{
    "info": {
        "nct_id": "NCT02324231",
        "official_title": "SPOG 2015 FN Definition. A Swiss Pediatric Oncology Group (SPOG) Initiated Multi-center Open-label Randomized Controlled Multiple Crossover Non-inferiority Trial on Safety of a High Versus Low Temperature Limit Defining Fever in Pediatric Patients With Cancer at Risk for Fever in Chemotherapy-induced Neutropenia (FN)",
        "inclusion_criteria": "* Chemotherapy treatment because of any malignancy for at least 2 months at time of recruitment for myelosuppressive therapy, or at least 1 cycle of myeloablative chemotherapy followed by autologous hematopoietic stem cell transplantation\n* Age ≥12 months and <18 years at time of recruitment\n* Written informed consent from patients and/or parents\nHealthy volunteers allowed\nMust have minimum age of 1 Year\nMust have maximum age of 18 Years",
        "exclusion_criteria": "* Infants <1 years old (reason: differences in temperature measurement method)\n* Past allogeneic hematopoietic stem cell transplantation\n* Denied written informed consent from patients and/or parents",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Chemotherapy treatment because of any malignancy for at least 2 months at time of recruitment for myelosuppressive therapy, or at least 1 cycle of myeloablative chemotherapy followed by autologous hematopoietic stem cell transplantation",
                "criterions": [
                    {
                        "exact_snippets": "Chemotherapy treatment because of any malignancy for at least 2 months",
                        "criterion": "chemotherapy treatment duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "myelosuppressive therapy",
                        "criterion": "myelosuppressive therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "at least 1 cycle of myeloablative chemotherapy",
                        "criterion": "myeloablative chemotherapy cycles",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "cycle"
                            }
                        }
                    },
                    {
                        "exact_snippets": "autologous hematopoietic stem cell transplantation",
                        "criterion": "autologous hematopoietic stem cell transplantation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Chemotherapy treatment because of any malignancy for at least 2 months",
                                        "criterion": "chemotherapy treatment duration",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 2,
                                                "unit": "months"
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                                        }
                                    },
                                    {
                                        "exact_snippets": "myelosuppressive therapy",
                                        "criterion": "myelosuppressive therapy",
                                        "requirement": {
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                                            "expected_value": true
                                        }
                                    }
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                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "at least 1 cycle of myeloablative chemotherapy",
                                        "criterion": "myeloablative chemotherapy cycles",
                                        "requirement": {
                                            "requirement_type": "quantity",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 1,
                                                "unit": "cycle"
                                            }
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                                    },
                                    {
                                        "exact_snippets": "autologous hematopoietic stem cell transplantation",
                                        "criterion": "autologous hematopoietic stem cell transplantation",
                                        "requirement": {
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                                            "expected_value": true
                                        }
                                    }
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                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "at least 1 cycle of myeloablative chemotherapy",
                                "criterion": "myeloablative chemotherapy cycles",
                                "requirement": {
                                    "requirement_type": "quantity",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "cycle"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "autologous hematopoietic stem cell transplantation",
                                "criterion": "autologous hematopoietic stem cell transplantation",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age ≥12 months and <18 years at time of recruitment",
                "criterions": [
                    {
                        "exact_snippets": "Age ≥12 months and <18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 12,
                                        "unit": "months"
                                    },
                                    {
                                        "operator": "<",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Age ≥12 months and <18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 12,
                                        "unit": "months"
                                    },
                                    {
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                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Written informed consent from patients and/or parents",
                "criterions": [
                    {
                        "exact_snippets": "Written informed consent from patients and/or parents",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Written informed consent from patients and/or parents",
                        "criterion": "informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 1 Year",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 1 Year",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "Year"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 1 Year",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "Year"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Infants <1 years old (reason: differences in temperature measurement method)",
                "criterions": [
                    {
                        "exact_snippets": "Infants <1 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 1,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Infants <1 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 1,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Past allogeneic hematopoietic stem cell transplantation",
                "criterions": [
                    {
                        "exact_snippets": "Past allogeneic hematopoietic stem cell transplantation",
                        "criterion": "allogeneic hematopoietic stem cell transplantation",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Past allogeneic hematopoietic stem cell transplantation",
                    "criterion": "allogeneic hematopoietic stem cell transplantation",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Denied written informed consent from patients and/or parents",
                "criterions": [
                    {
                        "exact_snippets": "Denied written informed consent from patients",
                        "criterion": "written informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Denied written informed consent from ... parents",
                        "criterion": "written informed consent from parents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "Denied written informed consent from patients",
                        "criterion": "written informed consent",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Denied written informed consent from ... parents",
                        "criterion": "written informed consent from parents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}