{
    "info": {
        "nct_id": "NCT05009082",
        "official_title": "Niraparib vs Niraparib in Combination With Bevacizumab in Patients With Carboplatinum-taxane Based Chemotherapy in Advanced Ovarian Cancer (A Multicentre Randomised Phase III Trial)",
        "inclusion_criteria": "1. Signed written informed consent obtained prior to initiation of any study-specific procedures and treatment as confirmation of the patient's awareness and willingness to comply with the study requirements.\n2. Female patients ≥ 18 years with histologically confirmed primary advanced invasive high grade epithelial ovarian cancer, peritoneal cancer, or fallopian tube cancer FIGO III/IV (except FIGO stage IIIA2 without nodal involvement) according to recent FIGO classification (= FIGO stage IIIB - IV according to FIGO 2009 classification).\n3. All patients must have had either upfront primary debulking surgery OR plan to undergo chemotherapy with interval debulking surgery.\n4. Patients must have available tumor samples to be sent to central laboratory as formalin-fixed, paraffin-embedded (FFPE) sample for determination of BRCA status prior to randomization for stratification.\n5. Patients must be able to commence systemic therapy within 8 weeks of cytoreductive surgery.\n6. Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1.\n7. Estimated life expectancy > 3 months.\n8. Adequate bone marrow function (within 28 days prior to day 1, cycle 1)\n\n   * Absolute Neutrophil Count (ANC) ≥ 1.5 x 10^9/L\n   * Platelets (PLT) ≥ 100 x 10^9/L\n   * Hemoglobin (Hb) ≥ 9 g/dL (can be post-transfusion)\n9. Adequate coagulation parameters (within 28 days prior to day 1, cycle 1)\n\n   * Patients not receiving anticoagulant medication who have an International Normalized Ratio (INR) ≤ 1.5 and an Activated ProThrombin Time (aPTT) ≤ 1.5 x institutional upper limit of normal (ULN).\n   * The use of full-dose oral or parenteral anticoagulants is permitted as long as the INR or aPTT is within therapeutic limits (according to institution medical standard) and the patient has been on a stable dose of anticoagulants for at least two weeks at the time of day 1, cycle 1.\n10. Adequate liver and kidney function (within 28 days prior to day 1, cycle 1)\n\n    * Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome) OR direct bilirubin ≤ 1.0 x ULN.\n    * Aspartate aminotransferase / Serum Glutamic Oxaloacetic Transaminase (ASAT/SGOT) and Alanine aminotransferase / Serum Glutamic Pyruvate Transaminase (ALAT/SGPT) ≤ 2.5 x ULN, unless liver metastases are present, in case of liver metastases values must be ≤ 5 x ULN.\n    * Urine dipstick for proteinuria < 2+. If urine dipstick is ≥ 2+, 24 hour urine must demonstrate ≤ 1 g of protein in 24 hours.\n    * Serum creatinine ≤ 1.5 x upper limit of normal (ULN) or calculated creatinine clearance ≥ 30 mL/min using the Cockcroft-Gault equation.\n11. Patients must have normal blood pressure (BP) or adequately treated and controlled BP, with a systolic BP of ≤ 140 mmHg and diastolic BP of ≤ 90 mmHg for eligibility. Patients must have a BP of ≤ 140/90 mmHg taken in the clinic setting by a medical professional within 4 weeks prior to day 1, cycle 1.\n12. Negative urine or serum pregnancy test within 7 days prior to day 1, cycle 1 in women of childbearing potential (WOCBP), confirmed prior to treatment on day 1.\n13. For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use a highly effective contraceptive method with a failure rate of < 1% per year during the treatment period and for at least 6 months after administration of the last dose of medication.\n\n    A woman is considered to be of childbearing potential if she is postmenarcheal, has not reached a postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries, fallopian tubes, and/or uterus).\n\n    Examples of contraceptive methods with a failure rate of < 1% per year include but are not limited to bilateral tubal ligation and/or occlusion, male sterilization, and intrauterine devices. The reliability of sexual abstinence should be evaluated in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception.\n14. Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures, that include the completion of patient-reported outcomes questionnaires.\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Non-epithelial tumor origin of the ovary.\n2. Ovarian tumors of low malignant potential (e.g. borderline tumors) and low grade tumors.\n3. Planned intraperitoneal cytotoxic chemotherapy.\n4. Malignancies other than ovarian cancer within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death (e.g., 5-year OS rate > 90%) and treated with expected curative outcome (such as adequately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, ductal carcinoma in situ of the breast, or stage I p53 wild type endometrial cancer).\n5. Prior systemic treatment for ovarian cancer.\n6. Prior treatment with Poly adenosine diphosphate ribose polymerase (PARP) inhibitor.\n7. Administration of other simultaneous chemotherapy drugs, any other anticancer therapy or anti-neoplastic hormonal therapy, or simultaneous radiotherapy during the trial treatment period (hormonal replacement therapy is permitted).\n8. Prior randomization in this trial.\n9. Major surgery within 1 week of starting study treatment or patient who has not completely recovered from the effects of any major surgery. Core biopsy or other minor surgical procedure within 7 days prior to day 1, cycle 1 is permitted.\n10. History or clinical suspicion of brain metastases or spinal cord compression. CT/MRI of the brain is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected brain metastases. Spinal MRI is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected spinal cord compression.\n11. Significant traumatic injury during 4 weeks preceding the potential first dose of bevacizumab.\n12. Previous Cerebro-Vascular Accident (CVA), Transient Ischemic Attack (TIA) or Sub-Arachnoids Hemorrhage (SAH) within 6 months prior to day 1, cycle 1.\n13. History or evidence of thrombotic or hemorrhagic disorders within 3 months prior to day 1, cycle 1.\n14. History or evidence upon neurological examination of central nervous system (CNS) disease, unless adequately treated with standard medical therapy e.g. uncontrolled seizures.\n15. Pregnant or lactating women.\n16. Treatment with any other investigational agent, or participation in another clinical trial testing a drug within 4 weeks or 5 times the half-life of the drug, whichever is longer, prior to day 1, cycle 1 or concomitantly with this trial.\n17. Known hypersensitivity to bevacizumab and its excipients, Chinese hamster ovary cell products or other recombinant human or humanized antibodies. Known hypersensitivity to niraparib, paclitaxel and carboplatin and its components or excipients.\n18. Non-healing wound, active ulcer or bone fracture. Patients with granulating incisions healing by secondary intention with no evidence of facial dehiscence or infection are eligible but require 3-weekly wound examinations.\n19. Clinically significant cardiovascular disease, including\n\n    * Myocardial infarction or unstable angina within 6 months of day 1, cycle 1\n    * New York Heart Association (NYHA) Grade 2 Congestive Heart Failure (CHF),\n    * Poorly controlled cardiac arrhythmia despite medication (patients with rate-controlled atrial fibrillation are eligible)\n    * Grade ≥ 3 peripheral vascular disease (i.e. symptomatic and interfering with activity of daily living (ADL) requiring repair or revision)\n    * Significant vascular disease including aortic aneurysm requiring surgical repair\n20. Pre-existing sensory or motor neuropathy ≥ Grade 2.\n21. Any prior history of hypertensive crisis (CTCAE grade 4) or hypertensive encephalopathy.\n22. Patients with a history of or current Nephrotic syndrome.\n23. Bowel obstruction (including subocclusive disease).\n24. History of abdominal fistula or tracheoesophageal fistula or gastrointestinal perforation or active gastrointestinal bleeding or anastomotic insufficiency within 6 months of day 1, cycle 1.\n25. Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of niraparib.\n26. Evidence of any other disease, metabolic dysfunction, physical examination finding or laboratory finding giving reasonable suspicion of a disease or condition that contra-indicates the use of an investigational drug or puts the patient at high risk for treatment-related complications.\n27. Any known history or current diagnosis of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).\n28. Previous allogeneic bone marrow transplant or previous solid organ transplantation.\n29. Current or recent (within 10 days prior to day 1, cycle 1) chronic use of aspirin > 325 mg/day. Patients treated with other inhibitors of platelet aggregation such as clopidogrel, prasugrel, ticlopidine, tirofibane or dipyridamole should not be included into the trial.\n30. Patients considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection. This includes also any psychiatric disorder that prohibits obtaining informed consent.\n31. Patient has known active hepatitis B or hepatitis C.\n32. Patient has a history of Posterior Reversible Encephalopathy Syndrome (PRES).",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. Signed written informed consent obtained prior to initiation of any study-specific procedures and treatment as confirmation of the patient's awareness and willingness to comply with the study requirements.",
                "criterions": [
                    {
                        "exact_snippets": "Signed written informed consent obtained",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Signed written informed consent obtained",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Female patients ≥ 18 years with histologically confirmed primary advanced invasive high grade epithelial ovarian cancer, peritoneal cancer, or fallopian tube cancer FIGO III/IV (except FIGO stage IIIA2 without nodal involvement) according to recent FIGO classification (= FIGO stage IIIB - IV according to FIGO 2009 classification).",
                "criterions": [
                    {
                        "exact_snippets": "Female patients",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "female"
                        }
                    },
                    {
                        "exact_snippets": "≥ 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed primary advanced invasive high grade epithelial ovarian cancer",
                        "criterion": "epithelial ovarian cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "histologically confirmed primary advanced invasive high grade epithelial ovarian cancer",
                        "criterion": "epithelial ovarian cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "primary advanced invasive high grade"
                        }
                    },
                    {
                        "exact_snippets": "peritoneal cancer",
                        "criterion": "peritoneal cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "fallopian tube cancer",
                        "criterion": "fallopian tube cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "FIGO III/IV",
                        "criterion": "FIGO stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "except FIGO stage IIIA2 without nodal involvement",
                        "criterion": "FIGO stage IIIA2 without nodal involvement",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Female patients",
                                "criterion": "gender",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": "female"
                                }
                            },
                            {
                                "exact_snippets": "≥ 18 years",
                                "criterion": "age",
                                "requirement": {
                                    "requirement_type": "minimum",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "histologically confirmed primary advanced invasive high grade epithelial ovarian cancer",
                                        "criterion": "epithelial ovarian cancer",
                                        "requirement": {
                                            "requirement_type": "confirmation",
                                            "expected_value": "histologically confirmed"
                                        }
                                    },
                                    {
                                        "exact_snippets": "histologically confirmed primary advanced invasive high grade epithelial ovarian cancer",
                                        "criterion": "epithelial ovarian cancer",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "primary advanced invasive high grade"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "peritoneal cancer",
                                "criterion": "peritoneal cancer",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "fallopian tube cancer",
                                "criterion": "fallopian tube cancer",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "FIGO III/IV",
                                "criterion": "FIGO stage",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": [
                                        "III",
                                        "IV"
                                    ]
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "except FIGO stage IIIA2 without nodal involvement",
                                    "criterion": "FIGO stage IIIA2 without nodal involvement",
                                    "requirement": {
                                        "requirement_type": "exclusion",
                                        "expected_value": true
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. All patients must have had either upfront primary debulking surgery OR plan to undergo chemotherapy with interval debulking surgery.",
                "criterions": [
                    {
                        "exact_snippets": "upfront primary debulking surgery",
                        "criterion": "upfront primary debulking surgery",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "plan to undergo chemotherapy with interval debulking surgery",
                        "criterion": "chemotherapy with interval debulking surgery",
                        "requirement": {
                            "requirement_type": "plan",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "upfront primary debulking surgery",
                        "criterion": "upfront primary debulking surgery",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "plan to undergo chemotherapy with interval debulking surgery",
                        "criterion": "chemotherapy with interval debulking surgery",
                        "requirement": {
                            "requirement_type": "plan",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Patients must have available tumor samples to be sent to central laboratory as formalin-fixed, paraffin-embedded (FFPE) sample for determination of BRCA status prior to randomization for stratification.",
                "criterions": [
                    {
                        "exact_snippets": "available tumor samples",
                        "criterion": "tumor samples",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "formalin-fixed, paraffin-embedded (FFPE) sample",
                        "criterion": "sample type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "formalin-fixed, paraffin-embedded (FFPE)"
                        }
                    },
                    {
                        "exact_snippets": "determination of BRCA status",
                        "criterion": "BRCA status",
                        "requirement": {
                            "requirement_type": "determination",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "available tumor samples",
                        "criterion": "tumor samples",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "formalin-fixed, paraffin-embedded (FFPE) sample",
                        "criterion": "sample type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "formalin-fixed, paraffin-embedded (FFPE)"
                        }
                    },
                    {
                        "exact_snippets": "determination of BRCA status",
                        "criterion": "BRCA status",
                        "requirement": {
                            "requirement_type": "determination",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Patients must be able to commence systemic therapy within 8 weeks of cytoreductive surgery.",
                "criterions": [
                    {
                        "exact_snippets": "Patients must be able to commence systemic therapy",
                        "criterion": "ability to commence systemic therapy",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "within 8 weeks of cytoreductive surgery",
                        "criterion": "time since cytoreductive surgery",
                        "requirement": {
                            "requirement_type": "time since surgery",
                            "expected_value": {
                                "operator": "<=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients must be able to commence systemic therapy",
                        "criterion": "ability to commence systemic therapy",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "within 8 weeks of cytoreductive surgery",
                        "criterion": "time since cytoreductive surgery",
                        "requirement": {
                            "requirement_type": "time since surgery",
                            "expected_value": {
                                "operator": "<=",
                                "value": 8,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1.",
                "criterions": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "7. Estimated life expectancy > 3 months.",
                "criterions": [
                    {
                        "exact_snippets": "Estimated life expectancy > 3 months.",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Estimated life expectancy > 3 months.",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "8. Adequate bone marrow function (within 28 days prior to day 1, cycle 1)",
                "criterions": [
                    {
                        "exact_snippets": "Adequate bone marrow function",
                        "criterion": "bone marrow function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": "adequate"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate bone marrow function",
                        "criterion": "bone marrow function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": "adequate"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute Neutrophil Count (ANC) ≥ 1.5 x 10^9/L",
                "criterions": [
                    {
                        "exact_snippets": "Absolute Neutrophil Count (ANC) ≥ 1.5 x 10^9/L",
                        "criterion": "Absolute Neutrophil Count (ANC)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1.5,
                                "unit": "x 10^9/L"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute Neutrophil Count (ANC) ≥ 1.5 x 10^9/L",
                        "criterion": "Absolute Neutrophil Count (ANC)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1.5,
                                "unit": "x 10^9/L"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelets (PLT) ≥ 100 x 10^9/L",
                "criterions": [
                    {
                        "exact_snippets": "Platelets (PLT) ≥ 100 x 10^9/L",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100,
                                "unit": "x 10^9/L"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelets (PLT) ≥ 100 x 10^9/L",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100,
                                "unit": "x 10^9/L"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin (Hb) ≥ 9 g/dL (can be post-transfusion)",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin (Hb) ≥ 9 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 9,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "can be post-transfusion",
                        "criterion": "post-transfusion hemoglobin level",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin (Hb) ≥ 9 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 9,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "can be post-transfusion",
                        "criterion": "post-transfusion hemoglobin level",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "9. Adequate coagulation parameters (within 28 days prior to day 1, cycle 1)",
                "criterions": [
                    {
                        "exact_snippets": "Adequate coagulation parameters",
                        "criterion": "coagulation parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": "adequate"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate coagulation parameters",
                        "criterion": "coagulation parameters",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": "adequate"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients not receiving anticoagulant medication who have an International Normalized Ratio (INR) ≤ 1.5 and an Activated ProThrombin Time (aPTT) ≤ 1.5 x institutional upper limit of normal (ULN).",
                "criterions": [
                    {
                        "exact_snippets": "Patients not receiving anticoagulant medication",
                        "criterion": "anticoagulant medication",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "International Normalized Ratio (INR) ≤ 1.5",
                        "criterion": "International Normalized Ratio (INR)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Activated ProThrombin Time (aPTT) ≤ 1.5 x institutional upper limit of normal (ULN)",
                        "criterion": "Activated ProThrombin Time (aPTT)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "x institutional upper limit of normal (ULN)"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients not receiving anticoagulant medication",
                                "criterion": "anticoagulant medication",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "International Normalized Ratio (INR) ≤ 1.5",
                                "criterion": "International Normalized Ratio (INR)",
                                "requirement": {
                                    "requirement_type": "value",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1.5,
                                        "unit": "N/A"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Activated ProThrombin Time (aPTT) ≤ 1.5 x institutional upper limit of normal (ULN)",
                        "criterion": "Activated ProThrombin Time (aPTT)",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "x institutional upper limit of normal (ULN)"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* The use of full-dose oral or parenteral anticoagulants is permitted as long as the INR or aPTT is within therapeutic limits (according to institution medical standard) and the patient has been on a stable dose of anticoagulants for at least two weeks at the time of day 1, cycle 1.",
                "criterions": [
                    {
                        "exact_snippets": "use of full-dose oral or parenteral anticoagulants is permitted",
                        "criterion": "anticoagulant use",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "INR or aPTT is within therapeutic limits",
                        "criterion": "INR or aPTT",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": "therapeutic limits"
                        }
                    },
                    {
                        "exact_snippets": "patient has been on a stable dose of anticoagulants for at least two weeks",
                        "criterion": "stable dose of anticoagulants",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "use of full-dose oral or parenteral anticoagulants is permitted",
                                "criterion": "anticoagulant use",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "INR or aPTT is within therapeutic limits",
                                "criterion": "INR or aPTT",
                                "requirement": {
                                    "requirement_type": "range",
                                    "expected_value": "therapeutic limits"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "patient has been on a stable dose of anticoagulants for at least two weeks",
                        "criterion": "stable dose of anticoagulants",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "10. Adequate liver and kidney function (within 28 days prior to day 1, cycle 1)",
                "criterions": [
                    {
                        "exact_snippets": "Adequate liver ... function",
                        "criterion": "liver function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... kidney function",
                        "criterion": "kidney function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate liver ... function",
                        "criterion": "liver function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... kidney function",
                        "criterion": "kidney function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome) OR direct bilirubin ≤ 1.0 x ULN.",
                "criterions": [
                    {
                        "exact_snippets": "Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome)",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 1.5,
                                        "unit": "x ULN"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome)",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 2.0,
                                        "unit": "x ULN"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome)",
                        "criterion": "total bilirubin",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "Gilbert's syndrome"
                        }
                    },
                    {
                        "exact_snippets": "direct bilirubin ≤ 1.0 x ULN",
                        "criterion": "direct bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 1.0,
                                        "unit": "x ULN"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "condition": {
                            "and_criteria": [
                                {
                                    "and_criteria": [
                                        {
                                            "exact_snippets": "Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome)",
                                            "criterion": "total bilirubin",
                                            "requirement": {
                                                "requirement_type": "level",
                                                "expected_value": {
                                                    "comparisons": [
                                                        {
                                                            "operator": "<=",
                                                            "value": 1.5,
                                                            "unit": "x ULN"
                                                        }
                                                    ]
                                                }
                                            }
                                        },
                                        {
                                            "not_criteria": {
                                                "exact_snippets": "Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome)",
                                                "criterion": "total bilirubin",
                                                "requirement": {
                                                    "requirement_type": "condition",
                                                    "expected_value": "Gilbert's syndrome"
                                                }
                                            }
                                        }
                                    ]
                                },
                                {
                                    "and_criteria": [
                                        {
                                            "exact_snippets": "Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome)",
                                            "criterion": "total bilirubin",
                                            "requirement": {
                                                "requirement_type": "level",
                                                "expected_value": {
                                                    "comparisons": [
                                                        {
                                                            "operator": "<=",
                                                            "value": 2.0,
                                                            "unit": "x ULN"
                                                        }
                                                    ]
                                                }
                                            }
                                        },
                                        {
                                            "exact_snippets": "Total bilirubin ≤ 1.5 x ULN (≤ 2.0 x ULN in patients with known Gilbert's syndrome)",
                                            "criterion": "total bilirubin",
                                            "requirement": {
                                                "requirement_type": "condition",
                                                "expected_value": "Gilbert's syndrome"
                                            }
                                        }
                                    ]
                                }
                            ]
                        },
                        "then_criteria": null,
                        "else_criteria": null
                    },
                    {
                        "exact_snippets": "direct bilirubin ≤ 1.0 x ULN",
                        "criterion": "direct bilirubin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 1.0,
                                        "unit": "x ULN"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Aspartate aminotransferase / Serum Glutamic Oxaloacetic Transaminase (ASAT/SGOT) and Alanine aminotransferase / Serum Glutamic Pyruvate Transaminase (ALAT/SGPT) ≤ 2.5 x ULN, unless liver metastases are present, in case of liver metastases values must be ≤ 5 x ULN.",
                "criterions": [
                    {
                        "exact_snippets": "Aspartate aminotransferase / Serum Glutamic Oxaloacetic Transaminase (ASAT/SGOT) ... ≤ 2.5 x ULN",
                        "criterion": "Aspartate aminotransferase (ASAT/SGOT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Alanine aminotransferase / Serum Glutamic Pyruvate Transaminase (ALAT/SGPT) ... ≤ 2.5 x ULN",
                        "criterion": "Alanine aminotransferase (ALAT/SGPT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "liver metastases ... in case of liver metastases values must be ≤ 5 x ULN",
                        "criterion": "liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "liver metastases ... in case of liver metastases values must be ≤ 5 x ULN",
                        "criterion": "liver metastases",
                        "requirement": {
                            "requirement_type": "ASAT/SGOT level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "liver metastases ... in case of liver metastases values must be ≤ 5 x ULN",
                        "criterion": "liver metastases",
                        "requirement": {
                            "requirement_type": "ALAT/SGPT level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "and_criteria": [
                                {
                                    "exact_snippets": "Aspartate aminotransferase / Serum Glutamic Oxaloacetic Transaminase (ASAT/SGOT) ... ≤ 2.5 x ULN",
                                    "criterion": "Aspartate aminotransferase (ASAT/SGOT)",
                                    "requirement": {
                                        "requirement_type": "level",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 2.5,
                                            "unit": "x ULN"
                                        }
                                    }
                                },
                                {
                                    "exact_snippets": "Alanine aminotransferase / Serum Glutamic Pyruvate Transaminase (ALAT/SGPT) ... ≤ 2.5 x ULN",
                                    "criterion": "Alanine aminotransferase (ALAT/SGPT)",
                                    "requirement": {
                                        "requirement_type": "level",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 2.5,
                                            "unit": "x ULN"
                                        }
                                    }
                                }
                            ]
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": {
                    "and_criteria": [
                        {
                            "exact_snippets": "liver metastases ... in case of liver metastases values must be ≤ 5 x ULN",
                            "criterion": "liver metastases",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        },
                        {
                            "and_criteria": [
                                {
                                    "exact_snippets": "liver metastases ... in case of liver metastases values must be ≤ 5 x ULN",
                                    "criterion": "liver metastases",
                                    "requirement": {
                                        "requirement_type": "ASAT/SGOT level",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 5,
                                            "unit": "x ULN"
                                        }
                                    }
                                },
                                {
                                    "exact_snippets": "liver metastases ... in case of liver metastases values must be ≤ 5 x ULN",
                                    "criterion": "liver metastases",
                                    "requirement": {
                                        "requirement_type": "ALAT/SGPT level",
                                        "expected_value": {
                                            "operator": "<=",
                                            "value": 5,
                                            "unit": "x ULN"
                                        }
                                    }
                                }
                            ]
                        }
                    ]
                }
            }
        },
        {
            "identified_line": {
                "line": "12. Negative urine or serum pregnancy test within 7 days prior to day 1, cycle 1 in women of childbearing potential (WOCBP), confirmed prior to treatment on day 1.",
                "criterions": [
                    {
                        "exact_snippets": "Negative urine or serum pregnancy test ... in women of childbearing potential (WOCBP)",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "women of childbearing potential (WOCBP)",
                        "criterion": "gender and reproductive status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "women of childbearing potential"
                        }
                    },
                    {
                        "exact_snippets": "within 7 days prior to day 1, cycle 1 ... confirmed prior to treatment on day 1",
                        "criterion": "timing of pregnancy test",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "within 7 days prior to day 1, cycle 1 and confirmed prior to treatment on day 1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Negative urine or serum pregnancy test ... in women of childbearing potential (WOCBP)",
                                "criterion": "pregnancy test",
                                "requirement": {
                                    "requirement_type": "result",
                                    "expected_value": "negative"
                                }
                            },
                            {
                                "exact_snippets": "women of childbearing potential (WOCBP)",
                                "criterion": "gender and reproductive status",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "women of childbearing potential"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "within 7 days prior to day 1, cycle 1 ... confirmed prior to treatment on day 1",
                        "criterion": "timing of pregnancy test",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "within 7 days prior to day 1, cycle 1 and confirmed prior to treatment on day 1"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "13. For women of childbearing potential: agreement to remain abstinent (refrain from heterosexual intercourse) or use a highly effective contraceptive method with a failure rate of < 1% per year during the treatment period and for at least 6 months after administration of the last dose of medication.",
                "criterions": [
                    {
                        "exact_snippets": "women of childbearing potential",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "agreement to remain abstinent (refrain from heterosexual intercourse)",
                        "criterion": "abstinence",
                        "requirement": {
                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "use a highly effective contraceptive method with a failure rate of < 1% per year",
                        "criterion": "contraceptive method",
                        "requirement": {
                            "requirement_type": "failure rate",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "% per year"
                            }
                        }
                    },
                    {
                        "exact_snippets": "during the treatment period and for at least 6 months after administration of the last dose of medication",
                        "criterion": "contraceptive duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "during the treatment period and for at least 6 months after administration of the last dose of medication"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "women of childbearing potential",
                    "criterion": "childbearing potential",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "or_criteria": [
                        {
                            "exact_snippets": "agreement to remain abstinent (refrain from heterosexual intercourse)",
                            "criterion": "abstinence",
                            "requirement": {
                                "requirement_type": "agreement",
                                "expected_value": true
                            }
                        },
                        {
                            "and_criteria": [
                                {
                                    "exact_snippets": "use a highly effective contraceptive method with a failure rate of < 1% per year",
                                    "criterion": "contraceptive method",
                                    "requirement": {
                                        "requirement_type": "failure rate",
                                        "expected_value": {
                                            "operator": "<",
                                            "value": 1,
                                            "unit": "% per year"
                                        }
                                    }
                                },
                                {
                                    "exact_snippets": "during the treatment period and for at least 6 months after administration of the last dose of medication",
                                    "criterion": "contraceptive duration",
                                    "requirement": {
                                        "requirement_type": "duration",
                                        "expected_value": "during the treatment period and for at least 6 months after administration of the last dose of medication"
                                    }
                                }
                            ]
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "A woman is considered to be of childbearing potential if she is postmenarcheal, has not reached a postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries, fallopian tubes, and/or uterus).",
                "criterions": [
                    {
                        "exact_snippets": "postmenarcheal",
                        "criterion": "menarcheal status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "postmenarcheal"
                        }
                    },
                    {
                        "exact_snippets": "postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause)",
                        "criterion": "menopausal status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "not postmenopausal"
                        }
                    },
                    {
                        "exact_snippets": "postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause)",
                        "criterion": "menopausal status",
                        "requirement": {
                            "requirement_type": "duration of amenorrhea",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "surgical sterilization (removal of ovaries, fallopian tubes, and/or uterus)",
                        "criterion": "surgical sterilization",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "not undergone"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause)",
                                "criterion": "menopausal status",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "not postmenopausal"
                                }
                            },
                            {
                                "exact_snippets": "postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause)",
                                "criterion": "menopausal status",
                                "requirement": {
                                    "requirement_type": "duration of amenorrhea",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 12,
                                        "unit": "months"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "postmenarcheal",
                        "criterion": "menarcheal status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "postmenarcheal"
                        }
                    },
                    {
                        "exact_snippets": "surgical sterilization (removal of ovaries, fallopian tubes, and/or uterus)",
                        "criterion": "surgical sterilization",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "not undergone"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Examples of contraceptive methods with a failure rate of < 1% per year include but are not limited to bilateral tubal ligation and/or occlusion, male sterilization, and intrauterine devices. The reliability of sexual abstinence should be evaluated in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception.",
                "criterions": [
                    {
                        "exact_snippets": "contraceptive methods with a failure rate of < 1% per year",
                        "criterion": "contraceptive method failure rate",
                        "requirement": {
                            "requirement_type": "failure rate",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "% per year"
                            }
                        }
                    },
                    {
                        "exact_snippets": "reliability of sexual abstinence",
                        "criterion": "sexual abstinence reliability",
                        "requirement": {
                            "requirement_type": "evaluation",
                            "expected_value": "in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient"
                        }
                    },
                    {
                        "exact_snippets": "Periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception",
                        "criterion": "contraceptive method acceptability",
                        "requirement": {
                            "requirement_type": "acceptability",
                            "expected_value": [
                                "Periodic abstinence",
                                "withdrawal"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "contraceptive methods with a failure rate of < 1% per year",
                                        "criterion": "contraceptive method failure rate",
                                        "requirement": {
                                            "requirement_type": "failure rate",
                                            "expected_value": {
                                                "operator": "<",
                                                "value": 1,
                                                "unit": "% per year"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "reliability of sexual abstinence",
                                        "criterion": "sexual abstinence reliability",
                                        "requirement": {
                                            "requirement_type": "evaluation",
                                            "expected_value": "in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient"
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "reliability of sexual abstinence",
                                "criterion": "sexual abstinence reliability",
                                "requirement": {
                                    "requirement_type": "evaluation",
                                    "expected_value": "in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient"
                                }
                            }
                        ]
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "Periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception",
                            "criterion": "contraceptive method acceptability",
                            "requirement": {
                                "requirement_type": "acceptability",
                                "expected_value": [
                                    "Periodic abstinence",
                                    "withdrawal"
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "1. Non-epithelial tumor origin of the ovary.",
                "criterions": [
                    {
                        "exact_snippets": "Non-epithelial tumor origin of the ovary.",
                        "criterion": "tumor origin",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "non-epithelial"
                        }
                    },
                    {
                        "exact_snippets": "Non-epithelial tumor origin of the ovary.",
                        "criterion": "tumor origin",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "ovary"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Non-epithelial tumor origin of the ovary.",
                        "criterion": "tumor origin",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "non-epithelial"
                        }
                    },
                    {
                        "exact_snippets": "Non-epithelial tumor origin of the ovary.",
                        "criterion": "tumor origin",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "ovary"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Ovarian tumors of low malignant potential (e.g. borderline tumors) and low grade tumors.",
                "criterions": [
                    {
                        "exact_snippets": "Ovarian tumors of low malignant potential (e.g. borderline tumors)",
                        "criterion": "ovarian tumors",
                        "requirement": {
                            "requirement_type": "malignant potential",
                            "expected_value": "low"
                        }
                    },
                    {
                        "exact_snippets": "low grade tumors",
                        "criterion": "tumors",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "low"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Ovarian tumors of low malignant potential (e.g. borderline tumors)",
                        "criterion": "ovarian tumors",
                        "requirement": {
                            "requirement_type": "malignant potential",
                            "expected_value": "low"
                        }
                    },
                    {
                        "exact_snippets": "low grade tumors",
                        "criterion": "tumors",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "low"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Planned intraperitoneal cytotoxic chemotherapy.",
                "criterions": [
                    {
                        "exact_snippets": "Planned intraperitoneal cytotoxic chemotherapy",
                        "criterion": "intraperitoneal cytotoxic chemotherapy",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Planned intraperitoneal cytotoxic chemotherapy",
                        "criterion": "intraperitoneal cytotoxic chemotherapy",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Malignancies other than ovarian cancer within 5 years prior to randomization, with the exception of those with a negligible risk of metastasis or death (e.g., 5-year OS rate > 90%) and treated with expected curative outcome (such as adequately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, ductal carcinoma in situ of the breast, or stage I p53 wild type endometrial cancer).",
                "criterions": [
                    {
                        "exact_snippets": "Malignancies other than ovarian cancer within 5 years prior to randomization",
                        "criterion": "other malignancies",
                        "requirement": {
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
                                "operator": "<",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Malignancies other than ovarian cancer within 5 years prior to randomization",
                        "criterion": "other malignancies",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "other than ovarian cancer"
                        }
                    },
                    {
                        "exact_snippets": "with the exception of those with a negligible risk of metastasis or death",
                        "criterion": "risk of metastasis or death",
                        "requirement": {
                            "requirement_type": "risk level",
                            "expected_value": "negligible"
                        }
                    },
                    {
                        "exact_snippets": "5-year OS rate > 90%",
                        "criterion": "5-year overall survival rate",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": ">",
                                "value": 90,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "treated with expected curative outcome",
                        "criterion": "treatment outcome",
                        "requirement": {
                            "requirement_type": "expected outcome",
                            "expected_value": "curative"
                        }
                    },
                    {
                        "exact_snippets": "adequately treated carcinoma in situ of the cervix",
                        "criterion": "carcinoma in situ of the cervix",
                        "requirement": {
                            "requirement_type": "treatment adequacy",
                            "expected_value": "adequately treated"
                        }
                    },
                    {
                        "exact_snippets": "non-melanoma skin carcinoma",
                        "criterion": "non-melanoma skin carcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "ductal carcinoma in situ of the breast",
                        "criterion": "ductal carcinoma in situ of the breast",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "stage I p53 wild type endometrial cancer",
                        "criterion": "stage I p53 wild type endometrial cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Malignancies other than ovarian cancer within 5 years prior to randomization",
                                "criterion": "other malignancies",
                                "requirement": {
                                    "requirement_type": "time since diagnosis",
                                    "expected_value": {
                                        "operator": "<",
                                        "value": 5,
                                        "unit": "years"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Malignancies other than ovarian cancer within 5 years prior to randomization",
                                "criterion": "other malignancies",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "other than ovarian cancer"
                                }
                            }
                        ]
                    },
                    {
                        "not_criteria": {
                            "or_criteria": [
                                {
                                    "and_criteria": [
                                        {
                                            "exact_snippets": "with the exception of those with a negligible risk of metastasis or death",
                                            "criterion": "risk of metastasis or death",
                                            "requirement": {
                                                "requirement_type": "risk level",
                                                "expected_value": "negligible"
                                            }
                                        },
                                        {
                                            "exact_snippets": "5-year OS rate > 90%",
                                            "criterion": "5-year overall survival rate",
                                            "requirement": {
                                                "requirement_type": "comparison",
                                                "expected_value": {
                                                    "operator": ">",
                                                    "value": 90,
                                                    "unit": "%"
                                                }
                                            }
                                        },
                                        {
                                            "exact_snippets": "treated with expected curative outcome",
                                            "criterion": "treatment outcome",
                                            "requirement": {
                                                "requirement_type": "expected outcome",
                                                "expected_value": "curative"
                                            }
                                        }
                                    ]
                                },
                                {
                                    "exact_snippets": "adequately treated carcinoma in situ of the cervix",
                                    "criterion": "carcinoma in situ of the cervix",
                                    "requirement": {
                                        "requirement_type": "treatment adequacy",
                                        "expected_value": "adequately treated"
                                    }
                                },
                                {
                                    "exact_snippets": "non-melanoma skin carcinoma",
                                    "criterion": "non-melanoma skin carcinoma",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                },
                                {
                                    "exact_snippets": "ductal carcinoma in situ of the breast",
                                    "criterion": "ductal carcinoma in situ of the breast",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                },
                                {
                                    "exact_snippets": "stage I p53 wild type endometrial cancer",
                                    "criterion": "stage I p53 wild type endometrial cancer",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Prior systemic treatment for ovarian cancer.",
                "criterions": [
                    {
                        "exact_snippets": "Prior systemic treatment for ovarian cancer",
                        "criterion": "systemic treatment for ovarian cancer",
                        "requirement": {
                            "requirement_type": "prior",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Prior systemic treatment for ovarian cancer",
                    "criterion": "systemic treatment for ovarian cancer",
                    "requirement": {
                        "requirement_type": "prior",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "6. Prior treatment with Poly adenosine diphosphate ribose polymerase (PARP) inhibitor.",
                "criterions": [
                    {
                        "exact_snippets": "Prior treatment with Poly adenosine diphosphate ribose polymerase (PARP) inhibitor.",
                        "criterion": "prior treatment with PARP inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Prior treatment with Poly adenosine diphosphate ribose polymerase (PARP) inhibitor.",
                        "criterion": "prior treatment with PARP inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "7. Administration of other simultaneous chemotherapy drugs, any other anticancer therapy or anti-neoplastic hormonal therapy, or simultaneous radiotherapy during the trial treatment period (hormonal replacement therapy is permitted).",
                "criterions": [
                    {
                        "exact_snippets": "Administration of other simultaneous chemotherapy drugs",
                        "criterion": "simultaneous chemotherapy drugs",
                        "requirement": {
                            "requirement_type": "administration",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "any other anticancer therapy",
                        "criterion": "anticancer therapy",
                        "requirement": {
                            "requirement_type": "administration",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "anti-neoplastic hormonal therapy",
                        "criterion": "anti-neoplastic hormonal therapy",
                        "requirement": {
                            "requirement_type": "administration",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "simultaneous radiotherapy during the trial treatment period",
                        "criterion": "simultaneous radiotherapy",
                        "requirement": {
                            "requirement_type": "administration",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Administration of other simultaneous chemotherapy drugs",
                                "criterion": "simultaneous chemotherapy drugs",
                                "requirement": {
                                    "requirement_type": "administration",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "simultaneous radiotherapy during the trial treatment period",
                                "criterion": "simultaneous radiotherapy",
                                "requirement": {
                                    "requirement_type": "administration",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "any other anticancer therapy",
                        "criterion": "anticancer therapy",
                        "requirement": {
                            "requirement_type": "administration",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "anti-neoplastic hormonal therapy",
                        "criterion": "anti-neoplastic hormonal therapy",
                        "requirement": {
                            "requirement_type": "administration",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "8. Prior randomization in this trial.",
                "criterions": [
                    {
                        "exact_snippets": "Prior randomization in this trial.",
                        "criterion": "prior randomization",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Prior randomization in this trial.",
                    "criterion": "prior randomization",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "9. Major surgery within 1 week of starting study treatment or patient who has not completely recovered from the effects of any major surgery. Core biopsy or other minor surgical procedure within 7 days prior to day 1, cycle 1 is permitted.",
                "criterions": [
                    {
                        "exact_snippets": "Major surgery within 1 week of starting study treatment",
                        "criterion": "major surgery",
                        "requirement": {
                            "requirement_type": "time since surgery",
                            "expected_value": {
                                "operator": "<",
                                "value": 1,
                                "unit": "week"
                            }
                        }
                    },
                    {
                        "exact_snippets": "patient who has not completely recovered from the effects of any major surgery",
                        "criterion": "recovery from major surgery",
                        "requirement": {
                            "requirement_type": "recovery status",
                            "expected_value": "not completely recovered"
                        }
                    },
                    {
                        "exact_snippets": "Core biopsy or other minor surgical procedure within 7 days prior to day 1, cycle 1 is permitted",
                        "criterion": "minor surgical procedure",
                        "requirement": {
                            "requirement_type": "time since procedure",
                            "expected_value": {
                                "operator": "<=",
                                "value": 7,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Major surgery within 1 week of starting study treatment",
                                        "criterion": "major surgery",
                                        "requirement": {
                                            "requirement_type": "time since surgery",
                                            "expected_value": {
                                                "operator": "<",
                                                "value": 1,
                                                "unit": "week"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "patient who has not completely recovered from the effects of any major surgery",
                                        "criterion": "recovery from major surgery",
                                        "requirement": {
                                            "requirement_type": "recovery status",
                                            "expected_value": "not completely recovered"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Core biopsy or other minor surgical procedure within 7 days prior to day 1, cycle 1 is permitted",
                                        "criterion": "minor surgical procedure",
                                        "requirement": {
                                            "requirement_type": "time since procedure",
                                            "expected_value": {
                                                "operator": "<=",
                                                "value": 7,
                                                "unit": "days"
                                            }
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "16. Treatment with any other investigational agent, or participation in another clinical trial testing a drug within 4 weeks or 5 times the half-life of the drug, whichever is longer, prior to day 1, cycle 1 or concomitantly with this trial.",
                "criterions": [
                    {
                        "exact_snippets": "Treatment with any other investigational agent",
                        "criterion": "treatment with investigational agent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "participation in another clinical trial",
                        "criterion": "participation in another clinical trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "testing a drug within 4 weeks or 5 times the half-life of the drug, whichever is longer, prior to day 1, cycle 1",
                        "criterion": "time since last drug trial participation",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "concomitantly with this trial",
                        "criterion": "concomitant participation in another trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Treatment with any other investigational agent",
                                        "criterion": "treatment with investigational agent",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "testing a drug within 4 weeks or 5 times the half-life of the drug, whichever is longer, prior to day 1, cycle 1",
                                        "criterion": "time since last drug trial participation",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": {
                                                "comparisons": [
                                                    {
                                                        "operator": ">=",
                                                        "value": 4,
                                                        "unit": "weeks"
                                                    }
                                                ]
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "participation in another clinical trial",
                                "criterion": "participation in another clinical trial",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "concomitantly with this trial",
                        "criterion": "concomitant participation in another trial",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "18. Non-healing wound, active ulcer or bone fracture. Patients with granulating incisions healing by secondary intention with no evidence of facial dehiscence or infection are eligible but require 3-weekly wound examinations.",
                "criterions": [
                    {
                        "exact_snippets": "Non-healing wound",
                        "criterion": "wound",
                        "requirement": {
                            "requirement_type": "healing status",
                            "expected_value": "non-healing"
                        }
                    },
                    {
                        "exact_snippets": "active ulcer",
                        "criterion": "ulcer",
                        "requirement": {
                            "requirement_type": "activity status",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "bone fracture",
                        "criterion": "bone fracture",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "granulating incisions healing by secondary intention",
                        "criterion": "granulating incisions",
                        "requirement": {
                            "requirement_type": "healing method",
                            "expected_value": "secondary intention"
                        }
                    },
                    {
                        "exact_snippets": "no evidence of facial dehiscence",
                        "criterion": "facial dehiscence",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no evidence of ... infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "evidence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Non-healing wound",
                                        "criterion": "wound",
                                        "requirement": {
                                            "requirement_type": "healing status",
                                            "expected_value": "non-healing"
                                        }
                                    },
                                    {
                                        "exact_snippets": "active ulcer",
                                        "criterion": "ulcer",
                                        "requirement": {
                                            "requirement_type": "activity status",
                                            "expected_value": "active"
                                        }
                                    },
                                    {
                                        "exact_snippets": "bone fracture",
                                        "criterion": "bone fracture",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "granulating incisions healing by secondary intention",
                                        "criterion": "granulating incisions",
                                        "requirement": {
                                            "requirement_type": "healing method",
                                            "expected_value": "secondary intention"
                                        }
                                    },
                                    {
                                        "exact_snippets": "no evidence of facial dehiscence",
                                        "criterion": "facial dehiscence",
                                        "requirement": {
                                            "requirement_type": "evidence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "no evidence of ... infection",
                                        "criterion": "infection",
                                        "requirement": {
                                            "requirement_type": "evidence",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "19. Clinically significant cardiovascular disease, including",
                "criterions": [
                    {
                        "exact_snippets": "Clinically significant cardiovascular disease",
                        "criterion": "cardiovascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Clinically significant cardiovascular disease",
                        "criterion": "cardiovascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Myocardial infarction or unstable angina within 6 months of day 1, cycle 1",
                "criterions": [
                    {
                        "exact_snippets": "Myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "unstable angina",
                        "criterion": "unstable angina",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "unstable angina",
                        "criterion": "unstable angina",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* New York Heart Association (NYHA) Grade 2 Congestive Heart Failure (CHF),",
                "criterions": [
                    {
                        "exact_snippets": "New York Heart Association (NYHA) Grade 2 Congestive Heart Failure (CHF)",
                        "criterion": "New York Heart Association (NYHA) Grade",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "2"
                        }
                    },
                    {
                        "exact_snippets": "Congestive Heart Failure (CHF)",
                        "criterion": "Congestive Heart Failure (CHF)",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "New York Heart Association (NYHA) Grade 2 Congestive Heart Failure (CHF)",
                        "criterion": "New York Heart Association (NYHA) Grade",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "2"
                        }
                    },
                    {
                        "exact_snippets": "Congestive Heart Failure (CHF)",
                        "criterion": "Congestive Heart Failure (CHF)",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Poorly controlled cardiac arrhythmia despite medication (patients with rate-controlled atrial fibrillation are eligible)",
                "criterions": [
                    {
                        "exact_snippets": "Poorly controlled cardiac arrhythmia despite medication",
                        "criterion": "cardiac arrhythmia",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "poorly controlled despite medication"
                        }
                    },
                    {
                        "exact_snippets": "rate-controlled atrial fibrillation",
                        "criterion": "atrial fibrillation",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "rate-controlled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "Poorly controlled cardiac arrhythmia despite medication",
                            "criterion": "cardiac arrhythmia",
                            "requirement": {
                                "requirement_type": "control",
                                "expected_value": "poorly controlled despite medication"
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "rate-controlled atrial fibrillation",
                            "criterion": "atrial fibrillation",
                            "requirement": {
                                "requirement_type": "control",
                                "expected_value": "rate-controlled"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Grade ≥ 3 peripheral vascular disease (i.e. symptomatic and interfering with activity of daily living (ADL) requiring repair or revision)",
                "criterions": [
                    {
                        "exact_snippets": "Grade ≥ 3 peripheral vascular disease",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "symptomatic and interfering with activity of daily living (ADL)",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "symptomatic",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "symptomatic and interfering with activity of daily living (ADL)",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "interference with activity of daily living (ADL)",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "requiring repair or revision",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "treatment requirement",
                            "expected_value": [
                                "repair",
                                "revision"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Grade ≥ 3 peripheral vascular disease",
                                        "criterion": "peripheral vascular disease",
                                        "requirement": {
                                            "requirement_type": "grade",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 3,
                                                "unit": "N/A"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "symptomatic and interfering with activity of daily living (ADL)",
                                        "criterion": "peripheral vascular disease",
                                        "requirement": {
                                            "requirement_type": "symptomatic",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "symptomatic and interfering with activity of daily living (ADL)",
                                "criterion": "peripheral vascular disease",
                                "requirement": {
                                    "requirement_type": "interference with activity of daily living (ADL)",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "requiring repair or revision",
                        "criterion": "peripheral vascular disease",
                        "requirement": {
                            "requirement_type": "treatment requirement",
                            "expected_value": [
                                "repair",
                                "revision"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Significant vascular disease including aortic aneurysm requiring surgical repair",
                "criterions": [
                    {
                        "exact_snippets": "Significant vascular disease",
                        "criterion": "vascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    },
                    {
                        "exact_snippets": "aortic aneurysm requiring surgical repair",
                        "criterion": "aortic aneurysm",
                        "requirement": {
                            "requirement_type": "treatment",
                            "expected_value": "surgical repair"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Significant vascular disease",
                                "criterion": "vascular disease",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "significant"
                                }
                            },
                            {
                                "exact_snippets": "aortic aneurysm requiring surgical repair",
                                "criterion": "aortic aneurysm",
                                "requirement": {
                                    "requirement_type": "treatment",
                                    "expected_value": "surgical repair"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Significant vascular disease",
                        "criterion": "vascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "20. Pre-existing sensory or motor neuropathy ≥ Grade 2.",
                "criterions": [
                    {
                        "exact_snippets": "Pre-existing sensory or motor neuropathy ≥ Grade 2.",
                        "criterion": "sensory or motor neuropathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "Grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Pre-existing sensory or motor neuropathy ≥ Grade 2.",
                    "criterion": "sensory or motor neuropathy",
                    "requirement": {
                        "requirement_type": "severity",
                        "expected_value": {
                            "operator": ">=",
                            "value": 2,
                            "unit": "Grade"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "21. Any prior history of hypertensive crisis (CTCAE grade 4) or hypertensive encephalopathy.",
                "criterions": [
                    {
                        "exact_snippets": "prior history of hypertensive crisis (CTCAE grade 4)",
                        "criterion": "hypertensive crisis",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "prior history of hypertensive crisis (CTCAE grade 4)",
                        "criterion": "hypertensive crisis",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "CTCAE grade 4"
                        }
                    },
                    {
                        "exact_snippets": "prior history of ... hypertensive encephalopathy",
                        "criterion": "hypertensive encephalopathy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "prior history of hypertensive crisis (CTCAE grade 4)",
                                "criterion": "hypertensive crisis",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "prior history of hypertensive crisis (CTCAE grade 4)",
                                "criterion": "hypertensive crisis",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "CTCAE grade 4"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "prior history of ... hypertensive encephalopathy",
                        "criterion": "hypertensive encephalopathy",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "22. Patients with a history of or current Nephrotic syndrome.",
                "criterions": [
                    {
                        "exact_snippets": "history of or current Nephrotic syndrome",
                        "criterion": "Nephrotic syndrome",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "history of or current Nephrotic syndrome",
                    "criterion": "Nephrotic syndrome",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "23. Bowel obstruction (including subocclusive disease).",
                "criterions": [
                    {
                        "exact_snippets": "Bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "subocclusive disease",
                        "criterion": "subocclusive disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "subocclusive disease",
                        "criterion": "subocclusive disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "24. History of abdominal fistula or tracheoesophageal fistula or gastrointestinal perforation or active gastrointestinal bleeding or anastomotic insufficiency within 6 months of day 1, cycle 1.",
                "criterions": [
                    {
                        "exact_snippets": "History of abdominal fistula",
                        "criterion": "abdominal fistula",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "tracheoesophageal fistula",
                        "criterion": "tracheoesophageal fistula",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "gastrointestinal perforation",
                        "criterion": "gastrointestinal perforation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "active gastrointestinal bleeding",
                        "criterion": "active gastrointestinal bleeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "anastomotic insufficiency within 6 months of day 1, cycle 1",
                        "criterion": "anastomotic insufficiency",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "anastomotic insufficiency within 6 months of day 1, cycle 1",
                        "criterion": "anastomotic insufficiency",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 6 months of day 1, cycle 1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History of abdominal fistula",
                                "criterion": "abdominal fistula",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "tracheoesophageal fistula",
                                "criterion": "tracheoesophageal fistula",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "gastrointestinal perforation",
                                "criterion": "gastrointestinal perforation",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "active gastrointestinal bleeding",
                                "criterion": "active gastrointestinal bleeding",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "anastomotic insufficiency within 6 months of day 1, cycle 1",
                                "criterion": "anastomotic insufficiency",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "anastomotic insufficiency within 6 months of day 1, cycle 1",
                                "criterion": "anastomotic insufficiency",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "within 6 months of day 1, cycle 1"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "25. Patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of niraparib.",
                "criterions": [
                    {
                        "exact_snippets": "Patients unable to swallow orally administered medication",
                        "criterion": "ability to swallow medication",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients with gastrointestinal disorders likely to interfere with absorption of niraparib",
                        "criterion": "gastrointestinal disorders",
                        "requirement": {
                            "requirement_type": "interference with absorption of niraparib",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Patients unable to swallow orally administered medication",
                        "criterion": "ability to swallow medication",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients with gastrointestinal disorders likely to interfere with absorption of niraparib",
                        "criterion": "gastrointestinal disorders",
                        "requirement": {
                            "requirement_type": "interference with absorption of niraparib",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "26. Evidence of any other disease, metabolic dysfunction, physical examination finding or laboratory finding giving reasonable suspicion of a disease or condition that contra-indicates the use of an investigational drug or puts the patient at high risk for treatment-related complications.",
                "criterions": [
                    {
                        "exact_snippets": "Evidence of any other disease",
                        "criterion": "other disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "metabolic dysfunction",
                        "criterion": "metabolic dysfunction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "physical examination finding",
                        "criterion": "physical examination finding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "laboratory finding",
                        "criterion": "laboratory finding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Evidence of any other disease",
                                        "criterion": "other disease",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "giving reasonable suspicion of a disease or condition that contra-indicates the use of an investigational drug or puts the patient at high risk for treatment-related complications",
                                        "criterion": "reasonable suspicion of contra-indicating disease or high risk for treatment-related complications",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "metabolic dysfunction",
                                        "criterion": "metabolic dysfunction",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "giving reasonable suspicion of a disease or condition that contra-indicates the use of an investigational drug or puts the patient at high risk for treatment-related complications",
                                        "criterion": "reasonable suspicion of contra-indicating disease or high risk for treatment-related complications",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "physical examination finding",
                                        "criterion": "physical examination finding",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "giving reasonable suspicion of a disease or condition that contra-indicates the use of an investigational drug or puts the patient at high risk for treatment-related complications",
                                        "criterion": "reasonable suspicion of contra-indicating disease or high risk for treatment-related complications",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "laboratory finding",
                                        "criterion": "laboratory finding",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "giving reasonable suspicion of a disease or condition that contra-indicates the use of an investigational drug or puts the patient at high risk for treatment-related complications",
                                        "criterion": "reasonable suspicion of contra-indicating disease or high risk for treatment-related complications",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "27. Any known history or current diagnosis of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).",
                "criterions": [
                    {
                        "exact_snippets": "Any known history or current diagnosis of myelodysplastic syndrome (MDS)",
                        "criterion": "myelodysplastic syndrome (MDS)",
                        "requirement": {
                            "requirement_type": "history or diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Any known history or current diagnosis of ... acute myeloid leukemia (AML)",
                        "criterion": "acute myeloid leukemia (AML)",
                        "requirement": {
                            "requirement_type": "history or diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Any known history or current diagnosis of myelodysplastic syndrome (MDS)",
                        "criterion": "myelodysplastic syndrome (MDS)",
                        "requirement": {
                            "requirement_type": "history or diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Any known history or current diagnosis of ... acute myeloid leukemia (AML)",
                        "criterion": "acute myeloid leukemia (AML)",
                        "requirement": {
                            "requirement_type": "history or diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "28. Previous allogeneic bone marrow transplant or previous solid organ transplantation.",
                "criterions": [
                    {
                        "exact_snippets": "Previous allogeneic bone marrow transplant",
                        "criterion": "allogeneic bone marrow transplant",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "previous solid organ transplantation",
                        "criterion": "solid organ transplantation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Previous allogeneic bone marrow transplant",
                        "criterion": "allogeneic bone marrow transplant",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "previous solid organ transplantation",
                        "criterion": "solid organ transplantation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "29. Current or recent (within 10 days prior to day 1, cycle 1) chronic use of aspirin > 325 mg/day. Patients treated with other inhibitors of platelet aggregation such as clopidogrel, prasugrel, ticlopidine, tirofibane or dipyridamole should not be included into the trial.",
                "criterions": [
                    {
                        "exact_snippets": "Current or recent (within 10 days prior to day 1, cycle 1) chronic use of aspirin > 325 mg/day.",
                        "criterion": "aspirin use",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "current or recent (within 10 days prior to day 1, cycle 1)"
                        }
                    },
                    {
                        "exact_snippets": "Current or recent (within 10 days prior to day 1, cycle 1) chronic use of aspirin > 325 mg/day.",
                        "criterion": "aspirin use",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": {
                                "operator": ">",
                                "value": 325,
                                "unit": "mg/day"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Patients treated with other inhibitors of platelet aggregation such as clopidogrel, prasugrel, ticlopidine, tirofibane or dipyridamole should not be included into the trial.",
                        "criterion": "use of platelet aggregation inhibitors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Patients treated with other inhibitors of platelet aggregation such as clopidogrel, prasugrel, ticlopidine, tirofibane or dipyridamole should not be included into the trial.",
                        "criterion": "use of platelet aggregation inhibitors",
                        "requirement": {
                            "requirement_type": "specific drugs",
                            "expected_value": [
                                "clopidogrel",
                                "prasugrel",
                                "ticlopidine",
                                "tirofibane",
                                "dipyridamole"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Current or recent (within 10 days prior to day 1, cycle 1) chronic use of aspirin > 325 mg/day.",
                                        "criterion": "aspirin use",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": "current or recent (within 10 days prior to day 1, cycle 1)"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Current or recent (within 10 days prior to day 1, cycle 1) chronic use of aspirin > 325 mg/day.",
                                        "criterion": "aspirin use",
                                        "requirement": {
                                            "requirement_type": "dosage",
                                            "expected_value": {
                                                "operator": ">",
                                                "value": 325,
                                                "unit": "mg/day"
                                            }
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Patients treated with other inhibitors of platelet aggregation such as clopidogrel, prasugrel, ticlopidine, tirofibane or dipyridamole should not be included into the trial.",
                                        "criterion": "use of platelet aggregation inhibitors",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "Patients treated with other inhibitors of platelet aggregation such as clopidogrel, prasugrel, ticlopidine, tirofibane or dipyridamole should not be included into the trial.",
                                        "criterion": "use of platelet aggregation inhibitors",
                                        "requirement": {
                                            "requirement_type": "specific drugs",
                                            "expected_value": [
                                                "clopidogrel",
                                                "prasugrel",
                                                "ticlopidine",
                                                "tirofibane",
                                                "dipyridamole"
                                            ]
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "30. Patients considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection. This includes also any psychiatric disorder that prohibits obtaining informed consent.",
                "criterions": [
                    {
                        "exact_snippets": "poor medical risk due to a serious, uncontrolled medical disorder",
                        "criterion": "medical disorder",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "poor medical risk due to a serious, uncontrolled medical disorder",
                        "criterion": "medical disorder",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "poor medical risk due to a ... non-malignant systemic disease",
                        "criterion": "non-malignant systemic disease",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "poor medical risk due to a ... active, uncontrolled infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "poor medical risk due to a ... active, uncontrolled infection",
                        "criterion": "infection",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "psychiatric disorder that prohibits obtaining informed consent",
                        "criterion": "psychiatric disorder",
                        "requirement": {
                            "requirement_type": "impact",
                            "expected_value": "prohibits obtaining informed consent"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "poor medical risk due to a serious, uncontrolled medical disorder",
                                        "criterion": "medical disorder",
                                        "requirement": {
                                            "requirement_type": "severity",
                                            "expected_value": "serious"
                                        }
                                    },
                                    {
                                        "exact_snippets": "poor medical risk due to a serious, uncontrolled medical disorder",
                                        "criterion": "medical disorder",
                                        "requirement": {
                                            "requirement_type": "control",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "poor medical risk due to a ... non-malignant systemic disease",
                                "criterion": "non-malignant systemic disease",
                                "requirement": {
                                    "requirement_type": "control",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "poor medical risk due to a ... active, uncontrolled infection",
                                "criterion": "infection",
                                "requirement": {
                                    "requirement_type": "activity",
                                    "expected_value": "active"
                                }
                            },
                            {
                                "exact_snippets": "poor medical risk due to a ... active, uncontrolled infection",
                                "criterion": "infection",
                                "requirement": {
                                    "requirement_type": "control",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "psychiatric disorder that prohibits obtaining informed consent",
                        "criterion": "psychiatric disorder",
                        "requirement": {
                            "requirement_type": "impact",
                            "expected_value": "prohibits obtaining informed consent"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "32. Patient has a history of Posterior Reversible Encephalopathy Syndrome (PRES).",
                "criterions": [
                    {
                        "exact_snippets": "history of Posterior Reversible Encephalopathy Syndrome (PRES)",
                        "criterion": "Posterior Reversible Encephalopathy Syndrome (PRES)",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "history of Posterior Reversible Encephalopathy Syndrome (PRES)",
                    "criterion": "Posterior Reversible Encephalopathy Syndrome (PRES)",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "17. Known hypersensitivity to bevacizumab and its excipients, Chinese hamster ovary cell products or other recombinant human or humanized antibodies. Known hypersensitivity to niraparib, paclitaxel and carboplatin and its components or excipients.",
                "criterions": [
                    {
                        "exact_snippets": "Known hypersensitivity to bevacizumab and its excipients",
                        "criterion": "hypersensitivity to bevacizumab",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... Chinese hamster ovary cell products",
                        "criterion": "hypersensitivity to Chinese hamster ovary cell products",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... other recombinant human or humanized antibodies",
                        "criterion": "hypersensitivity to other recombinant human or humanized antibodies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to niraparib",
                        "criterion": "hypersensitivity to niraparib",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to paclitaxel",
                        "criterion": "hypersensitivity to paclitaxel",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... carboplatin and its components or excipients",
                        "criterion": "hypersensitivity to carboplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Known hypersensitivity to bevacizumab and its excipients",
                                        "criterion": "hypersensitivity to bevacizumab",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "hypersensitivity to ... Chinese hamster ovary cell products",
                                        "criterion": "hypersensitivity to Chinese hamster ovary cell products",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "hypersensitivity to ... other recombinant human or humanized antibodies",
                                        "criterion": "hypersensitivity to other recombinant human or humanized antibodies",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "hypersensitivity to niraparib",
                                        "criterion": "hypersensitivity to niraparib",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "hypersensitivity to paclitaxel",
                                        "criterion": "hypersensitivity to paclitaxel",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "hypersensitivity to ... carboplatin and its components or excipients",
                                        "criterion": "hypersensitivity to carboplatin",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "31. Patient has known active hepatitis B or hepatitis C.",
                "criterions": [
                    {
                        "exact_snippets": "known active hepatitis B",
                        "criterion": "hepatitis B",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "known active hepatitis C",
                        "criterion": "hepatitis C",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "known active hepatitis B",
                        "criterion": "hepatitis B",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "known active hepatitis C",
                        "criterion": "hepatitis C",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Urine dipstick for proteinuria < 2+. If urine dipstick is ≥ 2+, 24 hour urine must demonstrate ≤ 1 g of protein in 24 hours.",
                "criterions": [
                    {
                        "exact_snippets": "Urine dipstick for proteinuria < 2+",
                        "criterion": "urine dipstick proteinuria",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "+"
                            }
                        }
                    },
                    {
                        "exact_snippets": "If urine dipstick is ≥ 2+, 24 hour urine must demonstrate ≤ 1 g of protein in 24 hours",
                        "criterion": "24 hour urine protein",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "g"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Serum creatinine ≤ 1.5 x upper limit of normal (ULN) or calculated creatinine clearance ≥ 30 mL/min using the Cockcroft-Gault equation.",
                "criterions": [
                    {
                        "exact_snippets": "Serum creatinine ≤ 1.5 x upper limit of normal (ULN)",
                        "criterion": "serum creatinine",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "calculated creatinine clearance ≥ 30 mL/min using the Cockcroft-Gault equation",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "calculation",
                            "expected_value": "Cockcroft-Gault equation"
                        }
                    },
                    {
                        "exact_snippets": "calculated creatinine clearance ≥ 30 mL/min using the Cockcroft-Gault equation",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "11. Patients must have normal blood pressure (BP) or adequately treated and controlled BP, with a systolic BP of ≤ 140 mmHg and diastolic BP of ≤ 90 mmHg for eligibility. Patients must have a BP of ≤ 140/90 mmHg taken in the clinic setting by a medical professional within 4 weeks prior to day 1, cycle 1.",
                "criterions": [
                    {
                        "exact_snippets": "normal blood pressure (BP) or adequately treated and controlled BP",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": [
                                "normal",
                                "adequately treated and controlled"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "systolic BP of ≤ 140 mmHg",
                        "criterion": "systolic blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 140,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "diastolic BP of ≤ 90 mmHg",
                        "criterion": "diastolic blood pressure",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "BP of ≤ 140/90 mmHg taken in the clinic setting by a medical professional within 4 weeks prior to day 1, cycle 1",
                        "criterion": "blood pressure measurement",
                        "requirement": {
                            "requirement_type": "setting",
                            "expected_value": "clinic"
                        }
                    },
                    {
                        "exact_snippets": "BP of ≤ 140/90 mmHg taken in the clinic setting by a medical professional within 4 weeks prior to day 1, cycle 1",
                        "criterion": "blood pressure measurement",
                        "requirement": {
                            "requirement_type": "professional",
                            "expected_value": "medical professional"
                        }
                    },
                    {
                        "exact_snippets": "BP of ≤ 140/90 mmHg taken in the clinic setting by a medical professional within 4 weeks prior to day 1, cycle 1",
                        "criterion": "blood pressure measurement",
                        "requirement": {
                            "requirement_type": "timeframe",
                            "expected_value": "within 4 weeks prior to day 1, cycle 1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "14. Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures, that include the completion of patient-reported outcomes questionnaires.",
                "criterions": [
                    {
                        "exact_snippets": "Willingness and ability to comply with scheduled visits",
                        "criterion": "compliance with scheduled visits",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with scheduled visits",
                        "criterion": "compliance with scheduled visits",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... treatment plans",
                        "criterion": "compliance with treatment plans",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... treatment plans",
                        "criterion": "compliance with treatment plans",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... laboratory tests",
                        "criterion": "compliance with laboratory tests",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... laboratory tests",
                        "criterion": "compliance with laboratory tests",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... other study procedures",
                        "criterion": "compliance with other study procedures",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... other study procedures",
                        "criterion": "compliance with other study procedures",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... completion of patient-reported outcomes questionnaires",
                        "criterion": "completion of patient-reported outcomes questionnaires",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willingness and ability to comply with ... completion of patient-reported outcomes questionnaires",
                        "criterion": "completion of patient-reported outcomes questionnaires",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "10. History or clinical suspicion of brain metastases or spinal cord compression. CT/MRI of the brain is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected brain metastases. Spinal MRI is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected spinal cord compression.",
                "criterions": [
                    {
                        "exact_snippets": "History or clinical suspicion of brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "history or suspicion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "History or clinical suspicion of ... spinal cord compression",
                        "criterion": "spinal cord compression",
                        "requirement": {
                            "requirement_type": "history or suspicion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "CT/MRI of the brain is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected brain metastases",
                        "criterion": "CT/MRI of the brain",
                        "requirement": {
                            "requirement_type": "mandatory",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "CT/MRI of the brain is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected brain metastases",
                        "criterion": "CT/MRI of the brain",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Spinal MRI is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected spinal cord compression",
                        "criterion": "Spinal MRI",
                        "requirement": {
                            "requirement_type": "mandatory",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Spinal MRI is mandatory (within 4 weeks prior to day 1, cycle 1) in case of suspected spinal cord compression",
                        "criterion": "Spinal MRI",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": {
                                "operator": "<=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "11. Significant traumatic injury during 4 weeks preceding the potential first dose of bevacizumab.",
                "criterions": [
                    {
                        "exact_snippets": "Significant traumatic injury during 4 weeks preceding the potential first dose of bevacizumab.",
                        "criterion": "traumatic injury",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "significant"
                        }
                    },
                    {
                        "exact_snippets": "Significant traumatic injury during 4 weeks preceding the potential first dose of bevacizumab.",
                        "criterion": "traumatic injury",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "4 weeks preceding the potential first dose of bevacizumab"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "12. Previous Cerebro-Vascular Accident (CVA), Transient Ischemic Attack (TIA) or Sub-Arachnoids Hemorrhage (SAH) within 6 months prior to day 1, cycle 1.",
                "criterions": [
                    {
                        "exact_snippets": "Previous Cerebro-Vascular Accident (CVA) ... within 6 months prior to day 1, cycle 1.",
                        "criterion": "Cerebro-Vascular Accident (CVA)",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Previous ... Transient Ischemic Attack (TIA) ... within 6 months prior to day 1, cycle 1.",
                        "criterion": "Transient Ischemic Attack (TIA)",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Previous ... Sub-Arachnoids Hemorrhage (SAH) within 6 months prior to day 1, cycle 1.",
                        "criterion": "Sub-Arachnoids Hemorrhage (SAH)",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "13. History or evidence of thrombotic or hemorrhagic disorders within 3 months prior to day 1, cycle 1.",
                "criterions": [
                    {
                        "exact_snippets": "History or evidence of thrombotic ... disorders within 3 months prior to day 1, cycle 1.",
                        "criterion": "thrombotic disorders",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "History or evidence of thrombotic ... disorders within 3 months prior to day 1, cycle 1.",
                        "criterion": "thrombotic disorders",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 3 months prior to day 1, cycle 1"
                        }
                    },
                    {
                        "exact_snippets": "History or evidence of ... hemorrhagic disorders within 3 months prior to day 1, cycle 1.",
                        "criterion": "hemorrhagic disorders",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "History or evidence of ... hemorrhagic disorders within 3 months prior to day 1, cycle 1.",
                        "criterion": "hemorrhagic disorders",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 3 months prior to day 1, cycle 1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "14. History or evidence upon neurological examination of central nervous system (CNS) disease, unless adequately treated with standard medical therapy e.g. uncontrolled seizures.",
                "criterions": [
                    {
                        "exact_snippets": "History or evidence upon neurological examination of central nervous system (CNS) disease",
                        "criterion": "central nervous system (CNS) disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "unless adequately treated with standard medical therapy",
                        "criterion": "adequate treatment with standard medical therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "uncontrolled seizures",
                        "criterion": "uncontrolled seizures",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "15. Pregnant or lactating women.",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}