{
    "info": {
        "nct_id": "NCT00690872",
        "official_title": "Phase II Trial Evaluating Efficacy of a Strategy Employing Combination Gemcitabine and Carboplatin Chemotherapy Followed by EBV-Specific Cytotoxic T-Lymphocytes in Patients With Metastatic or Locally Recurrent EBV-Positive Nasopharyngeal Carcinoma",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 21 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Biopsy-proven nasopharyngeal carcinoma (NPC)\n\n  * WHO type 2/3 disease\n  * Metastatic or locally recurrent disease\n* Epstein-Barr virus (EBV)-positive disease as confirmed by in situ hybridization assay or PCR amplification for EBV-encoded RNA expression\n* Radiologically measurable disease\n\nPATIENT CHARACTERISTICS:\n\n* ECOG performance status 0-2\n* Life expectancy > 3 months\n* ANC > 1,200/mm^3\n* Platelet count ≥ 100,000/mm^3\n* Hemoglobin ≥ 8 g/dL\n* Bilirubin < 2 times upper limit of normal (ULN)\n* AST and ALT < 3 times ULN\n* Creatinine clearance ≥ 40 mL/min\n* Corrected calcium normal\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception\n* No concurrent severe illness, including any of the following:\n\n  * Chronic obstructive pulmonary disease\n  * Ischemic heart disease\n  * Active congestive cardiac failure\n  * Active angina pectoris\n  * Uncontrolled arrhythmia\n  * Uncontrolled hypertension\n* No concurrent severe infections\n* HIV negative\n\nPRIOR CONCURRENT THERAPY:\n\n* No more than one line of prior chemotherapy for metastatic disease\n* No prior gemcitabine hydrochloride\n* Prior platinum agents allowed\n* At least 1 month since prior investigational therapy"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 21 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 21 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 21,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 21 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 21,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Biopsy-proven nasopharyngeal carcinoma (NPC)",
                "criterions": [
                    {
                        "exact_snippets": "Biopsy-proven nasopharyngeal carcinoma (NPC)",
                        "criterion": "nasopharyngeal carcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis method",
                            "expected_value": "biopsy-proven"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Biopsy-proven nasopharyngeal carcinoma (NPC)",
                        "criterion": "nasopharyngeal carcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis method",
                            "expected_value": "biopsy-proven"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WHO type 2/3 disease",
                "criterions": [
                    {
                        "exact_snippets": "WHO type 2/3 disease",
                        "criterion": "disease type",
                        "requirement": {
                            "requirement_type": "classification",
                            "expected_value": [
                                "WHO type 2",
                                "WHO type 3"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WHO type 2/3 disease",
                        "criterion": "disease type",
                        "requirement": {
                            "requirement_type": "classification",
                            "expected_value": [
                                "WHO type 2",
                                "WHO type 3"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Metastatic or locally recurrent disease",
                "criterions": [
                    {
                        "exact_snippets": "Metastatic",
                        "criterion": "metastatic disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "locally recurrent disease",
                        "criterion": "locally recurrent disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Metastatic",
                        "criterion": "metastatic disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "locally recurrent disease",
                        "criterion": "locally recurrent disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Epstein-Barr virus (EBV)-positive disease as confirmed by in situ hybridization assay or PCR amplification for EBV-encoded RNA expression",
                "criterions": [
                    {
                        "exact_snippets": "Epstein-Barr virus (EBV)-positive disease",
                        "criterion": "Epstein-Barr virus (EBV) status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    },
                    {
                        "exact_snippets": "confirmed by in situ hybridization assay",
                        "criterion": "confirmation method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "in situ hybridization assay"
                        }
                    },
                    {
                        "exact_snippets": "confirmed by ... PCR amplification for EBV-encoded RNA expression",
                        "criterion": "confirmation method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "PCR amplification for EBV-encoded RNA expression"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Epstein-Barr virus (EBV)-positive disease",
                                "criterion": "Epstein-Barr virus (EBV) status",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": "positive"
                                }
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "confirmed by in situ hybridization assay",
                                        "criterion": "confirmation method",
                                        "requirement": {
                                            "requirement_type": "method",
                                            "expected_value": "in situ hybridization assay"
                                        }
                                    },
                                    {
                                        "exact_snippets": "confirmed by ... PCR amplification for EBV-encoded RNA expression",
                                        "criterion": "confirmation method",
                                        "requirement": {
                                            "requirement_type": "method",
                                            "expected_value": "PCR amplification for EBV-encoded RNA expression"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Radiologically measurable disease",
                "criterions": [
                    {
                        "exact_snippets": "Radiologically measurable disease",
                        "criterion": "disease",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": "radiologically measurable"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Radiologically measurable disease",
                        "criterion": "disease",
                        "requirement": {
                            "requirement_type": "measurability",
                            "expected_value": "radiologically measurable"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG performance status 0-2",
                "criterions": [
                    {
                        "exact_snippets": "ECOG performance status 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ECOG performance status 0-2",
                        "criterion": "ECOG performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy > 3 months",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy > 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy > 3 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 3,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ANC > 1,200/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "ANC > 1,200/mm^3",
                        "criterion": "ANC",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1200,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "ANC > 1,200/mm^3",
                        "criterion": "ANC",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1200,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count ≥ 100,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin ≥ 8 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin < 2 times upper limit of normal (ULN)",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin < 2 times upper limit of normal (ULN)",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times upper limit of normal (ULN)"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin < 2 times upper limit of normal (ULN)",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<",
                                "value": 2,
                                "unit": "times upper limit of normal (ULN)"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST and ALT < 3 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "AST and ALT < 3 times ULN",
                        "criterion": "AST",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AST and ALT < 3 times ULN",
                        "criterion": "ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "AST and ALT < 3 times ULN",
                        "criterion": "AST",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AST and ALT < 3 times ULN",
                        "criterion": "ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Chronic obstructive pulmonary disease",
                "criterions": [
                    {
                        "exact_snippets": "Chronic obstructive pulmonary disease",
                        "criterion": "chronic obstructive pulmonary disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chronic obstructive pulmonary disease",
                        "criterion": "chronic obstructive pulmonary disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Ischemic heart disease",
                "criterions": [
                    {
                        "exact_snippets": "Ischemic heart disease",
                        "criterion": "ischemic heart disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Ischemic heart disease",
                        "criterion": "ischemic heart disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active congestive cardiac failure",
                "criterions": [
                    {
                        "exact_snippets": "Active congestive cardiac failure",
                        "criterion": "congestive cardiac failure",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Active congestive cardiac failure",
                        "criterion": "congestive cardiac failure",
                        "requirement": {
                            "requirement_type": "activity",
                            "expected_value": "active"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Active angina pectoris",
                "criterions": [
                    {
                        "exact_snippets": "Active angina pectoris",
                        "criterion": "angina pectoris",
                        "requirement": {
                            "requirement_type": "activity status",
                            "expected_value": "active"
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Active angina pectoris",
                    "criterion": "angina pectoris",
                    "requirement": {
                        "requirement_type": "activity status",
                        "expected_value": "active"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled arrhythmia",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled arrhythmia",
                        "criterion": "arrhythmia",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Uncontrolled arrhythmia",
                        "criterion": "arrhythmia",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Uncontrolled hypertension",
                "criterions": [
                    {
                        "exact_snippets": "Uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "uncontrolled"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Uncontrolled hypertension",
                        "criterion": "hypertension",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "uncontrolled"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* HIV negative",
                "criterions": [
                    {
                        "exact_snippets": "HIV negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "HIV negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
                "criterions": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No more than one line of prior chemotherapy for metastatic disease",
                "criterions": [
                    {
                        "exact_snippets": "No more than one line of prior chemotherapy for metastatic disease",
                        "criterion": "prior chemotherapy for metastatic disease",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "line"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No more than one line of prior chemotherapy for metastatic disease",
                        "criterion": "prior chemotherapy for metastatic disease",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "line"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior platinum agents allowed",
                "criterions": [
                    {
                        "exact_snippets": "Prior platinum agents allowed",
                        "criterion": "prior platinum agents",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Prior platinum agents allowed",
                        "criterion": "prior platinum agents",
                        "requirement": {
                            "requirement_type": "allowance",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 1 month since prior investigational therapy",
                "criterions": [
                    {
                        "exact_snippets": "At least 1 month since prior investigational therapy",
                        "criterion": "time since prior investigational therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 1 month since prior investigational therapy",
                        "criterion": "time since prior investigational therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Creatinine clearance ≥ 40 mL/min",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine clearance ≥ 40 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">=",
                                "value": 40,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Corrected calcium normal",
                "criterions": [
                    {
                        "exact_snippets": "Corrected calcium normal",
                        "criterion": "corrected calcium",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "normal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception",
                "criterions": [
                    {
                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "effectiveness",
                            "expected_value": "effective"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent severe illness, including any of the following:",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent severe illness",
                        "criterion": "severe illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent severe infections",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent severe infections",
                        "criterion": "severe infections",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent severe infections",
                    "criterion": "severe infections",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No prior gemcitabine hydrochloride",
                "criterions": [
                    {
                        "exact_snippets": "No prior gemcitabine hydrochloride",
                        "criterion": "prior gemcitabine hydrochloride",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior gemcitabine hydrochloride",
                    "criterion": "prior gemcitabine hydrochloride",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}