{
    "info": {
        "nct_id": "NCT01291420",
        "official_title": "Therapeutic Efficacy of Wilms' Tumor Gene (WT1) MRNA-electroporated Autologous Dendritic Cell Vaccination in Patients with Solid Tumors: a Phase I/feasibility Study",
        "inclusion_criteria": "1. Tumor type:\n\n   Metastatic or Locally Advanced Breast Cancer; Malignant Mesothelioma; Glioblastoma Multiforme (Grade IV); Sarcoma's; Colorectal tumors or rare tumors (less than 500 patients a year)\n2. Extent of disease:\n\n   * Metastatic Breast Cancer or High Risk Locally Advanced Breast Cancer\n\n     * Partial or Complete response after first line chemotherapy for both metastatic or locally advanced breast cancer. Minimal metastatic disease under hormonal treatment\n     * High risk Locally Advanced breast cancer defined as (and/or):\n\n       * Age < 60 years old\n       * ER, PR and Her-2 Neu negative tumors\n       * > 4 lymphnodes at initial presentation\n       * Mastitis Carcinomatosis\n       * Pregnancy associated Breast Cancer\n   * Malignant Mesothelioma:\n\n     * Partial or Complete response after first line chemotherapy not amendable for surgery\n     * Adjuvant after debulking surgery\n   * Glioblastoma Multiforme\n\n     * In Recurrent Disease after optimal treatment according to Stupp regimen\n     * In primary disease after debulking surgery, Temodal/radiotherapy and Temodal chemotherapy for 6 months\n   * Sarcoma's\n\n     * After adjuvant chemotherapy for uterine sarcoma's\n     * After Optimal or Debulking Surgery for liposarcoma's, synovial cell sarcoma's\n     * Recurrent sarcoma's with limited disease\n   * Colorectal tumors\n\n     * K-ras wild-type tumors with inoperable lymphnode metastasis after standard chemotherapy (FOLFOX, FOLFIRI)\n3. Patient Characteristics\n\n   * Prior treatments: Patients must have received at least one prior chemotherapeutic regimen and must be more than 1 month past the last treatment.\n   * Age: ≥ 18 years old\n   * Performance status: WHO PS grade 0-1 (Appendix B)\n   * Objectively assessable parameters of life expectancy: more than 3 months\n   * Prior and concomitant associated diseases allowed with the exception of underlying autoimmune disease and positive serology for HIV/HBV/HCV\n   * No concomitant use of immunosuppressive drugs, hormonal treatment for breast cancer is allowed in case of stable disease\n   * Adequate renal and liver function, i.e. creatinin and bilirubin = 1.2 times the upper limit of normal\n   * Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial\n   * Women of child-bearing potential should use adequate contraception prior to study entry and for the duration of study participation\nHealthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "1. Subjects with concurrent additional malignancy (with exception of non-melanoma skin cancers and carcinoma in situ of the cervix)\n2. Subjects who are pregnant\n3. Subjects who have sensitivity to drugs that provide local anesthesia\n4. Subjects needing corticosteroids 1 mg/kg during vaccination; corticosteroids are allowed as part of their treatment when taken ≥ 30 days before the start of vaccination.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "1. Tumor type:",
                "criterions": [
                    {
                        "exact_snippets": "Tumor type",
                        "criterion": "tumor type",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Tumor type",
                        "criterion": "tumor type",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Metastatic or Locally Advanced Breast Cancer; Malignant Mesothelioma; Glioblastoma Multiforme (Grade IV); Sarcoma's; Colorectal tumors or rare tumors (less than 500 patients a year)",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic or Locally Advanced Breast Cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "metastatic",
                                "locally advanced"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Malignant Mesothelioma",
                        "criterion": "mesothelioma",
                        "requirement": {
                            "requirement_type": "malignancy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Glioblastoma Multiforme (Grade IV)",
                        "criterion": "glioblastoma multiforme",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "IV"
                        }
                    },
                    {
                        "exact_snippets": "Sarcoma's",
                        "criterion": "sarcoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Colorectal tumors",
                        "criterion": "colorectal tumors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "rare tumors (less than 500 patients a year)",
                        "criterion": "rare tumors",
                        "requirement": {
                            "requirement_type": "incidence",
                            "expected_value": {
                                "operator": "<",
                                "value": 500,
                                "unit": "patients per year"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Metastatic or Locally Advanced Breast Cancer",
                                "criterion": "breast cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": [
                                        "metastatic",
                                        "locally advanced"
                                    ]
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Malignant Mesothelioma",
                        "criterion": "mesothelioma",
                        "requirement": {
                            "requirement_type": "malignancy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Glioblastoma Multiforme (Grade IV)",
                        "criterion": "glioblastoma multiforme",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": "IV"
                        }
                    },
                    {
                        "exact_snippets": "Sarcoma's",
                        "criterion": "sarcoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Colorectal tumors",
                        "criterion": "colorectal tumors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "rare tumors (less than 500 patients a year)",
                        "criterion": "rare tumors",
                        "requirement": {
                            "requirement_type": "incidence",
                            "expected_value": {
                                "operator": "<",
                                "value": 500,
                                "unit": "patients per year"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "2. Extent of disease:",
                "criterions": [
                    {
                        "exact_snippets": "Extent of disease",
                        "criterion": "extent of disease",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Extent of disease",
                        "criterion": "extent of disease",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Metastatic Breast Cancer or High Risk Locally Advanced Breast Cancer",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic Breast Cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "metastatic"
                        }
                    },
                    {
                        "exact_snippets": "High Risk Locally Advanced Breast Cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "risk",
                            "expected_value": "high"
                        }
                    },
                    {
                        "exact_snippets": "High Risk Locally Advanced Breast Cancer",
                        "criterion": "breast cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": "locally advanced"
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Metastatic Breast Cancer",
                                "criterion": "breast cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "metastatic"
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "High Risk Locally Advanced Breast Cancer",
                                "criterion": "breast cancer",
                                "requirement": {
                                    "requirement_type": "risk",
                                    "expected_value": "high"
                                }
                            },
                            {
                                "exact_snippets": "High Risk Locally Advanced Breast Cancer",
                                "criterion": "breast cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": "locally advanced"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Partial or Complete response after first line chemotherapy for both metastatic or locally advanced breast cancer. Minimal metastatic disease under hormonal treatment",
                "criterions": [
                    {
                        "exact_snippets": "Partial or Complete response after first line chemotherapy",
                        "criterion": "response to first line chemotherapy",
                        "requirement": {
                            "requirement_type": "response",
                            "expected_value": [
                                "Partial",
                                "Complete"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "metastatic or locally advanced breast cancer",
                        "criterion": "breast cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "metastatic",
                                "locally advanced"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "Minimal metastatic disease under hormonal treatment",
                        "criterion": "metastatic disease status under hormonal treatment",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "Minimal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Partial or Complete response after first line chemotherapy",
                                        "criterion": "response to first line chemotherapy",
                                        "requirement": {
                                            "requirement_type": "response",
                                            "expected_value": [
                                                "Partial",
                                                "Complete"
                                            ]
                                        }
                                    },
                                    {
                                        "exact_snippets": "metastatic or locally advanced breast cancer",
                                        "criterion": "breast cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": [
                                                "metastatic",
                                                "locally advanced"
                                            ]
                                        }
                                    }
                                ]
                            },
                            {
                                "exact_snippets": "Minimal metastatic disease under hormonal treatment",
                                "criterion": "metastatic disease status under hormonal treatment",
                                "requirement": {
                                    "requirement_type": "status",
                                    "expected_value": "Minimal"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* High risk Locally Advanced breast cancer defined as (and/or):",
                "criterions": [
                    {
                        "exact_snippets": "High risk Locally Advanced breast cancer",
                        "criterion": "Locally Advanced breast cancer",
                        "requirement": {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "High risk Locally Advanced breast cancer",
                        "criterion": "Locally Advanced breast cancer",
                        "requirement": {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age < 60 years old",
                "criterions": [
                    {
                        "exact_snippets": "Age < 60 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 60,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age < 60 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": "<",
                                "value": 60,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ER, PR and Her-2 Neu negative tumors",
                "criterions": [
                    {
                        "exact_snippets": "ER ... negative tumors",
                        "criterion": "ER status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "PR ... negative tumors",
                        "criterion": "PR status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "Her-2 Neu negative tumors",
                        "criterion": "Her-2 Neu status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ER ... negative tumors",
                        "criterion": "ER status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "PR ... negative tumors",
                        "criterion": "PR status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    },
                    {
                        "exact_snippets": "Her-2 Neu negative tumors",
                        "criterion": "Her-2 Neu status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* > 4 lymphnodes at initial presentation",
                "criterions": [
                    {
                        "exact_snippets": "> 4 lymphnodes at initial presentation",
                        "criterion": "lymph nodes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "> 4 lymphnodes at initial presentation",
                        "criterion": "lymph nodes",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 4,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Mastitis Carcinomatosis",
                "criterions": [
                    {
                        "exact_snippets": "Mastitis Carcinomatosis",
                        "criterion": "Mastitis Carcinomatosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Mastitis Carcinomatosis",
                        "criterion": "Mastitis Carcinomatosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Pregnancy associated Breast Cancer",
                "criterions": [
                    {
                        "exact_snippets": "Pregnancy associated Breast Cancer",
                        "criterion": "Pregnancy associated Breast Cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pregnancy associated Breast Cancer",
                        "criterion": "Pregnancy associated Breast Cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Malignant Mesothelioma:",
                "criterions": [
                    {
                        "exact_snippets": "Malignant Mesothelioma",
                        "criterion": "Malignant Mesothelioma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Malignant Mesothelioma",
                        "criterion": "Malignant Mesothelioma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Partial or Complete response after first line chemotherapy not amendable for surgery",
                "criterions": [
                    {
                        "exact_snippets": "Partial or Complete response after first line chemotherapy",
                        "criterion": "response to first line chemotherapy",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "Partial",
                                "Complete"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "not amendable for surgery",
                        "criterion": "surgical amendability",
                        "requirement": {
                            "requirement_type": "amendability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Partial or Complete response after first line chemotherapy",
                        "criterion": "response to first line chemotherapy",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "Partial",
                                "Complete"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "not amendable for surgery",
                        "criterion": "surgical amendability",
                        "requirement": {
                            "requirement_type": "amendability",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adjuvant after debulking surgery",
                "criterions": [
                    {
                        "exact_snippets": "Adjuvant after debulking surgery",
                        "criterion": "adjuvant therapy",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "after debulking surgery"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adjuvant after debulking surgery",
                        "criterion": "adjuvant therapy",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "after debulking surgery"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Glioblastoma Multiforme",
                "criterions": [
                    {
                        "exact_snippets": "Glioblastoma Multiforme",
                        "criterion": "Glioblastoma Multiforme",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Glioblastoma Multiforme",
                        "criterion": "Glioblastoma Multiforme",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* In Recurrent Disease after optimal treatment according to Stupp regimen",
                "criterions": [
                    {
                        "exact_snippets": "Recurrent Disease",
                        "criterion": "disease recurrence",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "optimal treatment according to Stupp regimen",
                        "criterion": "treatment history",
                        "requirement": {
                            "requirement_type": "specific treatment",
                            "expected_value": "Stupp regimen"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recurrent Disease",
                        "criterion": "disease recurrence",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "optimal treatment according to Stupp regimen",
                        "criterion": "treatment history",
                        "requirement": {
                            "requirement_type": "specific treatment",
                            "expected_value": "Stupp regimen"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Sarcoma's",
                "criterions": [
                    {
                        "exact_snippets": "Sarcoma's",
                        "criterion": "sarcoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Sarcoma's",
                        "criterion": "sarcoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* After adjuvant chemotherapy for uterine sarcoma's",
                "criterions": [
                    {
                        "exact_snippets": "adjuvant chemotherapy",
                        "criterion": "adjuvant chemotherapy",
                        "requirement": {
                            "requirement_type": "completion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "uterine sarcoma",
                        "criterion": "uterine sarcoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "adjuvant chemotherapy",
                        "criterion": "adjuvant chemotherapy",
                        "requirement": {
                            "requirement_type": "completion",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "uterine sarcoma",
                        "criterion": "uterine sarcoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* After Optimal or Debulking Surgery for liposarcoma's, synovial cell sarcoma's",
                "criterions": [
                    {
                        "exact_snippets": "After Optimal or Debulking Surgery",
                        "criterion": "surgery type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": [
                                "Optimal",
                                "Debulking"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "liposarcoma's",
                        "criterion": "liposarcoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "synovial cell sarcoma's",
                        "criterion": "synovial cell sarcoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "After Optimal or Debulking Surgery",
                                "criterion": "surgery type",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": [
                                        "Optimal",
                                        "Debulking"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "liposarcoma's",
                                "criterion": "liposarcoma",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "After Optimal or Debulking Surgery",
                                "criterion": "surgery type",
                                "requirement": {
                                    "requirement_type": "type",
                                    "expected_value": [
                                        "Optimal",
                                        "Debulking"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "synovial cell sarcoma's",
                                "criterion": "synovial cell sarcoma",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Recurrent sarcoma's with limited disease",
                "criterions": [
                    {
                        "exact_snippets": "Recurrent sarcoma's",
                        "criterion": "sarcoma",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "limited disease",
                        "criterion": "disease extent",
                        "requirement": {
                            "requirement_type": "extent",
                            "expected_value": "limited"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recurrent sarcoma's",
                        "criterion": "sarcoma",
                        "requirement": {
                            "requirement_type": "recurrence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "limited disease",
                        "criterion": "disease extent",
                        "requirement": {
                            "requirement_type": "extent",
                            "expected_value": "limited"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Colorectal tumors",
                "criterions": [
                    {
                        "exact_snippets": "Colorectal tumors",
                        "criterion": "colorectal tumors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Colorectal tumors",
                        "criterion": "colorectal tumors",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* K-ras wild-type tumors with inoperable lymphnode metastasis after standard chemotherapy (FOLFOX, FOLFIRI)",
                "criterions": [
                    {
                        "exact_snippets": "K-ras wild-type tumors",
                        "criterion": "K-ras mutation status",
                        "requirement": {
                            "requirement_type": "mutation status",
                            "expected_value": "wild-type"
                        }
                    },
                    {
                        "exact_snippets": "inoperable lymphnode metastasis",
                        "criterion": "lymphnode metastasis operability",
                        "requirement": {
                            "requirement_type": "operability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "after standard chemotherapy (FOLFOX, FOLFIRI)",
                        "criterion": "prior chemotherapy regimens",
                        "requirement": {
                            "requirement_type": "regimen",
                            "expected_value": [
                                "FOLFOX",
                                "FOLFIRI"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "K-ras wild-type tumors",
                        "criterion": "K-ras mutation status",
                        "requirement": {
                            "requirement_type": "mutation status",
                            "expected_value": "wild-type"
                        }
                    },
                    {
                        "exact_snippets": "inoperable lymphnode metastasis",
                        "criterion": "lymphnode metastasis operability",
                        "requirement": {
                            "requirement_type": "operability",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "after standard chemotherapy (FOLFOX, FOLFIRI)",
                        "criterion": "prior chemotherapy regimens",
                        "requirement": {
                            "requirement_type": "regimen",
                            "expected_value": [
                                "FOLFOX",
                                "FOLFIRI"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Patient Characteristics",
                "criterions": [
                    {
                        "exact_snippets": "Patient Characteristics",
                        "criterion": "patient characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patient Characteristics",
                        "criterion": "patient characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior treatments: Patients must have received at least one prior chemotherapeutic regimen and must be more than 1 month past the last treatment.",
                "criterions": [
                    {
                        "exact_snippets": "Patients must have received at least one prior chemotherapeutic regimen",
                        "criterion": "prior chemotherapeutic regimen",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "regimen"
                            }
                        }
                    },
                    {
                        "exact_snippets": "must be more than 1 month past the last treatment",
                        "criterion": "time since last treatment",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Patients must have received at least one prior chemotherapeutic regimen",
                        "criterion": "prior chemotherapeutic regimen",
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                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "regimen"
                            }
                        }
                    },
                    {
                        "exact_snippets": "must be more than 1 month past the last treatment",
                        "criterion": "time since last treatment",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Age: ≥ 18 years old",
                "criterions": [
                    {
                        "exact_snippets": "Age: ≥ 18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age: ≥ 18 years old",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Performance status: WHO PS grade 0-1 (Appendix B)",
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                    {
                        "exact_snippets": "Performance status: WHO PS grade 0-1",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "WHO PS grade"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "WHO PS grade"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status: WHO PS grade 0-1",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "grade",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "WHO PS grade"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 1,
                                        "unit": "WHO PS grade"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Objectively assessable parameters of life expectancy: more than 3 months",
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                    {
                        "exact_snippets": "life expectancy: more than 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "life expectancy: more than 3 months",
                        "criterion": "life expectancy",
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                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concomitant use of immunosuppressive drugs, hormonal treatment for breast cancer is allowed in case of stable disease",
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                    {
                        "exact_snippets": "No concomitant use of immunosuppressive drugs",
                        "criterion": "immunosuppressive drugs",
                        "requirement": {
                            "requirement_type": "concomitant use",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "hormonal treatment for breast cancer is allowed in case of stable disease",
                        "criterion": "hormonal treatment for breast cancer",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": "in case of stable disease"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "hormonal treatment for breast cancer is allowed in case of stable disease",
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                        "requirement_type": "allowance",
                        "expected_value": "in case of stable disease"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "No concomitant use of immunosuppressive drugs",
                    "criterion": "immunosuppressive drugs",
                    "requirement": {
                        "requirement_type": "concomitant use",
                        "expected_value": false
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                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* Adequate renal and liver function, i.e. creatinin and bilirubin = 1.2 times the upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "Adequate renal ... creatinin ... = 1.2 times the upper limit of normal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate renal ... creatinin ... = 1.2 times the upper limit of normal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "creatinine level",
                            "expected_value": {
                                "operator": "=",
                                "value": 1.2,
                                "unit": "times the upper limit of normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... liver function, ... bilirubin = 1.2 times the upper limit of normal",
                        "criterion": "liver function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Adequate ... liver function, ... bilirubin = 1.2 times the upper limit of normal",
                        "criterion": "liver function",
                        "requirement": {
                            "requirement_type": "bilirubin level",
                            "expected_value": {
                                "operator": "=",
                                "value": 1.2,
                                "unit": "times the upper limit of normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Adequate renal ... creatinin ... = 1.2 times the upper limit of normal",
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                                "requirement": {
                                    "requirement_type": "adequacy",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Adequate renal ... creatinin ... = 1.2 times the upper limit of normal",
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                                    "requirement_type": "creatinine level",
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                                        "operator": "=",
                                        "value": 1.2,
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                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Adequate ... liver function, ... bilirubin = 1.2 times the upper limit of normal",
                                "criterion": "liver function",
                                "requirement": {
                                    "requirement_type": "adequacy",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "Adequate ... liver function, ... bilirubin = 1.2 times the upper limit of normal",
                                "criterion": "liver function",
                                "requirement": {
                                    "requirement_type": "bilirubin level",
                                    "expected_value": {
                                        "operator": "=",
                                        "value": 1.2,
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                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial",
                "criterions": [
                    {
                        "exact_snippets": "Absence of any psychological ... condition potentially hampering compliance with the study protocol and follow-up schedule",
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                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Absence of any ... familial ... condition potentially hampering compliance with the study protocol and follow-up schedule",
                        "criterion": "familial condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Absence of any ... sociological ... condition potentially hampering compliance with the study protocol and follow-up schedule",
                        "criterion": "sociological condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "Absence of any ... geographical condition potentially hampering compliance with the study protocol and follow-up schedule",
                        "criterion": "geographical condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Absence of any psychological ... condition potentially hampering compliance with the study protocol and follow-up schedule",
                                "criterion": "psychological condition",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "Absence of any ... familial ... condition potentially hampering compliance with the study protocol and follow-up schedule",
                                "criterion": "familial condition",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Absence of any ... sociological ... condition potentially hampering compliance with the study protocol and follow-up schedule",
                                "criterion": "sociological condition",
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                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "Absence of any ... geographical condition potentially hampering compliance with the study protocol and follow-up schedule",
                                "criterion": "geographical condition",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Women of child-bearing potential should use adequate contraception prior to study entry and for the duration of study participation",
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                    {
                        "exact_snippets": "Women of child-bearing potential",
                        "criterion": "child-bearing potential",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "use adequate contraception",
                        "criterion": "contraception use",
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                            "requirement_type": "presence",
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                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Women of child-bearing potential",
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                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "exact_snippets": "use adequate contraception",
                    "criterion": "contraception use",
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                        "requirement_type": "presence",
                        "expected_value": true
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                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
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                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
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                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior and concomitant associated diseases allowed with the exception of underlying autoimmune disease and positive serology for HIV/HBV/HCV",
                "criterions": [
                    {
                        "exact_snippets": "underlying autoimmune disease",
                        "criterion": "underlying autoimmune disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "positive serology for HIV",
                        "criterion": "HIV serology",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "positive serology for HBV",
                        "criterion": "HBV serology",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "positive serology for HCV",
                        "criterion": "HCV serology",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "not_criteria": {
                                "exact_snippets": "underlying autoimmune disease",
                                "criterion": "underlying autoimmune disease",
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                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "positive serology for HIV",
                            "criterion": "HIV serology",
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                                "requirement_type": "result",
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                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "positive serology for HBV",
                            "criterion": "HBV serology",
                            "requirement": {
                                "requirement_type": "result",
                                "expected_value": "positive"
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "positive serology for HCV",
                            "criterion": "HCV serology",
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                                "requirement_type": "result",
                                "expected_value": "positive"
                            }
                        }
                    }
                ]
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        }
    ],
    "exclusion_lines": [
        {
            "identified_line": {
                "line": "2. Subjects who are pregnant",
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                    {
                        "exact_snippets": "Subjects who are pregnant",
                        "criterion": "pregnancy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Subjects who are pregnant",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "3. Subjects who have sensitivity to drugs that provide local anesthesia",
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                    {
                        "exact_snippets": "sensitivity to drugs that provide local anesthesia",
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                            "requirement_type": "presence",
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                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "sensitivity to drugs that provide local anesthesia",
                    "criterion": "sensitivity to local anesthesia drugs",
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                        "requirement_type": "presence",
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                    }
                }
            }
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* In primary disease after debulking surgery, Temodal/radiotherapy and Temodal chemotherapy for 6 months",
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                    {
                        "exact_snippets": "primary disease after debulking surgery",
                        "criterion": "primary disease",
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                            "requirement_type": "treatment history",
                            "expected_value": "after debulking surgery"
                        }
                    },
                    {
                        "exact_snippets": "Temodal/radiotherapy",
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                            "requirement_type": "type",
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                                "Temodal",
                                "radiotherapy"
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                        }
                    },
                    {
                        "exact_snippets": "Temodal chemotherapy for 6 months",
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                            "requirement_type": "duration",
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                                "operator": "=",
                                "value": 6,
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                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "primary disease after debulking surgery",
                                "criterion": "primary disease",
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                                    "requirement_type": "treatment history",
                                    "expected_value": "after debulking surgery"
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                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "Temodal/radiotherapy",
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                                    },
                                    {
                                        "exact_snippets": "Temodal/radiotherapy",
                                        "criterion": "treatment",
                                        "requirement": {
                                            "requirement_type": "type",
                                            "expected_value": [
                                                "radiotherapy"
                                            ]
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "Temodal chemotherapy for 6 months",
                        "criterion": "treatment duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [
        {
            "identified_line": {
                "line": "1. Subjects with concurrent additional malignancy (with exception of non-melanoma skin cancers and carcinoma in situ of the cervix)",
                "criterions": [
                    {
                        "exact_snippets": "Subjects with concurrent additional malignancy",
                        "criterion": "concurrent additional malignancy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "with exception of non-melanoma skin cancers",
                        "criterion": "non-melanoma skin cancers",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "carcinoma in situ of the cervix",
                        "criterion": "carcinoma in situ of the cervix",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Subjects with concurrent additional malignancy",
                    "criterion": "concurrent additional malignancy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "and_criteria": [
                        {
                            "not_criteria": {
                                "exact_snippets": "with exception of non-melanoma skin cancers",
                                "criterion": "non-melanoma skin cancers",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        },
                        {
                            "not_criteria": {
                                "exact_snippets": "carcinoma in situ of the cervix",
                                "criterion": "carcinoma in situ of the cervix",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        }
                    ]
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "4. Subjects needing corticosteroids 1 mg/kg during vaccination; corticosteroids are allowed as part of their treatment when taken ≥ 30 days before the start of vaccination.",
                "criterions": [
                    {
                        "exact_snippets": "Subjects needing corticosteroids 1 mg/kg during vaccination",
                        "criterion": "corticosteroid use during vaccination",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "corticosteroids are allowed ... when taken ≥ 30 days before the start of vaccination",
                        "criterion": "corticosteroid use before vaccination",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Subjects needing corticosteroids 1 mg/kg during vaccination",
                    "criterion": "corticosteroid use during vaccination",
                    "requirement": {
                        "requirement_type": "necessity",
                        "expected_value": true
                    }
                },
                "then_criteria": {
                    "not_criteria": {
                        "exact_snippets": "corticosteroids are allowed ... when taken ≥ 30 days before the start of vaccination",
                        "criterion": "corticosteroid use before vaccination",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                },
                "else_criteria": null
            }
        }
    ],
    "failed_miscellaneous": []
}