{
    "info": {
        "nct_id": "NCT00093548",
        "official_title": "A Phase I/II Trial Testing Immunization With AFP + GM-CSF Plasmid Prime And AFP Adenoviral Vector Boost In Patients With Hepatocellular Carcinoma (AFP Prime-Boost Protocol)",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Diagnosis of hepatocellular carcinoma\n\n  * Stage II-IVA disease\n\n    * No active disease after local or regional therapy (e.g., surgical resection, radiofrequency ablation, cryoablation, or ethanol injection)\n* Serum alpha fetoprotein > upper limit of normal\n* HLA-A*0201 positive by DNA subtyping\n\nPATIENT CHARACTERISTICS:\n\nAge\n\n* Over 18\n\nPerformance status\n\n* Karnofsky 70-100%\n\nLife expectancy\n\n* Not specified\n\nHematopoietic\n\n* Hemoglobin > 9.0 g/dL (transfusion independent)\n* Platelet count > 50,000/mm^3\n* Absolute neutrophil count > 1,000/mm^3\n\nHepatic\n\n* Child Pugh class A or B liver function\n* Hepatitis B or C viral infection allowed\n\nRenal\n\n* Not specified\n\nCardiovascular\n\n* No New York Heart Association class III or IV cardiac insufficiency\n* No coronary artery disease\n\nImmunologic\n\n* HIV negative\n* No other acute viral, bacterial, or fungal infection requiring therapy\n* No allergy to study agents\n* No history of opportunistic infection\n* No high serum titer of neutralizing anti-adenoviral antibodies\n* No congenital or acquired condition resulting in an inability to generate an immune response\n\nOther\n\n* Not pregnant\n* Negative pregnancy test\n* Fertile patients must use effective double-method (including a barrier method) contraception\n* No other condition that would preclude study participation\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy\n\n* Not specified\n\nChemotherapy\n\n* At least 30 days since prior chemotherapy\n* No concurrent cytotoxic chemotherapy\n\nEndocrine therapy\n\n* At least 30 days since prior steroid therapy\n* No concurrent steroid therapy, including corticosteroids\n\nRadiotherapy\n\n* Not specified\n\nSurgery\n\n* See Disease Characteristics\n* No prior organ allograft\n\nOther\n\n* At least 2 weeks since prior therapy for acute infection\n* No concurrent immunosuppressive therapy\n* No concurrent cyclosporine"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
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                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Diagnosis of hepatocellular carcinoma",
                "criterions": [
                    {
                        "exact_snippets": "Diagnosis of hepatocellular carcinoma",
                        "criterion": "hepatocellular carcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Diagnosis of hepatocellular carcinoma",
                        "criterion": "hepatocellular carcinoma",
                        "requirement": {
                            "requirement_type": "diagnosis",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Stage II-IVA disease",
                "criterions": [
                    {
                        "exact_snippets": "Stage II-IVA disease",
                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "stage"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "stage"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Stage II-IVA disease",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 2,
                                        "unit": "stage"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 4,
                                        "unit": "stage"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No active disease after local or regional therapy (e.g., surgical resection, radiofrequency ablation, cryoablation, or ethanol injection)",
                "criterions": [
                    {
                        "exact_snippets": "No active disease after local or regional therapy",
                        "criterion": "active disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "local or regional therapy (e.g., surgical resection, radiofrequency ablation, cryoablation, or ethanol injection)",
                        "criterion": "local or regional therapy",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "surgical resection",
                                "radiofrequency ablation",
                                "cryoablation",
                                "ethanol injection"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No active disease after local or regional therapy",
                        "criterion": "active disease",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "local or regional therapy (e.g., surgical resection, radiofrequency ablation, cryoablation, or ethanol injection)",
                        "criterion": "local or regional therapy",
                        "requirement": {
                            "requirement_type": "types",
                            "expected_value": [
                                "surgical resection",
                                "radiofrequency ablation",
                                "cryoablation",
                                "ethanol injection"
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Serum alpha fetoprotein > upper limit of normal",
                "criterions": [
                    {
                        "exact_snippets": "Serum alpha fetoprotein > upper limit of normal",
                        "criterion": "serum alpha fetoprotein",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Serum alpha fetoprotein > upper limit of normal",
                        "criterion": "serum alpha fetoprotein",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 1,
                                "unit": "ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* HLA-A*0201 positive by DNA subtyping",
                "criterions": [
                    {
                        "exact_snippets": "HLA-A*0201 positive by DNA subtyping",
                        "criterion": "HLA-A*0201",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "HLA-A*0201 positive by DNA subtyping",
                        "criterion": "HLA-A*0201",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": "positive"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age",
                "criterions": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Over 18",
                "criterions": [
                    {
                        "exact_snippets": "Over 18",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Over 18",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status",
                "criterions": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky 70-100%",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky 70-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 70,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Karnofsky 70-100%",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 70,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic",
                        "criterion": "hematopoietic",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hemoglobin > 9.0 g/dL (transfusion independent)",
                "criterions": [
                    {
                        "exact_snippets": "Hemoglobin > 9.0 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 9.0,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "transfusion independent",
                        "criterion": "transfusion independence",
                        "requirement": {
                            "requirement_type": "independence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hemoglobin > 9.0 g/dL",
                        "criterion": "hemoglobin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 9.0,
                                "unit": "g/dL"
                            }
                        }
                    },
                    {
                        "exact_snippets": "transfusion independent",
                        "criterion": "transfusion independence",
                        "requirement": {
                            "requirement_type": "independence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count > 50,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count > 50,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 50000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count > 50,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 50000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count > 1,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count > 1,000/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute neutrophil count > 1,000/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 1000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hepatitis B or C viral infection allowed",
                "criterions": [
                    {
                        "exact_snippets": "Hepatitis B or C viral infection allowed",
                        "criterion": "Hepatitis B viral infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Hepatitis B or C viral infection allowed",
                        "criterion": "Hepatitis C viral infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Hepatitis B or C viral infection allowed",
                        "criterion": "Hepatitis B viral infection",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "Hepatitis B or C viral infection allowed",
                        "criterion": "Hepatitis C viral infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Renal",
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                    {
                        "exact_snippets": "Renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Renal",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Cardiovascular",
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                    {
                        "exact_snippets": "Cardiovascular",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cardiovascular",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No New York Heart Association class III or IV cardiac insufficiency",
                "criterions": [
                    {
                        "exact_snippets": "No New York Heart Association class III or IV cardiac insufficiency",
                        "criterion": "New York Heart Association cardiac insufficiency",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<",
                                "value": 3,
                                "unit": "class"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No New York Heart Association class III or IV cardiac insufficiency",
                    "criterion": "New York Heart Association cardiac insufficiency",
                    "requirement": {
                        "requirement_type": "severity",
                        "expected_value": {
                            "operator": "<",
                            "value": 3,
                            "unit": "class"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Immunologic",
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                    {
                        "exact_snippets": "Immunologic",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Immunologic",
                        "criterion": "immunologic status",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* HIV negative",
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                    {
                        "exact_snippets": "HIV negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "HIV negative",
                        "criterion": "HIV status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other acute viral, bacterial, or fungal infection requiring therapy",
                "criterions": [
                    {
                        "exact_snippets": "No other acute viral ... infection requiring therapy",
                        "criterion": "acute viral infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other ... bacterial ... infection requiring therapy",
                        "criterion": "bacterial infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other ... fungal infection requiring therapy",
                        "criterion": "fungal infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "No other acute viral ... infection requiring therapy",
                        "criterion": "acute viral infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other ... bacterial ... infection requiring therapy",
                        "criterion": "bacterial infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No other ... fungal infection requiring therapy",
                        "criterion": "fungal infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No allergy to study agents",
                "criterions": [
                    {
                        "exact_snippets": "No allergy to study agents",
                        "criterion": "allergy to study agents",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No allergy to study agents",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
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                    {
                        "exact_snippets": "high serum titer of neutralizing anti-adenoviral antibodies",
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                            "requirement_type": "level",
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                                "operator": "<",
                                "value": 1,
                                "unit": "high"
                            }
                        }
                    }
                ]
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                        "exact_snippets": "high serum titer of neutralizing anti-adenoviral antibodies",
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                                "operator": "<",
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                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
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                    {
                        "exact_snippets": "No congenital or acquired condition resulting in an inability to generate an immune response",
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                            "requirement_type": "presence",
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                        }
                    }
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                    "exact_snippets": "No congenital or acquired condition resulting in an inability to generate an immune response",
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                    }
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                        "exact_snippets": "Negative pregnancy test",
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                    }
                ]
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            "logical_structure": {
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                    {
                        "exact_snippets": "Negative pregnancy test",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective double-method (including a barrier method) contraception",
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                    {
                        "exact_snippets": "Fertile patients",
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                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective double-method (including a barrier method) contraception",
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                            "requirement_type": "method",
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                        }
                    }
                ]
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                "condition": {
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                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No other condition that would preclude study participation",
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                    {
                        "exact_snippets": "No other condition that would preclude study participation",
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                            "requirement_type": "presence",
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                        }
                    }
                ]
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                        "exact_snippets": "No other condition that would preclude study participation",
                        "criterion": "other condition",
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                            "requirement_type": "presence",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Biologic therapy",
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                    {
                        "exact_snippets": "Biologic therapy",
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                            "requirement_type": "presence",
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                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Biologic therapy",
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                            "requirement_type": "presence",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Chemotherapy",
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                    {
                        "exact_snippets": "Chemotherapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chemotherapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent cytotoxic chemotherapy",
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                    {
                        "exact_snippets": "No concurrent cytotoxic chemotherapy",
                        "criterion": "cytotoxic chemotherapy",
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                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent cytotoxic chemotherapy",
                    "criterion": "cytotoxic chemotherapy",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Endocrine therapy",
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                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 30 days since prior steroid therapy",
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                    {
                        "exact_snippets": "At least 30 days since prior steroid therapy",
                        "criterion": "steroid therapy",
                        "requirement": {
                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 30 days since prior steroid therapy",
                        "criterion": "steroid therapy",
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                            "requirement_type": "time since last treatment",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent steroid therapy, including corticosteroids",
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                    {
                        "exact_snippets": "No concurrent steroid therapy, including corticosteroids",
                        "criterion": "steroid therapy",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
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            "logical_structure": {
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                    "exact_snippets": "No concurrent steroid therapy, including corticosteroids",
                    "criterion": "steroid therapy",
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                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Radiotherapy",
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                    {
                        "exact_snippets": "Radiotherapy",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Radiotherapy",
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                            "requirement_type": "presence",
                            "expected_value": true
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                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Surgery",
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                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* See Disease Characteristics",
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                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
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                            "requirement_type": "N/A",
                            "expected_value": "refer to disease characteristics section"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
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                            "requirement_type": "N/A",
                            "expected_value": "refer to disease characteristics section"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
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            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* At least 30 days since prior chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "at least 30 days since prior chemotherapy",
                        "criterion": "prior chemotherapy",
                        "requirement": {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "at least 30 days since prior chemotherapy",
                        "criterion": "prior chemotherapy",
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                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* At least 2 weeks since prior therapy for acute infection",
                "criterions": [
                    {
                        "exact_snippets": "at least 2 weeks since prior therapy for acute infection",
                        "criterion": "time since prior therapy for acute infection",
                        "requirement": {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "at least 2 weeks since prior therapy for acute infection",
                        "criterion": "time since prior therapy for acute infection",
                        "requirement": {
                            "requirement_type": "time since",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Child Pugh class A or B liver function",
                "criterions": [
                    {
                        "exact_snippets": "Child Pugh class A or B liver function",
                        "criterion": "liver function",
                        "requirement": {
                            "requirement_type": "Child Pugh class",
                            "expected_value": [
                                "A",
                                "B"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "Child Pugh class A or B liver function",
                        "criterion": "liver function",
                        "requirement": {
                            "requirement_type": "Child Pugh class",
                            "expected_value": "A"
                        }
                    },
                    {
                        "exact_snippets": "Child Pugh class A or B liver function",
                        "criterion": "liver function",
                        "requirement": {
                            "requirement_type": "Child Pugh class",
                            "expected_value": "B"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No coronary artery disease",
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                    {
                        "exact_snippets": "No coronary artery disease",
                        "criterion": "coronary artery disease",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No coronary artery disease",
                    "criterion": "coronary artery disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No history of opportunistic infection",
                "criterions": [
                    {
                        "exact_snippets": "No history of opportunistic infection",
                        "criterion": "opportunistic infection",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No history of opportunistic infection",
                    "criterion": "opportunistic infection",
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                        "requirement_type": "history",
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                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant",
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                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
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                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "Not pregnant",
                    "criterion": "pregnancy",
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                        "requirement_type": "status",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No prior organ allograft",
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                    {
                        "exact_snippets": "No prior organ allograft",
                        "criterion": "organ allograft",
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                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior organ allograft",
                    "criterion": "organ allograft",
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                        "requirement_type": "history",
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                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent immunosuppressive therapy",
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                    {
                        "exact_snippets": "No concurrent immunosuppressive therapy",
                        "criterion": "immunosuppressive therapy",
                        "requirement": {
                            "requirement_type": "concurrency",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent immunosuppressive therapy",
                    "criterion": "immunosuppressive therapy",
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                        "requirement_type": "concurrency",
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                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent cyclosporine",
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                    {
                        "exact_snippets": "No concurrent cyclosporine",
                        "criterion": "cyclosporine",
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                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent cyclosporine",
                    "criterion": "cyclosporine",
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                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}