{
    "info": {
        "nct_id": "NCT02858804",
        "official_title": "EDOCH Alternating With DHAP Regimen Combined Rituximab or Not to Treat New Diagnosed Younger (Age≤65 Years) Mantle Cell Lymphoma in China: A Multicentre Phase III Trial",
        "inclusion_criteria": "* age≤65 years\n* diagnosis with mantle cell lymphoma\n* Ann Arbor stage II,III or IV\n* ECOG≤1 or if ECOG≥2 but recover after pretreatment.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 65 Years",
        "exclusion_criteria": "* with centre neural system involvement\n* serious complications such as uncontrolled diabetes, gastric ulcer or other serious angiocardiopathy determined by the physician\n* HIV positive or active HBV infection or other uncontrolled systematic infection\n* clinical central nervous dysfunction\n* serious surgery within 30 days\n* pregnancy or baby nursing period or un-contracepted child bearing period woman.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* age≤65 years",
                "criterions": [
                    {
                        "exact_snippets": "age≤65 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "age≤65 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* diagnosis with mantle cell lymphoma",
                "criterions": [
                    {
                        "exact_snippets": "diagnosis with mantle cell lymphoma",
                        "criterion": "mantle cell lymphoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "diagnosis with mantle cell lymphoma",
                        "criterion": "mantle cell lymphoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Ann Arbor stage II,III or IV",
                "criterions": [
                    {
                        "exact_snippets": "Ann Arbor stage II,III or IV",
                        "criterion": "Ann Arbor stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "II",
                                "III",
                                "IV"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Ann Arbor stage II,III or IV",
                        "criterion": "Ann Arbor stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "II",
                                "III",
                                "IV"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG≤1 or if ECOG≥2 but recover after pretreatment.",
                "criterions": [
                    {
                        "exact_snippets": "ECOG≤1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ECOG≥2 ... recover after pretreatment",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ECOG≥2 ... recover after pretreatment",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "recovery",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "ECOG≤1",
                                "criterion": "ECOG performance status",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "N/A"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "ECOG≥2 ... recover after pretreatment",
                                "criterion": "ECOG performance status",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "ECOG≥2 ... recover after pretreatment",
                                "criterion": "ECOG performance status",
                                "requirement": {
                                    "requirement_type": "recovery",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 65 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 65 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 65 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 65,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* with centre neural system involvement",
                "criterions": [
                    {
                        "exact_snippets": "centre neural system involvement",
                        "criterion": "central nervous system involvement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "centre neural system involvement",
                        "criterion": "central nervous system involvement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* serious complications such as uncontrolled diabetes, gastric ulcer or other serious angiocardiopathy determined by the physician",
                "criterions": [
                    {
                        "exact_snippets": "serious complications such as uncontrolled diabetes",
                        "criterion": "diabetes",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "serious complications such as ... gastric ulcer",
                        "criterion": "gastric ulcer",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
                        "exact_snippets": "serious complications such as ... other serious angiocardiopathy",
                        "criterion": "angiocardiopathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "serious complications such as uncontrolled diabetes",
                                "criterion": "diabetes",
                                "requirement": {
                                    "requirement_type": "control",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "serious complications such as ... gastric ulcer",
                                "criterion": "gastric ulcer",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "serious"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "serious complications such as ... other serious angiocardiopathy",
                        "criterion": "angiocardiopathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* clinical central nervous dysfunction",
                "criterions": [
                    {
                        "exact_snippets": "clinical central nervous dysfunction",
                        "criterion": "central nervous dysfunction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "clinical central nervous dysfunction",
                    "criterion": "central nervous dysfunction",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* serious surgery within 30 days",
                "criterions": [
                    {
                        "exact_snippets": "serious surgery within 30 days",
                        "criterion": "serious surgery",
                        "requirement": {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": "<=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "serious surgery within 30 days",
                    "criterion": "serious surgery",
                    "requirement": {
                        "requirement_type": "time since",
                        "expected_value": {
                            "operator": "<=",
                            "value": 30,
                            "unit": "days"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* pregnancy or baby nursing period or un-contracepted child bearing period woman.",
                "criterions": [
                    {
                        "exact_snippets": "pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "baby nursing period",
                        "criterion": "baby nursing period",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "un-contracepted child bearing period woman",
                        "criterion": "un-contracepted child bearing period",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "pregnancy",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "baby nursing period",
                        "criterion": "baby nursing period",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "un-contracepted child bearing period woman",
                        "criterion": "un-contracepted child bearing period",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "* HIV positive or active HBV infection or other uncontrolled systematic infection",
                "criterions": [
                    {
                        "exact_snippets": "HIV positive",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "active HBV infection",
                        "criterion": "HBV infection",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "active"
                        }
                    },
                    {
                        "exact_snippets": "other uncontrolled systematic infection",
                        "criterion": "systematic infection",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "uncontrolled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        }
    ],
    "failed_miscellaneous": []
}