{
    "info": {
        "nct_id": "NCT00014248",
        "official_title": "A Phase I Study And Pharmacokinetics Of Adenosine 5'- Triphosphate (ATP) When Administered By Intravenous Infusion On A Multiple Weekly Dose Schedule To Patients With Advanced Malignancies (Solid Tumors)",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically or cytologically confirmed advanced solid tumor that is not curable by conventional therapy\n* Brain metastases allowed if adequately controlled with radiotherapy\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* Over 18\n\nPerformance status:\n\n* Karnofsky 60-100%\n\nLife expectancy:\n\n* At least 12 weeks\n\nHematopoietic:\n\n* WBC at least 3,500/mm^3\n* Absolute neutrophil count at least 2,000/mm^3\n* Platelet count at least 100,000/mm^3\n\nHepatic:\n\n* SGOT and SGPT no greater than 3 times normal\n* Bilirubin no greater than 2.0 mg/dL\n\nRenal:\n\n* Creatinine no greater than 1.5 mg/dL\n* Creatinine clearance greater than 60 mL/min\n* BUN no greater than 25 mg/dL\n\nCardiovascular:\n\n* Adequate cardiovascular function\n* No congestive heart failure (New York Heart Association class III or IV heart disease)\n* No angina pectoris AND/OR\n* No significant arrhythmia\n* No myocardial infarction within the past 6 months\n* No clinically significant ischemic cardiac disease currently under treatment\n* No clinically significant conduction system disease in the absence of a pacemaker (e.g., sick sinus syndrome, or second or third degree atrioventricular block)\n\nPulmonary:\n\n* Adequate pulmonary function\n* No clinical evidence of acute chronic obstructive pulmonary disease\n* FEV1 at least 50% predicted\n* Arterial oxygen tension at least 90% by pulse oximetry and on breathing room air\n* No asthma OR\n* No evidence of more than 20% reversibility in FEV1 with albuterol therapy\n\nOther:\n\n* Not pregnant or nursing\n* Fertile patients must use effective contraception\n* No history of severe adverse reaction to adenosine\n* No uncontrolled medical illness\n* No average daily pain scores of at least 5 on a simple Visual Analogue Self pain assessment (0-10) scale\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy:\n\n* Not specified\n\nChemotherapy:\n\n* At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered\n\nEndocrine therapy:\n\n* Not specified\n\nRadiotherapy:\n\n* See Disease Characteristics\n* At least 3 weeks since prior radiotherapy and recovered\n\nSurgery:\n\n* Not specified\n\nOther:\n\n* At least 30 days since prior investigational therapy\n* At least 14 days since prior long-term theophylline, dipyridamole, or dipyridamole/aspirin therapy\n* No concurrent long-term theophylline, dipyridamole, or dipyridamole/aspirin therapy\n* No concurrent maintenance anti-anginal drug therapy"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically or cytologically confirmed advanced solid tumor that is not curable by conventional therapy",
                "criterions": [
                    {
                        "exact_snippets": "Histologically or cytologically confirmed advanced solid tumor",
                        "criterion": "advanced solid tumor",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "not curable by conventional therapy",
                        "criterion": "curability by conventional therapy",
                        "requirement": {
                            "requirement_type": "curability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Histologically or cytologically confirmed advanced solid tumor",
                                "criterion": "advanced solid tumor",
                                "requirement": {
                                    "requirement_type": "confirmation method",
                                    "expected_value": [
                                        "histologically",
                                        "cytologically"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "not curable by conventional therapy",
                                "criterion": "curability by conventional therapy",
                                "requirement": {
                                    "requirement_type": "curability",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Brain metastases allowed if adequately controlled with radiotherapy",
                "criterions": [
                    {
                        "exact_snippets": "Brain metastases allowed ... adequately controlled with radiotherapy",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "adequately controlled with radiotherapy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Brain metastases allowed ... adequately controlled with radiotherapy",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "control",
                            "expected_value": "adequately controlled with radiotherapy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age:",
                "criterions": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Over 18",
                "criterions": [
                    {
                        "exact_snippets": "Over 18",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Over 18",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "value",
                            "expected_value": {
                                "operator": ">",
                                "value": 18,
                                "unit": "years"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status:",
                "criterions": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Karnofsky 60-100%",
                "criterions": [
                    {
                        "exact_snippets": "Karnofsky 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Karnofsky 60-100%",
                        "criterion": "Karnofsky performance status",
                        "requirement": {
                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 60,
                                        "unit": "%"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 100,
                                        "unit": "%"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy:",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 12 weeks",
                "criterions": [
                    {
                        "exact_snippets": "At least 12 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 12 weeks",
                        "criterion": "duration",
                        "requirement": {
                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic:",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* WBC at least 3,500/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "WBC at least 3,500/mm^3",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "WBC at least 3,500/mm^3",
                        "criterion": "WBC",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute neutrophil count at least 2,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Absolute neutrophil count at least 2,000/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute neutrophil count at least 2,000/mm^3",
                        "criterion": "absolute neutrophil count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 2000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count at least 100,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count at least 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count at least 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hepatic:",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hepatic",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* SGOT and SGPT no greater than 3 times normal",
                "criterions": [
                    {
                        "exact_snippets": "SGOT ... no greater than 3 times normal",
                        "criterion": "SGOT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "times normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "SGPT no greater than 3 times normal",
                        "criterion": "SGPT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "times normal"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "SGOT ... no greater than 3 times normal",
                        "criterion": "SGOT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "times normal"
                            }
                        }
                    },
                    {
                        "exact_snippets": "SGPT no greater than 3 times normal",
                        "criterion": "SGPT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 3,
                                "unit": "times normal"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin no greater than 2.0 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin no greater than 2.0 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Bilirubin no greater than 2.0 mg/dL",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2.0,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Renal:",
                "criterions": [
                    {
                        "exact_snippets": "Renal:",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Renal:",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine no greater than 1.5 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine no greater than 1.5 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine no greater than 1.5 mg/dL",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine clearance greater than 60 mL/min",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine clearance greater than 60 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 60,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine clearance greater than 60 mL/min",
                        "criterion": "creatinine clearance",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 60,
                                "unit": "mL/min"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* BUN no greater than 25 mg/dL",
                "criterions": [
                    {
                        "exact_snippets": "BUN no greater than 25 mg/dL",
                        "criterion": "BUN",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 25,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "BUN no greater than 25 mg/dL",
                        "criterion": "BUN",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 25,
                                "unit": "mg/dL"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Cardiovascular:",
                "criterions": [
                    {
                        "exact_snippets": "Cardiovascular:",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Cardiovascular:",
                        "criterion": "cardiovascular condition",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate cardiovascular function",
                "criterions": [
                    {
                        "exact_snippets": "Adequate cardiovascular function",
                        "criterion": "cardiovascular function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate cardiovascular function",
                        "criterion": "cardiovascular function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No congestive heart failure (New York Heart Association class III or IV heart disease)",
                "criterions": [
                    {
                        "exact_snippets": "No congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "New York Heart Association class III or IV heart disease",
                        "criterion": "New York Heart Association class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "!=",
                                "value": 3,
                                "unit": "class"
                            }
                        }
                    },
                    {
                        "exact_snippets": "New York Heart Association class III or IV heart disease",
                        "criterion": "New York Heart Association class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "!=",
                                "value": 4,
                                "unit": "class"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "No congestive heart failure",
                                "criterion": "congestive heart failure",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "New York Heart Association class III or IV heart disease",
                                "criterion": "New York Heart Association class",
                                "requirement": {
                                    "requirement_type": "severity",
                                    "expected_value": {
                                        "operator": "!=",
                                        "value": 3,
                                        "unit": "class"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "New York Heart Association class III or IV heart disease",
                        "criterion": "New York Heart Association class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "!=",
                                "value": 4,
                                "unit": "class"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No angina pectoris AND/OR",
                "criterions": [
                    {
                        "exact_snippets": "No angina pectoris",
                        "criterion": "angina pectoris",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "exact_snippets": "No angina pectoris",
                                "criterion": "angina pectoris",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "No angina pectoris",
                                "criterion": "angina pectoris",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No significant arrhythmia",
                "criterions": [
                    {
                        "exact_snippets": "No significant arrhythmia",
                        "criterion": "arrhythmia",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not significant"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No significant arrhythmia",
                        "criterion": "arrhythmia",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not significant"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No myocardial infarction within the past 6 months",
                "criterions": [
                    {
                        "exact_snippets": "No myocardial infarction within the past 6 months",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "time since last occurrence",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No myocardial infarction within the past 6 months",
                    "criterion": "myocardial infarction",
                    "requirement": {
                        "requirement_type": "time since last occurrence",
                        "expected_value": {
                            "operator": ">=",
                            "value": 6,
                            "unit": "months"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No clinically significant conduction system disease in the absence of a pacemaker (e.g., sick sinus syndrome, or second or third degree atrioventricular block)",
                "criterions": [
                    {
                        "exact_snippets": "No clinically significant conduction system disease",
                        "criterion": "conduction system disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "absence of a pacemaker",
                        "criterion": "pacemaker",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "sick sinus syndrome",
                        "criterion": "sick sinus syndrome",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "second or third degree atrioventricular block",
                        "criterion": "atrioventricular block",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "absence of a pacemaker",
                            "criterion": "pacemaker",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        },
                        {
                            "exact_snippets": "sick sinus syndrome",
                            "criterion": "sick sinus syndrome",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        },
                        {
                            "exact_snippets": "second or third degree atrioventricular block",
                            "criterion": "atrioventricular block",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        }
                    ]
                },
                "then_criteria": {
                    "exact_snippets": "No clinically significant conduction system disease",
                    "criterion": "conduction system disease",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "Pulmonary:",
                "criterions": [
                    {
                        "exact_snippets": "Pulmonary:",
                        "criterion": "pulmonary function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Pulmonary:",
                        "criterion": "pulmonary function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Adequate pulmonary function",
                "criterions": [
                    {
                        "exact_snippets": "Adequate pulmonary function",
                        "criterion": "pulmonary function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Adequate pulmonary function",
                        "criterion": "pulmonary function",
                        "requirement": {
                            "requirement_type": "adequacy",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No clinical evidence of acute chronic obstructive pulmonary disease",
                "criterions": [
                    {
                        "exact_snippets": "No clinical evidence of acute chronic obstructive pulmonary disease",
                        "criterion": "acute chronic obstructive pulmonary disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "No clinical evidence of acute chronic obstructive pulmonary disease",
                        "criterion": "acute chronic obstructive pulmonary disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* FEV1 at least 50% predicted",
                "criterions": [
                    {
                        "exact_snippets": "FEV1 at least 50% predicted",
                        "criterion": "FEV1",
                        "requirement": {
                            "requirement_type": "percentage of predicted",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "FEV1 at least 50% predicted",
                        "criterion": "FEV1",
                        "requirement": {
                            "requirement_type": "percentage of predicted",
                            "expected_value": {
                                "operator": ">=",
                                "value": 50,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Arterial oxygen tension at least 90% by pulse oximetry and on breathing room air",
                "criterions": [
                    {
                        "exact_snippets": "Arterial oxygen tension at least 90% by pulse oximetry",
                        "criterion": "arterial oxygen tension",
                        "requirement": {
                            "requirement_type": "measurement",
                            "expected_value": {
                                "operator": ">=",
                                "value": 90,
                                "unit": "%"
                            }
                        }
                    },
                    {
                        "exact_snippets": "Arterial oxygen tension at least 90% by pulse oximetry",
                        "criterion": "arterial oxygen tension",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": "pulse oximetry"
                        }
                    },
                    {
                        "exact_snippets": "on breathing room air",
                        "criterion": "breathing condition",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "room air"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Arterial oxygen tension at least 90% by pulse oximetry",
                                "criterion": "arterial oxygen tension",
                                "requirement": {
                                    "requirement_type": "measurement",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 90,
                                        "unit": "%"
                                    }
                                }
                            },
                            {
                                "exact_snippets": "Arterial oxygen tension at least 90% by pulse oximetry",
                                "criterion": "arterial oxygen tension",
                                "requirement": {
                                    "requirement_type": "method",
                                    "expected_value": "pulse oximetry"
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "on breathing room air",
                        "criterion": "breathing condition",
                        "requirement": {
                            "requirement_type": "condition",
                            "expected_value": "room air"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No asthma OR",
                "criterions": [
                    {
                        "exact_snippets": "No asthma",
                        "criterion": "asthma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "No asthma",
                        "criterion": "asthma",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No evidence of more than 20% reversibility in FEV1 with albuterol therapy",
                "criterions": [
                    {
                        "exact_snippets": "No evidence of more than 20% reversibility in FEV1 with albuterol therapy",
                        "criterion": "FEV1 reversibility",
                        "requirement": {
                            "requirement_type": "reversibility",
                            "expected_value": {
                                "operator": "<=",
                                "value": 20,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No evidence of more than 20% reversibility in FEV1 with albuterol therapy",
                    "criterion": "FEV1 reversibility",
                    "requirement": {
                        "requirement_type": "reversibility",
                        "expected_value": {
                            "operator": "<=",
                            "value": 20,
                            "unit": "%"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception",
                "criterions": [
                    {
                        "exact_snippets": "Fertile patients",
                        "criterion": "fertility",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "fertile"
                        }
                    },
                    {
                        "exact_snippets": "must use effective contraception",
                        "criterion": "contraception use",
                        "requirement": {
                            "requirement_type": "necessity",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "exact_snippets": "Fertile patients",
                    "criterion": "fertility",
                    "requirement": {
                        "requirement_type": "status",
                        "expected_value": "fertile"
                    }
                },
                "then_criteria": {
                    "exact_snippets": "must use effective contraception",
                    "criterion": "contraception use",
                    "requirement": {
                        "requirement_type": "necessity",
                        "expected_value": true
                    }
                },
                "else_criteria": null
            }
        },
        {
            "identified_line": {
                "line": "* No history of severe adverse reaction to adenosine",
                "criterions": [
                    {
                        "exact_snippets": "No history of severe adverse reaction to adenosine",
                        "criterion": "severe adverse reaction to adenosine",
                        "requirement": {
                            "requirement_type": "history",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No history of severe adverse reaction to adenosine",
                    "criterion": "severe adverse reaction to adenosine",
                    "requirement": {
                        "requirement_type": "history",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No average daily pain scores of at least 5 on a simple Visual Analogue Self pain assessment (0-10) scale",
                "criterions": [
                    {
                        "exact_snippets": "average daily pain scores ... at least 5 ... Visual Analogue Self pain assessment (0-10) scale",
                        "criterion": "average daily pain score",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": {
                                "operator": "<",
                                "value": 5,
                                "unit": "score"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "average daily pain scores ... at least 5 ... Visual Analogue Self pain assessment (0-10) scale",
                    "criterion": "average daily pain score",
                    "requirement": {
                        "requirement_type": "severity",
                        "expected_value": {
                            "operator": "<",
                            "value": 5,
                            "unit": "score"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
                "criterions": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
                        "criterion": "prior concurrent therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Biologic therapy:",
                "criterions": [
                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Biologic therapy",
                        "criterion": "biologic therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Chemotherapy:",
                "criterions": [
                    {
                        "exact_snippets": "Chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Chemotherapy",
                        "criterion": "chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin) and recovered",
                "criterions": [
                    {
                        "exact_snippets": "At least 3 weeks since prior chemotherapy",
                        "criterion": "time since prior chemotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "6 weeks for nitrosoureas or mitomycin",
                        "criterion": "time since prior nitrosoureas or mitomycin",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 6,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "recovered",
                        "criterion": "recovery from prior treatment",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "At least 3 weeks since prior chemotherapy",
                                        "criterion": "time since prior chemotherapy",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 3,
                                                "unit": "weeks"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "recovered",
                                        "criterion": "recovery from prior treatment",
                                        "requirement": {
                                            "requirement_type": "status",
                                            "expected_value": "recovered"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "6 weeks for nitrosoureas or mitomycin",
                                        "criterion": "time since prior nitrosoureas or mitomycin",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": {
                                                "operator": ">=",
                                                "value": 6,
                                                "unit": "weeks"
                                            }
                                        }
                                    },
                                    {
                                        "exact_snippets": "recovered",
                                        "criterion": "recovery from prior treatment",
                                        "requirement": {
                                            "requirement_type": "status",
                                            "expected_value": "recovered"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Endocrine therapy:",
                "criterions": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Radiotherapy:",
                "criterions": [
                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Radiotherapy",
                        "criterion": "radiotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* See Disease Characteristics",
                "criterions": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "see referenced section"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Disease Characteristics",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "see referenced section"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 3 weeks since prior radiotherapy and recovered",
                "criterions": [
                    {
                        "exact_snippets": "At least 3 weeks since prior radiotherapy",
                        "criterion": "time since prior radiotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "recovered",
                        "criterion": "recovery from prior radiotherapy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 3 weeks since prior radiotherapy",
                        "criterion": "time since prior radiotherapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 3,
                                "unit": "weeks"
                            }
                        }
                    },
                    {
                        "exact_snippets": "recovered",
                        "criterion": "recovery from prior radiotherapy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "recovered"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Surgery:",
                "criterions": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Surgery",
                        "criterion": "surgery",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 30 days since prior investigational therapy",
                "criterions": [
                    {
                        "exact_snippets": "At least 30 days since prior investigational therapy",
                        "criterion": "time since prior investigational therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 30 days since prior investigational therapy",
                        "criterion": "time since prior investigational therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 30,
                                "unit": "days"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 14 days since prior long-term theophylline, dipyridamole, or dipyridamole/aspirin therapy",
                "criterions": [
                    {
                        "exact_snippets": "At least 14 days since prior long-term theophylline",
                        "criterion": "prior long-term theophylline therapy",
                        "requirement": {
                            "requirement_type": "time since cessation",
                            "expected_value": {
                                "operator": ">=",
                                "value": 14,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "At least 14 days since prior long-term ... dipyridamole",
                        "criterion": "prior long-term dipyridamole therapy",
                        "requirement": {
                            "requirement_type": "time since cessation",
                            "expected_value": {
                                "operator": ">=",
                                "value": 14,
                                "unit": "days"
                            }
                        }
                    },
                    {
                        "exact_snippets": "At least 14 days since prior long-term ... dipyridamole/aspirin therapy",
                        "criterion": "prior long-term dipyridamole/aspirin therapy",
                        "requirement": {
                            "requirement_type": "time since cessation",
                            "expected_value": {
                                "operator": ">=",
                                "value": 14,
                                "unit": "days"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "At least 14 days since prior long-term theophylline",
                                "criterion": "prior long-term theophylline therapy",
                                "requirement": {
                                    "requirement_type": "time since cessation",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 14,
                                        "unit": "days"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "At least 14 days since prior long-term ... dipyridamole",
                                "criterion": "prior long-term dipyridamole therapy",
                                "requirement": {
                                    "requirement_type": "time since cessation",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 14,
                                        "unit": "days"
                                    }
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "At least 14 days since prior long-term ... dipyridamole/aspirin therapy",
                                "criterion": "prior long-term dipyridamole/aspirin therapy",
                                "requirement": {
                                    "requirement_type": "time since cessation",
                                    "expected_value": {
                                        "operator": ">=",
                                        "value": 14,
                                        "unit": "days"
                                    }
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent long-term theophylline, dipyridamole, or dipyridamole/aspirin therapy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent long-term theophylline",
                        "criterion": "theophylline therapy",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No concurrent long-term theophylline",
                        "criterion": "theophylline therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "long-term"
                        }
                    },
                    {
                        "exact_snippets": "No concurrent long-term ... dipyridamole",
                        "criterion": "dipyridamole therapy",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No concurrent long-term ... dipyridamole",
                        "criterion": "dipyridamole therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "long-term"
                        }
                    },
                    {
                        "exact_snippets": "No concurrent long-term ... dipyridamole/aspirin therapy",
                        "criterion": "dipyridamole/aspirin therapy",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "No concurrent long-term ... dipyridamole/aspirin therapy",
                        "criterion": "dipyridamole/aspirin therapy",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": "long-term"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "No concurrent long-term theophylline",
                                        "criterion": "theophylline therapy",
                                        "requirement": {
                                            "requirement_type": "concurrent use",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "No concurrent long-term theophylline",
                                        "criterion": "theophylline therapy",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": "long-term"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "No concurrent long-term ... dipyridamole",
                                        "criterion": "dipyridamole therapy",
                                        "requirement": {
                                            "requirement_type": "concurrent use",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "No concurrent long-term ... dipyridamole",
                                        "criterion": "dipyridamole therapy",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": "long-term"
                                        }
                                    }
                                ]
                            },
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "No concurrent long-term ... dipyridamole/aspirin therapy",
                                        "criterion": "dipyridamole/aspirin therapy",
                                        "requirement": {
                                            "requirement_type": "concurrent use",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "No concurrent long-term ... dipyridamole/aspirin therapy",
                                        "criterion": "dipyridamole/aspirin therapy",
                                        "requirement": {
                                            "requirement_type": "duration",
                                            "expected_value": "long-term"
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not specified",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* No clinically significant ischemic cardiac disease currently under treatment",
                "criterions": [
                    {
                        "exact_snippets": "clinically significant ischemic cardiac disease",
                        "criterion": "ischemic cardiac disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "clinically significant"
                        }
                    },
                    {
                        "exact_snippets": "currently under treatment",
                        "criterion": "treatment status",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "and_criteria": [
                                {
                                    "exact_snippets": "clinically significant ischemic cardiac disease",
                                    "criterion": "ischemic cardiac disease",
                                    "requirement": {
                                        "requirement_type": "severity",
                                        "expected_value": "clinically significant"
                                    }
                                },
                                {
                                    "exact_snippets": "currently under treatment",
                                    "criterion": "treatment status",
                                    "requirement": {
                                        "requirement_type": "presence",
                                        "expected_value": true
                                    }
                                }
                            ]
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No uncontrolled medical illness",
                "criterions": [
                    {
                        "exact_snippets": "No uncontrolled medical illness",
                        "criterion": "uncontrolled medical illness",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No uncontrolled medical illness",
                    "criterion": "uncontrolled medical illness",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent maintenance anti-anginal drug therapy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent maintenance anti-anginal drug therapy",
                        "criterion": "anti-anginal drug therapy",
                        "requirement": {
                            "requirement_type": "concurrent maintenance",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent maintenance anti-anginal drug therapy",
                    "criterion": "anti-anginal drug therapy",
                    "requirement": {
                        "requirement_type": "concurrent maintenance",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}