{
    "info": {
        "nct_id": "NCT03421782",
        "official_title": "Nonpharmacologic Interventions for Fatigue in Patients With Cancer",
        "inclusion_criteria": "* Diagnosed with advanced prostate cancer\n* Currently treated with hormone therapy-based regimen, including selective estrogen receptor modulators (SERMs), aromatase inhibitors, selective estrogen receptor down regulators (SERDs), CYP17A1 inhibitors, gonadotrophin releasing hormone (GnRH) agonists/antagonists, and antiandrogens; concurrent anti-HER2 therapy and other targeted therapy (e.g., CDK4/6 inhibitor, mTOR inhibitor) is permitted; must have started the current regimen at least 4 weeks prior to enrollment\n* A response of at least 4 on a 10 point scale (with 0 = not tired at all and 10 = extremely tired) to the question ?how tired did you feel in the past week??\n* Sedentary activity pattern (Average < 90 minutes per week of moderate-to-vigorous intensity sports activity based on patient self-report) within the past year\n* Physically able to exercise and physician consent to start an exercise program\n* Regular access to a computer with internet service\n* Must be able to read and understand English\n* Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines\nHealthy volunteers allowed",
        "exclusion_criteria": "* Evidence of disease progression at the time of enrollment\n* Treatment with cytotoxic chemotherapy within 3 months prior to enrollment\n* Prior cognitive-behavioral therapy",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Diagnosed with advanced prostate cancer",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosed with advanced prostate cancer",
                        "criterion": "prostate cancer",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "advanced"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosed with advanced prostate cancer",
                        "criterion": "prostate cancer",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": "advanced"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Currently treated with hormone therapy-based regimen, including selective estrogen receptor modulators (SERMs), aromatase inhibitors, selective estrogen receptor down regulators (SERDs), CYP17A1 inhibitors, gonadotrophin releasing hormone (GnRH) agonists/antagonists, and antiandrogens; concurrent anti-HER2 therapy and other targeted therapy (e.g., CDK4/6 inhibitor, mTOR inhibitor) is permitted; must have started the current regimen at least 4 weeks prior to enrollment",
                "criterions": [
                    {
                        "exact_snippets": "Currently treated with hormone therapy-based regimen, including selective estrogen receptor modulators (SERMs), aromatase inhibitors, selective estrogen receptor down regulators (SERDs), CYP17A1 inhibitors, gonadotrophin releasing hormone (GnRH) agonists/antagonists, and antiandrogens",
                        "criterion": "hormone therapy-based regimen",
                        "requirement": {
                            "requirement_type": "currently treated",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "concurrent anti-HER2 therapy and other targeted therapy (e.g., CDK4/6 inhibitor, mTOR inhibitor) is permitted",
                        "criterion": "concurrent anti-HER2 therapy and other targeted therapy",
                        "requirement": {
                            "requirement_type": "permitted",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "must have started the current regimen at least 4 weeks prior to enrollment",
                        "criterion": "current regimen start time",
                        "requirement": {
                            "requirement_type": "time since start",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Currently treated with hormone therapy-based regimen, including selective estrogen receptor modulators (SERMs), aromatase inhibitors, selective estrogen receptor down regulators (SERDs), CYP17A1 inhibitors, gonadotrophin releasing hormone (GnRH) agonists/antagonists, and antiandrogens",
                                "criterion": "hormone therapy-based regimen",
                                "requirement": {
                                    "requirement_type": "currently treated",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "must have started the current regimen at least 4 weeks prior to enrollment",
                                "criterion": "current regimen start time",
                                "requirement": {
                                    "requirement_type": "time since start",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "concurrent anti-HER2 therapy and other targeted therapy (e.g., CDK4/6 inhibitor, mTOR inhibitor) is permitted",
                        "criterion": "concurrent anti-HER2 therapy and other targeted therapy",
                        "requirement": {
                            "requirement_type": "permitted",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* A response of at least 4 on a 10 point scale (with 0 = not tired at all and 10 = extremely tired) to the question ?how tired did you feel in the past week??",
                "criterions": [
                    {
                        "exact_snippets": "A response of at least 4 on a 10 point scale ... to the question ?how tired did you feel in the past week??",
                        "criterion": "tiredness",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "A response of at least 4 on a 10 point scale ... to the question ?how tired did you feel in the past week??",
                        "criterion": "tiredness",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Sedentary activity pattern (Average < 90 minutes per week of moderate-to-vigorous intensity sports activity based on patient self-report) within the past year",
                "criterions": [
                    {
                        "exact_snippets": "Sedentary activity pattern (Average < 90 minutes per week of moderate-to-vigorous intensity sports activity",
                        "criterion": "sedentary activity pattern",
                        "requirement": {
                            "requirement_type": "average weekly activity",
                            "expected_value": {
                                "operator": "<",
                                "value": 90,
                                "unit": "minutes"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Sedentary activity pattern (Average < 90 minutes per week of moderate-to-vigorous intensity sports activity",
                        "criterion": "sedentary activity pattern",
                        "requirement": {
                            "requirement_type": "average weekly activity",
                            "expected_value": {
                                "operator": "<",
                                "value": 90,
                                "unit": "minutes"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Physically able to exercise and physician consent to start an exercise program",
                "criterions": [
                    {
                        "exact_snippets": "Physically able to exercise",
                        "criterion": "physical ability to exercise",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "physician consent to start an exercise program",
                        "criterion": "physician consent for exercise program",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Physically able to exercise",
                        "criterion": "physical ability to exercise",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "physician consent to start an exercise program",
                        "criterion": "physician consent for exercise program",
                        "requirement": {
                            "requirement_type": "consent",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Regular access to a computer with internet service",
                "criterions": [
                    {
                        "exact_snippets": "Regular access to a computer",
                        "criterion": "computer access",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "internet service",
                        "criterion": "internet access",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Regular access to a computer",
                        "criterion": "computer access",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "internet service",
                        "criterion": "internet access",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Must be able to read and understand English",
                "criterions": [
                    {
                        "exact_snippets": "Must be able to read and understand English",
                        "criterion": "English language proficiency",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be able to read and understand English",
                        "criterion": "English language proficiency",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines",
                "criterions": [
                    {
                        "exact_snippets": "Able to provide informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willing to sign an approved consent form",
                        "criterion": "consent form signing",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Able to provide informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "willing to sign an approved consent form",
                        "criterion": "consent form signing",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Evidence of disease progression at the time of enrollment",
                "criterions": [
                    {
                        "exact_snippets": "Evidence of disease progression",
                        "criterion": "disease progression",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Evidence of disease progression",
                    "criterion": "disease progression",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Treatment with cytotoxic chemotherapy within 3 months prior to enrollment",
                "criterions": [
                    {
                        "exact_snippets": "Treatment with cytotoxic chemotherapy within 3 months prior to enrollment",
                        "criterion": "cytotoxic chemotherapy treatment",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Treatment with cytotoxic chemotherapy within 3 months prior to enrollment",
                    "criterion": "cytotoxic chemotherapy treatment",
                    "requirement": {
                        "requirement_type": "time since last treatment",
                        "expected_value": {
                            "operator": "<=",
                            "value": 3,
                            "unit": "months"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Prior cognitive-behavioral therapy",
                "criterions": [
                    {
                        "exact_snippets": "Prior cognitive-behavioral therapy",
                        "criterion": "cognitive-behavioral therapy",
                        "requirement": {
                            "requirement_type": "prior treatment",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Prior cognitive-behavioral therapy",
                    "criterion": "cognitive-behavioral therapy",
                    "requirement": {
                        "requirement_type": "prior treatment",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}