{
    "info": {
        "nct_id": "NCT02714920",
        "official_title": "DNA Repair Enzyme Signature Associated With Response to Chemo- and Radio-therapy in Head and Neck Cancer: ChemRadAssay",
        "inclusion_criteria": "* Age over 18 years old;\n* HNSCC proven on a biopsy, located in the oral cavity or the oropharynx (the tumor must be accessible to a biopsy during an outpatient visit);\n* Tumor accessible to a biopsy under local anesthesia;\n* TNM classification: any stage except M1;\n* Eligible for radiotherapy as a curative treatment;\n* No surgery planned as exclusive treatment;\n* Able to comply with the scheduled visits;\n* Affiliated to or beneficiary of a social security system (or equivalent) ;\n* Having given written informed consent prior to any procedure related to the study.\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Recurrence or second cancer in a previously irradiated area;\n* Nasopharyngeal carcinoma;\n* Tumor requiring general anesthesia to perform the biopsy;\n* Radiotherapy planned to be provided outside of the investigation center;\n* Pregnant or lactating woman;\n* Adult ward of court (under guardianship or trusteeship).",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Age over 18 years old;",
                "criterions": [
                    {
                        "exact_snippets": "Age over 18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age over 18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Tumor accessible to a biopsy under local anesthesia;",
                "criterions": [
                    {
                        "exact_snippets": "Tumor accessible to a biopsy",
                        "criterion": "tumor accessibility",
                        "requirement": {
                            "requirement_type": "accessibility",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "under local anesthesia",
                        "criterion": "biopsy anesthesia type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "local"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Tumor accessible to a biopsy",
                        "criterion": "tumor accessibility",
                        "requirement": {
                            "requirement_type": "accessibility",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "under local anesthesia",
                        "criterion": "biopsy anesthesia type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "local"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Eligible for radiotherapy as a curative treatment;",
                "criterions": [
                    {
                        "exact_snippets": "Eligible for radiotherapy as a curative treatment",
                        "criterion": "radiotherapy eligibility",
                        "requirement": {
                            "requirement_type": "purpose",
                            "expected_value": "curative treatment"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Eligible for radiotherapy as a curative treatment",
                        "criterion": "radiotherapy eligibility",
                        "requirement": {
                            "requirement_type": "purpose",
                            "expected_value": "curative treatment"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No surgery planned as exclusive treatment;",
                "criterions": [
                    {
                        "exact_snippets": "No surgery planned as exclusive treatment",
                        "criterion": "surgery as exclusive treatment",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No surgery planned as exclusive treatment",
                        "criterion": "surgery as exclusive treatment",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Able to comply with the scheduled visits;",
                "criterions": [
                    {
                        "exact_snippets": "Able to comply with the scheduled visits",
                        "criterion": "compliance with scheduled visits",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Able to comply with the scheduled visits",
                        "criterion": "compliance with scheduled visits",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Affiliated to or beneficiary of a social security system (or equivalent) ;",
                "criterions": [
                    {
                        "exact_snippets": "Affiliated to or beneficiary of a social security system (or equivalent)",
                        "criterion": "social security system affiliation",
                        "requirement": {
                            "requirement_type": "affiliation",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Affiliated to or beneficiary of a social security system (or equivalent)",
                        "criterion": "social security system affiliation",
                        "requirement": {
                            "requirement_type": "affiliation",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Having given written informed consent prior to any procedure related to the study.",
                "criterions": [
                    {
                        "exact_snippets": "given written informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "given written informed consent",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Recurrence or second cancer in a previously irradiated area;",
                "criterions": [
                    {
                        "exact_snippets": "Recurrence ... in a previously irradiated area",
                        "criterion": "recurrence",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "previously irradiated area"
                        }
                    },
                    {
                        "exact_snippets": "second cancer in a previously irradiated area",
                        "criterion": "second cancer",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "previously irradiated area"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Recurrence ... in a previously irradiated area",
                        "criterion": "recurrence",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "previously irradiated area"
                        }
                    },
                    {
                        "exact_snippets": "second cancer in a previously irradiated area",
                        "criterion": "second cancer",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "previously irradiated area"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Nasopharyngeal carcinoma;",
                "criterions": [
                    {
                        "exact_snippets": "Nasopharyngeal carcinoma",
                        "criterion": "nasopharyngeal carcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Nasopharyngeal carcinoma",
                    "criterion": "nasopharyngeal carcinoma",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Tumor requiring general anesthesia to perform the biopsy;",
                "criterions": [
                    {
                        "exact_snippets": "Tumor requiring general anesthesia to perform the biopsy",
                        "criterion": "tumor biopsy",
                        "requirement": {
                            "requirement_type": "anesthesia requirement",
                            "expected_value": "general anesthesia"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Tumor requiring general anesthesia to perform the biopsy",
                        "criterion": "tumor biopsy",
                        "requirement": {
                            "requirement_type": "anesthesia requirement",
                            "expected_value": "general anesthesia"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Radiotherapy planned to be provided outside of the investigation center;",
                "criterions": [
                    {
                        "exact_snippets": "Radiotherapy planned to be provided outside of the investigation center",
                        "criterion": "radiotherapy location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "outside of the investigation center"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Radiotherapy planned to be provided outside of the investigation center",
                        "criterion": "radiotherapy location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "outside of the investigation center"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant or lactating woman;",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating",
                        "criterion": "lactation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adult ward of court (under guardianship or trusteeship).",
                "criterions": [
                    {
                        "exact_snippets": "Adult ward of court (under guardianship or trusteeship)",
                        "criterion": "ward of court status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "under guardianship or trusteeship"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adult ward of court (under guardianship or trusteeship)",
                        "criterion": "ward of court status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "under guardianship or trusteeship"
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* HNSCC proven on a biopsy, located in the oral cavity or the oropharynx (the tumor must be accessible to a biopsy during an outpatient visit);",
                "criterions": [
                    {
                        "exact_snippets": "HNSCC proven on a biopsy",
                        "criterion": "HNSCC",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "located in the oral cavity or the oropharynx",
                        "criterion": "tumor location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "oral cavity",
                                "oropharynx"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "the tumor must be accessible to a biopsy during an outpatient visit",
                        "criterion": "tumor accessibility",
                        "requirement": {
                            "requirement_type": "accessibility",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "HNSCC proven on a biopsy",
                                "criterion": "HNSCC",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "located in the oral cavity or the oropharynx",
                                        "criterion": "tumor location",
                                        "requirement": {
                                            "requirement_type": "location",
                                            "expected_value": "oral cavity"
                                        }
                                    },
                                    {
                                        "exact_snippets": "located in the oral cavity or the oropharynx",
                                        "criterion": "tumor location",
                                        "requirement": {
                                            "requirement_type": "location",
                                            "expected_value": "oropharynx"
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "the tumor must be accessible to a biopsy during an outpatient visit",
                        "criterion": "tumor accessibility",
                        "requirement": {
                            "requirement_type": "accessibility",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* TNM classification: any stage except M1;",
                "criterions": [
                    {
                        "exact_snippets": "TNM classification: any stage except M1",
                        "criterion": "TNM classification",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "any stage except M1"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "TNM classification: any stage except M1",
                    "criterion": "TNM classification",
                    "requirement": {
                        "requirement_type": "stage",
                        "expected_value": "M1"
                    }
                }
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}