{
    "info": {
        "nct_id": "NCT01463631",
        "official_title": "A Phase 1 Study of LY3007113, a p38 MAPK Inhibitor, in Patients With Advanced Cancer",
        "inclusion_criteria": "* Have histological or cytological evidence of a diagnosis of cancer that is advanced and/or metastatic for which available standard therapies have failed to provide clinical benefit for their disease\n* For Dose Escalation (Part A): cancer, either a solid tumor or a lymphoma\n* For Dose Confirmation (Part B): cancer, either a solid tumor or a lymphoma\n* Have the presence of measureable or non-measureable disease (Part A) or measureable disease (Part B) as defined by the Response Evaluation Criteria in Solid Tumors or the Revised Response Criteria for Malignant Lymphoma\n* Have adequate hematologic, hepatic and renal function\n* Have a performance status less than or equal to 2 on the Eastern Cooperative Oncology Group scale\n* Have discontinued all previous therapies for cancer (including chemotherapy, radiotherapy, and immunotherapy) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents\n* Have an estimated life expectancy of greater than or equal to 12 weeks\n* Are able to swallow capsules\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "* Have an echocardiogram with clinically significant abnormalities\n* For Dose Escalation (Part A): Have central nervous system malignancy or metastasis\n* For Dose Confirmation (Part B): Have symptomatic central nervous system malignancy or metastasis\n* Have an acute leukemia\n* Have a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in complete remission and stopped all therapy for that disease for a minimum of 3 years\n* Have received an autologous or allogeneic stem-cell transplant within 75 days of the initial dose of study drug",
        "miscellaneous_criteria": ""
    },
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                "line": "* Have adequate hematologic, hepatic and renal function",
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                        "exact_snippets": "adequate hematologic ... function",
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                        "exact_snippets": "adequate ... renal function",
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                        "exact_snippets": "adequate hematologic ... function",
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                "line": "* Have a performance status less than or equal to 2 on the Eastern Cooperative Oncology Group scale",
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                    {
                        "exact_snippets": "cancer, either a solid tumor or a lymphoma",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "solid tumor"
                        }
                    },
                    {
                        "exact_snippets": "cancer, either a solid tumor or a lymphoma",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "lymphoma"
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}