{
    "info": {
        "nct_id": "NCT03996265",
        "official_title": "Randomized Placebo-Controlled Trial of Bupropion for Cancer Related Fatigue",
        "inclusion_criteria": "* Be at least 18 years of age\n* Be diagnosed with cancer\n* Have stable disease or no evidence of disease\n* Report WORST level of fatigue in the past week as moderate to severe (i.e., a score >= 4 on a 0-10 scale, screening measures, question 1)\n* Have completed surgery, radiation, and/or systemic intravenous anticancer therapy (e.g., chemotherapy, targeted therapy, immunotherapy) 2 or more months prior to enrollment. Participants currently receiving oral maintenance, targeted, or hormonal therapy are eligible. Participants receiving intravenous supportive therapy (e.g., bisphosphonates) are eligible\n* Able to read and speak English\n* Currently not pregnant or breastfeeding. Women of child-bearing potential must agree to use adequate contraception, i.e., abstinence, IUD (intrauterine device), hormonal contraceptive (birth control pills) or barrier method (condoms) prior to study entry and for the duration of study participation\n* Be capable of providing written informed consent\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Be currently taking any medications that contain bupropion (e.g., Wellbutrin, Forfivo, Aplenzin, or Zyban\n* Be taking a monoamine oxidase inhibitor (MAOI), linezolid, or methylene blue within 2 weeks prior to enrollment\n* Be taking any anti-psychotic medications within a week prior to enrollment\n* Have a history of renal impairment (i.e., glomerular filtration rate < 45)\n* Have a history of cirrhosis (i.e., Child-Pugh score >= 5)\n* Have a history of seizures\n* Have a history of bulimia or anorexia nervosa\n* Report a history of sensitivity to bupropion\n* Report an allergy to lactose\n* Have a psychiatric or neurological disorder that would interfere with study participation per physician or physician's designee",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Be at least 18 years of age",
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                    {
                        "exact_snippets": "at least 18 years of age",
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                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
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                        }
                    }
                ]
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                        "exact_snippets": "at least 18 years of age",
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                                "value": 18,
                                "unit": "years"
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Be diagnosed with cancer",
                "criterions": [
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                        "exact_snippets": "diagnosed with cancer",
                        "criterion": "cancer diagnosis",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
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                "and_criteria": [
                    {
                        "exact_snippets": "diagnosed with cancer",
                        "criterion": "cancer diagnosis",
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                            "expected_value": true
                        }
                    }
                ]
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        },
        {
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                "line": "* Have stable disease or no evidence of disease",
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                        }
                    },
                    {
                        "exact_snippets": "no evidence of disease",
                        "criterion": "disease evidence",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
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                    {
                        "exact_snippets": "no evidence of disease",
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                        }
                    }
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            }
        },
        {
            "identified_line": {
                "line": "* Report WORST level of fatigue in the past week as moderate to severe (i.e., a score >= 4 on a 0-10 scale, screening measures, question 1)",
                "criterions": [
                    {
                        "exact_snippets": "WORST level of fatigue in the past week as moderate to severe (i.e., a score >= 4 on a 0-10 scale",
                        "criterion": "fatigue level",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "score on a 0-10 scale"
                            }
                        }
                    }
                ]
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                        "exact_snippets": "WORST level of fatigue in the past week as moderate to severe (i.e., a score >= 4 on a 0-10 scale",
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* Have completed surgery, radiation, and/or systemic intravenous anticancer therapy (e.g., chemotherapy, targeted therapy, immunotherapy) 2 or more months prior to enrollment. Participants currently receiving oral maintenance, targeted, or hormonal therapy are eligible. Participants receiving intravenous supportive therapy (e.g., bisphosphonates) are eligible",
                "criterions": [
                    {
                        "exact_snippets": "Have completed surgery, radiation, and/or systemic intravenous anticancer therapy ... 2 or more months prior to enrollment.",
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                            "requirement_type": "time since completion",
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                                "operator": ">=",
                                "value": 2,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Participants currently receiving oral maintenance, targeted, or hormonal therapy are eligible.",
                        "criterion": "current oral maintenance, targeted, or hormonal therapy",
                        "requirement": {
                            "requirement_type": "eligibility",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Participants receiving intravenous supportive therapy (e.g., bisphosphonates) are eligible",
                        "criterion": "current intravenous supportive therapy",
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                                    "requirement_type": "time since completion",
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                                        "unit": "months"
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                                }
                            },
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                                    "expected_value": true
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        },
        {
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                "line": "* Able to read and speak English",
                "criterions": [
                    {
                        "exact_snippets": "Able to read and speak English",
                        "criterion": "English language proficiency",
                        "requirement": {
                            "requirement_type": "ability to read",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Able to read and speak English",
                        "criterion": "English language proficiency",
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                            "requirement_type": "ability to speak",
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                        }
                    }
                ]
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                        "exact_snippets": "Able to read and speak English",
                        "criterion": "English language proficiency",
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                            "requirement_type": "ability to read",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Able to read and speak English",
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                            "requirement_type": "ability to speak",
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                        }
                    }
                ]
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        },
        {
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                "line": "* Currently not pregnant or breastfeeding. Women of child-bearing potential must agree to use adequate contraception, i.e., abstinence, IUD (intrauterine device), hormonal contraceptive (birth control pills) or barrier method (condoms) prior to study entry and for the duration of study participation",
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                    {
                        "exact_snippets": "Currently not pregnant",
                        "criterion": "pregnancy status",
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                            "requirement_type": "status",
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                        }
                    },
                    {
                        "exact_snippets": "not ... breastfeeding",
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                        "requirement": {
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                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Women of child-bearing potential must agree to use adequate contraception",
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                            "requirement_type": "agreement",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "adequate contraception, i.e., abstinence, IUD (intrauterine device), hormonal contraceptive (birth control pills) or barrier method (condoms)",
                        "criterion": "contraception methods",
                        "requirement": {
                            "requirement_type": "methods",
                            "expected_value": [
                                "abstinence",
                                "IUD",
                                "hormonal contraceptive",
                                "barrier method"
                            ]
                        }
                    }
                ]
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                                }
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                            }
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                                    "hormonal contraceptive",
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                    }
                ]
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        },
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                    {
                        "exact_snippets": "capable of providing written informed consent",
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            "identified_line": {
                "line": "Healthy volunteers allowed",
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                        "exact_snippets": "Healthy volunteers allowed",
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        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
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                        "exact_snippets": "minimum age of 18 Years",
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                                "operator": ">=",
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                                "unit": "Years"
                            }
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "minimum age of 18 Years",
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    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Be currently taking any medications that contain bupropion (e.g., Wellbutrin, Forfivo, Aplenzin, or Zyban",
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                    {
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                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Be taking a monoamine oxidase inhibitor (MAOI), linezolid, or methylene blue within 2 weeks prior to enrollment",
                "criterions": [
                    {
                        "exact_snippets": "Be taking a monoamine oxidase inhibitor (MAOI)",
                        "criterion": "monoamine oxidase inhibitor (MAOI) usage",
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                        }
                    },
                    {
                        "exact_snippets": "Be taking ... linezolid",
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                    },
                    {
                        "exact_snippets": "Be taking ... methylene blue",
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                        }
                    }
                ]
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            "logical_structure": {
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                                "exact_snippets": "Be taking a monoamine oxidase inhibitor (MAOI)",
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                                    "expected_value": true
                                }
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                                "exact_snippets": "within 2 weeks prior to enrollment",
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                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "weeks"
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                                }
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                    {
                        "and_criteria": [
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                                "exact_snippets": "Be taking ... linezolid",
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                                "exact_snippets": "within 2 weeks prior to enrollment",
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                        "and_criteria": [
                            {
                                "exact_snippets": "Be taking ... methylene blue",
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                                }
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                                "exact_snippets": "within 2 weeks prior to enrollment",
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        },
        {
            "identified_line": {
                "line": "* Be taking any anti-psychotic medications within a week prior to enrollment",
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                        "exact_snippets": "Be taking any anti-psychotic medications within a week prior to enrollment",
                        "criterion": "anti-psychotic medications",
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                        }
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                    "exact_snippets": "Be taking any anti-psychotic medications within a week prior to enrollment",
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                    }
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        },
        {
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                "line": "* Have a history of renal impairment (i.e., glomerular filtration rate < 45)",
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                        "exact_snippets": "history of renal impairment",
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                    },
                    {
                        "exact_snippets": "glomerular filtration rate < 45",
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                "line": "* Have a history of cirrhosis (i.e., Child-Pugh score >= 5)",
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                }
            }
        },
        {
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                    {
                        "exact_snippets": "history of ... anorexia nervosa",
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        {
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        },
        {
            "identified_line": {
                "line": "* Report an allergy to lactose",
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            "identified_line": {
                "line": "* Have a psychiatric or neurological disorder that would interfere with study participation per physician or physician's designee",
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                        "exact_snippets": "Have a psychiatric or neurological disorder",
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                "and_criteria": [
                    {
                        "exact_snippets": "Have a psychiatric or neurological disorder",
                        "criterion": "psychiatric or neurological disorder",
                        "requirement": {
                            "requirement_type": "interference with study participation",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "per physician or physician's designee",
                        "criterion": "physician or physician's designee",
                        "requirement": {
                            "requirement_type": "approval",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}