{
    "info": {
        "nct_id": "NCT03689231",
        "official_title": "Volumetric Imaging Follow up of Patients With Liver Metastases of Small Intestinal Neuroendocrine Tumors (NETs).",
        "inclusion_criteria": "* Well differentiated intestinal neuroendocrine tumor with at least one liver metastasis\n* The liver metastasis must be visible and measurable on CT scans or MRI\n* Patients monitored without invasive liver treatment : surgery, RF ablation / Trans-arterial chemoembolization\n* Patients monitored without systemic treatment such as: Chemotherapy, Everolimus, Sunitinib (Somatostatin analogues allowed)\n* Surgery of the primary tumor allowed\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Other type of NETs\n* Absence of liver metastases\n* Liver metastases not visible on CT scans/MRI, poorly limited lesions and small target lesions ( less than 10mm) that are difficult to measure\n* Lesions visible only on diffusion-weighted imaging -MRI acquisitions, thus presenting poorly limited contours\n* Invasive liver treatment : surgery, Radio frequency / Trans-arterial chemoembolization\n* Systemic treatments: Chemotherapy / Everolimus / Sunitinib\n* Insufficient follow-up data",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Well differentiated intestinal neuroendocrine tumor with at least one liver metastasis",
                "criterions": [
                    {
                        "exact_snippets": "Well differentiated intestinal neuroendocrine tumor",
                        "criterion": "intestinal neuroendocrine tumor",
                        "requirement": {
                            "requirement_type": "differentiation",
                            "expected_value": "well differentiated"
                        }
                    },
                    {
                        "exact_snippets": "at least one liver metastasis",
                        "criterion": "liver metastasis",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "metastasis"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Well differentiated intestinal neuroendocrine tumor",
                        "criterion": "intestinal neuroendocrine tumor",
                        "requirement": {
                            "requirement_type": "differentiation",
                            "expected_value": "well differentiated"
                        }
                    },
                    {
                        "exact_snippets": "at least one liver metastasis",
                        "criterion": "liver metastasis",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "metastasis"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* The liver metastasis must be visible and measurable on CT scans or MRI",
                "criterions": [
                    {
                        "exact_snippets": "liver metastasis must be visible",
                        "criterion": "liver metastasis",
                        "requirement": {
                            "requirement_type": "visibility",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "liver metastasis ... measurable on CT scans or MRI",
                        "criterion": "liver metastasis",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "liver metastasis must be visible",
                                "criterion": "liver metastasis",
                                "requirement": {
                                    "requirement_type": "visibility",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "liver metastasis ... measurable on CT scans or MRI",
                                "criterion": "liver metastasis",
                                "requirement": {
                                    "requirement_type": "measurability",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "liver metastasis must be visible",
                                "criterion": "liver metastasis",
                                "requirement": {
                                    "requirement_type": "visibility",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "liver metastasis ... measurable on CT scans or MRI",
                                "criterion": "liver metastasis",
                                "requirement": {
                                    "requirement_type": "measurability",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients monitored without invasive liver treatment : surgery, RF ablation / Trans-arterial chemoembolization",
                "criterions": [
                    {
                        "exact_snippets": "Patients monitored without invasive liver treatment : surgery",
                        "criterion": "invasive liver treatment",
                        "requirement": {
                            "requirement_type": "absence",
                            "expected_value": [
                                "surgery"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Patients monitored without invasive liver treatment : ... RF ablation",
                        "criterion": "invasive liver treatment",
                        "requirement": {
                            "requirement_type": "absence",
                            "expected_value": [
                                "RF ablation"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Patients monitored without invasive liver treatment : ... Trans-arterial chemoembolization",
                        "criterion": "invasive liver treatment",
                        "requirement": {
                            "requirement_type": "absence",
                            "expected_value": [
                                "Trans-arterial chemoembolization"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Patients monitored without invasive liver treatment : surgery",
                                "criterion": "invasive liver treatment",
                                "requirement": {
                                    "requirement_type": "absence",
                                    "expected_value": [
                                        "surgery"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "Patients monitored without invasive liver treatment : ... RF ablation",
                                "criterion": "invasive liver treatment",
                                "requirement": {
                                    "requirement_type": "absence",
                                    "expected_value": [
                                        "RF ablation"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Patients monitored without invasive liver treatment : ... Trans-arterial chemoembolization",
                        "criterion": "invasive liver treatment",
                        "requirement": {
                            "requirement_type": "absence",
                            "expected_value": [
                                "Trans-arterial chemoembolization"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients monitored without systemic treatment such as: Chemotherapy, Everolimus, Sunitinib (Somatostatin analogues allowed)",
                "criterions": [
                    {
                        "exact_snippets": "Patients monitored without systemic treatment such as: Chemotherapy",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Patients monitored without systemic treatment such as: ... Everolimus",
                        "criterion": "Everolimus treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Patients monitored without systemic treatment such as: ... Sunitinib",
                        "criterion": "Sunitinib treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "(Somatostatin analogues allowed)",
                        "criterion": "Somatostatin analogues",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Patients monitored without systemic treatment such as: Chemotherapy",
                                        "criterion": "systemic treatment",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "Patients monitored without systemic treatment such as: ... Everolimus",
                                        "criterion": "Everolimus treatment",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Patients monitored without systemic treatment such as: ... Sunitinib",
                                "criterion": "Sunitinib treatment",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "(Somatostatin analogues allowed)",
                        "criterion": "Somatostatin analogues",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Surgery of the primary tumor allowed",
                "criterions": [
                    {
                        "exact_snippets": "Surgery of the primary tumor allowed",
                        "criterion": "surgery of the primary tumor",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgery of the primary tumor allowed",
                        "criterion": "surgery of the primary tumor",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Other type of NETs",
                "criterions": [
                    {
                        "exact_snippets": "Other type of NETs",
                        "criterion": "type of NETs",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "other"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Other type of NETs",
                    "criterion": "type of NETs",
                    "requirement": {
                        "requirement_type": "type",
                        "expected_value": "other"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Absence of liver metastases",
                "criterions": [
                    {
                        "exact_snippets": "Absence of liver metastases",
                        "criterion": "liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Absence of liver metastases",
                    "criterion": "liver metastases",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Liver metastases not visible on CT scans/MRI, poorly limited lesions and small target lesions ( less than 10mm) that are difficult to measure",
                "criterions": [
                    {
                        "exact_snippets": "Liver metastases not visible on CT scans/MRI",
                        "criterion": "liver metastases visibility",
                        "requirement": {
                            "requirement_type": "visibility",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "poorly limited lesions",
                        "criterion": "lesion limitation",
                        "requirement": {
                            "requirement_type": "limitation",
                            "expected_value": "poorly limited"
                        }
                    },
                    {
                        "exact_snippets": "small target lesions ( less than 10mm)",
                        "criterion": "target lesion size",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": "<",
                                "value": 10,
                                "unit": "mm"
                            }
                        }
                    },
                    {
                        "exact_snippets": "small target lesions ... that are difficult to measure",
                        "criterion": "target lesion measurability",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": "difficult to measure"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Liver metastases not visible on CT scans/MRI",
                                "criterion": "liver metastases visibility",
                                "requirement": {
                                    "requirement_type": "visibility",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "poorly limited lesions",
                                "criterion": "lesion limitation",
                                "requirement": {
                                    "requirement_type": "limitation",
                                    "expected_value": "poorly limited"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "small target lesions ( less than 10mm)",
                                "criterion": "target lesion size",
                                "requirement": {
                                    "requirement_type": "size",
                                    "expected_value": {
                                        "operator": "<",
                                        "value": 10,
                                        "unit": "mm"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "small target lesions ... that are difficult to measure",
                                "criterion": "target lesion measurability",
                                "requirement": {
                                    "requirement_type": "measurability",
                                    "expected_value": "difficult to measure"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Lesions visible only on diffusion-weighted imaging -MRI acquisitions, thus presenting poorly limited contours",
                "criterions": [
                    {
                        "exact_snippets": "Lesions visible only on diffusion-weighted imaging -MRI acquisitions",
                        "criterion": "lesions",
                        "requirement": {
                            "requirement_type": "visibility",
                            "expected_value": "only on diffusion-weighted imaging -MRI acquisitions"
                        }
                    },
                    {
                        "exact_snippets": "presenting poorly limited contours",
                        "criterion": "lesion contours",
                        "requirement": {
                            "requirement_type": "definition",
                            "expected_value": "poorly limited"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Lesions visible only on diffusion-weighted imaging -MRI acquisitions",
                        "criterion": "lesions",
                        "requirement": {
                            "requirement_type": "visibility",
                            "expected_value": "only on diffusion-weighted imaging -MRI acquisitions"
                        }
                    },
                    {
                        "exact_snippets": "presenting poorly limited contours",
                        "criterion": "lesion contours",
                        "requirement": {
                            "requirement_type": "definition",
                            "expected_value": "poorly limited"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Invasive liver treatment : surgery, Radio frequency / Trans-arterial chemoembolization",
                "criterions": [
                    {
                        "exact_snippets": "Invasive liver treatment : surgery",
                        "criterion": "invasive liver treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "surgery"
                        }
                    },
                    {
                        "exact_snippets": "Invasive liver treatment : ... Radio frequency",
                        "criterion": "invasive liver treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Radio frequency"
                        }
                    },
                    {
                        "exact_snippets": "Invasive liver treatment : ... Trans-arterial chemoembolization",
                        "criterion": "invasive liver treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Trans-arterial chemoembolization"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Invasive liver treatment : surgery",
                                "criterion": "invasive liver treatment",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "surgery"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Invasive liver treatment : ... Radio frequency",
                                "criterion": "invasive liver treatment",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "Radio frequency"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Invasive liver treatment : ... Trans-arterial chemoembolization",
                                "criterion": "invasive liver treatment",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "Trans-arterial chemoembolization"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Systemic treatments: Chemotherapy / Everolimus / Sunitinib",
                "criterions": [
                    {
                        "exact_snippets": "Systemic treatments: Chemotherapy",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Chemotherapy"
                        }
                    },
                    {
                        "exact_snippets": "Systemic treatments: ... Everolimus",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Everolimus"
                        }
                    },
                    {
                        "exact_snippets": "Systemic treatments: ... Sunitinib",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Sunitinib"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Systemic treatments: Chemotherapy",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Chemotherapy"
                        }
                    },
                    {
                        "exact_snippets": "Systemic treatments: ... Everolimus",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Everolimus"
                        }
                    },
                    {
                        "exact_snippets": "Systemic treatments: ... Sunitinib",
                        "criterion": "systemic treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "Sunitinib"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Insufficient follow-up data",
                "criterions": [
                    {
                        "exact_snippets": "Insufficient follow-up data",
                        "criterion": "follow-up data",
                        "requirement": {
                            "requirement_type": "sufficiency",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Insufficient follow-up data",
                    "criterion": "follow-up data",
                    "requirement": {
                        "requirement_type": "sufficiency",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}