{
    "info": {
        "nct_id": "NCT03300765",
        "official_title": "Intensity Modulated Radiation Therapy Combined With Apatinib for Inoperable or Iodine Refractory Thyroid Cancer: A Phase II Single-arm Study",
        "inclusion_criteria": "* Ability to understand character and individual consequences of the clinical trial. Willing to sign the written informed consent; Informed consent must be signed before the enrollment in the trial;\n* Aged ≥ 18 years old;\n* Pathologically confirmed inoperable or iodine refractory thyroid cancer, or postoperative residual disease detected by imaging studies, or progression disease within 12 months before enrollment. (all with measurable disease ≥10mm according to RECIST 1.1);\n* ECOG0-2;\n* Adequate laboratory values within 14 dyas of enrollment to study defined as follows: N ≥ 1500/mm^3; PLT ≥ 80,000/mm^3; HB≥90g/L;total bilirubin < 1.25ULN; AST/ALT < 2.5 ULN or < 5 ULN with metastasis; SCr ≤1ULN; CCR > 50ml/min;\n* The survival period is expected to be greater than 3 months;\n* Willing to accept adequate contraception for patients with childbearing potential.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 80 Years",
        "exclusion_criteria": "* Take chemotherapeutic chemotherapy (the use of low-dose chemotherapy for radiosensitization was allowed) or thalidomide and its derivative treatments;\n* Take VEGFR-TKI within 1 month, such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib;\n* Allergic to apainib;\n* Uncontrolled high blood pressure and heart disease;\n* Patients with gastrointestinal bleeding risk;\n* Coagulation disorders(INR>1.5×ULNAPTT>1.5×ULN);\n* Uroprotein positive (Uroprotein≥2+ or 24-hour urinary protein quantity >1.0g);\n* Pregnant or lactating women.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Ability to understand character and individual consequences of the clinical trial. Willing to sign the written informed consent; Informed consent must be signed before the enrollment in the trial;",
                "criterions": [
                    {
                        "exact_snippets": "Ability to understand character and individual consequences of the clinical trial.",
                        "criterion": "understanding of trial consequences",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Willing to sign the written informed consent",
                        "criterion": "willingness to sign informed consent",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Informed consent must be signed before the enrollment in the trial",
                        "criterion": "informed consent signed",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "before enrollment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Ability to understand character and individual consequences of the clinical trial.",
                                "criterion": "understanding of trial consequences",
                                "requirement": {
                                    "requirement_type": "ability",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Willing to sign the written informed consent",
                                "criterion": "willingness to sign informed consent",
                                "requirement": {
                                    "requirement_type": "willingness",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Informed consent must be signed before the enrollment in the trial",
                        "criterion": "informed consent signed",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "before enrollment"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Aged ≥ 18 years old;",
                "criterions": [
                    {
                        "exact_snippets": "Aged ≥ 18 years old;",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Aged ≥ 18 years old;",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum age",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pathologically confirmed inoperable or iodine refractory thyroid cancer, or postoperative residual disease detected by imaging studies, or progression disease within 12 months before enrollment. (all with measurable disease ≥10mm according to RECIST 1.1);",
                "criterions": [
                    {
                        "exact_snippets": "Pathologically confirmed inoperable or iodine refractory thyroid cancer",
                        "criterion": "thyroid cancer",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "pathologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "Pathologically confirmed inoperable or iodine refractory thyroid cancer",
                        "criterion": "thyroid cancer",
                        "requirement": {
                            "requirement_type": "operability",
                            "expected_value": "inoperable"
                        }
                    },
                    {
                        "exact_snippets": "Pathologically confirmed inoperable or iodine refractory thyroid cancer",
                        "criterion": "thyroid cancer",
                        "requirement": {
                            "requirement_type": "iodine refractoriness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "postoperative residual disease detected by imaging studies",
                        "criterion": "postoperative residual disease",
                        "requirement": {
                            "requirement_type": "detection",
                            "expected_value": "imaging studies"
                        }
                    },
                    {
                        "exact_snippets": "progression disease within 12 months before enrollment",
                        "criterion": "progression disease",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "within 12 months before enrollment"
                        }
                    },
                    {
                        "exact_snippets": "measurable disease ≥10mm according to RECIST 1.1",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 10,
                                "unit": "mm"
                            }
                        }
                    },
                    {
                        "exact_snippets": "measurable disease ≥10mm according to RECIST 1.1",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "measurement standard",
                            "expected_value": "RECIST 1.1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "exact_snippets": "Pathologically confirmed inoperable or iodine refractory thyroid cancer",
                                                "criterion": "thyroid cancer",
                                                "requirement": {
                                                    "requirement_type": "confirmation",
                                                    "expected_value": "pathologically confirmed"
                                                }
                                            },
                                            {
                                                "exact_snippets": "Pathologically confirmed inoperable or iodine refractory thyroid cancer",
                                                "criterion": "thyroid cancer",
                                                "requirement": {
                                                    "requirement_type": "operability",
                                                    "expected_value": "inoperable"
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "exact_snippets": "Pathologically confirmed inoperable or iodine refractory thyroid cancer",
                                        "criterion": "thyroid cancer",
                                        "requirement": {
                                            "requirement_type": "iodine refractoriness",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "postoperative residual disease detected by imaging studies",
                                "criterion": "postoperative residual disease",
                                "requirement": {
                                    "requirement_type": "detection",
                                    "expected_value": "imaging studies"
                                }
                            },
                            {
                                "exact_snippets": "progression disease within 12 months before enrollment",
                                "criterion": "progression disease",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "within 12 months before enrollment"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "measurable disease ≥10mm according to RECIST 1.1",
                                "criterion": "measurable disease",
                                "requirement": {
                                    "requirement_type": "size",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 10,
                                        "unit": "mm"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "measurable disease ≥10mm according to RECIST 1.1",
                                "criterion": "measurable disease",
                                "requirement": {
                                    "requirement_type": "measurement standard",
                                    "expected_value": "RECIST 1.1"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG0-2;",
                "criterions": [
                    {
                        "exact_snippets": "ECOG0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* The survival period is expected to be greater than 3 months;",
                "criterions": [
                    {
                        "exact_snippets": "The survival period is expected to be greater than 3 months",
                        "criterion": "survival period",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "The survival period is expected to be greater than 3 months",
                        "criterion": "survival period",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Willing to accept adequate contraception for patients with childbearing potential.",
                "criterions": [
                    {
                        "exact_snippets": "Willing to accept adequate contraception",
                        "criterion": "contraception acceptance",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "patients with childbearing potential",
                        "criterion": "childbearing potential",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "patients with childbearing potential",
                    "criterion": "childbearing potential",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "Willing to accept adequate contraception",
                    "criterion": "contraception acceptance",
                    "requirement": {
                        "requirement_type": "willingness",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 80 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 80 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 80,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Take chemotherapeutic chemotherapy (the use of low-dose chemotherapy for radiosensitization was allowed) or thalidomide and its derivative treatments;",
                "criterions": [
                    {
                        "exact_snippets": "Take chemotherapeutic chemotherapy",
                        "criterion": "chemotherapeutic chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "thalidomide and its derivative treatments",
                        "criterion": "thalidomide and its derivative treatments",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Take chemotherapeutic chemotherapy",
                                "criterion": "chemotherapeutic chemotherapy",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "the use of low-dose chemotherapy for radiosensitization was allowed",
                                    "criterion": "low-dose chemotherapy for radiosensitization",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "thalidomide and its derivative treatments",
                        "criterion": "thalidomide and its derivative treatments",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Allergic to apainib;",
                "criterions": [
                    {
                        "exact_snippets": "Allergic to apainib",
                        "criterion": "allergy",
                        "requirement": {
                            "requirement_type": "substance",
                            "expected_value": "apainib"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Allergic to apainib",
                    "criterion": "allergy",
                    "requirement": {
                        "requirement_type": "substance",
                        "expected_value": "apainib"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled high blood pressure and heart disease;",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled high blood pressure",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "heart disease",
                        "criterion": "heart disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Uncontrolled high blood pressure",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "heart disease",
                        "criterion": "heart disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients with gastrointestinal bleeding risk;",
                "criterions": [
                    {
                        "exact_snippets": "gastrointestinal bleeding risk",
                        "criterion": "gastrointestinal bleeding risk",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "gastrointestinal bleeding risk",
                    "criterion": "gastrointestinal bleeding risk",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Coagulation disorders(INR>1.5×ULNAPTT>1.5×ULN);",
                "criterions": [
                    {
                        "exact_snippets": "Coagulation disorders(INR>1.5×ULN",
                        "criterion": "INR",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.5,
                                "unit": "ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Coagulation disorders(...APTT>1.5×ULN)",
                        "criterion": "APTT",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.5,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Coagulation disorders(INR>1.5×ULN",
                        "criterion": "INR",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.5,
                                "unit": "ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Coagulation disorders(...APTT>1.5×ULN)",
                        "criterion": "APTT",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.5,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Uroprotein positive (Uroprotein≥2+ or 24-hour urinary protein quantity >1.0g);",
                "criterions": [
                    {
                        "exact_snippets": "Uroprotein positive (Uroprotein≥2+",
                        "criterion": "Uroprotein",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "Uroprotein positive (Uroprotein≥2+",
                        "criterion": "Uroprotein",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "+"
                            }
                        }
                    },
                    {
                        "exact_snippets": "24-hour urinary protein quantity >1.0g",
                        "criterion": "24-hour urinary protein quantity",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.0,
                                "unit": "g"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Uroprotein positive (Uroprotein≥2+",
                                "criterion": "Uroprotein",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": "positive"
                                }
                            },
                            {
                                "exact_snippets": "Uroprotein positive (Uroprotein≥2+",
                                "criterion": "Uroprotein",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "+"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "24-hour urinary protein quantity >1.0g",
                        "criterion": "24-hour urinary protein quantity",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1.0,
                                "unit": "g"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant or lactating women.",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Adequate laboratory values within 14 dyas of enrollment to study defined as follows: N ≥ 1500/mm^3; PLT ≥ 80,000/mm^3; HB≥90g/L;total bilirubin < 1.25ULN; AST/ALT < 2.5 ULN or < 5 ULN with metastasis; SCr ≤1ULN; CCR > 50ml/min;",
                "criterions": [
                    {
                        "exact_snippets": "N ≥ 1500/mm^3",
                        "criterion": "neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    },
                    {
                        "exact_snippets": "PLT ≥ 80,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 80000,
                                "unit": "mm^3"
                            }
                        }
                    },
                    {
                        "exact_snippets": "HB≥90g/L",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 90,
                                "unit": "g/L"
                            }
                        }
                    },
                    {
                        "exact_snippets": "total bilirubin < 1.25ULN",
                        "criterion": "total bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 1.25,
                                "unit": "ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AST/ALT < 2.5 ULN or < 5 ULN with metastasis",
                        "criterion": "AST/ALT levels",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": [
                                "> 2.5 ULN",
                                "< 5 ULN with metastasis"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "SCr ≤1ULN",
                        "criterion": "serum creatinine level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "CCR > 50ml/min",
                        "criterion": "creatinine clearance rate",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "ml/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "and_criteria": [
                                            {
                                                "and_criteria": [
                                                    {
                                                        "and_criteria": [
                                                            {
                                                                "exact_snippets": "N ≥ 1500/mm^3",
                                                                "criterion": "neutrophil count",
                                                                "requirement": {
                                                                    "requirement_type": "quantity",
                                                                    "expected_value": {
                                                                        "operator": ">=",
                                                                        "value": 1500,
                                                                        "unit": "mm^3"
                                                                    }
                                                                }
                                                            },
                                                            {
                                                                "exact_snippets": "PLT ≥ 80,000/mm^3",
                                                                "criterion": "platelet count",
                                                                "requirement": {
                                                                    "requirement_type": "quantity",
                                                                    "expected_value": {
                                                                        "operator": ">=",
                                                                        "value": 80000,
                                                                        "unit": "mm^3"
                                                                    }
                                                                }
                                                            }
                                                        ]
                                                    },
                                                    {
                                                        "exact_snippets": "HB≥90g/L",
                                                        "criterion": "hemoglobin level",
                                                        "requirement": {
                                                            "requirement_type": "quantity",
                                                            "expected_value": {
                                                                "operator": ">=",
                                                                "value": 90,
                                                                "unit": "g/L"
                                                            }
                                                        }
                                                    }
                                                ]
                                            },
                                            {
                                                "exact_snippets": "total bilirubin < 1.25ULN",
                                                "criterion": "total bilirubin level",
                                                "requirement": {
                                                    "requirement_type": "quantity",
                                                    "expected_value": {
                                                        "operator": "<",
                                                        "value": 1.25,
                                                        "unit": "ULN"
                                                    }
                                                }
                                            }
                                        ]
                                    },
                                    {
                                        "or_criteria": [
                                            {
                                                "exact_snippets": "AST/ALT < 2.5 ULN or < 5 ULN with metastasis",
                                                "criterion": "AST/ALT levels",
                                                "requirement": {
                                                    "requirement_type": "quantity",
                                                    "expected_value": "< 2.5 ULN"
                                                }
                                            },
                                            {
                                                "exact_snippets": "AST/ALT < 2.5 ULN or < 5 ULN with metastasis",
                                                "criterion": "AST/ALT levels",
                                                "requirement": {
                                                    "requirement_type": "quantity",
                                                    "expected_value": "< 5 ULN with metastasis"
                                                }
                                            }
                                        ]
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "SCr ≤1ULN",
                                "criterion": "serum creatinine level",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "ULN"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "CCR > 50ml/min",
                        "criterion": "creatinine clearance rate",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 50,
                                "unit": "ml/min"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* Take VEGFR-TKI within 1 month, such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib;",
                "criterions": [
                    {
                        "exact_snippets": "Take VEGFR-TKI within 1 month",
                        "criterion": "VEGFR-TKI intake",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    },
                    {
                        "exact_snippets": "such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib",
                        "criterion": "specific VEGFR-TKI drugs",
                        "requirement": {
                            "requirement_type": "drug names",
                            "expected_value": [
                                "vandetanib",
                                "cabozantinib",
                                "lenvatinib",
                                "sunitinib",
                                "sorafenib"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Take VEGFR-TKI within 1 month",
                                "criterion": "VEGFR-TKI intake",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "month"
                                    }
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib",
                                        "criterion": "specific VEGFR-TKI drugs",
                                        "requirement": {
                                            "requirement_type": "drug names",
                                            "expected_value": "vandetanib"
                                        }
                                    },
                                    {
                                        "exact_snippets": "such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib",
                                        "criterion": "specific VEGFR-TKI drugs",
                                        "requirement": {
                                            "requirement_type": "drug names",
                                            "expected_value": "cabozantinib"
                                        }
                                    },
                                    {
                                        "exact_snippets": "such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib",
                                        "criterion": "specific VEGFR-TKI drugs",
                                        "requirement": {
                                            "requirement_type": "drug names",
                                            "expected_value": "lenvatinib"
                                        }
                                    },
                                    {
                                        "exact_snippets": "such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib",
                                        "criterion": "specific VEGFR-TKI drugs",
                                        "requirement": {
                                            "requirement_type": "drug names",
                                            "expected_value": "sunitinib"
                                        }
                                    },
                                    {
                                        "exact_snippets": "such as vandetanib, cabozantinib, lenvatinib, sunitinib and sorafenib",
                                        "criterion": "specific VEGFR-TKI drugs",
                                        "requirement": {
                                            "requirement_type": "drug names",
                                            "expected_value": "sorafenib"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}