-102) ... treated participants are eligible",
                        "criterion": "prior treatment with trifluridine/tipiracil (TAS-102)",
                        "requirement": {
                            "requirement_type": "treatment history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Prior ... Regorafenib treated participants are eligible",
                        "criterion": "prior treatment with Regorafenib",
                        "requirement": {
                            "requirement_type": "treatment history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Participants who are considered ineligible for ... standard therapy",
                                        "criterion": "eligibility for standard therapy",
                                        "requirement": {
                                            "requirement_type": "eligibility",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "Participants who are ... intolerant of standard therapy",
                                        "criterion": "tolerance to standard therapy",
                                        "requirement": {
                                            "requirement_type": "tolerance",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Prior trifluridine/tipiracil (TAS-102) ... treated participants are eligible",
                                "criterion": "prior treatment with trifluridine/tipiracil (TAS-102)",
                                "requirement": {
                                    "requirement_type": "treatment history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Prior ... Regorafenib treated participants are eligible",
                                "criterion": "prior treatment with Regorafenib",
                                "requirement": {
                                    "requirement_type": "treatment history",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "For Part 6 only - Participants with advanced histologically or cytologically confirmed solid tumors harboring MET mutations including: mutations in the tyrosine kinase domain, the juxtamembrane region and the extracellular domain (as locally determined by next-generation sequencing (NGS) or a validated qPCR on tissue), who are not amenable to surgical resection and who have disease progression after at least one prior systemic therapy and/or who have no satisfactory alternative treatment options.",
                "criterions": [
                    {
                        "exact_snippets": "advanced histologically or cytologically confirmed solid tumors",
                        "criterion": "solid tumors",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically or cytologically"
                        }
                    },
                    {
                        "exact_snippets": "advanced histologically or cytologically confirmed solid tumors",
                        "criterion": "solid tumors",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "advanced"
                        }
                    },
                    {
                        "exact_snippets": "solid tumors harboring MET mutations",
                        "criterion": "MET mutations",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "mutations in the tyrosine kinase domain",
                        "criterion": "MET mutations in the tyrosine kinase domain",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "mutations in ... the juxtamembrane region",
                        "criterion": "MET mutations in the juxtamembrane region",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "mutations in ... the extracellular domain",
                        "criterion": "MET mutations in the extracellular domain",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "not amenable to surgical resection",
                        "criterion": "surgical resection",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "disease progression after at least one prior systemic therapy",
                        "criterion": "disease progression after systemic therapy",
                        "requirement": {
                            "requirement_type": "number of prior therapies",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "therapy"
                            }
                        }
                    },
                    {
                        "exact_snippets": "no satisfactory alternative treatment options",
                        "criterion": "alternative treatment options",
                        "requirement": {
                            "requirement_type": "satisfaction",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "advanced histologically or cytologically confirmed solid tumors",
                                "criterion": "solid tumors",
                                "requirement": {
                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically or cytologically"
                                }
                            },
                            {
                                "exact_snippets": "advanced histologically or cytologically confirmed solid tumors",
                                "criterion": "solid tumors",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "advanced"
                                }
                            },
                            {
                                "exact_snippets": "solid tumors harboring MET mutations",
                                "criterion": "MET mutations",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "mutations in the tyrosine kinase domain",
                                        "criterion": "MET mutations in the tyrosine kinase domain",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "mutations in ... the juxtamembrane region",
                                        "criterion": "MET mutations in the juxtamembrane region",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "mutations in ... the extracellular domain",
                                        "criterion": "MET mutations in the extracellular domain",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "not amenable to surgical resection",
                        "criterion": "surgical resection",
                        "requirement": {
                            "requirement_type": "amenability",
                            "expected_value": false
                        }
                    },
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "disease progression after at least one prior systemic therapy",
                                "criterion": "disease progression after systemic therapy",
                                "requirement": {
                                    "requirement_type": "number of prior therapies",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "therapy"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "no satisfactory alternative treatment options",
                                "criterion": "alternative treatment options",
                                "requirement": {
                                    "requirement_type": "satisfaction",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Intolerant to the standard treatment are eligible",
                "criterions": [
                    {
                        "exact_snippets": "Intolerant to the standard treatment",
                        "criterion": "treatment intolerance",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Intolerant to the standard treatment",
                        "criterion": "treatment intolerance",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* For Part 7 (CRC combination) only: Participants with history of advanced histopathologically or cytologically confirmed CRC that does not harbor the mutation and are not dMMR+/MSI-H with progression on:",
                "criterions": [
                    {
                        "exact_snippets": "history of advanced histopathologically or cytologically confirmed CRC",
                        "criterion": "advanced CRC",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histopathologically or cytologically"
                        }
                    },
                    {
                        "exact_snippets": "does not harbor the mutation",
                        "criterion": "mutation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "are not dMMR+/MSI-H",
                        "criterion": "dMMR+/MSI-H",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "For Part 7 (CRC combination) only",
                    "criterion": "Part 7 (CRC combination)",
                    "requirement": {
                        "requirement_type": "participation",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": "history of advanced histopathologically or cytologically confirmed CRC",
                            "criterion": "advanced CRC",
                            "requirement": {
                                "requirement_type": "confirmation",
                                "expected_value": "histopathologically or cytologically"
                            }
                        },
                        {
                            "exact_snippets": "does not harbor the mutation",
                            "criterion": "mutation",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        },
                        {
                            "exact_snippets": "are not dMMR+/MSI-H",
                            "criterion": "dMMR+/MSI-H",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine)",
                "criterions": [
                    {
                        "exact_snippets": "A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine)",
                        "criterion": "fluoropyrimidine",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "A fluoropyrimidine (e.g., 5-fluorouracil or capecitabine)",
                        "criterion": "fluoropyrimidine",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Oxaliplatin",
                "criterions": [
                    {
                        "exact_snippets": "Oxaliplatin",
                        "criterion": "oxaliplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Oxaliplatin",
                        "criterion": "oxaliplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Irinotecan",
                "criterions": [
                    {
                        "exact_snippets": "Irinotecan",
                        "criterion": "irinotecan",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Irinotecan",
                        "criterion": "irinotecan",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, anti-EGFR (including, but not limited to cetuximab or panitumumab)",
                "criterions": [
                    {
                        "exact_snippets": "anti-EGFR (including, but not limited to cetuximab or panitumumab)",
                        "criterion": "anti-EGFR treatment",
                        "requirement": {
                            "requirement_type": "applicability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "anti-EGFR (including, but not limited to cetuximab or panitumumab)",
                    "criterion": "anti-EGFR treatment",
                    "requirement": {
                        "requirement_type": "applicability",
                        "expected_value": true
                    }
                },
                "then_criteria": null,
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept)",
                "criterions": [
                    {
                        "exact_snippets": "anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept)",
                        "criterion": "anti-VEGF monoclonal antibody",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "If applicable",
                    "criterion": "applicability",
                    "requirement": {
                        "requirement_type": "applicability",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "anti-vascular endothelial growth factor (VEGF) monoclonal antibody (including but not limited to bevacizumab, ramucirumab, or aflibercept)",
                    "criterion": "anti-VEGF monoclonal antibody",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* If applicable, targeted therapy Participants who are considered ineligible for or are intolerant of standard therapy per investigator are eligible. Participants treated previously with TAS-102 or regorafenib are not eligible.",
                "criterions": [
                    {
                        "exact_snippets": "targeted therapy Participants",
                        "criterion": "targeted therapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "considered ineligible for or are intolerant of standard therapy",
                        "criterion": "standard therapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "considered ineligible for or are intolerant of standard therapy",
                        "criterion": "standard therapy",
                        "requirement": {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Participants treated previously with TAS-102 or regorafenib are not eligible",
                        "criterion": "previous treatment with TAS-102 or regorafenib",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "and_criteria": [
                                {
                                    "exact_snippets": "targeted therapy Participants",
                                    "criterion": "targeted therapy",
                                    "requirement": {
                                        "requirement_type": "eligibility",
                                        "expected_value": true
                                    }
                                },
                                {
                                    "or_criteria": [
                                        {
                                            "exact_snippets": "considered ineligible for or are intolerant of standard therapy",
                                            "criterion": "standard therapy",
                                            "requirement": {
                                                "requirement_type": "eligibility",
                                                "expected_value": false
                                            }
                                        },
                                        {
                                            "exact_snippets": "considered ineligible for or are intolerant of standard therapy",
                                            "criterion": "standard therapy",
                                            "requirement": {
                                                "requirement_type": "tolerance",
                                                "expected_value": false
                                            }
                                        }
                                    ]
                                }
                            ]
                        }
                    ]
                },
                "then_criteria": {
                    "not_criteria": {
                        "exact_snippets": "Participants treated previously with TAS-102 or regorafenib are not eligible",
                        "criterion": "previous treatment with TAS-102 or regorafenib",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Laboratory values meeting the criteria outlined in the protocol.",
                "criterions": [
                    {
                        "exact_snippets": "Laboratory values meeting the criteria outlined in the protocol.",
                        "criterion": "laboratory values",
                        "requirement": {
                            "requirement_type": "protocol compliance",
                            "expected_value": "meeting the criteria outlined in the protocol"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Laboratory values meeting the criteria outlined in the protocol.",
                        "criterion": "laboratory values",
                        "requirement": {
                            "requirement_type": "protocol compliance",
                            "expected_value": "meeting the criteria outlined in the protocol"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platinum-based chemotherapy doublet and tyrosine kinase inhibitor(s) (TKI[s]) for non- squamous mutEGFR NSCLC (Part 2ii).",
                "criterions": [
                    {
                        "exact_snippets": "Platinum-based chemotherapy doublet",
                        "criterion": "chemotherapy regimen",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "platinum-based doublet"
                        }
                    },
                    {
                        "exact_snippets": "tyrosine kinase inhibitor(s) (TKI[s])",
                        "criterion": "treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "tyrosine kinase inhibitor(s)"
                        }
                    },
                    {
                        "exact_snippets": "non-squamous mutEGFR NSCLC",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "subtype",
                            "expected_value": "non-squamous mutEGFR NSCLC"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Platinum-based chemotherapy doublet",
                                "criterion": "chemotherapy regimen",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "platinum-based doublet"
                                }
                            },
                            {
                                "exact_snippets": "tyrosine kinase inhibitor(s) (TKI[s])",
                                "criterion": "treatment",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "tyrosine kinase inhibitor(s)"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "non-squamous mutEGFR NSCLC",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "subtype",
                            "expected_value": "non-squamous mutEGFR NSCLC"
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, nor any evidence of active ILD or on screening chest CT scan..",
                "criterions": [
                    {
                        "exact_snippets": "History of interstitial lung disease (ILD)",
                        "criterion": "interstitial lung disease (ILD)",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "pneumonitis that required treatment with systemic steroids",
                        "criterion": "pneumonitis",
                        "requirement": {
                            "requirement_type": "treatment with systemic steroids",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "any evidence of active ILD",
                        "criterion": "active interstitial lung disease (ILD)",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "on screening chest CT scan",
                        "criterion": "active interstitial lung disease (ILD)",
                        "requirement": {
                            "requirement_type": "screening chest CT scan",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "History of interstitial lung disease (ILD)",
                            "criterion": "interstitial lung disease (ILD)",
                            "requirement": {
                                "requirement_type": "history",
                                "expected_value": false
                            }
                        }
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "pneumonitis that required treatment with systemic steroids",
                                "criterion": "pneumonitis",
                                "requirement": {
                                    "requirement_type": "treatment with systemic steroids",
                                    "expected_value": true
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "not_criteria": {
                                            "exact_snippets": "any evidence of active ILD",
                                            "criterion": "active interstitial lung disease (ILD)",
                                            "requirement": {
                                                "requirement_type": "presence",
                                                "expected_value": false
                                            }
                                        }
                                    },
                                    {
                                        "not_criteria": {
                                            "exact_snippets": "on screening chest CT scan",
                                            "criterion": "active interstitial lung disease (ILD)",
                                            "requirement": {
                                                "requirement_type": "screening chest CT scan",
                                                "expected_value": false
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis.",
                "criterions": [
                    {
                        "exact_snippets": "History of idiopathic pulmonary fibrosis",
                        "criterion": "idiopathic pulmonary fibrosis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... organizing pneumonia",
                        "criterion": "organizing pneumonia",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... bronchiolitis obliterans",
                        "criterion": "bronchiolitis obliterans",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... drug-induced pneumonitis",
                        "criterion": "drug-induced pneumonitis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... idiopathic pneumonitis",
                        "criterion": "idiopathic pneumonitis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "History of idiopathic pulmonary fibrosis",
                        "criterion": "idiopathic pulmonary fibrosis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... organizing pneumonia",
                        "criterion": "organizing pneumonia",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... bronchiolitis obliterans",
                        "criterion": "bronchiolitis obliterans",
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                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... drug-induced pneumonitis",
                        "criterion": "drug-induced pneumonitis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of ... idiopathic pneumonitis",
                        "criterion": "idiopathic pneumonitis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History of clinically significant, intercurrent lung-specific illnesses, as noted in the protocol.",
                "criterions": [
                    {
                        "exact_snippets": "History of clinically significant, intercurrent lung-specific illnesses",
                        "criterion": "lung-specific illnesses",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of clinically significant, intercurrent lung-specific illnesses",
                        "criterion": "lung-specific illnesses",
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                            "requirement_type": "clinical significance",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History of clinically significant, intercurrent lung-specific illnesses",
                        "criterion": "lung-specific illnesses",
                        "requirement": {
                            "requirement_type": "intercurrent",
                            "expected_value": true
                        }
                    }
                ]
            },
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of clinically significant, intercurrent lung-specific illnesses",
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                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "History of clinically significant, intercurrent lung-specific illnesses",
                                "criterion": "lung-specific illnesses",
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                                    "expected_value": true
                                }
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                        "exact_snippets": "History of clinically significant, intercurrent lung-specific illnesses",
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                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Platinum-based chemotherapy and an immune checkpoint inhibitor and/or appropriate targeted therapy for an actionable gene alteration, if applicable, for non-squamous wtEGFR NSCLC (Part 2i) and squamous NSCLC (Part 2iii).",
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                    {
                        "exact_snippets": "Platinum-based chemotherapy",
                        "criterion": "platinum-based chemotherapy",
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                            "requirement_type": "treatment",
                            "expected_value": true
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                    },
                    {
                        "exact_snippets": "immune checkpoint inhibitor",
                        "criterion": "immune checkpoint inhibitor",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": true
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                    },
                    {
                        "exact_snippets": "appropriate targeted therapy for an actionable gene alteration",
                        "criterion": "targeted therapy for actionable gene alteration",
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                            "requirement_type": "treatment",
                            "expected_value": true
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                    },
                    {
                        "exact_snippets": "non-squamous wtEGFR NSCLC",
                        "criterion": "non-squamous wtEGFR NSCLC",
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                            "requirement_type": "condition",
                            "expected_value": true
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                    },
                    {
                        "exact_snippets": "squamous NSCLC",
                        "criterion": "squamous NSCLC",
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                            "requirement_type": "condition",
                            "expected_value": true
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                ]
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                    {
                        "or_criteria": [
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                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
                                                    {
                                                        "exact_snippets": "Platinum-based chemotherapy",
                                                        "criterion": "platinum-based chemotherapy",
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                                                            "requirement_type": "treatment",
                                                            "expected_value": true
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                                                    },
                                                    {
                                                        "exact_snippets": "immune checkpoint inhibitor",
                                                        "criterion": "immune checkpoint inhibitor",
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                                                            "requirement_type": "treatment",
                                                            "expected_value": true
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                                                    }
                                                ]
                                            },
                                            {
                                                "exact_snippets": "non-squamous wtEGFR NSCLC",
                                                "criterion": "non-squamous wtEGFR NSCLC",
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                                                    "requirement_type": "condition",
                                                    "expected_value": true
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                                    {
                                        "exact_snippets": "squamous NSCLC",
                                        "criterion": "squamous NSCLC",
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                                ]
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                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
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                                                        "exact_snippets": "Platinum-based chemotherapy",
                                                        "criterion": "platinum-based chemotherapy",
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                                                            "requirement_type": "treatment",
                                                            "expected_value": true
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                                                    },
                                                    {
                                                        "exact_snippets": "targeted therapy for an actionable gene alteration",
                                                        "criterion": "targeted therapy for actionable gene alteration",
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                                                            "requirement_type": "treatment",
                                                            "expected_value": true
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                                                    }
                                                ]
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                                            {
                                                "exact_snippets": "non-squamous wtEGFR NSCLC",
                                                "criterion": "non-squamous wtEGFR NSCLC",
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                                                    "expected_value": true
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                                        ]
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                                    {
                                        "exact_snippets": "squamous NSCLC",
                                        "criterion": "squamous NSCLC",
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                                            "expected_value": true
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                                    }
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                        ]
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        },
        {
            "identified_line": {
                "line": "* For Part 3 only - Participants with advanced GEA that has progressed after treatment with at least 1 prior cytotoxic chemotherapeutic regimen for locally advanced or metastatic disease and have not received more than 2 prior lines of cytotoxic chemotherapy regimens. Participants must have progressed on",
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                    {
                        "exact_snippets": "advanced GEA",
                        "criterion": "advanced GEA",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
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                    },
                    {
                        "exact_snippets": "progressed after treatment with at least 1 prior cytotoxic chemotherapeutic regimen",
                        "criterion": "progression after treatment",
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                            "requirement_type": "treatment type",
                            "expected_value": "cytotoxic chemotherapeutic regimen"
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                    },
                    {
                        "exact_snippets": "progressed after treatment with at least 1 prior cytotoxic chemotherapeutic regimen",
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                        "requirement": {
                            "requirement_type": "progression",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "progressed after treatment with at least 1 prior cytotoxic chemotherapeutic regimen",
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                            "requirement_type": "minimum prior treatments",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "regimen"
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                        }
                    },
                    {
                        "exact_snippets": "not received more than 2 prior lines of cytotoxic chemotherapy regimens",
                        "criterion": "prior lines of cytotoxic chemotherapy regimens",
                        "requirement": {
                            "requirement_type": "maximum prior treatments",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "lines"
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                ]
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                "criterion": "failed",
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            }
        },
        {
            "identified_line": {
                "line": "* For Part 5 only - participants with advanced histologically or cytologically confirmed solid tumors characterized by MET amplification who are not amenable to surgical resection and who have disease progression after at least one prior systemic therapy and/or who have no satisfactory alternative treatment options. Participants who are intolerant to standard treatment are eligible.",
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                        "exact_snippets": "advanced histologically or cytologically confirmed solid tumors",
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                            "expected_value": "histologically or cytologically"
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                    },
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                        "exact_snippets": "advanced histologically or cytologically confirmed solid tumors",
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                            "expected_value": "advanced"
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                    },
                    {
                        "exact_snippets": "characterized by MET amplification",
                        "criterion": "MET amplification",
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                    {
                        "exact_snippets": "not amenable to surgical resection",
                        "criterion": "surgical resection",
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                    },
                    {
                        "exact_snippets": "disease progression after at least one prior systemic therapy",
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                        "exact_snippets": "no satisfactory alternative treatment options",
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                        "exact_snippets": "Participants who are intolerant to standard treatment are eligible",
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                "line": "* Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.",
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                                "1"
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                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.",
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                            "expected_value": "0"
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                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.",
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                    }
                ]
            }
        }
    ],
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        {
            "identified_line": {
                "line": "* For Part 7 only: Prior TAS-102 or regorafenib treated participants are not eligible.",
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                        "exact_snippets": "Prior TAS-102 ... treated participants are not eligible.",
                        "criterion": "TAS-102 treatment",
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                            "requirement_type": "prior treatment",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Prior ... regorafenib treated participants are not eligible.",
                        "criterion": "regorafenib treatment",
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                            "exact_snippets": "Prior TAS-102 ... treated participants are not eligible.",
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                            }
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                            "exact_snippets": "Prior ... regorafenib treated participants are not eligible.",
                            "criterion": "regorafenib treatment",
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    ],
    "failed_miscellaneous": []
}