{
    "info": {
        "nct_id": "NCT00354601",
        "official_title": "A Phase II Study of Weekly Docetaxel and Capecitabine for Persistent or Recurrent Platinum Resistant Epithelial Carcinoma of the Ovary, Fallopian Tube or Peritoneum",
        "inclusion_criteria": "DISEASE CHARACTERISTICS:\n\n* Diagnosis of 1 of the following:\n\n  * Ovarian epithelial adenocarcinoma\n  * Fallopian tube cancer\n  * Peritoneal cavity cancer\n* Recurrent or persistent disease after no more than 2 prior treatment regimens (1 regimen for primary disease and/or 1 regimen for recurrent disease)\n* Platinum-resistant disease, defined as 1 of the following:\n\n  * Treatment-free interval < 6 months after platinum-based therapy\n  * Disease progression during platinum-based therapy\n* Measurable disease by physical exam, chest x-ray, CT scan, or MRI\n* No brain metastases\n\nPATIENT CHARACTERISTICS:\n\n* Gynecologic Oncology Group performance status 0-2\n* Life expectancy > 6 months\n* Absolute neutrophil count ≥ 1,500/mm³\n* Platelet count ≥ 100,000/mm³\n* Hemoglobin ≥ 8 g/dL\n* Creatinine clearance ≥ 50 mL/min\n* Bilirubin normal\n* AST or ALT and alkaline phosphatase (AP) meeting 1 of the following criteria:\n\n  * AST or ALT ≤ 5 times upper limit of normal (ULN) AND AP normal\n  * AST or ALT ≤ 1.5 times ULN AND AP ≤ 2.5 times ULN\n  * AST or ALT normal AND AP ≤ 5 times ULN\n* No peripheral neuropathy > grade 2\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception during and for 6 months after completion of study treatment\n* No other concurrent malignancy except for curatively treated nonmelanoma skin cancer\n* No prior invasive malignancy < 5 years after curative therapy\n* No serious uncontrolled medical or psychiatric illness that would preclude study participation or limit survival to < 6 months\n* No history of severe hypersensitivity reaction to drugs formulated with polysorbate 80 or to fluoropyrimidine therapy or fluorouracil\n* No inability to tolerate oral medication due to bowel obstruction, lack of physical integrity of the upper gastrointestinal tract, inability to swallow, or malabsorption syndrome\n* No serious concurrent infections\n* No clinically significant cardiac disease not well controlled with medication, including any of the following:\n\n  * Congestive heart failure\n  * Symptomatic coronary artery disease\n  * Symptomatic cardiac arrhythmias\n  * Myocardial infarction within the past 12 months\n\nPRIOR CONCURRENT THERAPY:\n\n* See Disease Characteristics\n* No prior docetaxel or capecitabine or other fluoropyrimidine therapy\n* Recovered from prior therapy\n* At least 2 weeks since prior major surgery\n* At least 4 weeks since prior chemotherapy, hormone therapy, or radiotherapy\n* No other concurrent chemotherapeutic agents, biological therapy, radiotherapy, or other investigational agents\nHealthy volunteers allowed\nMust be FEMALE\nMust have minimum age of 18 Years\nMust have maximum age of 120 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Diagnosis of 1 of the following:",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of 1 of the following",
                        "criterion": "diagnosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosis of 1 of the following",
                        "criterion": "diagnosis",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Ovarian epithelial adenocarcinoma",
                "criterions": [
                    {
                        "exact_snippets": "Ovarian epithelial adenocarcinoma",
                        "criterion": "ovarian epithelial adenocarcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Ovarian epithelial adenocarcinoma",
                        "criterion": "ovarian epithelial adenocarcinoma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fallopian tube cancer",
                "criterions": [
                    {
                        "exact_snippets": "Fallopian tube cancer",
                        "criterion": "fallopian tube cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Fallopian tube cancer",
                        "criterion": "fallopian tube cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Peritoneal cavity cancer",
                "criterions": [
                    {
                        "exact_snippets": "Peritoneal cavity cancer",
                        "criterion": "peritoneal cavity cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Peritoneal cavity cancer",
                        "criterion": "peritoneal cavity cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Recurrent or persistent disease after no more than 2 prior treatment regimens (1 regimen for primary disease and/or 1 regimen for recurrent disease)",
                "criterions": [
                    {
                        "exact_snippets": "Recurrent or persistent disease",
                        "criterion": "disease status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "recurrent",
                                "persistent"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "no more than 2 prior treatment regimens",
                        "criterion": "prior treatment regimens",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "regimens"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Recurrent or persistent disease",
                        "criterion": "disease status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": [
                                "recurrent",
                                "persistent"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "no more than 2 prior treatment regimens",
                        "criterion": "prior treatment regimens",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "regimens"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platinum-resistant disease, defined as 1 of the following:",
                "criterions": [
                    {
                        "exact_snippets": "Platinum-resistant disease",
                        "criterion": "platinum-resistant disease",
                        "requirement": {
                            "requirement_type": "definition",
                            "expected_value": "1 of the following"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platinum-resistant disease",
                        "criterion": "platinum-resistant disease",
                        "requirement": {
                            "requirement_type": "definition",
                            "expected_value": "1 of the following"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Treatment-free interval < 6 months after platinum-based therapy",
                "criterions": [
                    {
                        "exact_snippets": "Treatment-free interval < 6 months",
                        "criterion": "treatment-free interval",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "after platinum-based therapy",
                        "criterion": "prior therapy",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "platinum-based"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Treatment-free interval < 6 months",
                        "criterion": "treatment-free interval",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": "<",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    },
                    {
                        "exact_snippets": "after platinum-based therapy",
                        "criterion": "prior therapy",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "platinum-based"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Disease progression during platinum-based therapy",
                "criterions": [
                    {
                        "exact_snippets": "Disease progression during platinum-based therapy",
                        "criterion": "disease progression",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "during platinum-based therapy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Disease progression during platinum-based therapy",
                        "criterion": "disease progression",
                        "requirement": {
                            "requirement_type": "timing",
                            "expected_value": "during platinum-based therapy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No brain metastases",
                "criterions": [
                    {
                        "exact_snippets": "No brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Gynecologic Oncology Group performance status 0-2",
                "criterions": [
                    {
                        "exact_snippets": "Gynecologic Oncology Group performance status 0-2",
                        "criterion": "Gynecologic Oncology Group performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Gynecologic Oncology Group performance status 0-2",
                        "criterion": "Gynecologic Oncology Group performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Life expectancy > 6 months",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy > 6 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy > 6 months",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count ≥ 1,500/mm³",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,500/mm³",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute neutrophil count ≥ 1,500/mm³",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count ≥ 100,000/mm³",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000/mm³",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count ≥ 100,000/mm³",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm³"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin ≥ 8 g/dL",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin ≥ 8 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">=",
                                "value": 8,
                                "unit": "g/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine clearance ≥ 50 mL/min",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine clearance ≥ 50 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine clearance ≥ 50 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin normal",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin normal",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "normal"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin normal",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "normal"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST or ALT and alkaline phosphatase (AP) meeting 1 of the following criteria:",
                "criterions": [
                    {
                        "exact_snippets": "AST or ALT",
                        "criterion": "AST or ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "meeting 1 of the following criteria"
                        }
                    },
                    {
                        "exact_snippets": "alkaline phosphatase (AP)",
                        "criterion": "alkaline phosphatase (AP)",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "meeting 1 of the following criteria"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "AST or ALT",
                                "criterion": "AST or ALT",
                                "requirement": {
                                    "requirement_type": "level",
                                    "expected_value": "meeting 1 of the following criteria"
                                }
                            },
                            {
                                "exact_snippets": "alkaline phosphatase (AP)",
                                "criterion": "alkaline phosphatase (AP)",
                                "requirement": {
                                    "requirement_type": "level",
                                    "expected_value": "meeting 1 of the following criteria"
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST or ALT ≤ 1.5 times ULN AND AP ≤ 2.5 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "AST or ALT ≤ 1.5 times ULN",
                        "criterion": "AST or ALT levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AP ≤ 2.5 times ULN",
                        "criterion": "AP levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "AST or ALT ≤ 1.5 times ULN",
                        "criterion": "AST or ALT levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "AP ≤ 2.5 times ULN",
                        "criterion": "AP levels",
                        "requirement": {
                            "requirement_type": "comparison",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* AST or ALT normal AND AP ≤ 5 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "AST or ALT normal",
                        "criterion": "AST or ALT levels",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "normal"
                        }
                    },
                    {
                        "exact_snippets": "AP ≤ 5 times ULN",
                        "criterion": "AP levels",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "AST or ALT normal",
                        "criterion": "AST or ALT levels",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": "normal"
                        }
                    },
                    {
                        "exact_snippets": "AP ≤ 5 times ULN",
                        "criterion": "AP levels",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No serious concurrent infections",
                "criterions": [
                    {
                        "exact_snippets": "No serious concurrent infections",
                        "criterion": "concurrent infections",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not serious"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No serious concurrent infections",
                        "criterion": "concurrent infections",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not serious"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Congestive heart failure",
                "criterions": [
                    {
                        "exact_snippets": "Congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Symptomatic coronary artery disease",
                "criterions": [
                    {
                        "exact_snippets": "Symptomatic coronary artery disease",
                        "criterion": "coronary artery disease",
                        "requirement": {
                            "requirement_type": "symptomatic",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Symptomatic coronary artery disease",
                        "criterion": "coronary artery disease",
                        "requirement": {
                            "requirement_type": "symptomatic",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Symptomatic cardiac arrhythmias",
                "criterions": [
                    {
                        "exact_snippets": "Symptomatic cardiac arrhythmias",
                        "criterion": "cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "symptomatic",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Symptomatic cardiac arrhythmias",
                        "criterion": "cardiac arrhythmias",
                        "requirement": {
                            "requirement_type": "symptomatic",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Myocardial infarction within the past 12 months",
                "criterions": [
                    {
                        "exact_snippets": "Myocardial infarction within the past 12 months",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "occurrence",
                            "expected_value": {
                                "operator": "<=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Myocardial infarction within the past 12 months",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "occurrence",
                            "expected_value": {
                                "operator": "<=",
                                "value": 12,
                                "unit": "months"
                            }
                        }
                    }
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        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                            "requirement_type": "presence",
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                ]
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            "logical_structure": {
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                    }
                ]
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        },
        {
            "identified_line": {
                "line": "* See Disease Characteristics",
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                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
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                            "requirement_type": "N/A",
                            "expected_value": "refer to disease characteristics section"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
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                            "requirement_type": "N/A",
                            "expected_value": "refer to disease characteristics section"
                        }
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        },
        {
            "identified_line": {
                "line": "* No prior docetaxel or capecitabine or other fluoropyrimidine therapy",
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                    {
                        "exact_snippets": "No prior docetaxel",
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                            "requirement_type": "presence",
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                    },
                    {
                        "exact_snippets": "No prior ... capecitabine",
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                    {
                        "exact_snippets": "No prior ... other fluoropyrimidine therapy",
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                        "and_criteria": [
                            {
                                "exact_snippets": "No prior docetaxel",
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                                    "requirement_type": "presence",
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                                }
                            },
                            {
                                "exact_snippets": "No prior ... capecitabine",
                                "criterion": "prior capecitabine therapy",
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                                    "requirement_type": "presence",
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                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "No prior ... other fluoropyrimidine therapy",
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                "line": "* Recovered from prior therapy",
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                    {
                        "exact_snippets": "Recovered from prior therapy",
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                            "requirement_type": "status",
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                    }
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            "logical_structure": {
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                    {
                        "exact_snippets": "Recovered from prior therapy",
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                            "requirement_type": "status",
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        {
            "identified_line": {
                "line": "* At least 2 weeks since prior major surgery",
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                    {
                        "exact_snippets": "At least 2 weeks since prior major surgery",
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
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            "logical_structure": {
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                    {
                        "exact_snippets": "At least 2 weeks since prior major surgery",
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
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                ]
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        },
        {
            "identified_line": {
                "line": "* At least 4 weeks since prior chemotherapy, hormone therapy, or radiotherapy",
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                    {
                        "exact_snippets": "At least 4 weeks since prior chemotherapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
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                    {
                        "exact_snippets": "At least 4 weeks since prior ... hormone therapy",
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                            "requirement_type": "duration",
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                                "value": 4,
                                "unit": "weeks"
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                    {
                        "exact_snippets": "At least 4 weeks since prior ... radiotherapy",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 4,
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            "logical_structure": {
                "and_criteria": [
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                            {
                                "exact_snippets": "At least 4 weeks since prior chemotherapy",
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                                        "operator": ">=",
                                        "value": 4,
                                        "unit": "weeks"
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                                "exact_snippets": "At least 4 weeks since prior ... hormone therapy",
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                                "exact_snippets": "At least 4 weeks since prior ... radiotherapy",
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                                        "operator": ">=",
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                        ]
                    }
                ]
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        },
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            "identified_line": {
                "line": "* No other concurrent chemotherapeutic agents, biological therapy, radiotherapy, or other investigational agents",
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                        "exact_snippets": "No other concurrent chemotherapeutic agents",
                        "criterion": "concurrent chemotherapeutic agents",
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                    {
                        "exact_snippets": "No other concurrent ... biological therapy",
                        "criterion": "concurrent biological therapy",
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                        }
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                    {
                        "exact_snippets": "No other concurrent ... radiotherapy",
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                    {
                        "exact_snippets": "No other concurrent ... investigational agents",
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                        }
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                ]
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                    {
                        "exact_snippets": "No other concurrent ... biological therapy",
                        "criterion": "concurrent biological therapy",
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                        }
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                    {
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                        }
                    }
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            "identified_line": {
                "line": "Healthy volunteers allowed",
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                            "requirement_type": "status",
                            "expected_value": "healthy"
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                        "exact_snippets": "Healthy volunteers allowed",
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            "identified_line": {
                "line": "Must be FEMALE",
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                        "exact_snippets": "Must be FEMALE",
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                            "requirement_type": "expected_value",
                            "expected_value": "female"
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                    }
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                        "exact_snippets": "Must be FEMALE",
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                            "expected_value": "female"
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                    }
                ]
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        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
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                        "exact_snippets": "minimum age of 18 Years",
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                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
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                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "minimum age of 18 Years",
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                            "requirement_type": "minimum",
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                                "operator": ">=",
                                "value": 18,
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            "identified_line": {
                "line": "Must have maximum age of 120 Years",
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                        "exact_snippets": "maximum age of 120 Years",
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                            "requirement_type": "maximum",
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                                "operator": "<=",
                                "value": 120,
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                        "exact_snippets": "maximum age of 120 Years",
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                            "requirement_type": "maximum",
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                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
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                        }
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        },
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            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
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        },
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                "line": "* Not pregnant or nursing",
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                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
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                            "requirement_type": "status",
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                    },
                    {
                        "exact_snippets": "not ... nursing",
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                            "expected_value": false
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                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
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                            "requirement_type": "status",
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                    },
                    {
                        "exact_snippets": "not ... nursing",
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                        "criterion": "hypersensitivity reaction to drugs formulated with polysorbate 80",
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                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No history of severe hypersensitivity reaction ... to fluoropyrimidine therapy",
                        "criterion": "hypersensitivity reaction to fluoropyrimidine therapy",
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                            "requirement_type": "history",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No history of severe hypersensitivity reaction ... to fluorouracil",
                        "criterion": "hypersensitivity reaction to fluorouracil",
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                            "requirement_type": "history",
                            "expected_value": false
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                    }
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                                    "requirement_type": "history",
                                    "expected_value": false
                                }
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                            {
                                "exact_snippets": "No history of severe hypersensitivity reaction ... to fluoropyrimidine therapy",
                                "criterion": "hypersensitivity reaction to fluoropyrimidine therapy",
                                "requirement": {
                                    "requirement_type": "history",
                                    "expected_value": false
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                            }
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                    {
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                            "expected_value": false
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                ]
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    ],
    "exclusion_lines": [],
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                "line": "* Measurable disease by physical exam, chest x-ray, CT scan, or MRI",
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                        "exact_snippets": "Measurable disease by physical exam, chest x-ray, CT scan, or MRI",
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                            "requirement_type": "detection method",
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                                "physical exam",
                                "chest x-ray",
                                "CT scan",
                                "MRI"
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                            "requirement_type": "detection method",
                            "expected_value": "physical exam"
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                        "exact_snippets": "Measurable disease by physical exam, chest x-ray, CT scan, or MRI",
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                            "requirement_type": "detection method",
                            "expected_value": "chest x-ray"
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                            "requirement_type": "detection method",
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                            "requirement_type": "detection method",
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                                        "unit": "times ULN"
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                                        "operator": "<=",
                                        "value": 5,
                                        "unit": "times ULN"
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                "line": "* No peripheral neuropathy > grade 2",
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                        "exact_snippets": "No peripheral neuropathy > grade 2",
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                            "requirement_type": "severity",
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                                "operator": "<=",
                                "value": 2,
                                "unit": "grade"
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                "not_criteria": {
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                            "operator": ">",
                            "value": 2,
                            "unit": "grade"
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            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
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                        "exact_snippets": "Negative pregnancy test",
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                            "requirement_type": "result",
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        },
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                "line": "* Fertile patients must use effective contraception during and for 6 months after completion of study treatment",
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                            "requirement_type": "status",
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                    {
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                            "requirement_type": "necessity",
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        },
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                "line": "* No other concurrent malignancy except for curatively treated nonmelanoma skin cancer",
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                        "exact_snippets": "No other concurrent malignancy",
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                            "requirement_type": "presence",
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                    {
                        "exact_snippets": "except for curatively treated nonmelanoma skin cancer",
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            "identified_line": {
                "line": "* No prior invasive malignancy < 5 years after curative therapy",
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                        "exact_snippets": "No prior invasive malignancy < 5 years after curative therapy",
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                            "requirement_type": "time since curative therapy",
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                                "operator": "<",
                                "value": 5,
                                "unit": "years"
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                    "requirement_type": "failed",
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                "line": "* No serious uncontrolled medical or psychiatric illness that would preclude study participation or limit survival to < 6 months",
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                    {
                        "exact_snippets": "serious uncontrolled medical ... illness",
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                    {
                        "exact_snippets": "serious uncontrolled ... psychiatric illness",
                        "criterion": "uncontrolled psychiatric illness",
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                            "requirement_type": "severity",
                            "expected_value": "not serious"
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                    },
                    {
                        "exact_snippets": "limit survival to < 6 months",
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                            "requirement_type": "duration",
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                                "operator": "<",
                                "value": 6,
                                "unit": "months"
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                        }
                    }
                ]
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            "logical_structure": {
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        {
            "identified_line": {
                "line": "* No inability to tolerate oral medication due to bowel obstruction, lack of physical integrity of the upper gastrointestinal tract, inability to swallow, or malabsorption syndrome",
                "criterions": [
                    {
                        "exact_snippets": "inability to tolerate oral medication due to bowel obstruction",
                        "criterion": "bowel obstruction",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "inability to tolerate oral medication due to ... lack of physical integrity of the upper gastrointestinal tract",
                        "criterion": "physical integrity of the upper gastrointestinal tract",
                        "requirement": {
                            "requirement_type": "integrity",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "inability to tolerate oral medication due to ... inability to swallow",
                        "criterion": "ability to swallow",
                        "requirement": {
                            "requirement_type": "ability",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "inability to tolerate oral medication due to ... malabsorption syndrome",
                        "criterion": "malabsorption syndrome",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No clinically significant cardiac disease not well controlled with medication, including any of the following:",
                "criterions": [
                    {
                        "exact_snippets": "clinically significant cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    },
                    {
                        "exact_snippets": "clinically significant cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "clinically significant cardiac disease",
                                "criterion": "cardiac disease",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": "clinically significant"
                                }
                            },
                            {
                                "not_criteria": {
                                    "exact_snippets": "clinically significant cardiac disease",
                                    "criterion": "cardiac disease",
                                    "requirement": {
                                        "requirement_type": "control",
                                        "expected_value": true
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        }
    ],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}