{
    "info": {
        "nct_id": "NCT02443948",
        "official_title": "Circulating Cell-free Tumor DNA in the Plasma of Patients With Gastrointestinal Stromal Tumors (GIST): Detection and Correlation With Disease Status Assessed by Conventional Technique. Prospective Observational Study",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Impossibility to ensure adequate clinical and serum sample follow-up\n* Serious psychiatric disease that precludes informed consent or limits compliance",
        "miscellaneous_criteria": "* Male or female patients aged >= 18 years\n* Histologically confirmed diagnosis of GIST of any anatomical location either by biopsy or surgical specimen\n* Available archival tumor tissue\n* Signed informed consent form"
    },
    "inclusion_lines": [
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                        "exact_snippets": "Healthy volunteers allowed",
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                        }
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                ]
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        },
        {
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                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
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                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
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            },
            "logical_structure": {
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                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
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                        }
                    }
                ]
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        }
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        {
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                "criterions": [
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                            "requirement_type": "severity",
                            "expected_value": "serious"
                        }
                    },
                    {
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                        "criterion": "ability to provide informed consent",
                        "requirement": {
                            "requirement_type": "capability",
                            "expected_value": false
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                    },
                    {
                        "exact_snippets": "limits compliance",
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                                "criterion": "psychiatric disease",
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                                    "requirement_type": "severity",
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    ],
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        {
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                    }
                ]
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        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
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                "criterions": [
                    {
                        "exact_snippets": "Male or female patients",
                        "criterion": "gender",
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                            "expected_value": [
                                "male",
                                "female"
                            ]
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                    },
                    {
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                            "expected_value": {
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                                "value": 18,
                                "unit": "years"
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            "logical_structure": {
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                    {
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                                }
                            },
                            {
                                "exact_snippets": "Male or female patients",
                                "criterion": "gender",
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                                }
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                    {
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                            "expected_value": {
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                                "unit": "years"
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                        }
                    }
                ]
            }
        },
        {
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                "criterions": [
                    {
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                        "criterion": "GIST diagnosis",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "GIST of any anatomical location",
                        "criterion": "GIST anatomical location",
                        "requirement": {
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                        }
                    },
                    {
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                                "surgical specimen"
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                    }
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            },
            "logical_structure": {
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                    {
                        "and_criteria": [
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                                "exact_snippets": "Histologically confirmed diagnosis of GIST",
                                "criterion": "GIST diagnosis",
                                "requirement": {
                                    "requirement_type": "confirmation method",
                                    "expected_value": "histologically confirmed"
                                }
                            },
                            {
                                "exact_snippets": "GIST of any anatomical location",
                                "criterion": "GIST anatomical location",
                                "requirement": {
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                                }
                            }
                        ]
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        }
    ]
}