{
    "info": {
        "nct_id": "NCT00462657",
        "official_title": "Early Diagnosis of Invasive Aspergillosis in a High Risk Group of Patients Using Serum and Bronchoalveolar Lavage Fluid Real Time PCR and Galactomannan ELISA",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* At high risk for developing invasive aspergillosis (IA) due to any of the following risk factors:\n\n  * Diagnosis of acute myeloid leukemia, myelodysplastic syndromes, or acute lymphoblastic leukemia AND meets ≥ 1 of the following criteria:\n\n    * Receiving intensive chemotherapy with expected duration of neutropenia (ANC < 500/mm³) of > 10 days\n    * Receiving high-dose steroids\n  * Concurrent treatment with allogeneic hematopoietic stem cell transplantation (HSCT)\n  * Requirement for high-dose steroids for graft-versus-host disease after HSCT\n  * History of probable or proven IA and receiving chemotherapy\n* No preexisting chest disease\n\nPATIENT CHARACTERISTICS:\n\n* Not specified\n\nPRIOR CONCURRENT THERAPY:\n\n* See Disease Characteristics"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At high risk for developing invasive aspergillosis (IA) due to any of the following risk factors:",
                "criterions": [
                    {
                        "exact_snippets": "high risk for developing invasive aspergillosis (IA)",
                        "criterion": "risk for developing invasive aspergillosis (IA)",
                        "requirement": {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "high risk for developing invasive aspergillosis (IA)",
                        "criterion": "risk for developing invasive aspergillosis (IA)",
                        "requirement": {
                            "requirement_type": "risk level",
                            "expected_value": "high"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Receiving intensive chemotherapy with expected duration of neutropenia (ANC < 500/mm³) of > 10 days",
                "criterions": [
                    {
                        "exact_snippets": "Receiving intensive chemotherapy",
                        "criterion": "intensive chemotherapy",
                        "requirement": {
                            "requirement_type": "receiving",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "expected duration of neutropenia (ANC < 500/mm³) of > 10 days",
                        "criterion": "neutropenia duration",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">",
                                        "value": 10,
                                        "unit": "days"
                                    }
                                ]
                            }
                        }
                    },
                    {
                        "exact_snippets": "expected duration of neutropenia (ANC < 500/mm³) of > 10 days",
                        "criterion": "neutropenia duration",
                        "requirement": {
                            "requirement_type": "ANC",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": "<",
                                        "value": 500,
                                        "unit": "mm³"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Receiving intensive chemotherapy",
                        "criterion": "intensive chemotherapy",
                        "requirement": {
                            "requirement_type": "receiving",
                            "expected_value": true
                        }
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "expected duration of neutropenia (ANC < 500/mm³) of > 10 days",
                                "criterion": "neutropenia duration",
                                "requirement": {
                                    "requirement_type": "duration",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": ">",
                                                "value": 10,
                                                "unit": "days"
                                            }
                                        ]
                                    }
                                }
                            },
                            {
                                "exact_snippets": "expected duration of neutropenia (ANC < 500/mm³) of > 10 days",
                                "criterion": "neutropenia duration",
                                "requirement": {
                                    "requirement_type": "ANC",
                                    "expected_value": {
                                        "comparisons": [
                                            {
                                                "operator": "<",
                                                "value": 500,
                                                "unit": "mm³"
                                            }
                                        ]
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Receiving high-dose steroids",
                "criterions": [
                    {
                        "exact_snippets": "Receiving high-dose steroids",
                        "criterion": "steroid dosage",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": "high-dose"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Receiving high-dose steroids",
                        "criterion": "steroid dosage",
                        "requirement": {
                            "requirement_type": "dosage",
                            "expected_value": "high-dose"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Concurrent treatment with allogeneic hematopoietic stem cell transplantation (HSCT)",
                "criterions": [
                    {
                        "exact_snippets": "Concurrent treatment with allogeneic hematopoietic stem cell transplantation (HSCT)",
                        "criterion": "allogeneic hematopoietic stem cell transplantation (HSCT)",
                        "requirement": {
                            "requirement_type": "concurrent treatment",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Concurrent treatment with allogeneic hematopoietic stem cell transplantation (HSCT)",
                        "criterion": "allogeneic hematopoietic stem cell transplantation (HSCT)",
                        "requirement": {
                            "requirement_type": "concurrent treatment",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Requirement for high-dose steroids for graft-versus-host disease after HSCT",
                "criterions": [
                    {
                        "exact_snippets": "Requirement for high-dose steroids for graft-versus-host disease after HSCT",
                        "criterion": "high-dose steroids",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "graft-versus-host disease after HSCT",
                        "criterion": "graft-versus-host disease",
                        "requirement": {
                            "requirement_type": "post-HSCT",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Requirement for high-dose steroids for graft-versus-host disease after HSCT",
                        "criterion": "high-dose steroids",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "graft-versus-host disease after HSCT",
                        "criterion": "graft-versus-host disease",
                        "requirement": {
                            "requirement_type": "post-HSCT",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* History of probable or proven IA and receiving chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "History of probable or proven IA",
                        "criterion": "IA (Invasive Aspergillosis)",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "receiving chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "current treatment",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "History of probable or proven IA",
                        "criterion": "IA (Invasive Aspergillosis)",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "receiving chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "current treatment",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
                "criterions": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* See Disease Characteristics",
                "criterions": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "see details"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "see details"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Diagnosis of acute myeloid leukemia, myelodysplastic syndromes, or acute lymphoblastic leukemia AND meets ≥ 1 of the following criteria:",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of acute myeloid leukemia",
                        "criterion": "acute myeloid leukemia",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosis of ... myelodysplastic syndromes",
                        "criterion": "myelodysplastic syndromes",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Diagnosis of ... acute lymphoblastic leukemia",
                        "criterion": "acute lymphoblastic leukemia",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No preexisting chest disease",
                "criterions": [
                    {
                        "exact_snippets": "No preexisting chest disease",
                        "criterion": "chest disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No preexisting chest disease",
                    "criterion": "chest disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}