{
    "info": {
        "nct_id": "NCT04803773",
        "official_title": "MRI-guided Focused Ultrasound for Bone Tumors Treatment: Feasibility Study for the Treatment of Bone Metastases and osteoïd Osteoma",
        "inclusion_criteria": "* Subject with one or more painful bone metastases (EVA≥5)\n* Subject with sub-perolate or cortical osteoid osteoma\n* For people with painful bone metastases: first-line treatment or radiotherapy failure\n* Weight < 140kg.\n* Target tumor accessible by HIFU-MRI\n* Maximum size of the lesion - 20cm²\n* Depth of the lesion to be treated - 4mm and 10cm\n* Subject affiliated with a health insurance social protection.\n* A subject capable of understanding research objectives and risks and giving informed and signed consent\n* Subject who has been informed of the pre-medical visit results\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* MRI contraindication\n* Contraindication to the use of a gadolinium contrast or hypersensitivity to gadoteric acid, meglumine or any drug containing gadolinium\n* General anesthesia contraindication\n* Non-reversible hemostasis disorders\n* Previous injury on the area to be treated (radiotherapy, surgery, ...)\n* Tumors located on the spine or skull\n* Tumors located on the ribs\n* Pathological fracture\n* For Osteoid Osteoma: nidus more than 1cm deep within cortical bone\n* Pregnant woman (pregnancy test, urinary or HCG dosage, negative to inclusion) or lactating\n* existence of dermatological pathologies\n* Subject with a known latex allergy\n* Subject under safeguarding of justice, under guardianship or curatorship\n* Subject in an exclusion period by a previous or ongoing study",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Subject with one or more painful bone metastases (EVA≥5)",
                "criterions": [
                    {
                        "exact_snippets": "one or more painful bone metastases",
                        "criterion": "painful bone metastases",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "EVA≥5",
                        "criterion": "EVA",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "one or more painful bone metastases",
                        "criterion": "painful bone metastases",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "EVA≥5",
                        "criterion": "EVA",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* For people with painful bone metastases: first-line treatment or radiotherapy failure",
                "criterions": [
                    {
                        "exact_snippets": "painful bone metastases",
                        "criterion": "bone metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "painful bone metastases",
                        "criterion": "bone metastases",
                        "requirement": {
                            "requirement_type": "painful",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "first-line treatment or radiotherapy failure",
                        "criterion": "treatment history",
                        "requirement": {
                            "requirement_type": "first-line treatment",
                            "expected_value": "failure"
                        }
                    },
                    {
                        "exact_snippets": "first-line treatment or radiotherapy failure",
                        "criterion": "treatment history",
                        "requirement": {
                            "requirement_type": "radiotherapy",
                            "expected_value": "failure"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "painful bone metastases",
                            "criterion": "bone metastases",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        },
                        {
                            "exact_snippets": "painful bone metastases",
                            "criterion": "bone metastases",
                            "requirement": {
                                "requirement_type": "painful",
                                "expected_value": true
                            }
                        }
                    ]
                },
                "then_criteria": {
                    "or_criteria": [
                        {
                            "exact_snippets": "first-line treatment or radiotherapy failure",
                            "criterion": "treatment history",
                            "requirement": {
                                "requirement_type": "first-line treatment",
                                "expected_value": "failure"
                            }
                        },
                        {
                            "exact_snippets": "first-line treatment or radiotherapy failure",
                            "criterion": "treatment history",
                            "requirement": {
                                "requirement_type": "radiotherapy",
                                "expected_value": "failure"
                            }
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Weight < 140kg.",
                "criterions": [
                    {
                        "exact_snippets": "Weight < 140kg",
                        "criterion": "weight",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 140,
                                "unit": "kg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Weight < 140kg",
                        "criterion": "weight",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 140,
                                "unit": "kg"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Target tumor accessible by HIFU-MRI",
                "criterions": [
                    {
                        "exact_snippets": "Target tumor accessible by HIFU-MRI",
                        "criterion": "target tumor",
                        "requirement": {
                            "requirement_type": "accessibility",
                            "expected_value": "HIFU-MRI"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Target tumor accessible by HIFU-MRI",
                        "criterion": "target tumor",
                        "requirement": {
                            "requirement_type": "accessibility",
                            "expected_value": "HIFU-MRI"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Maximum size of the lesion - 20cm²",
                "criterions": [
                    {
                        "exact_snippets": "Maximum size of the lesion - 20cm²",
                        "criterion": "lesion size",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<=",
                                "value": 20,
                                "unit": "cm²"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Maximum size of the lesion - 20cm²",
                        "criterion": "lesion size",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<=",
                                "value": 20,
                                "unit": "cm²"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Depth of the lesion to be treated - 4mm and 10cm",
                "criterions": [
                    {
                        "exact_snippets": "Depth of the lesion to be treated - 4mm and 10cm",
                        "criterion": "lesion depth",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "=",
                                        "value": 4,
                                        "unit": "mm"
                                    },
                                    {
                                        "operator": "=",
                                        "value": 10,
                                        "unit": "cm"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Depth of the lesion to be treated - 4mm and 10cm",
                        "criterion": "lesion depth",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "=",
                                        "value": 4,
                                        "unit": "mm"
                                    },
                                    {
                                        "operator": "=",
                                        "value": 10,
                                        "unit": "cm"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Subject affiliated with a health insurance social protection.",
                "criterions": [
                    {
                        "exact_snippets": "Subject affiliated with a health insurance social protection.",
                        "criterion": "health insurance social protection affiliation",
                        "requirement": {
                            "requirement_type": "affiliation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Subject affiliated with a health insurance social protection.",
                        "criterion": "health insurance social protection affiliation",
                        "requirement": {
                            "requirement_type": "affiliation",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* A subject capable of understanding research objectives and risks and giving informed and signed consent",
                "criterions": [
                    {
                        "exact_snippets": "capable of understanding research objectives and risks",
                        "criterion": "understanding of research objectives and risks",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "giving informed and signed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "capable of understanding research objectives and risks",
                        "criterion": "understanding of research objectives and risks",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "giving informed and signed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Subject who has been informed of the pre-medical visit results",
                "criterions": [
                    {
                        "exact_snippets": "Subject who has been informed of the pre-medical visit results",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "informed"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Subject who has been informed of the pre-medical visit results",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "informed"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* MRI contraindication",
                "criterions": [
                    {
                        "exact_snippets": "MRI contraindication",
                        "criterion": "MRI contraindication",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "MRI contraindication",
                    "criterion": "MRI contraindication",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Contraindication to the use of a gadolinium contrast or hypersensitivity to gadoteric acid, meglumine or any drug containing gadolinium",
                "criterions": [
                    {
                        "exact_snippets": "Contraindication to the use of a gadolinium contrast",
                        "criterion": "gadolinium contrast use",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to gadoteric acid",
                        "criterion": "hypersensitivity to gadoteric acid",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... meglumine",
                        "criterion": "hypersensitivity to meglumine",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "hypersensitivity to ... any drug containing gadolinium",
                        "criterion": "hypersensitivity to any drug containing gadolinium",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Contraindication to the use of a gadolinium contrast",
                                "criterion": "gadolinium contrast use",
                                "requirement": {
                                    "requirement_type": "contraindication",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "hypersensitivity to gadoteric acid",
                                "criterion": "hypersensitivity to gadoteric acid",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "hypersensitivity to ... meglumine",
                                "criterion": "hypersensitivity to meglumine",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "hypersensitivity to ... any drug containing gadolinium",
                                "criterion": "hypersensitivity to any drug containing gadolinium",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* General anesthesia contraindication",
                "criterions": [
                    {
                        "exact_snippets": "General anesthesia contraindication",
                        "criterion": "general anesthesia",
                        "requirement": {
                            "requirement_type": "contraindication",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "General anesthesia contraindication",
                    "criterion": "general anesthesia",
                    "requirement": {
                        "requirement_type": "contraindication",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Non-reversible hemostasis disorders",
                "criterions": [
                    {
                        "exact_snippets": "Non-reversible hemostasis disorders",
                        "criterion": "hemostasis disorders",
                        "requirement": {
                            "requirement_type": "reversibility",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Non-reversible hemostasis disorders",
                    "criterion": "hemostasis disorders",
                    "requirement": {
                        "requirement_type": "reversibility",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous injury on the area to be treated (radiotherapy, surgery, ...)",
                "criterions": [
                    {
                        "exact_snippets": "Previous injury on the area to be treated",
                        "criterion": "previous injury on treatment area",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Previous injury on the area to be treated",
                        "criterion": "previous injury on treatment area",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Tumors located on the spine or skull",
                "criterions": [
                    {
                        "exact_snippets": "Tumors located on the spine",
                        "criterion": "tumor location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "spine"
                        }
                    },
                    {
                        "exact_snippets": "Tumors located on the ... skull",
                        "criterion": "tumor location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "skull"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Tumors located on the spine",
                        "criterion": "tumor location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "spine"
                        }
                    },
                    {
                        "exact_snippets": "Tumors located on the ... skull",
                        "criterion": "tumor location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "skull"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Tumors located on the ribs",
                "criterions": [
                    {
                        "exact_snippets": "Tumors located on the ribs",
                        "criterion": "tumor location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "ribs"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Tumors located on the ribs",
                    "criterion": "tumor location",
                    "requirement": {
                        "requirement_type": "location",
                        "expected_value": "ribs"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pathological fracture",
                "criterions": [
                    {
                        "exact_snippets": "Pathological fracture",
                        "criterion": "pathological fracture",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Pathological fracture",
                    "criterion": "pathological fracture",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* For Osteoid Osteoma: nidus more than 1cm deep within cortical bone",
                "criterions": [
                    {
                        "exact_snippets": "Osteoid Osteoma",
                        "criterion": "osteoid osteoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "nidus more than 1cm deep within cortical bone",
                        "criterion": "nidus depth",
                        "requirement": {
                            "requirement_type": "depth",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "cm"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Osteoid Osteoma",
                    "criterion": "osteoid osteoma",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "nidus more than 1cm deep within cortical bone",
                    "criterion": "nidus depth",
                    "requirement": {
                        "requirement_type": "depth",
                        "expected_value": {
                            "operator": ">",
                            "value": 1,
                            "unit": "cm"
                        }
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant woman (pregnancy test, urinary or HCG dosage, negative to inclusion) or lactating",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant woman (pregnancy test, urinary or HCG dosage, negative to inclusion)",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "test",
                            "expected_value": [
                                "pregnancy test",
                                "urinary",
                                "HCG dosage"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Pregnant woman (pregnancy test, urinary or HCG dosage, negative to inclusion)",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "lactating",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Pregnant woman (pregnancy test, urinary or HCG dosage, negative to inclusion)",
                                        "criterion": "pregnancy",
                                        "requirement": {
                                            "requirement_type": "test",
                                            "expected_value": [
                                                "pregnancy test",
                                                "urinary",
                                                "HCG dosage"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "Pregnant woman (pregnancy test, urinary or HCG dosage, negative to inclusion)",
                                        "criterion": "pregnancy",
                                        "requirement": {
                                            "requirement_type": "result",
                                            "expected_value": "negative"
                                        }
                                    }
                                ]
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "lactating",
                                    "criterion": "lactation",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": false
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "lactating",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* existence of dermatological pathologies",
                "criterions": [
                    {
                        "exact_snippets": "existence of dermatological pathologies",
                        "criterion": "dermatological pathologies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "existence of dermatological pathologies",
                    "criterion": "dermatological pathologies",
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                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Subject with a known latex allergy",
                "criterions": [
                    {
                        "exact_snippets": "known latex allergy",
                        "criterion": "latex allergy",
                        "requirement": {
                            "requirement_type": "presence",
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                        }
                    }
                ]
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            "logical_structure": {
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                    "criterion": "latex allergy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Subject under safeguarding of justice, under guardianship or curatorship",
                "criterions": [
                    {
                        "exact_snippets": "Subject under safeguarding of justice",
                        "criterion": "safeguarding of justice",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "under guardianship",
                        "criterion": "guardianship",
                        "requirement": {
                            "requirement_type": "presence",
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                        }
                    },
                    {
                        "exact_snippets": "under ... curatorship",
                        "criterion": "curatorship",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
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                        "and_criteria": [
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                                "exact_snippets": "Subject under safeguarding of justice",
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                                    "requirement_type": "presence",
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                                }
                            }
                        ]
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                            {
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                                "criterion": "guardianship",
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                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "under ... curatorship",
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                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Subject in an exclusion period by a previous or ongoing study",
                "criterions": [
                    {
                        "exact_snippets": "Subject in an exclusion period by a previous or ongoing study",
                        "criterion": "exclusion period",
                        "requirement": {
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                        }
                    }
                ]
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                    "criterion": "exclusion period",
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                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Subject with sub-perolate or cortical osteoid osteoma",
                "criterions": [
                    {
                        "exact_snippets": "sub-perolate or cortical osteoid osteoma",
                        "criterion": "osteoid osteoma",
                        "requirement": {
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                                "sub-perolate",
                                "cortical"
                            ]
                        }
                    }
                ]
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                            "expected_value": "sub-perolate"
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    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}