{
    "info": {
        "nct_id": "NCT02215720",
        "official_title": "Phase I Study of Temsirolimus and Cetuximab in Adults Patients With Advanced or Metastatic Solid Tumors",
        "inclusion_criteria": "* Patients with malignant tumor confirmed histologically or cytologically who does not respond to usual therapeutics or for whom there is no curative treatment\n* Age >/= 18 years\n* ECOG 0 or 1\n* Life expectancy >/= 12 weeks\n* Grade </=1 for all adverse effects related to previous therapy or surgery (except for alopecia)\n* Appropriate organic functions as defined:\n* ASAT and ALAT </= 2.5xLSN or ASAT and ALAT </= 5xLSN in case of inappropriate hepatic function due to the underlying disease\n* Bilirubin </= 1.5xLSN\n* Albumin >/= 3.0 g/dL\n* Neutrophil counts (PNN) >/= 1 500/mL\n* Platelets >/= 100 000/mL\n* Hemoglobin >/= 9.0 g/dL\n* Creatinin </= 1.5xLSN\n* Cooperative patients able to respect the protocol\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Treatment by chemotherapy, radiotherapy, surgery or the two compounds of the study within 4 weeks before the inclusion\n* Previous treatment with an association of mTOR inhibitor or EGFR inhibitor\n* Diagnosis of a secondary cancer within the last 3 years except for a basal-cell carcinoma, cutaneous spinocellular cancer or in situ carcinoma well treated\n* Grade >/= 2 nephropathy according to NCI CTCAE\n* Current treatment with curative dose of coumadin or heparin of low molecular weight\n* Previous uncontrolled brain metastases, medullar compression or carcinomatosis meningitis or any proof of leptomeningeal pathology or metastasis.\n* Presence of one og those pathologies during the last 12 months before the inclusion:\n* myocardial infarction\n* angina pectoris\n* bypass of coronal or peripheral arteries\n* heart failure\n* stroke\n* cerebral bleeding\n* pulmonary embolism\n* Grade 3 bleeding according to NCI CTCAE criteria less than 3 weeks before treatment start\n* Uncontrolled high blood pressure (>150/100mhHg)\n* Grade >/=2 heart rate disorder, atrial fibrillation whichever the grade, lengthen of QTC >450 msec for male or >470 msec for female.\n* Patients HIV positive\n* Pregnant or breastfeeding woman\n* Patients with psychiatric disorder\n* Active alcoholism\n* Previous pulmonary interstitial disease\n* Previous hypersensitivity to antihistamine treatment and/or medical contraindication for an antihistamine or corticoid treatment",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Patients with malignant tumor confirmed histologically or cytologically who does not respond to usual therapeutics or for whom there is no curative treatment",
                "criterions": [
                    {
                        "exact_snippets": "malignant tumor confirmed histologically or cytologically",
                        "criterion": "malignant tumor",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "does not respond to usual therapeutics",
                        "criterion": "response to usual therapeutics",
                        "requirement": {
                            "requirement_type": "response",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no curative treatment",
                        "criterion": "availability of curative treatment",
                        "requirement": {
                            "requirement_type": "availability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "malignant tumor confirmed histologically or cytologically",
                                        "criterion": "malignant tumor",
                                        "requirement": {
                                            "requirement_type": "confirmation method",
                                            "expected_value": [
                                                "histologically",
                                                "cytologically"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "does not respond to usual therapeutics",
                                        "criterion": "response to usual therapeutics",
                                        "requirement": {
                                            "requirement_type": "response",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "no curative treatment",
                                "criterion": "availability of curative treatment",
                                "requirement": {
                                    "requirement_type": "availability",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age >/= 18 years",
                "criterions": [
                    {
                        "exact_snippets": "Age >/= 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age >/= 18 years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy >/= 12 weeks",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy >/= 12 weeks",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy >/= 12 weeks",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Grade </=1 for all adverse effects related to previous therapy or surgery (except for alopecia)",
                "criterions": [
                    {
                        "exact_snippets": "Grade </=1 for all adverse effects related to previous therapy or surgery",
                        "criterion": "adverse effects related to previous therapy or surgery",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "Grade"
                            }
                        }
                    },
                    {
                        "exact_snippets": "except for alopecia",
                        "criterion": "alopecia",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Grade </=1 for all adverse effects related to previous therapy or surgery",
                                "criterion": "adverse effects related to previous therapy or surgery",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "Grade"
                                    }
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "except for alopecia",
                                    "criterion": "alopecia",
                                    "requirement": {
                                        "requirement_type": "exclusion",
                                        "expected_value": true
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Appropriate organic functions as defined:",
                "criterions": [
                    {
                        "exact_snippets": "Appropriate organic functions",
                        "criterion": "organic functions",
                        "requirement": {
                            "requirement_type": "appropriateness",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Appropriate organic functions",
                        "criterion": "organic functions",
                        "requirement": {
                            "requirement_type": "appropriateness",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ASAT and ALAT </= 2.5xLSN or ASAT and ALAT </= 5xLSN in case of inappropriate hepatic function due to the underlying disease",
                "criterions": [
                    {
                        "exact_snippets": "ASAT and ALAT </= 2.5xLSN",
                        "criterion": "ASAT and ALAT levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "xLSN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ASAT and ALAT </= 5xLSN in case of inappropriate hepatic function due to the underlying disease",
                        "criterion": "ASAT and ALAT levels in case of inappropriate hepatic function due to the underlying disease",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "xLSN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "ASAT and ALAT </= 2.5xLSN",
                                "criterion": "ASAT and ALAT levels",
                                "requirement": {
                                    "requirement_type": "comparison",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2.5,
                                        "unit": "xLSN"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "ASAT and ALAT </= 5xLSN in case of inappropriate hepatic function due to the underlying disease",
                                "criterion": "ASAT and ALAT levels in case of inappropriate hepatic function due to the underlying disease",
                                "requirement": {
                                    "requirement_type": "comparison",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "xLSN"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin </= 1.5xLSN",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin </= 1.5xLSN",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 1.5,
                                        "unit": "xLSN"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin </= 1.5xLSN",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 1.5,
                                        "unit": "xLSN"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Albumin >/= 3.0 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Albumin >/= 3.0 g/dL",
                        "criterion": "albumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 3.0,
                                        "unit": "g/dL"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Albumin >/= 3.0 g/dL",
                        "criterion": "albumin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 3.0,
                                        "unit": "g/dL"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Neutrophil counts (PNN) >/= 1 500/mL",
                "criterions": [
                    {
                        "exact_snippets": "Neutrophil counts (PNN) >/= 1 500/mL",
                        "criterion": "neutrophil counts",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1500,
                                        "unit": "mL"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Neutrophil counts (PNN) >/= 1 500/mL",
                        "criterion": "neutrophil counts",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1500,
                                        "unit": "mL"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelets >/= 100 000/mL",
                "criterions": [
                    {
                        "exact_snippets": "Platelets >/= 100 000/mL",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 100000,
                                        "unit": "mL"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelets >/= 100 000/mL",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 100000,
                                        "unit": "mL"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin >/= 9.0 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin >/= 9.0 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 9.0,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin >/= 9.0 g/dL",
                        "criterion": "hemoglobin",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 9.0,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinin </= 1.5xLSN",
                "criterions": [
                    {
                        "exact_snippets": "Creatinin </= 1.5xLSN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "xLSN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinin </= 1.5xLSN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "xLSN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Cooperative patients able to respect the protocol",
                "criterions": [
                    {
                        "exact_snippets": "Cooperative patients",
                        "criterion": "patient cooperation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "able to respect the protocol",
                        "criterion": "ability to respect protocol",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cooperative patients",
                        "criterion": "patient cooperation",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "able to respect the protocol",
                        "criterion": "ability to respect protocol",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* Treatment by chemotherapy, radiotherapy, surgery or the two compounds of the study within 4 weeks before the inclusion",
                "criterions": [
                    {
                        "exact_snippets": "Treatment by chemotherapy ... within 4 weeks before the inclusion",
                        "criterion": "chemotherapy treatment",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Treatment by ... radiotherapy ... within 4 weeks before the inclusion",
                        "criterion": "radiotherapy treatment",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Treatment by ... surgery ... within 4 weeks before the inclusion",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Treatment by ... the two compounds of the study within 4 weeks before the inclusion",
                        "criterion": "treatment with the two compounds of the study",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Treatment by chemotherapy ... within 4 weeks before the inclusion",
                                "criterion": "chemotherapy treatment",
                                "requirement": {
                                    "requirement_type": "time since last treatment",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Treatment by ... radiotherapy ... within 4 weeks before the inclusion",
                                "criterion": "radiotherapy treatment",
                                "requirement": {
                                    "requirement_type": "time since last treatment",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Treatment by ... surgery ... within 4 weeks before the inclusion",
                                "criterion": "surgery",
                                "requirement": {
                                    "requirement_type": "time since last treatment",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Treatment by ... the two compounds of the study within 4 weeks before the inclusion",
                                "criterion": "treatment with the two compounds of the study",
                                "requirement": {
                                    "requirement_type": "time since last treatment",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previous treatment with an association of mTOR inhibitor or EGFR inhibitor",
                "criterions": [
                    {
                        "exact_snippets": "Previous treatment with an association of mTOR inhibitor",
                        "criterion": "previous treatment with mTOR inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Previous treatment with an association of ... EGFR inhibitor",
                        "criterion": "previous treatment with EGFR inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Previous treatment with an association of mTOR inhibitor",
                        "criterion": "previous treatment with mTOR inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Previous treatment with an association of ... EGFR inhibitor",
                        "criterion": "previous treatment with EGFR inhibitor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Grade >/= 2 nephropathy according to NCI CTCAE",
                "criterions": [
                    {
                        "exact_snippets": "Grade >/= 2 nephropathy according to NCI CTCAE",
                        "criterion": "nephropathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Grade >/= 2 nephropathy according to NCI CTCAE",
                        "criterion": "nephropathy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "grade"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Current treatment with curative dose of coumadin or heparin of low molecular weight",
                "criterions": [
                    {
                        "exact_snippets": "Current treatment with curative dose of coumadin",
                        "criterion": "coumadin treatment",
                        "requirement": {
                            "requirement_type": "dose",
                            "expected_value": "curative"
                        }
                    },
                    {
                        "exact_snippets": "Current treatment with curative dose of ... heparin of low molecular weight",
                        "criterion": "heparin treatment",
                        "requirement": {
                            "requirement_type": "dose",
                            "expected_value": "curative"
                        }
                    },
                    {
                        "exact_snippets": "Current treatment with curative dose of ... heparin of low molecular weight",
                        "criterion": "heparin treatment",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "low molecular weight"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Current treatment with curative dose of coumadin",
                                "criterion": "coumadin treatment",
                                "requirement": {
                                    "requirement_type": "dose",
                                    "expected_value": "curative"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Current treatment with curative dose of ... heparin of low molecular weight",
                                "criterion": "heparin treatment",
                                "requirement": {
                                    "requirement_type": "dose",
                                    "expected_value": "curative"
                                }
                            },
                            {
                                "exact_snippets": "Current treatment with curative dose of ... heparin of low molecular weight",
                                "criterion": "heparin treatment",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": "low molecular weight"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previous uncontrolled brain metastases, medullar compression or carcinomatosis meningitis or any proof of leptomeningeal pathology or metastasis.",
                "criterions": [
                    {
                        "exact_snippets": "uncontrolled brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "medullar compression",
                        "criterion": "medullar compression",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "carcinomatosis meningitis",
                        "criterion": "carcinomatosis meningitis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "proof of leptomeningeal pathology",
                        "criterion": "leptomeningeal pathology",
                        "requirement": {
                            "requirement_type": "proof",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "proof of ... metastasis",
                        "criterion": "metastasis",
                        "requirement": {
                            "requirement_type": "proof",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "uncontrolled brain metastases",
                                "criterion": "brain metastases",
                                "requirement": {
                                    "requirement_type": "control",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "medullar compression",
                                "criterion": "medullar compression",
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                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "carcinomatosis meningitis",
                                "criterion": "carcinomatosis meningitis",
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                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "proof of leptomeningeal pathology",
                        "criterion": "leptomeningeal pathology",
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                            "requirement_type": "proof",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "proof of ... metastasis",
                        "criterion": "metastasis",
                        "requirement": {
                            "requirement_type": "proof",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* myocardial infarction",
                "criterions": [
                    {
                        "exact_snippets": "myocardial infarction",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "myocardial infarction",
                    "criterion": "myocardial infarction",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* angina pectoris",
                "criterions": [
                    {
                        "exact_snippets": "angina pectoris",
                        "criterion": "angina pectoris",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "angina pectoris",
                    "criterion": "angina pectoris",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* bypass of coronal or peripheral arteries",
                "criterions": [
                    {
                        "exact_snippets": "bypass of coronal or peripheral arteries",
                        "criterion": "bypass surgery",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "coronal arteries",
                                "peripheral arteries"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "bypass of coronal or peripheral arteries",
                        "criterion": "bypass surgery",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "coronal arteries",
                                "peripheral arteries"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* heart failure",
                "criterions": [
                    {
                        "exact_snippets": "heart failure",
                        "criterion": "heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "heart failure",
                    "criterion": "heart failure",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* stroke",
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                    {
                        "exact_snippets": "stroke",
                        "criterion": "stroke",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "stroke",
                        "criterion": "stroke",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* cerebral bleeding",
                "criterions": [
                    {
                        "exact_snippets": "cerebral bleeding",
                        "criterion": "cerebral bleeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "cerebral bleeding",
                    "criterion": "cerebral bleeding",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* pulmonary embolism",
                "criterions": [
                    {
                        "exact_snippets": "pulmonary embolism",
                        "criterion": "pulmonary embolism",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "pulmonary embolism",
                    "criterion": "pulmonary embolism",
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                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Grade 3 bleeding according to NCI CTCAE criteria less than 3 weeks before treatment start",
                "criterions": [
                    {
                        "exact_snippets": "Grade 3 bleeding according to NCI CTCAE criteria",
                        "criterion": "bleeding",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "Grade 3"
                        }
                    },
                    {
                        "exact_snippets": "Grade 3 bleeding according to NCI CTCAE criteria",
                        "criterion": "bleeding",
                        "requirement": {
                            "requirement_type": "standard",
                            "expected_value": "NCI CTCAE"
                        }
                    },
                    {
                        "exact_snippets": "less than 3 weeks before treatment start",
                        "criterion": "time since bleeding",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Grade 3 bleeding according to NCI CTCAE criteria",
                                "criterion": "bleeding",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "Grade 3"
                                }
                            },
                            {
                                "exact_snippets": "Grade 3 bleeding according to NCI CTCAE criteria",
                                "criterion": "bleeding",
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                                    "requirement_type": "standard",
                                    "expected_value": "NCI CTCAE"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "less than 3 weeks before treatment start",
                        "criterion": "time since bleeding",
                        "requirement": {
                            "requirement_type": "time since event",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled high blood pressure (>150/100mhHg)",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled high blood pressure (>150/100mhHg)",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Uncontrolled high blood pressure (>150/100mhHg)",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "systolic",
                            "expected_value": {
                                "operator": ">",
                                "value": 150,
                                "unit": "mmHg"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Uncontrolled high blood pressure (>150/100mhHg)",
                        "criterion": "blood pressure",
                        "requirement": {
                            "requirement_type": "diastolic",
                            "expected_value": {
                                "operator": ">",
                                "value": 100,
                                "unit": "mmHg"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Uncontrolled high blood pressure (>150/100mhHg)",
                                "criterion": "blood pressure",
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                                    "requirement_type": "systolic",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 150,
                                        "unit": "mmHg"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Uncontrolled high blood pressure (>150/100mhHg)",
                                "criterion": "blood pressure",
                                "requirement": {
                                    "requirement_type": "diastolic",
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                                        "operator": ">",
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                            }
                        ]
                    },
                    {
                        "exact_snippets": "Uncontrolled high blood pressure (>150/100mhHg)",
                        "criterion": "blood pressure",
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                            "requirement_type": "control",
                            "expected_value": false
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Grade >/=2 heart rate disorder, atrial fibrillation whichever the grade, lengthen of QTC >450 msec for male or >470 msec for female.",
                "criterions": [
                    {
                        "exact_snippets": "Grade >/=2 heart rate disorder",
                        "criterion": "heart rate disorder",
                        "requirement": {
                            "requirement_type": "grade",
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                                "operator": ">=",
                                "value": 2,
                                "unit": "N/A"
                            }
                        }
                    },
                    {
                        "exact_snippets": "atrial fibrillation whichever the grade",
                        "criterion": "atrial fibrillation",
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                    },
                    {
                        "exact_snippets": "lengthen of QTC >450 msec for male",
                        "criterion": "QTC interval",
                        "requirement": {
                            "requirement_type": "length",
                            "expected_value": {
                                "operator": ">",
                                "value": 450,
                                "unit": "msec"
                            }
                        }
                    },
                    {
                        "exact_snippets": "lengthen of QTC >450 msec for male",
                        "criterion": "QTC interval",
                        "requirement": {
                            "requirement_type": "gender",
                            "expected_value": "male"
                        }
                    },
                    {
                        "exact_snippets": "lengthen of QTC ... >470 msec for female",
                        "criterion": "QTC interval",
                        "requirement": {
                            "requirement_type": "length",
                            "expected_value": {
                                "operator": ">",
                                "value": 470,
                                "unit": "msec"
                            }
                        }
                    },
                    {
                        "exact_snippets": "lengthen of QTC ... >470 msec for female",
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                            "requirement_type": "gender",
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                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Grade >/=2 heart rate disorder",
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                                    "requirement_type": "grade",
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                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "atrial fibrillation whichever the grade",
                                "criterion": "atrial fibrillation",
                                "requirement": {
                                    "requirement_type": "grade",
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                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "lengthen of QTC >450 msec for male",
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                                    "requirement_type": "length",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 450,
                                        "unit": "msec"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "lengthen of QTC >450 msec for male",
                                "criterion": "QTC interval",
                                "requirement": {
                                    "requirement_type": "gender",
                                    "expected_value": "male"
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                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "lengthen of QTC ... >470 msec for female",
                                "criterion": "QTC interval",
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                                    "requirement_type": "length",
                                    "expected_value": {
                                        "operator": ">",
                                        "value": 470,
                                        "unit": "msec"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "lengthen of QTC ... >470 msec for female",
                                "criterion": "QTC interval",
                                "requirement": {
                                    "requirement_type": "gender",
                                    "expected_value": "female"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Patients HIV positive",
                "criterions": [
                    {
                        "exact_snippets": "Patients HIV positive",
                        "criterion": "HIV status",
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                            "requirement_type": "status",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Patients HIV positive",
                    "criterion": "HIV status",
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                        "requirement_type": "status",
                        "expected_value": "positive"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Patients with psychiatric disorder",
                "criterions": [
                    {
                        "exact_snippets": "psychiatric disorder",
                        "criterion": "psychiatric disorder",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "psychiatric disorder",
                        "criterion": "psychiatric disorder",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active alcoholism",
                "criterions": [
                    {
                        "exact_snippets": "Active alcoholism",
                        "criterion": "alcoholism",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "active"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Active alcoholism",
                    "criterion": "alcoholism",
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                        "requirement_type": "status",
                        "expected_value": "active"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous pulmonary interstitial disease",
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                    {
                        "exact_snippets": "Previous pulmonary interstitial disease",
                        "criterion": "pulmonary interstitial disease",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Previous pulmonary interstitial disease",
                    "criterion": "pulmonary interstitial disease",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Previous hypersensitivity to antihistamine treatment and/or medical contraindication for an antihistamine or corticoid treatment",
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                    {
                        "exact_snippets": "Previous hypersensitivity to antihistamine treatment",
                        "criterion": "hypersensitivity to antihistamine treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "medical contraindication for an antihistamine",
                        "criterion": "contraindication for antihistamine treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "medical contraindication for ... corticoid treatment",
                        "criterion": "contraindication for corticoid treatment",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Previous hypersensitivity to antihistamine treatment",
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                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "medical contraindication for an antihistamine",
                                "criterion": "contraindication for antihistamine treatment",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "medical contraindication for ... corticoid treatment",
                        "criterion": "contraindication for corticoid treatment",
                        "requirement": {
                            "requirement_type": "presence",
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Presence of one og those pathologies during the last 12 months before the inclusion:",
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                    {
                        "exact_snippets": "Presence of one of those pathologies during the last 12 months before the inclusion",
                        "criterion": "pathologies",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Presence of one of those pathologies during the last 12 months before the inclusion",
                        "criterion": "pathologies",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "last 12 months before the inclusion"
                        }
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                ]
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                        "and_criteria": [
                            {
                                "exact_snippets": "Presence of one of those pathologies during the last 12 months before the inclusion",
                                "criterion": "pathologies",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
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                            {
                                "exact_snippets": "Presence of one of those pathologies during the last 12 months before the inclusion",
                                "criterion": "pathologies",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "last 12 months before the inclusion"
                                }
                            }
                        ]
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                ]
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    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* ECOG 0 or 1",
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                    {
                        "exact_snippets": "ECOG 0 or 1",
                        "criterion": "ECOG performance status",
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                            "requirement_type": "value",
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                                "0",
                                "1"
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                        "exact_snippets": "ECOG 0 or 1",
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                    {
                        "exact_snippets": "ECOG 0 or 1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "1"
                        }
                    }
                ]
            }
        }
    ],
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        {
            "identified_line": {
                "line": "* Diagnosis of a secondary cancer within the last 3 years except for a basal-cell carcinoma, cutaneous spinocellular cancer or in situ carcinoma well treated",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of a secondary cancer within the last 3 years",
                        "criterion": "secondary cancer diagnosis",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "years"
                                    }
                                ]
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                        }
                    },
                    {
                        "exact_snippets": "except for a basal-cell carcinoma",
                        "criterion": "basal-cell carcinoma",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "cutaneous spinocellular cancer",
                        "criterion": "cutaneous spinocellular cancer",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "in situ carcinoma well treated",
                        "criterion": "in situ carcinoma",
                        "requirement": {
                            "requirement_type": "treatment status",
                            "expected_value": "well treated"
                        }
                    },
                    {
                        "exact_snippets": "in situ carcinoma well treated",
                        "criterion": "in situ carcinoma",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant or breastfeeding woman",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "breastfeeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "breastfeeding",
                        "criterion": "breastfeeding",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        }
    ],
    "failed_miscellaneous": []
}