{
    "info": {
        "nct_id": "NCT01695772",
        "official_title": "A Multi-Center, Single-Arm, Pilot Study of 5-FU Based Doublet Chemotherapy Plus Bevacizumab as Neoadjuvant Therapy for Patients With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer",
        "inclusion_criteria": "* Adult Chinese participants, 18-75 years of age\n* Histologically confirmed adenocarcinoma in colon or rectum with primary lesion surgically removed\n* Previously untreated unresectable liver-only metastases\n* Liver lesions determined to be unresectable by multidisciplinary team (MDT, consisting of experienced hepatic surgeons, medical oncologist and radiologist).\n* No previous treatment against liver metastases, including chemotherapy, surgery, radiotherapy, Transarterial chemoembolisation therapy (TACE) and target therapy\n* Adequate hematological, renal and hepatic function\n* Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1\n* Life expectancy greater than (>) 3 months\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 75 Years",
        "exclusion_criteria": "* The relapse has occurred within 6 months of completion of the adjuvant treatment\n* Expected impossible to achieve complete resection (R0 resection) and/or gain 30% residual liver volume even with responsive neoadjuvant therapy\n* Participant cannot tolerate the surgery\n* Other malignancies in the past 5 years, except for curatively treated basal cell carcinoma of the skin and/or in situ carcinoma of the cervix\n* Any extrahepatic metastases and/or recurrence of the primary tumor\n* Any residual toxicity from previous chemotherapy (except alopecia) of National Cancer Institute Common Toxicity Criteria (NCI CTC) v.4.0 grade 2\n* Hypertension crisis or encephalopathy\n* Pregnant or lactating women\n* Clinically significant cardiovascular disease\n* Evidence of bleeding diathesis or coagulopathy\n* Current or recent (within 10 days of study drug initiation) use of full dose of aspirin, clopidrogel or warfarin\n* History or evidence of Central Nervous System (CNS) disease (for example, primary brain tumor, seizures not controlled with standard medical therapy, any brain metastases, or history of stroke)",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Adult Chinese participants, 18-75 years of age",
                "criterions": [
                    {
                        "exact_snippets": "Adult Chinese participants",
                        "criterion": "ethnicity",
                        "requirement": {
                            "requirement_type": "specific ethnicity",
                            "expected_value": "Chinese"
                        }
                    },
                    {
                        "exact_snippets": "18-75 years of age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adult Chinese participants",
                        "criterion": "ethnicity",
                        "requirement": {
                            "requirement_type": "specific ethnicity",
                            "expected_value": "Chinese"
                        }
                    },
                    {
                        "exact_snippets": "18-75 years of age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 75,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Previously untreated unresectable liver-only metastases",
                "criterions": [
                    {
                        "exact_snippets": "Previously untreated",
                        "criterion": "treatment status",
                        "requirement": {
                            "requirement_type": "treatment history",
                            "expected_value": "untreated"
                        }
                    },
                    {
                        "exact_snippets": "unresectable",
                        "criterion": "resectability",
                        "requirement": {
                            "requirement_type": "surgical resectability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "liver-only metastases",
                        "criterion": "metastasis location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "liver-only"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Previously untreated",
                        "criterion": "treatment status",
                        "requirement": {
                            "requirement_type": "treatment history",
                            "expected_value": "untreated"
                        }
                    },
                    {
                        "exact_snippets": "unresectable",
                        "criterion": "resectability",
                        "requirement": {
                            "requirement_type": "surgical resectability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "liver-only metastases",
                        "criterion": "metastasis location",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": "liver-only"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Liver lesions determined to be unresectable by multidisciplinary team (MDT, consisting of experienced hepatic surgeons, medical oncologist and radiologist).",
                "criterions": [
                    {
                        "exact_snippets": "Liver lesions determined to be unresectable",
                        "criterion": "liver lesions",
                        "requirement": {
                            "requirement_type": "resectability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Liver lesions determined to be unresectable",
                        "criterion": "liver lesions",
                        "requirement": {
                            "requirement_type": "resectability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No previous treatment against liver metastases, including chemotherapy, surgery, radiotherapy, Transarterial chemoembolisation therapy (TACE) and target therapy",
                "criterions": [
                    {
                        "exact_snippets": "No previous treatment against liver metastases",
                        "criterion": "previous treatment against liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No previous treatment ... chemotherapy",
                        "criterion": "previous chemotherapy treatment against liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No previous treatment ... surgery",
                        "criterion": "previous surgery treatment against liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No previous treatment ... radiotherapy",
                        "criterion": "previous radiotherapy treatment against liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No previous treatment ... Transarterial chemoembolisation therapy (TACE)",
                        "criterion": "previous Transarterial chemoembolisation therapy (TACE) against liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No previous treatment ... target therapy",
                        "criterion": "previous target therapy against liver metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "No previous treatment against liver metastases",
                                "criterion": "previous treatment against liver metastases",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "No previous treatment ... chemotherapy",
                                        "criterion": "previous chemotherapy treatment against liver metastases",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "No previous treatment ... surgery",
                                        "criterion": "previous surgery treatment against liver metastases",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "No previous treatment ... radiotherapy",
                                        "criterion": "previous radiotherapy treatment against liver metastases",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "No previous treatment ... Transarterial chemoembolisation therapy (TACE)",
                                        "criterion": "previous Transarterial chemoembolisation therapy (TACE) against liver metastases",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "No previous treatment ... target therapy",
                                        "criterion": "previous target therapy against liver metastases",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate hematological, renal and hepatic function",
                "criterions": [
                    {
                        "exact_snippets": "Adequate hematological ... function",
                        "criterion": "hematological function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... renal ... function",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic function",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate hematological ... function",
                        "criterion": "hematological function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... renal ... function",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... hepatic function",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy greater than (>) 3 months",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy greater than (>) 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy greater than (>) 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 75 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 75 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 75,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "* The relapse has occurred within 6 months of completion of the adjuvant treatment",
                "criterions": [
                    {
                        "exact_snippets": "The relapse has occurred within 6 months of completion of the adjuvant treatment",
                        "criterion": "relapse timing",
                        "requirement": {
                            "requirement_type": "time since adjuvant treatment completion",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "The relapse has occurred within 6 months of completion of the adjuvant treatment",
                        "criterion": "relapse timing",
                        "requirement": {
                            "requirement_type": "time since adjuvant treatment completion",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<=",
                                        "value": 6,
                                        "unit": "months"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Expected impossible to achieve complete resection (R0 resection) and/or gain 30% residual liver volume even with responsive neoadjuvant therapy",
                "criterions": [
                    {
                        "exact_snippets": "Expected impossible to achieve complete resection (R0 resection)",
                        "criterion": "complete resection (R0 resection)",
                        "requirement": {
                            "requirement_type": "achievability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "gain 30% residual liver volume even with responsive neoadjuvant therapy",
                        "criterion": "residual liver volume",
                        "requirement": {
                            "requirement_type": "gain",
                            "expected_value": {
                                "operator": "=",
                                "value": 30,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Expected impossible to achieve complete resection (R0 resection)",
                                "criterion": "complete resection (R0 resection)",
                                "requirement": {
                                    "requirement_type": "achievability",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "gain 30% residual liver volume even with responsive neoadjuvant therapy",
                                "criterion": "residual liver volume",
                                "requirement": {
                                    "requirement_type": "gain",
                                    "expected_value": {
                                        "operator": "=",
                                        "value": 30,
                                        "unit": "%"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Participant cannot tolerate the surgery",
                "criterions": [
                    {
                        "exact_snippets": "Participant cannot tolerate the surgery",
                        "criterion": "surgery tolerance",
                        "requirement": {
                            "requirement_type": "tolerance",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Participant cannot tolerate the surgery",
                    "criterion": "surgery tolerance",
                    "requirement": {
                        "requirement_type": "tolerance",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Other malignancies in the past 5 years, except for curatively treated basal cell carcinoma of the skin and/or in situ carcinoma of the cervix",
                "criterions": [
                    {
                        "exact_snippets": "Other malignancies in the past 5 years",
                        "criterion": "other malignancies",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Other malignancies in the past 5 years",
                        "criterion": "other malignancies",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except for curatively treated basal cell carcinoma of the skin",
                        "criterion": "curatively treated basal cell carcinoma of the skin",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "except for ... in situ carcinoma of the cervix",
                        "criterion": "in situ carcinoma of the cervix",
                        "requirement": {
                            "requirement_type": "exclusion",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Other malignancies in the past 5 years",
                                        "criterion": "other malignancies",
                                        "requirement": {
                                            "requirement_type": "time frame",
                                            "expected_value": {
                                                "operator": "<=",
                                                "value": 5,
                                                "unit": "years"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "Other malignancies in the past 5 years",
                                        "criterion": "other malignancies",
                                        "requirement": {
                                            "requirement_type": "exclusion",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "except for curatively treated basal cell carcinoma of the skin",
                                    "criterion": "curatively treated basal cell carcinoma of the skin",
                                    "requirement": {
                                        "requirement_type": "exclusion",
                                        "expected_value": false
                                    }
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "except for ... in situ carcinoma of the cervix",
                                    "criterion": "in situ carcinoma of the cervix",
                                    "requirement": {
                                        "requirement_type": "exclusion",
                                        "expected_value": false
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Any extrahepatic metastases and/or recurrence of the primary tumor",
                "criterions": [
                    {
                        "exact_snippets": "extrahepatic metastases",
                        "criterion": "extrahepatic metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "recurrence of the primary tumor",
                        "criterion": "recurrence of the primary tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "extrahepatic metastases",
                        "criterion": "extrahepatic metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "recurrence of the primary tumor",
                        "criterion": "recurrence of the primary tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Any residual toxicity from previous chemotherapy (except alopecia) of National Cancer Institute Common Toxicity Criteria (NCI CTC) v.4.0 grade 2",
                "criterions": [
                    {
                        "exact_snippets": "Any residual toxicity from previous chemotherapy ... of National Cancer Institute Common Toxicity Criteria (NCI CTC) v.4.0 grade 2",
                        "criterion": "residual toxicity from previous chemotherapy",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "=",
                                "value": 2,
                                "unit": "NCI CTC v.4.0 grade"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "Any residual toxicity from previous chemotherapy ... of National Cancer Institute Common Toxicity Criteria (NCI CTC) v.4.0 grade 2",
                            "criterion": "residual toxicity from previous chemotherapy",
                            "requirement": {
                                "requirement_type": "severity",
                                "expected_value": {
                                    "operator": "=",
                                    "value": 2,
                                    "unit": "NCI CTC v.4.0 grade"
                                }
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "Any residual toxicity from previous chemotherapy ... of National Cancer Institute Common Toxicity Criteria (NCI CTC) v.4.0 grade 2",
                            "criterion": "residual toxicity from previous chemotherapy",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hypertension crisis or encephalopathy",
                "criterions": [
                    {
                        "exact_snippets": "Hypertension crisis",
                        "criterion": "hypertension crisis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "encephalopathy",
                        "criterion": "encephalopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Hypertension crisis",
                        "criterion": "hypertension crisis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "encephalopathy",
                        "criterion": "encephalopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnant or lactating women",
                "criterions": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "lactating women",
                        "criterion": "lactation status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Clinically significant cardiovascular disease",
                "criterions": [
                    {
                        "exact_snippets": "Clinically significant cardiovascular disease",
                        "criterion": "cardiovascular disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Clinically significant cardiovascular disease",
                    "criterion": "cardiovascular disease",
                    "requirement": {
                        "requirement_type": "severity",
                        "expected_value": "clinically significant"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Evidence of bleeding diathesis or coagulopathy",
                "criterions": [
                    {
                        "exact_snippets": "Evidence of bleeding diathesis",
                        "criterion": "bleeding diathesis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Evidence of ... coagulopathy",
                        "criterion": "coagulopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Evidence of bleeding diathesis",
                        "criterion": "bleeding diathesis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Evidence of ... coagulopathy",
                        "criterion": "coagulopathy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Current or recent (within 10 days of study drug initiation) use of full dose of aspirin, clopidrogel or warfarin",
                "criterions": [
                    {
                        "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of aspirin",
                        "criterion": "aspirin use",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "current or recent (within 10 days of study drug initiation)"
                        }
                    },
                    {
                        "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of aspirin",
                        "criterion": "aspirin use",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": "full dose"
                        }
                    },
                    {
                        "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... clopidrogel",
                        "criterion": "clopidrogel use",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "current or recent (within 10 days of study drug initiation)"
                        }
                    },
                    {
                        "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... clopidrogel",
                        "criterion": "clopidrogel use",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": "full dose"
                        }
                    },
                    {
                        "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... warfarin",
                        "criterion": "warfarin use",
                        "requirement": {
                            "requirement_type": "time frame",
                            "expected_value": "current or recent (within 10 days of study drug initiation)"
                        }
                    },
                    {
                        "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... warfarin",
                        "criterion": "warfarin use",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": "full dose"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of aspirin",
                                "criterion": "aspirin use",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "current or recent (within 10 days of study drug initiation)"
                                }
                            },
                            {
                                "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of aspirin",
                                "criterion": "aspirin use",
                                "requirement": {
                                    "requirement_type": "dosage",
                                    "expected_value": "full dose"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... clopidrogel",
                                "criterion": "clopidrogel use",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "current or recent (within 10 days of study drug initiation)"
                                }
                            },
                            {
                                "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... clopidrogel",
                                "criterion": "clopidrogel use",
                                "requirement": {
                                    "requirement_type": "dosage",
                                    "expected_value": "full dose"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... warfarin",
                                "criterion": "warfarin use",
                                "requirement": {
                                    "requirement_type": "time frame",
                                    "expected_value": "current or recent (within 10 days of study drug initiation)"
                                }
                            },
                            {
                                "exact_snippets": "Current or recent (within 10 days of study drug initiation) use of full dose of ... warfarin",
                                "criterion": "warfarin use",
                                "requirement": {
                                    "requirement_type": "dosage",
                                    "expected_value": "full dose"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History or evidence of Central Nervous System (CNS) disease (for example, primary brain tumor, seizures not controlled with standard medical therapy, any brain metastases, or history of stroke)",
                "criterions": [
                    {
                        "exact_snippets": "History or evidence of Central Nervous System (CNS) disease",
                        "criterion": "Central Nervous System (CNS) disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "primary brain tumor",
                        "criterion": "primary brain tumor",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "seizures not controlled with standard medical therapy",
                        "criterion": "seizures",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "not controlled with standard medical therapy"
                        }
                    },
                    {
                        "exact_snippets": "any brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "history of stroke",
                        "criterion": "stroke",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "History or evidence of Central Nervous System (CNS) disease",
                                "criterion": "Central Nervous System (CNS) disease",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "primary brain tumor",
                                        "criterion": "primary brain tumor",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "seizures not controlled with standard medical therapy",
                                        "criterion": "seizures",
                                        "requirement": {
                                            "requirement_type": "control",
                                            "expected_value": "not controlled with standard medical therapy"
                                        }
                                    },
                                    {
                                        "exact_snippets": "any brain metastases",
                                        "criterion": "brain metastases",
                                        "requirement": {
                                            "requirement_type": "presence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "history of stroke",
                                        "criterion": "stroke",
                                        "requirement": {
                                            "requirement_type": "history",
                                            "expected_value": true
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* Histologically confirmed adenocarcinoma in colon or rectum with primary lesion surgically removed",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed adenocarcinoma",
                        "criterion": "adenocarcinoma",
                        "requirement": {
                            "requirement_type": "confirmation",
                            "expected_value": "histologically confirmed"
                        }
                    },
                    {
                        "exact_snippets": "in colon or rectum",
                        "criterion": "location of adenocarcinoma",
                        "requirement": {
                            "requirement_type": "location",
                            "expected_value": [
                                "colon",
                                "rectum"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "primary lesion surgically removed",
                        "criterion": "primary lesion",
                        "requirement": {
                            "requirement_type": "surgical removal",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Histologically confirmed adenocarcinoma",
                                "criterion": "adenocarcinoma",
                                "requirement": {
                                    "requirement_type": "confirmation",
                                    "expected_value": "histologically confirmed"
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "in colon or rectum",
                                        "criterion": "location of adenocarcinoma",
                                        "requirement": {
                                            "requirement_type": "location",
                                            "expected_value": "colon"
                                        }
                                    },
                                    {
                                        "exact_snippets": "in colon or rectum",
                                        "criterion": "location of adenocarcinoma",
                                        "requirement": {
                                            "requirement_type": "location",
                                            "expected_value": "rectum"
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "primary lesion surgically removed",
                        "criterion": "primary lesion",
                        "requirement": {
                            "requirement_type": "surgical removal",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1",
                "criterions": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": [
                                "0",
                                "1"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "0"
                        }
                    },
                    {
                        "exact_snippets": "Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": "1"
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}