{
    "info": {
        "nct_id": "NCT01752101",
        "official_title": "Identification of a Plasma Proteomic Signature for Lung Cancer",
        "inclusion_criteria": "* age ≥ 40\n* any smoking status, e.g. current, former, or never\n* co-morbid conditions, e.g. COPD\n* Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity\n* Pathology: malignant - adenocarcinoma, squamous, or large cell\n* Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma)\n* Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B)\n* Clinical stage, Regional lymph nodes: N0 or N1 only\n* Clinical stage, Distant metastasis: M0 only\nHealthy volunteers allowed\nMust have minimum age of 40 Years",
        "exclusion_criteria": "* prior malignancy within 5 years of lung nodule diagnosis\n* No nodule size available\n* No pathology data available for those with\n* Current diagnosis of non-small cell lung cancer\n* Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1",
        "miscellaneous_criteria": ""
    },
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        {
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                "line": "* age ≥ 40",
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                    {
                        "exact_snippets": "age ≥ 40",
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                            "requirement_type": "N/A",
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                                "value": 40,
                                "unit": "N/A"
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                        "exact_snippets": "age ≥ 40",
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        },
        {
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                    {
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                        "exact_snippets": "COPD",
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                        "exact_snippets": "co-morbid conditions",
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                        "criterion": "COPD",
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        },
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                "line": "* Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity",
                "criterions": [
                    {
                        "exact_snippets": "Nodule size ≥ 4 mm and ≤ 30 mm",
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                            "requirement_type": "size",
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                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "mm"
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                                        "value": 30,
                                        "unit": "mm"
                                    }
                                ]
                            }
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                    },
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                        "exact_snippets": "up to Stage 2B eligible",
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                            "requirement_type": "stage",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "B"
                            }
                        }
                    },
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                            "expected_value": true
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                    },
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                        "exact_snippets": "ground glass opacity",
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                                "exact_snippets": "Nodule size ≥ 4 mm and ≤ 30 mm",
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                                                "operator": ">=",
                                                "value": 4,
                                                "unit": "mm"
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                                                "unit": "mm"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
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                                "criterion": "cancer stage",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": {
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                                        "value": 2.5,
                                        "unit": "B"
                                    }
                                }
                            }
                        ]
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                        "or_criteria": [
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                                "criterion": "nodule spiculation",
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                                }
                            },
                            {
                                "exact_snippets": "ground glass opacity",
                                "criterion": "ground glass opacity",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Clinical stage, Distant metastasis: M0 only",
                "criterions": [
                    {
                        "exact_snippets": "Distant metastasis: M0 only",
                        "criterion": "distant metastasis",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "M0"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
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                        "exact_snippets": "Distant metastasis: M0 only",
                        "criterion": "distant metastasis",
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                            "requirement_type": "stage",
                            "expected_value": "M0"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 40 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 40 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 40,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 40 Years",
                        "criterion": "age",
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                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 40,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma)",
                "criterions": [
                    {
                        "exact_snippets": "Pathology: benign - inflammatory (e.g. granulomatous, infectious)",
                        "criterion": "pathology",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "benign"
                        }
                    },
                    {
                        "exact_snippets": "Pathology: benign - inflammatory (e.g. granulomatous, infectious)",
                        "criterion": "pathology",
                        "requirement": {
                            "requirement_type": "subtype",
                            "expected_value": [
                                "inflammatory",
                                "granulomatous",
                                "infectious"
                            ]
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                    },
                    {
                        "exact_snippets": "Pathology: benign - non-inflammatory (e.g. hamartoma)",
                        "criterion": "pathology",
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                            "requirement_type": "type",
                            "expected_value": "benign"
                        }
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                        "exact_snippets": "Pathology: benign - non-inflammatory (e.g. hamartoma)",
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                            "expected_value": "non-inflammatory"
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                                        "infectious"
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    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* prior malignancy within 5 years of lung nodule diagnosis",
                "criterions": [
                    {
                        "exact_snippets": "prior malignancy within 5 years of lung nodule diagnosis",
                        "criterion": "prior malignancy",
                        "requirement": {
                            "requirement_type": "time since diagnosis",
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                                "operator": "<=",
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                                "unit": "years"
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                            "expected_value": {
                                "operator": "<=",
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                                "unit": "years"
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            "identified_line": {
                "line": "* No nodule size available",
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                            "requirement_type": "availability",
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                    }
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            "identified_line": {
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        },
        {
            "identified_line": {
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                    {
                        "exact_snippets": "Current diagnosis of non-small cell lung cancer",
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                            "requirement_type": "diagnosis",
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                        }
                    }
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                    }
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        },
        {
            "identified_line": {
                "line": "* Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1",
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                    {
                        "exact_snippets": "Clinical stage: Primary tumor ≥T3",
                        "criterion": "primary tumor stage",
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                            "requirement_type": "stage",
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                                "operator": ">=",
                                "value": 3,
                                "unit": "T"
                            }
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                    },
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                        "exact_snippets": "Regional lymph nodes: ≥N2",
                        "criterion": "regional lymph nodes stage",
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                            "requirement_type": "stage",
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                                "operator": ">=",
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                                "unit": "N"
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                        "criterion": "distant metastasis stage",
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                            "requirement_type": "stage",
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                                "operator": ">=",
                                "value": 1,
                                "unit": "M"
                            }
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "Clinical stage: Primary tumor ≥T3",
                        "criterion": "primary tumor stage",
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                            "requirement_type": "stage",
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                                "unit": "T"
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                    },
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                        "exact_snippets": "Regional lymph nodes: ≥N2",
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                            "requirement_type": "stage",
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                                "value": 2,
                                "unit": "N"
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                                "value": 1,
                                "unit": "M"
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                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Pathology: malignant - adenocarcinoma, squamous, or large cell",
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                    {
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                            "expected_value": true
                        }
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                    {
                        "exact_snippets": "Pathology: malignant - adenocarcinoma, squamous, or large cell",
                        "criterion": "pathology",
                        "requirement": {
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                            "expected_value": [
                                "adenocarcinoma",
                                "squamous",
                                "large cell"
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                        }
                    }
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                        "and_criteria": [
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                                "exact_snippets": "Pathology: malignant - adenocarcinoma, squamous, or large cell",
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                                    "expected_value": true
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                                            "expected_value": "adenocarcinoma"
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                                    {
                                        "exact_snippets": "Pathology: malignant - adenocarcinoma, squamous, or large cell",
                                        "criterion": "pathology",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": "squamous"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Pathology: malignant - adenocarcinoma, squamous, or large cell",
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                                    }
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            "identified_line": {
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                                "value": 2,
                                "unit": "T"
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                        "exact_snippets": "Clinical stage, Primary tumor: \u001aT2 (e.g. 1A, 1B, 2A and 2B)",
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                            "requirement_type": "stage",
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                        }
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                        "exact_snippets": "Clinical stage",
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                        "exact_snippets": "Clinical stage",
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                        }
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                        "exact_snippets": "Regional lymph nodes: N0 or N1 only",
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                        }
                    }
                ]
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        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}