{
    "info": {
        "nct_id": "NCT00665782",
        "official_title": "Stress Measures in Women With Newly Diagnosed Breast Cancer",
        "inclusion_criteria": "* Diagnosed with stage I-III invasive breast cancer or ductal carcinoma in situ of the breast within the past 2 weeks\n* Surgery for breast cancer planned\n* Hormone receptor status not specified\n* Female\n* Menopausal status not specified\n* Able to refrain from:\n\n  * Smoking cigarettes for the 24-hour period of saliva-sample collection\n  * Brushing teeth or eating for up to one hour prior to saliva collection\n* More than 1 year since prior therapy for another malignancy\n* At least 1 month since prior withdrawal from hormone-replacement product\n* Able to refrain from steroid inhalers for greater than 24 hours\n* No chronic oral steroids\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 120 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "* Diagnosed with stage I-III invasive breast cancer or ductal carcinoma in situ of the breast within the past 2 weeks",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosed with stage I-III invasive breast cancer",
                        "criterion": "invasive breast cancer",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 1,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 3,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "ductal carcinoma in situ of the breast",
                        "criterion": "ductal carcinoma in situ",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "within the past 2 weeks",
                        "criterion": "diagnosis timing",
                        "requirement": {
                            "requirement_type": "time since diagnosis",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Diagnosed with stage I-III invasive breast cancer",
                                "criterion": "invasive breast cancer",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": ">=",
                                                "value": 1,
                                                "unit": "N/A"
                                            },
                                            {
                                                "operator": "<=",
                                                "value": 3,
                                                "unit": "N/A"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
                                "exact_snippets": "within the past 2 weeks",
                                "criterion": "diagnosis timing",
                                "requirement": {
                                    "requirement_type": "time since diagnosis",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "ductal carcinoma in situ of the breast",
                                "criterion": "ductal carcinoma in situ",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "within the past 2 weeks",
                                "criterion": "diagnosis timing",
                                "requirement": {
                                    "requirement_type": "time since diagnosis",
                                    "expected_value": {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "weeks"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Surgery for breast cancer planned",
                "criterions": [
                    {
                        "exact_snippets": "Surgery for breast cancer planned",
                        "criterion": "surgery for breast cancer",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgery for breast cancer planned",
                        "criterion": "surgery for breast cancer",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hormone receptor status not specified",
                "criterions": [
                    {
                        "exact_snippets": "Hormone receptor status",
                        "criterion": "hormone receptor status",
                        "requirement": {
                            "requirement_type": "specification",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hormone receptor status",
                        "criterion": "hormone receptor status",
                        "requirement": {
                            "requirement_type": "specification",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Female",
                "criterions": [
                    {
                        "exact_snippets": "Female",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Female",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Menopausal status not specified",
                "criterions": [
                    {
                        "exact_snippets": "Menopausal status",
                        "criterion": "menopausal status",
                        "requirement": {
                            "requirement_type": "specification",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Menopausal status",
                        "criterion": "menopausal status",
                        "requirement": {
                            "requirement_type": "specification",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Able to refrain from:",
                "criterions": [
                    {
                        "exact_snippets": "Able to refrain from",
                        "criterion": "refrain from certain activities",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Able to refrain from",
                        "criterion": "refrain from certain activities",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Smoking cigarettes for the 24-hour period of saliva-sample collection",
                "criterions": [
                    {
                        "exact_snippets": "Smoking cigarettes for the 24-hour period of saliva-sample collection",
                        "criterion": "smoking",
                        "requirement": {
                            "requirement_type": "time period",
                            "expected_value": "24-hour period of saliva-sample collection"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Smoking cigarettes for the 24-hour period of saliva-sample collection",
                        "criterion": "smoking",
                        "requirement": {
                            "requirement_type": "time period",
                            "expected_value": "24-hour period of saliva-sample collection"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Brushing teeth or eating for up to one hour prior to saliva collection",
                "criterions": [
                    {
                        "exact_snippets": "Brushing teeth ... for up to one hour prior to saliva collection",
                        "criterion": "brushing teeth",
                        "requirement": {
                            "requirement_type": "time before saliva collection",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "hour"
                            }
                        }
                    },
                    {
                        "exact_snippets": "eating for up to one hour prior to saliva collection",
                        "criterion": "eating",
                        "requirement": {
                            "requirement_type": "time before saliva collection",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "hour"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Brushing teeth ... for up to one hour prior to saliva collection",
                        "criterion": "brushing teeth",
                        "requirement": {
                            "requirement_type": "time before saliva collection",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "hour"
                            }
                        }
                    },
                    {
                        "exact_snippets": "eating for up to one hour prior to saliva collection",
                        "criterion": "eating",
                        "requirement": {
                            "requirement_type": "time before saliva collection",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1,
                                "unit": "hour"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* More than 1 year since prior therapy for another malignancy",
                "criterions": [
                    {
                        "exact_snippets": "More than 1 year since prior therapy for another malignancy",
                        "criterion": "time since prior therapy for another malignancy",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "More than 1 year since prior therapy for another malignancy",
                        "criterion": "time since prior therapy for another malignancy",
                        "requirement": {
                            "requirement_type": "time elapsed",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 1 month since prior withdrawal from hormone-replacement product",
                "criterions": [
                    {
                        "exact_snippets": "At least 1 month since prior withdrawal from hormone-replacement product",
                        "criterion": "withdrawal from hormone-replacement product",
                        "requirement": {
                            "requirement_type": "time since withdrawal",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 1 month since prior withdrawal from hormone-replacement product",
                        "criterion": "withdrawal from hormone-replacement product",
                        "requirement": {
                            "requirement_type": "time since withdrawal",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "month"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Able to refrain from steroid inhalers for greater than 24 hours",
                "criterions": [
                    {
                        "exact_snippets": "Able to refrain from steroid inhalers for greater than 24 hours",
                        "criterion": "use of steroid inhalers",
                        "requirement": {
                            "requirement_type": "abstinence duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 24,
                                "unit": "hours"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Able to refrain from steroid inhalers for greater than 24 hours",
                        "criterion": "use of steroid inhalers",
                        "requirement": {
                            "requirement_type": "abstinence duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 24,
                                "unit": "hours"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must be FEMALE",
                "criterions": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Must be FEMALE",
                        "criterion": "gender",
                        "requirement": {
                            "requirement_type": "expected_value",
                            "expected_value": "female"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have maximum age of 120 Years",
                "criterions": [
                    {
                        "exact_snippets": "maximum age of 120 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "maximum age of 120 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [],
    "failed_inclusion": [
        {
            "identified_line": {
                "line": "* No chronic oral steroids",
                "criterions": [
                    {
                        "exact_snippets": "No chronic oral steroids",
                        "criterion": "chronic oral steroid use",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No chronic oral steroids",
                    "criterion": "chronic oral steroid use",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}