{
    "info": {
        "nct_id": "NCT03732482",
        "official_title": "A Phase II/III Study of Non Small Cell Lung Cancer Patient With/Without Synchronous Oral Temozolomide Capsules Combine With Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost With Hippocampus Protection",
        "inclusion_criteria": "1. Patients must have an estimated survival of at least 4 weeks\n2. Karnofsky Performance Status Scale (KPS) of 60-100.\n3. Patients' laboratory values had to meet these restrictions: hemoglobin>8 g/dL, platelets>70*109/L, white blood cells>4*109/L.\n4. Patients must sign a study specific informed consent form prior to study entry\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "1. Patients had major medical illnesses or psychiatric impairments which will prevent completion of the protocol therapy\n2. had received previous brain irradiation\n3. could not be regularly followed\n4. with leptomeningeal involvement",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. Patients must have an estimated survival of at least 4 weeks",
                "criterions": [
                    {
                        "exact_snippets": "estimated survival of at least 4 weeks",
                        "criterion": "estimated survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "estimated survival of at least 4 weeks",
                        "criterion": "estimated survival",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Karnofsky Performance Status Scale (KPS) of 60-100.",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky Performance Status Scale (KPS) of 60-100",
                        "criterion": "Karnofsky Performance Status Scale (KPS)",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Karnofsky Performance Status Scale (KPS) of 60-100",
                        "criterion": "Karnofsky Performance Status Scale (KPS)",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Patients' laboratory values had to meet these restrictions: hemoglobin>8 g/dL, platelets>70*109/L, white blood cells>4*109/L.",
                "criterions": [
                    {
                        "exact_snippets": "hemoglobin>8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "platelets>70*109/L",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "count",
                            "expected_value": {
                                "operator": ">",
                                "value": 70,
                                "unit": "*109/L"
                            }
                        }
                    },
                    {
                        "exact_snippets": "white blood cells>4*109/L",
                        "criterion": "white blood cell count",
                        "requirement": {
                            "requirement_type": "count",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "*109/L"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "hemoglobin>8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "platelets>70*109/L",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "count",
                            "expected_value": {
                                "operator": ">",
                                "value": 70,
                                "unit": "*109/L"
                            }
                        }
                    },
                    {
                        "exact_snippets": "white blood cells>4*109/L",
                        "criterion": "white blood cell count",
                        "requirement": {
                            "requirement_type": "count",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "*109/L"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "4. Patients must sign a study specific informed consent form prior to study entry",
                "criterions": [
                    {
                        "exact_snippets": "Patients must sign a study specific informed consent form",
                        "criterion": "informed consent form",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients must sign a study specific informed consent form",
                        "criterion": "informed consent form",
                        "requirement": {
                            "requirement_type": "signed",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 80 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "2. had received previous brain irradiation",
                "criterions": [
                    {
                        "exact_snippets": "had received previous brain irradiation",
                        "criterion": "previous brain irradiation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "had received previous brain irradiation",
                    "criterion": "previous brain irradiation",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "3. could not be regularly followed",
                "criterions": [
                    {
                        "exact_snippets": "could not be regularly followed",
                        "criterion": "follow-up capability",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "could not be regularly followed",
                    "criterion": "follow-up capability",
                    "requirement": {
                        "requirement_type": "capability",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "4. with leptomeningeal involvement",
                "criterions": [
                    {
                        "exact_snippets": "leptomeningeal involvement",
                        "criterion": "leptomeningeal involvement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "leptomeningeal involvement",
                    "criterion": "leptomeningeal involvement",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "1. Patients had major medical illnesses or psychiatric impairments which will prevent completion of the protocol therapy",
                "criterions": [
                    {
                        "exact_snippets": "major medical illnesses",
                        "criterion": "major medical illnesses",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "psychiatric impairments",
                        "criterion": "psychiatric impairments",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "major medical illnesses",
                        "criterion": "major medical illnesses",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "psychiatric impairments",
                        "criterion": "psychiatric impairments",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}