{
    "info": {
        "nct_id": "NCT04648462",
        "official_title": "Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology",
        "inclusion_criteria": "1. All brain tumors with a favorable prognosis (median survival > 10 year)\n2. Age ≥ 18 years\n3. ECOG performance status 0 - 1 / Karnofsky performance status 80 - 100\n4. No - minimal neurocognitive impairment\n5. Dosimetrical gain of protontherapy relative to photontherapy (≥5% on supratentorial brain dose or hippocampi)\n6. Informed consent\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Not eligible for chemotherapy\n2. Eligible for stereotactic radiotherapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. All brain tumors with a favorable prognosis (median survival > 10 year)",
                "criterions": [
                    {
                        "exact_snippets": "brain tumors",
                        "criterion": "brain tumors",
                        "requirement": {
                            "requirement_type": "prognosis",
                            "expected_value": "favorable"
                        }
                    },
                    {
                        "exact_snippets": "median survival > 10 year",
                        "criterion": "median survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "year"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "brain tumors",
                        "criterion": "brain tumors",
                        "requirement": {
                            "requirement_type": "prognosis",
                            "expected_value": "favorable"
                        }
                    },
                    {
                        "exact_snippets": "median survival > 10 year",
                        "criterion": "median survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 10,
                                "unit": "year"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Age ≥ 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Age ≥ 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age ≥ 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. ECOG performance status 0 - 1 / Karnofsky performance status 80 - 100",
                "criterions": [
                    {
                        "exact_snippets": "ECOG performance status 0 - 1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Karnofsky performance status 80 - 100",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 80,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "ECOG performance status 0 - 1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "Karnofsky performance status 80 - 100",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 80,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. No - minimal neurocognitive impairment",
                "criterions": [
                    {
                        "exact_snippets": "No - minimal neurocognitive impairment",
                        "criterion": "neurocognitive impairment",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "minimal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No - minimal neurocognitive impairment",
                        "criterion": "neurocognitive impairment",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "minimal"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Dosimetrical gain of protontherapy relative to photontherapy (≥5% on supratentorial brain dose or hippocampi)",
                "criterions": [
                    {
                        "exact_snippets": "Dosimetrical gain of protontherapy relative to photontherapy (≥5% on supratentorial brain dose",
                        "criterion": "dosimetrical gain of protontherapy relative to photontherapy on supratentorial brain dose",
                        "requirement": {
                            "requirement_type": "gain",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Dosimetrical gain of protontherapy relative to photontherapy (≥5% on ... hippocampi",
                        "criterion": "dosimetrical gain of protontherapy relative to photontherapy on hippocampi",
                        "requirement": {
                            "requirement_type": "gain",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Dosimetrical gain of protontherapy relative to photontherapy (≥5% on supratentorial brain dose",
                        "criterion": "dosimetrical gain of protontherapy relative to photontherapy on supratentorial brain dose",
                        "requirement": {
                            "requirement_type": "gain",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Dosimetrical gain of protontherapy relative to photontherapy (≥5% on ... hippocampi",
                        "criterion": "dosimetrical gain of protontherapy relative to photontherapy on hippocampi",
                        "requirement": {
                            "requirement_type": "gain",
                            "expected_value": {
                                "operator": ">=",
                                "value": 5,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. Informed consent",
                "criterions": [
                    {
                        "exact_snippets": "Informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "1. Not eligible for chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Not eligible for chemotherapy",
                        "criterion": "chemotherapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not eligible for chemotherapy",
                        "criterion": "chemotherapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Eligible for stereotactic radiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Eligible for stereotactic radiotherapy",
                        "criterion": "stereotactic radiotherapy eligibility",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Eligible for stereotactic radiotherapy",
                    "criterion": "stereotactic radiotherapy eligibility",
                    "requirement": {
                        "requirement_type": "eligibility",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}