{
    "info": {
        "nct_id": "NCT04624373",
        "official_title": "Molecular Analysis of the Surnantant of Echoguidated Bronchoscopic Cytopunctions in Lung Cancer",
        "inclusion_criteria": "* Age > 18 years-old\n* Patients planned for an EBUS-TBNA for\n\n  1. Suspicion of stage IV lung cancer (PET+ mediastinal node(s)) (Cohort 1)\n  2. Stage IV NSCLC with an EGFR, BRAF, HER2, MET mutation or ALK, RET or ROS1 rearranged NSCLC and acquired resistance to targeted therapy (Cohort 2)\n* Performance status 0-3\n* Informed consent\nMust have minimum age of 18 Years\nMust have maximum age of 65 Years",
        "exclusion_criteria": "* Refusal to participate\n* Patient under legal tutelage",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Age > 18 years-old",
                "criterions": [
                    {
                        "exact_snippets": "Age > 18 years-old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years-old"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age > 18 years-old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years-old"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients planned for an EBUS-TBNA for",
                "criterions": [
                    {
                        "exact_snippets": "planned for an EBUS-TBNA",
                        "criterion": "EBUS-TBNA procedure",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "planned for an EBUS-TBNA",
                        "criterion": "EBUS-TBNA procedure",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. Suspicion of stage IV lung cancer (PET+ mediastinal node(s)) (Cohort 1)",
                "criterions": [
                    {
                        "exact_snippets": "Suspicion of stage IV lung cancer",
                        "criterion": "stage IV lung cancer",
                        "requirement": {
                            "requirement_type": "suspicion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "PET+ mediastinal node(s)",
                        "criterion": "mediastinal node(s)",
                        "requirement": {
                            "requirement_type": "PET+",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Suspicion of stage IV lung cancer",
                        "criterion": "stage IV lung cancer",
                        "requirement": {
                            "requirement_type": "suspicion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "PET+ mediastinal node(s)",
                        "criterion": "mediastinal node(s)",
                        "requirement": {
                            "requirement_type": "PET+",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Stage IV NSCLC with an EGFR, BRAF, HER2, MET mutation or ALK, RET or ROS1 rearranged NSCLC and acquired resistance to targeted therapy (Cohort 2)",
                "criterions": [
                    {
                        "exact_snippets": "Stage IV NSCLC",
                        "criterion": "NSCLC stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "IV"
                        }
                    },
                    {
                        "exact_snippets": "EGFR, BRAF, HER2, MET mutation",
                        "criterion": "genetic mutation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "EGFR",
                                "BRAF",
                                "HER2",
                                "MET"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "ALK, RET or ROS1 rearranged",
                        "criterion": "genetic rearrangement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "ALK",
                                "RET",
                                "ROS1"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "acquired resistance to targeted therapy",
                        "criterion": "resistance to therapy",
                        "requirement": {
                            "requirement_type": "acquired resistance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Stage IV NSCLC",
                                "criterion": "NSCLC stage",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "IV"
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "EGFR, BRAF, HER2, MET mutation",
                                        "criterion": "genetic mutation",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": [
                                                "EGFR",
                                                "BRAF",
                                                "HER2",
                                                "MET"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "ALK, RET or ROS1 rearranged",
                                        "criterion": "genetic rearrangement",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": [
                                                "ALK",
                                                "RET",
                                                "ROS1"
                                            ]
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "acquired resistance to targeted therapy",
                        "criterion": "resistance to therapy",
                        "requirement": {
                            "requirement_type": "acquired resistance",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Performance status 0-3",
                "criterions": [
                    {
                        "exact_snippets": "Performance status 0-3",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Informed consent",
                "criterions": [
                    {
                        "exact_snippets": "Informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 65 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 65 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Refusal to participate",
                "criterions": [
                    {
                        "exact_snippets": "Refusal to participate",
                        "criterion": "participation",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patient under legal tutelage",
                "criterions": [
                    {
                        "exact_snippets": "Patient under legal tutelage",
                        "criterion": "legal tutelage",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_miscellaneous": []
}