{
    "info": {
        "nct_id": "NCT03133520",
        "official_title": "Effectiveness of High Flow Oxygen Therapy in Patients With Hematologic Malignancy Acute Hypoxemic Respiratory Failure",
        "inclusion_criteria": "* Known immunosuppression defined as haematological malignancy.\n* Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: (a) PaO2/FiO2<300 mmHg (b) PaCO2≤45 mmHg (c) SaO2<92%\n* Respiratory distress with a respiratory rate >22/min\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Refusal of study participation\n* Pregnancy or breastfeeding\n* Hypercapnia with a formal indication for non-invasive mechanical ventilation (NIMV) (PaCO2 ≥ 45 mmHg)\n* Patients whose clinicians have decided on NIMV (Non-Invasive Mechanical Ventilation) and IMV (Invasive Mechanical Ventilation)\n* Haemodynamic instability (mean arterial pressure <65 mmHg)\n* Vasopressor needs\n* Awareness confusion and disorientation",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Known immunosuppression defined as haematological malignancy.",
                "criterions": [
                    {
                        "exact_snippets": "Known immunosuppression defined as haematological malignancy.",
                        "criterion": "immunosuppression",
                        "requirement": {
                            "requirement_type": "definition",
                            "expected_value": "haematological malignancy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Known immunosuppression defined as haematological malignancy.",
                        "criterion": "immunosuppression",
                        "requirement": {
                            "requirement_type": "definition",
                            "expected_value": "haematological malignancy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: (a) PaO2/FiO2<300 mmHg (b) PaCO2≤45 mmHg (c) SaO2<92%",
                "criterions": [
                    {
                        "exact_snippets": "Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: (a) PaO2/FiO2<300 mmHg",
                        "criterion": "PaO2/FiO2",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<",
                                "value": 300,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: ... (b) PaCO2≤45 mmHg",
                        "criterion": "PaCO2",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 45,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: ... (c) SaO2<92%",
                        "criterion": "SaO2",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<",
                                "value": 92,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: (a) PaO2/FiO2<300 mmHg",
                        "criterion": "PaO2/FiO2",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<",
                                "value": 300,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: ... (b) PaCO2≤45 mmHg",
                        "criterion": "PaCO2",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 45,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Need for oxygen therapy defined as with oxygen free arterial blood gas examination one or more of the following: ... (c) SaO2<92%",
                        "criterion": "SaO2",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<",
                                "value": 92,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Respiratory distress with a respiratory rate >22/min",
                "criterions": [
                    {
                        "exact_snippets": "Respiratory distress",
                        "criterion": "respiratory distress",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "respiratory rate >22/min",
                        "criterion": "respiratory rate",
                        "requirement": {
                            "requirement_type": "rate",
                            "expected_value": {
                                "operator": ">",
                                "value": 22,
                                "unit": "min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Respiratory distress",
                        "criterion": "respiratory distress",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "respiratory rate >22/min",
                        "criterion": "respiratory rate",
                        "requirement": {
                            "requirement_type": "rate",
                            "expected_value": {
                                "operator": ">",
                                "value": 22,
                                "unit": "min"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Refusal of study participation",
                "criterions": [
                    {
                        "exact_snippets": "Refusal of study participation",
                        "criterion": "study participation",
                        "requirement": {
                            "requirement_type": "willingness",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Refusal of study participation",
                    "criterion": "study participation",
                    "requirement": {
                        "requirement_type": "willingness",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pregnancy or breastfeeding",
                "criterions": [
                    {
                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breastfeeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breastfeeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hypercapnia with a formal indication for non-invasive mechanical ventilation (NIMV) (PaCO2 ≥ 45 mmHg)",
                "criterions": [
                    {
                        "exact_snippets": "Hypercapnia",
                        "criterion": "hypercapnia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "formal indication for non-invasive mechanical ventilation (NIMV)",
                        "criterion": "indication for non-invasive mechanical ventilation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "PaCO2 ≥ 45 mmHg",
                        "criterion": "PaCO2 level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 45,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Hypercapnia",
                                "criterion": "hypercapnia",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "formal indication for non-invasive mechanical ventilation (NIMV)",
                                "criterion": "indication for non-invasive mechanical ventilation",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "PaCO2 ≥ 45 mmHg",
                        "criterion": "PaCO2 level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 45,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients whose clinicians have decided on NIMV (Non-Invasive Mechanical Ventilation) and IMV (Invasive Mechanical Ventilation)",
                "criterions": [
                    {
                        "exact_snippets": "clinicians have decided on NIMV (Non-Invasive Mechanical Ventilation)",
                        "criterion": "NIMV (Non-Invasive Mechanical Ventilation)",
                        "requirement": {
                            "requirement_type": "decision",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "clinicians have decided on ... IMV (Invasive Mechanical Ventilation)",
                        "criterion": "IMV (Invasive Mechanical Ventilation)",
                        "requirement": {
                            "requirement_type": "decision",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "clinicians have decided on NIMV (Non-Invasive Mechanical Ventilation)",
                                "criterion": "NIMV (Non-Invasive Mechanical Ventilation)",
                                "requirement": {
                                    "requirement_type": "decision",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "clinicians have decided on ... IMV (Invasive Mechanical Ventilation)",
                                "criterion": "IMV (Invasive Mechanical Ventilation)",
                                "requirement": {
                                    "requirement_type": "decision",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Haemodynamic instability (mean arterial pressure <65 mmHg)",
                "criterions": [
                    {
                        "exact_snippets": "Haemodynamic instability (mean arterial pressure <65 mmHg)",
                        "criterion": "haemodynamic instability",
                        "requirement": {
                            "requirement_type": "mean arterial pressure",
                            "expected_value": {
                                "operator": "<",
                                "value": 65,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Haemodynamic instability (mean arterial pressure <65 mmHg)",
                    "criterion": "haemodynamic instability",
                    "requirement": {
                        "requirement_type": "mean arterial pressure",
                        "expected_value": {
                            "operator": "<",
                            "value": 65,
                            "unit": "mmHg"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Vasopressor needs",
                "criterions": [
                    {
                        "exact_snippets": "Vasopressor needs",
                        "criterion": "vasopressor needs",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Vasopressor needs",
                    "criterion": "vasopressor needs",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Awareness confusion and disorientation",
                "criterions": [
                    {
                        "exact_snippets": "Awareness confusion",
                        "criterion": "awareness",
                        "requirement": {
                            "requirement_type": "state",
                            "expected_value": "confusion"
                        }
                    },
                    {
                        "exact_snippets": "disorientation",
                        "criterion": "orientation",
                        "requirement": {
                            "requirement_type": "state",
                            "expected_value": "disorientation"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Awareness confusion",
                        "criterion": "awareness",
                        "requirement": {
                            "requirement_type": "state",
                            "expected_value": "confusion"
                        }
                    },
                    {
                        "exact_snippets": "disorientation",
                        "criterion": "orientation",
                        "requirement": {
                            "requirement_type": "state",
                            "expected_value": "disorientation"
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}