{
    "info": {
        "nct_id": "NCT04089631",
        "official_title": "Circulating Tumour DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II Evaluation (CIRCULATE) AIO-KRK-0217",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "Inclusion criteria for screening phase:\n\n1. Resected colon cancer stage II, OR Resected rectal cancer stage II, if there was no indication for radiotherapy (i.e. due to the localisation in the upper third of the rectum ), so that the treatment follows the recommendations for colon cancer. Patients, in whom the tumour stage is not yet know, can be enrolled into the screening.\n2. Signed informed consent for the screening Phase\n\nInclusion criteria for the randomised phase:\n\n1. Resected colon cancer stage II, OR resected rectal cancer stage II, if there was no indication for radiotherapy (i.e. due to the localisation in the upper third of the rectum), so that the treatment follows the recommendations for colon cancer.\n2. Known microsatellite or mismatch repair status\n3. Confirmation, that the ctDNA result is available\n4. Signed second informed consent (for the randomised phase)\n\nExclusion criteria for Screening:\n\n1. Patients with known microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR)\n2. Known clinical high risk situation if it is regarded as certain indication for an adjuvant chemotherapy\n3. Patients, who have an obvious contra-indication for adjuvant chemotherapy (i.e. due to the performance status, comorbidity, active second cancer or age). It should be considered that patients with an age of more than 75 years frequently not fulfil criteria for adjuvant chemotherapy.\n4. R1- or R2-status (patients with [still] unknown R-status can be screened)\n5. Patients, in whom the randomisation or chemotherapy is unfeasible due to logistic reasons (travel distance, compliance)\n6. Age < 18 years\n7. Pregnant or breast feeding patients\n\nExclusion criteria for randomised phase:\n\n1. Patients with microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR)\n2. Known clinical high risk situation if it is regarded as certain indication for an adjuvant chemotherapy\n3. R1- or R2- status, or unknown R- status (Rx)\n4. Number of investigated lymph nodes < 10\n5. WHO performance status ≥ 2\n6. Colon or rectal cancer with UICC stage III or IV\n7. Second cancer, except\n\n   1. simultaneous or metachronous colon or rectal cancer with UICC stage ≤ I,\n   2. curatively treated basal cell carcinoma or squamous cell carcinoma of the skin and in-situ cervical carcinoma\n   3. tumours with a disease free survival of more than five years\n8. Contra indications for chemotherapy, especially:\n\n   1. Leukocytes < 3,0 Gpt/l\n   2. Neutrophil granulocytes < 1,5 Gpt/l\n   3. Thrombocytes < 100 Gpt/l\n   4. alanine aminotransferase (ALAT) or (aspartate aminotransferase) ASAT > 3x ULN\n   5. Creatinine clearance (calculated according Cockcroft-Gault) < 30 ml/min\n9. Comorbidities relevantly interfering with the prognosis of the patients, i.e.:\n\n   1. heart insufficiency NYHA III/IV\n   2. relevant coronary heart disease,\n   3. Diabetes mellitus with late sequelae\n10. Organ, stem cell or bone marrow transplantation\n11. Known hypersensitivity to capecitabine In case of known hypersensitivity to oxaliplatin, the patients can participate, but not receive oxaliplatin\n12. Medication with brivudine, sorivudine or analogues in the last four weeks before planned treatment start\n13. Known dihydropyrimidine dehydrogenase (DPD)-deficiency\n14. Acute infections\n15. Known HIV- infections, known active hepatitis B or C-infection\n16. Participation at another interventional study for medical treatment during the last four weeks before randomisation\n17. Neoadjuvant therapy before resection\n18. Patients, in whom the randomisation or chemotherapy is unfeasible due to logistic reasons (travel distance, compliance)\n19. Age < 18 years\n20. Pregnant or breast feeding patients\n21. Women of childbearing potential and men with partner with childbearing potential who are not willing to take appropriate precautions to avoid pregnancy with a highly effective method in case they are randomised to \"chemotherapy\""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
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                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
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            "logical_structure": {
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                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "expected_value": "healthy"
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                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "minimum age of 18 Years",
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                            "expected_value": {
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                                "value": 18,
                                "unit": "Years"
                            }
                        }
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                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
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                "line": "2. Signed informed consent for the screening Phase",
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                            "expected_value": "signed"
                        }
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                        "exact_snippets": "Signed informed consent",
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                "line": "1. Resected colon cancer stage II, OR resected rectal cancer stage II, if there was no indication for radiotherapy (i.e. due to the localisation in the upper third of the rectum), so that the treatment follows the recommendations for colon cancer.",
                "criterions": [
                    {
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                        "criterion": "colon cancer",
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                            "expected_value": "II"
                        }
                    },
                    {
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                        "requirement": {
                            "requirement_type": "resection",
                            "expected_value": true
                        }
                    },
                    {
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                        "criterion": "rectal cancer",
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                        }
                    },
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                        "criterion": "rectal cancer",
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                            "requirement_type": "resection",
                            "expected_value": true
                        }
                    },
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                        "criterion": "indication for radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
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                        "and_criteria": [
                            {
                                "exact_snippets": "Resected colon cancer stage II",
                                "criterion": "colon cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "II"
                                }
                            },
                            {
                                "exact_snippets": "Resected colon cancer stage II",
                                "criterion": "colon cancer",
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                                    "expected_value": true
                                }
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                                "exact_snippets": "resected rectal cancer stage II",
                                "criterion": "rectal cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "II"
                                }
                            },
                            {
                                "exact_snippets": "resected rectal cancer stage II",
                                "criterion": "rectal cancer",
                                "requirement": {
                                    "requirement_type": "resection",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "no indication for radiotherapy ... localisation in the upper third of the rectum",
                                "criterion": "indication for radiotherapy",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
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                "line": "2. Known microsatellite or mismatch repair status",
                "criterions": [
                    {
                        "exact_snippets": "microsatellite or mismatch repair status",
                        "criterion": "microsatellite or mismatch repair status",
                        "requirement": {
                            "requirement_type": "known",
                            "expected_value": true
                        }
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                ]
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                        "exact_snippets": "microsatellite or mismatch repair status",
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                            "expected_value": true
                        }
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                ]
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        },
        {
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                "line": "3. Confirmation, that the ctDNA result is available",
                "criterions": [
                    {
                        "exact_snippets": "ctDNA result is available",
                        "criterion": "ctDNA result",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
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                        "exact_snippets": "ctDNA result is available",
                        "criterion": "ctDNA result",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Signed second informed consent (for the randomised phase)",
                "criterions": [
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                        "exact_snippets": "Signed second informed consent (for the randomised phase)",
                        "criterion": "second informed consent",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
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            "logical_structure": {
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                        "exact_snippets": "Signed second informed consent (for the randomised phase)",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
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                "line": "1. Patients with known microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR)",
                "criterions": [
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                        "criterion": "microsatellite instability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "mismatch repair deficiency (dMMR)",
                        "criterion": "mismatch repair deficiency",
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                            "expected_value": true
                        }
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                        "exact_snippets": "known microsatellite instability (MSI-H)",
                        "criterion": "microsatellite instability",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
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                        "exact_snippets": "mismatch repair deficiency (dMMR)",
                        "criterion": "mismatch repair deficiency",
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        },
        {
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                "criterions": [
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                        "exact_snippets": "Known clinical high risk situation",
                        "criterion": "clinical high risk situation",
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                            "requirement_type": "presence",
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                        }
                    },
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                        "condition": {
                            "exact_snippets": "Known clinical high risk situation",
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                                "expected_value": true
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                        },
                        "then_criteria": {
                            "exact_snippets": "certain indication for an adjuvant chemotherapy",
                            "criterion": "indication for adjuvant chemotherapy",
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                        "else_criteria": null
                    }
                ]
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        },
        {
            "identified_line": {
                "line": "3. Patients, who have an obvious contra-indication for adjuvant chemotherapy (i.e. due to the performance status, comorbidity, active second cancer or age). It should be considered that patients with an age of more than 75 years frequently not fulfil criteria for adjuvant chemotherapy.",
                "criterions": [
                    {
                        "exact_snippets": "obvious contra-indication for adjuvant chemotherapy",
                        "criterion": "contra-indication for adjuvant chemotherapy",
                        "requirement": {
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                            "expected_value": true
                        }
                    },
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                        "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to the performance status",
                        "criterion": "performance status",
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                            "requirement_type": "impact",
                            "expected_value": "contra-indication for adjuvant chemotherapy"
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                    },
                    {
                        "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to ... comorbidity",
                        "criterion": "comorbidity",
                        "requirement": {
                            "requirement_type": "impact",
                            "expected_value": "contra-indication for adjuvant chemotherapy"
                        }
                    },
                    {
                        "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to ... active second cancer",
                        "criterion": "active second cancer",
                        "requirement": {
                            "requirement_type": "impact",
                            "expected_value": "contra-indication for adjuvant chemotherapy"
                        }
                    },
                    {
                        "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to ... age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "impact",
                            "expected_value": "contra-indication for adjuvant chemotherapy"
                        }
                    },
                    {
                        "exact_snippets": "patients with an age of more than 75 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": ">",
                                "value": 75,
                                "unit": "years"
                            }
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                    }
                ]
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                "condition": {
                    "exact_snippets": "obvious contra-indication for adjuvant chemotherapy",
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                        "expected_value": true
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                "then_criteria": {
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                            "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to the performance status",
                            "criterion": "performance status",
                            "requirement": {
                                "requirement_type": "impact",
                                "expected_value": "contra-indication for adjuvant chemotherapy"
                            }
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                        {
                            "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to ... comorbidity",
                            "criterion": "comorbidity",
                            "requirement": {
                                "requirement_type": "impact",
                                "expected_value": "contra-indication for adjuvant chemotherapy"
                            }
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                        {
                            "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to ... active second cancer",
                            "criterion": "active second cancer",
                            "requirement": {
                                "requirement_type": "impact",
                                "expected_value": "contra-indication for adjuvant chemotherapy"
                            }
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                        {
                            "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to ... age",
                            "criterion": "age",
                            "requirement": {
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                                "expected_value": "contra-indication for adjuvant chemotherapy"
                            }
                        },
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                            "and_criteria": [
                                {
                                    "exact_snippets": "contra-indication for adjuvant chemotherapy ... due to ... age",
                                    "criterion": "age",
                                    "requirement": {
                                        "requirement_type": "impact",
                                        "expected_value": "contra-indication for adjuvant chemotherapy"
                                    }
                                },
                                {
                                    "exact_snippets": "patients with an age of more than 75 years",
                                    "criterion": "age",
                                    "requirement": {
                                        "requirement_type": "comparison",
                                        "expected_value": {
                                            "operator": ">",
                                            "value": 75,
                                            "unit": "years"
                                        }
                                    }
                                }
                            ]
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "4. R1- or R2-status (patients with [still] unknown R-status can be screened)",
                "criterions": [
                    {
                        "exact_snippets": "R1- or R2-status",
                        "criterion": "R-status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "R1",
                                "R2"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "patients with [still] unknown R-status can be screened",
                        "criterion": "R-status",
                        "requirement": {
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                            "expected_value": "unknown"
                        }
                    }
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                        "and_criteria": [
                            {
                                "exact_snippets": "R1- or R2-status",
                                "criterion": "R-status",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": [
                                        "R1",
                                        "R2"
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                                }
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                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "patients with [still] unknown R-status can be screened",
                                "criterion": "R-status",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "unknown"
                                }
                            }
                        ]
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                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Patients, in whom the randomisation or chemotherapy is unfeasible due to logistic reasons (travel distance, compliance)",
                "criterions": [
                    {
                        "exact_snippets": "randomisation ... is unfeasible due to logistic reasons",
                        "criterion": "randomisation feasibility",
                        "requirement": {
                            "requirement_type": "feasibility",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "chemotherapy is unfeasible due to logistic reasons",
                        "criterion": "chemotherapy feasibility",
                        "requirement": {
                            "requirement_type": "feasibility",
                            "expected_value": false
                        }
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                        "exact_snippets": "randomisation ... is unfeasible due to logistic reasons",
                        "criterion": "randomisation feasibility",
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                            "requirement_type": "feasibility",
                            "expected_value": false
                        }
                    },
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                        "exact_snippets": "chemotherapy is unfeasible due to logistic reasons",
                        "criterion": "chemotherapy feasibility",
                        "requirement": {
                            "requirement_type": "feasibility",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. Age < 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Age < 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "years"
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                        "exact_snippets": "Age < 18 years",
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                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "years"
                            }
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                ]
            }
        },
        {
            "identified_line": {
                "line": "7. Pregnant or breast feeding patients",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
                        "criterion": "breastfeeding",
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                            "expected_value": false
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                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
                        "criterion": "breastfeeding",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
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                "line": "1. Patients with microsatellite instability (MSI-H) or mismatch repair deficiency (dMMR)",
                "criterions": [
                    {
                        "exact_snippets": "microsatellite instability (MSI-H)",
                        "criterion": "microsatellite instability",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "MSI-H"
                        }
                    },
                    {
                        "exact_snippets": "mismatch repair deficiency (dMMR)",
                        "criterion": "mismatch repair deficiency",
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                            "expected_value": "dMMR"
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                        "exact_snippets": "microsatellite instability (MSI-H)",
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                            "expected_value": "MSI-H"
                        }
                    },
                    {
                        "exact_snippets": "mismatch repair deficiency (dMMR)",
                        "criterion": "mismatch repair deficiency",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "dMMR"
                        }
                    }
                ]
            }
        },
        {
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                "line": "2. Known clinical high risk situation if it is regarded as certain indication for an adjuvant chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Known clinical high risk situation",
                        "criterion": "clinical high risk situation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "certain indication for an adjuvant chemotherapy",
                        "criterion": "indication for adjuvant chemotherapy",
                        "requirement": {
                            "requirement_type": "certainty",
                            "expected_value": true
                        }
                    }
                ]
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                "and_criteria": [
                    {
                        "condition": {
                            "exact_snippets": "Known clinical high risk situation",
                            "criterion": "clinical high risk situation",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        },
                        "then_criteria": {
                            "exact_snippets": "certain indication for an adjuvant chemotherapy",
                            "criterion": "indication for adjuvant chemotherapy",
                            "requirement": {
                                "requirement_type": "certainty",
                                "expected_value": true
                            }
                        },
                        "else_criteria": null
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. R1- or R2- status, or unknown R- status (Rx)",
                "criterions": [
                    {
                        "exact_snippets": "R1- or R2- status",
                        "criterion": "R-status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "R1",
                                "R2"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "unknown R- status (Rx)",
                        "criterion": "R-status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "unknown (Rx)"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "R1- or R2- status",
                        "criterion": "R-status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": [
                                "R1",
                                "R2"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "unknown R- status (Rx)",
                        "criterion": "R-status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "unknown (Rx)"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Number of investigated lymph nodes < 10",
                "criterions": [
                    {
                        "exact_snippets": "Number of investigated lymph nodes < 10",
                        "criterion": "investigated lymph nodes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 10,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Number of investigated lymph nodes < 10",
                        "criterion": "investigated lymph nodes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 10,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. WHO performance status ≥ 2",
                "criterions": [
                    {
                        "exact_snippets": "WHO performance status ≥ 2",
                        "criterion": "WHO performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WHO performance status ≥ 2",
                        "criterion": "WHO performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "6. Colon or rectal cancer with UICC stage III or IV",
                "criterions": [
                    {
                        "exact_snippets": "Colon or rectal cancer",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "colon",
                                "rectal"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "UICC stage III or IV",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "UICC stage III",
                                "UICC stage IV"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Colon or rectal cancer",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "colon",
                                "rectal"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "UICC stage III or IV",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "UICC stage III",
                                "UICC stage IV"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "7. Second cancer, except",
                "criterions": [
                    {
                        "exact_snippets": "Second cancer",
                        "criterion": "second cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Second cancer",
                        "criterion": "second cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. simultaneous or metachronous colon or rectal cancer with UICC stage ≤ I,",
                "criterions": [
                    {
                        "exact_snippets": "simultaneous or metachronous colon or rectal cancer",
                        "criterion": "colon or rectal cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "UICC stage ≤ I",
                        "criterion": "UICC stage",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "simultaneous or metachronous colon or rectal cancer",
                                "criterion": "colon or rectal cancer",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "UICC stage ≤ I",
                        "criterion": "UICC stage",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. curatively treated basal cell carcinoma or squamous cell carcinoma of the skin and in-situ cervical carcinoma",
                "criterions": [
                    {
                        "exact_snippets": "curatively treated basal cell carcinoma",
                        "criterion": "basal cell carcinoma",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "curatively treated"
                        }
                    },
                    {
                        "exact_snippets": "curatively treated ... squamous cell carcinoma of the skin",
                        "criterion": "squamous cell carcinoma of the skin",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "curatively treated"
                        }
                    },
                    {
                        "exact_snippets": "in-situ cervical carcinoma",
                        "criterion": "cervical carcinoma",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "in-situ"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "curatively treated basal cell carcinoma",
                                "criterion": "basal cell carcinoma",
                                "requirement": {
                                    "requirement_type": "treatment status",
                                    "expected_value": "curatively treated"
                                }
                            },
                            {
                                "exact_snippets": "curatively treated ... squamous cell carcinoma of the skin",
                                "criterion": "squamous cell carcinoma of the skin",
                                "requirement": {
                                    "requirement_type": "treatment status",
                                    "expected_value": "curatively treated"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "in-situ cervical carcinoma",
                        "criterion": "cervical carcinoma",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "in-situ"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. tumours with a disease free survival of more than five years",
                "criterions": [
                    {
                        "exact_snippets": "tumours with a disease free survival of more than five years",
                        "criterion": "disease free survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "tumours with a disease free survival of more than five years",
                        "criterion": "disease free survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "8. Contra indications for chemotherapy, especially:",
                "criterions": [
                    {
                        "exact_snippets": "Contra indications for chemotherapy",
                        "criterion": "contraindications for chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Contra indications for chemotherapy",
                        "criterion": "contraindications for chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. Leukocytes < 3,0 Gpt/l",
                "criterions": [
                    {
                        "exact_snippets": "Leukocytes < 3,0 Gpt/l",
                        "criterion": "leukocytes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 3.0,
                                "unit": "Gpt/l"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Leukocytes < 3,0 Gpt/l",
                        "criterion": "leukocytes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 3.0,
                                "unit": "Gpt/l"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Neutrophil granulocytes < 1,5 Gpt/l",
                "criterions": [
                    {
                        "exact_snippets": "Neutrophil granulocytes < 1,5 Gpt/l",
                        "criterion": "neutrophil granulocytes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "Gpt/l"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Neutrophil granulocytes < 1,5 Gpt/l",
                        "criterion": "neutrophil granulocytes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.5,
                                "unit": "Gpt/l"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Thrombocytes < 100 Gpt/l",
                "criterions": [
                    {
                        "exact_snippets": "Thrombocytes < 100 Gpt/l",
                        "criterion": "thrombocytes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 100,
                                "unit": "Gpt/l"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Thrombocytes < 100 Gpt/l",
                        "criterion": "thrombocytes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 100,
                                "unit": "Gpt/l"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. alanine aminotransferase (ALAT) or (aspartate aminotransferase) ASAT > 3x ULN",
                "criterions": [
                    {
                        "exact_snippets": "alanine aminotransferase (ALAT) ... > 3x ULN",
                        "criterion": "alanine aminotransferase (ALAT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "(aspartate aminotransferase) ASAT > 3x ULN",
                        "criterion": "aspartate aminotransferase (ASAT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "alanine aminotransferase (ALAT) ... > 3x ULN",
                        "criterion": "alanine aminotransferase (ALAT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "x ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "(aspartate aminotransferase) ASAT > 3x ULN",
                        "criterion": "aspartate aminotransferase (ASAT)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "x ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "5. Creatinine clearance (calculated according Cockcroft-Gault) < 30 ml/min",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine clearance ... < 30 ml/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "calculation method",
                            "expected_value": "Cockcroft-Gault"
                        }
                    },
                    {
                        "exact_snippets": "Creatinine clearance ... < 30 ml/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "ml/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine clearance ... < 30 ml/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "calculation method",
                            "expected_value": "Cockcroft-Gault"
                        }
                    },
                    {
                        "exact_snippets": "Creatinine clearance ... < 30 ml/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 30,
                                "unit": "ml/min"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "9. Comorbidities relevantly interfering with the prognosis of the patients, i.e.:",
                "criterions": [
                    {
                        "exact_snippets": "Comorbidities relevantly interfering with the prognosis of the patients",
                        "criterion": "comorbidities",
                        "requirement": {
                            "requirement_type": "interference with prognosis",
                            "expected_value": "relevant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Comorbidities relevantly interfering with the prognosis of the patients",
                        "criterion": "comorbidities",
                        "requirement": {
                            "requirement_type": "interference with prognosis",
                            "expected_value": "relevant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "1. heart insufficiency NYHA III/IV",
                "criterions": [
                    {
                        "exact_snippets": "heart insufficiency NYHA III/IV",
                        "criterion": "heart insufficiency",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "NYHA III",
                                "NYHA IV"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "heart insufficiency NYHA III/IV",
                        "criterion": "heart insufficiency",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "NYHA III",
                                "NYHA IV"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. relevant coronary heart disease,",
                "criterions": [
                    {
                        "exact_snippets": "relevant coronary heart disease",
                        "criterion": "coronary heart disease",
                        "requirement": {
                            "requirement_type": "relevance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "relevant coronary heart disease",
                        "criterion": "coronary heart disease",
                        "requirement": {
                            "requirement_type": "relevance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Diabetes mellitus with late sequelae",
                "criterions": [
                    {
                        "exact_snippets": "Diabetes mellitus with late sequelae",
                        "criterion": "diabetes mellitus",
                        "requirement": {
                            "requirement_type": "sequelae",
                            "expected_value": "late"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diabetes mellitus with late sequelae",
                        "criterion": "diabetes mellitus",
                        "requirement": {
                            "requirement_type": "sequelae",
                            "expected_value": "late"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "10. Organ, stem cell or bone marrow transplantation",
                "criterions": [
                    {
                        "exact_snippets": "Organ, stem cell or bone marrow transplantation",
                        "criterion": "transplantation",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "organ",
                                "stem cell",
                                "bone marrow"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Organ, stem cell or bone marrow transplantation",
                        "criterion": "transplantation",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "organ",
                                "stem cell",
                                "bone marrow"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "11. Known hypersensitivity to capecitabine In case of known hypersensitivity to oxaliplatin, the patients can participate, but not receive oxaliplatin",
                "criterions": [
                    {
                        "exact_snippets": "Known hypersensitivity to capecitabine",
                        "criterion": "hypersensitivity to capecitabine",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "known hypersensitivity to oxaliplatin",
                        "criterion": "hypersensitivity to oxaliplatin",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "known hypersensitivity to oxaliplatin",
                    "criterion": "hypersensitivity to oxaliplatin",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "Known hypersensitivity to capecitabine",
                    "criterion": "hypersensitivity to capecitabine",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                },
                "else_criteria": {
                    "not_criteria": {
                        "exact_snippets": "Known hypersensitivity to capecitabine",
                        "criterion": "hypersensitivity to capecitabine",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "12. Medication with brivudine, sorivudine or analogues in the last four weeks before planned treatment start",
                "criterions": [
                    {
                        "exact_snippets": "Medication with brivudine, sorivudine or analogues in the last four weeks before planned treatment start",
                        "criterion": "medication with brivudine, sorivudine or analogues",
                        "requirement": {
                            "requirement_type": "time since last use",
                            "expected_value": {
                                "operator": "<",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Medication with brivudine, sorivudine or analogues in the last four weeks before planned treatment start",
                    "criterion": "medication with brivudine, sorivudine or analogues",
                    "requirement": {
                        "requirement_type": "time since last use",
                        "expected_value": {
                            "operator": "<",
                            "value": 4,
                            "unit": "weeks"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "13. Known dihydropyrimidine dehydrogenase (DPD)-deficiency",
                "criterions": [
                    {
                        "exact_snippets": "Known dihydropyrimidine dehydrogenase (DPD)-deficiency",
                        "criterion": "dihydropyrimidine dehydrogenase (DPD) deficiency",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Known dihydropyrimidine dehydrogenase (DPD)-deficiency",
                    "criterion": "dihydropyrimidine dehydrogenase (DPD) deficiency",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "14. Acute infections",
                "criterions": [
                    {
                        "exact_snippets": "Acute infections",
                        "criterion": "acute infections",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Acute infections",
                        "criterion": "acute infections",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "16. Participation at another interventional study for medical treatment during the last four weeks before randomisation",
                "criterions": [
                    {
                        "exact_snippets": "Participation at another interventional study for medical treatment during the last four weeks before randomisation",
                        "criterion": "participation in another interventional study",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Participation at another interventional study for medical treatment during the last four weeks before randomisation",
                    "criterion": "participation in another interventional study",
                    "requirement": {
                        "requirement_type": "time frame",
                        "expected_value": {
                            "comparisons": [
                                {
                                    "operator": "<=",
                                    "value": 4,
                                    "unit": "weeks"
                                }
                            ]
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "17. Neoadjuvant therapy before resection",
                "criterions": [
                    {
                        "exact_snippets": "Neoadjuvant therapy before resection",
                        "criterion": "neoadjuvant therapy",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "before resection"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Neoadjuvant therapy before resection",
                        "criterion": "neoadjuvant therapy",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "before resection"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "18. Patients, in whom the randomisation or chemotherapy is unfeasible due to logistic reasons (travel distance, compliance)",
                "criterions": [
                    {
                        "exact_snippets": "randomisation or chemotherapy is unfeasible due to logistic reasons (travel distance, compliance)",
                        "criterion": "randomisation or chemotherapy feasibility",
                        "requirement": {
                            "requirement_type": "feasibility",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "randomisation or chemotherapy is unfeasible due to logistic reasons (travel distance, compliance)",
                    "criterion": "randomisation or chemotherapy feasibility",
                    "requirement": {
                        "requirement_type": "feasibility",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "19. Age < 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Age < 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age < 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "20. Pregnant or breast feeding patients",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breast feeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "21. Women of childbearing potential and men with partner with childbearing potential who are not willing to take appropriate precautions to avoid pregnancy with a highly effective method in case they are randomised to \"chemotherapy\"",
                "criterions": [
                    {
                        "exact_snippets": "Women of childbearing potential",
                        "criterion": "women of childbearing potential",
                        "requirement": {
                            "requirement_type": "willingness to take precautions",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "men with partner with childbearing potential",
                        "criterion": "men with partner with childbearing potential",
                        "requirement": {
                            "requirement_type": "willingness to take precautions",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "condition": {
                            "exact_snippets": "Women of childbearing potential",
                            "criterion": "women of childbearing potential",
                            "requirement": {
                                "requirement_type": "willingness to take precautions",
                                "expected_value": true
                            }
                        },
                        "then_criteria": {
                            "exact_snippets": "Women of childbearing potential",
                            "criterion": "women of childbearing potential",
                            "requirement": {
                                "requirement_type": "willingness to take precautions",
                                "expected_value": true
                            }
                        },
                        "else_criteria": null
                    },
                    {
                        "condition": {
                            "exact_snippets": "men with partner with childbearing potential",
                            "criterion": "men with partner with childbearing potential",
                            "requirement": {
                                "requirement_type": "willingness to take precautions",
                                "expected_value": true
                            }
                        },
                        "then_criteria": {
                            "exact_snippets": "men with partner with childbearing potential",
                            "criterion": "men with partner with childbearing potential",
                            "requirement": {
                                "requirement_type": "willingness to take precautions",
                                "expected_value": true
                            }
                        },
                        "else_criteria": null
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Inclusion criteria for screening phase:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "1. Resected colon cancer stage II, OR Resected rectal cancer stage II, if there was no indication for radiotherapy (i.e. due to the localisation in the upper third of the rectum ), so that the treatment follows the recommendations for colon cancer. Patients, in whom the tumour stage is not yet know, can be enrolled into the screening.",
                "criterions": [
                    {
                        "exact_snippets": "Resected colon cancer stage II",
                        "criterion": "colon cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "II"
                        }
                    },
                    {
                        "exact_snippets": "Resected colon cancer stage II",
                        "criterion": "colon cancer",
                        "requirement": {
                            "requirement_type": "resection",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Resected rectal cancer stage II",
                        "criterion": "rectal cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "II"
                        }
                    },
                    {
                        "exact_snippets": "Resected rectal cancer stage II",
                        "criterion": "rectal cancer",
                        "requirement": {
                            "requirement_type": "resection",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "no indication for radiotherapy ... localisation in the upper third of the rectum",
                        "criterion": "radiotherapy indication",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "tumour stage is not yet known",
                        "criterion": "tumour stage",
                        "requirement": {
                            "requirement_type": "knowledge",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Resected colon cancer stage II",
                                        "criterion": "colon cancer",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "II"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Resected colon cancer stage II",
                                        "criterion": "colon cancer",
                                        "requirement": {
                                            "requirement_type": "resection",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "Resected rectal cancer stage II",
                                                "criterion": "rectal cancer",
                                                "requirement": {
                                                    "requirement_type": "stage",
                                                    "expected_value": "II"
                                                }
                                            },
                                            {
                                                "exact_snippets": "Resected rectal cancer stage II",
                                                "criterion": "rectal cancer",
                                                "requirement": {
                                                    "requirement_type": "resection",
                                                    "expected_value": true
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "no indication for radiotherapy ... localisation in the upper third of the rectum",
                                        "criterion": "radiotherapy indication",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "tumour stage is not yet known",
                        "criterion": "tumour stage",
                        "requirement": {
                            "requirement_type": "knowledge",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Inclusion criteria for the randomised phase:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Exclusion criteria for Screening:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Exclusion criteria for randomised phase:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "15. Known HIV- infections, known active hepatitis B or C-infection",
                "criterions": [
                    {
                        "exact_snippets": "Known HIV- infections",
                        "criterion": "HIV infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "known active hepatitis B",
                        "criterion": "active hepatitis B infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "known active hepatitis C-infection",
                        "criterion": "active hepatitis C infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Known HIV- infections",
                                "criterion": "HIV infection",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "known active hepatitis B",
                                "criterion": "active hepatitis B infection",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "known active hepatitis C-infection",
                        "criterion": "active hepatitis C infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}