{
    "info": {
        "nct_id": "NCT00014131",
        "official_title": "Vaccine Biotherapy Of Cancer: Autologous Tumor Cells And Dendritic Cells As Active Specific Immunotherapy In Patients With Stage IV Renal Cell Carcinoma",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 16 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically confirmed renal cell carcinoma\n\n  * Stage III or IV disease involving invasions beyond Gerota's fascia, regional lymph node involvement, or distant metastases OR\n  * Recurrent disease involving lymph node metastases or soft tissue nodules\n* Measurable disease by anatomic-based radiological tests (unless no evidence of disease as documented by prior surgery)\n* Planned resection of tumor to establish an autologous tumor cell line\n* No active CNS metastases such as brain metastases, spinal cord compression, or leptomeningeal disease\n\n  * Prior brain metastases or spinal cord compression allowed provided there is radiographic evidence of lack of progression and no requirement for pharmacologic doses of corticosteroids\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* 16 and over\n\nPerformance status:\n\n* ECOG 0-2\n\nLife expectancy:\n\n* At least 4 months\n\nHematopoietic:\n\n* Hematocrit greater than 25%\n* Platelet count greater than 100,000/mm3\n* No ongoing transfusion requirements\n* No active blood clotting or bleeding diathesis\n\nHepatic:\n\n* Bilirubin no greater than 2.0 mg/dL\n* Albumin at least 3.0 g/dL\n* No significant hepatic dysfunction\n\nRenal:\n\n* Creatinine no greater than 2.0 mg/dL\n* No significant renal dysfunction\n\nCardiovascular:\n\n* No underlying cardiac disease associated with New York Heart Association class III or IV heart function\n* No unstable angina related to atherosclerotic cardiovascular disease\n\nOther:\n\n* No other malignancy within the past 5 years except carcinoma in situ, basal cell or localized squamous cell skin cancer, or localized prostate cancer\n* No active infection\n* No other active medical condition that could be eminently life threatening\n* Not pregnant\n* Fertile patients must use effective contraception\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy:\n\n* Other prior putative vaccines allowed\n* Recovered from prior biologic therapy\n* No concurrent biologic therapy except epoetin alfa for patients with hematocrit less than 36%\n\nChemotherapy:\n\n* At least 3 weeks since prior chemotherapy and recovered\n* No concurrent chemotherapy\n\nEndocrine therapy:\n\n* See Disease Characteristics\n* No concurrent corticosteroids\n\nRadiotherapy:\n\n* At least 3 weeks since prior radiotherapy (including whole-brain radiotherapy) and recovered\n* No concurrent radiotherapy\n\nSurgery:\n\n* See Disease Characteristics\n* Recovered from prior surgery\n\nOther:\n\n* Concurrent bisphosphonates allowed for patients with lytic bone metastases\n* No concurrent digoxin or other medications designed to improve cardiac output\n* No other concurrent anticancer therapy or investigational therapy"
    },
    "inclusion_lines": [
        {
            "identified_line": {
                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Must have minimum age of 16 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 16 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 16,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "minimum age of 16 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 16,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
                "criterions": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Histologically confirmed renal cell carcinoma",
                "criterions": [
                    {
                        "exact_snippets": "Histologically confirmed renal cell carcinoma",
                        "criterion": "renal cell carcinoma",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Histologically confirmed renal cell carcinoma",
                        "criterion": "renal cell carcinoma",
                        "requirement": {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Stage III or IV disease involving invasions beyond Gerota's fascia, regional lymph node involvement, or distant metastases OR",
                "criterions": [
                    {
                        "exact_snippets": "Stage III or IV disease",
                        "criterion": "disease stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "invasions beyond Gerota's fascia",
                        "criterion": "invasion beyond Gerota's fascia",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "regional lymph node involvement",
                        "criterion": "regional lymph node involvement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "distant metastases",
                        "criterion": "distant metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Stage III or IV disease",
                                "criterion": "disease stage",
                                "requirement": {
                                    "requirement_type": "stage",
                                    "expected_value": [
                                        "III",
                                        "IV"
                                    ]
                                }
                            },
                            {
                                "exact_snippets": "invasions beyond Gerota's fascia",
                                "criterion": "invasion beyond Gerota's fascia",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "regional lymph node involvement",
                        "criterion": "regional lymph node involvement",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "distant metastases",
                        "criterion": "distant metastases",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Recurrent disease involving lymph node metastases or soft tissue nodules",
                "criterions": [
                    {
                        "exact_snippets": "Recurrent disease",
                        "criterion": "disease recurrence",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "involving lymph node metastases",
                        "criterion": "lymph node metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "involving ... soft tissue nodules",
                        "criterion": "soft tissue nodules",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Recurrent disease",
                                "criterion": "disease recurrence",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "involving lymph node metastases",
                                "criterion": "lymph node metastases",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    },
                    {
                        "and_criteria": [
                            {
                                "exact_snippets": "Recurrent disease",
                                "criterion": "disease recurrence",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            },
                            {
                                "exact_snippets": "involving ... soft tissue nodules",
                                "criterion": "soft tissue nodules",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Measurable disease by anatomic-based radiological tests (unless no evidence of disease as documented by prior surgery)",
                "criterions": [
                    {
                        "exact_snippets": "Measurable disease by anatomic-based radiological tests",
                        "criterion": "measurable disease",
                        "requirement": {
                            "requirement_type": "detection method",
                            "expected_value": "anatomic-based radiological tests"
                        }
                    },
                    {
                        "exact_snippets": "no evidence of disease as documented by prior surgery",
                        "criterion": "evidence of disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no evidence of disease as documented by prior surgery",
                        "criterion": "evidence of disease",
                        "requirement": {
                            "requirement_type": "documentation method",
                            "expected_value": "prior surgery"
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "no evidence of disease as documented by prior surgery",
                            "criterion": "evidence of disease",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": false
                            }
                        },
                        {
                            "exact_snippets": "no evidence of disease as documented by prior surgery",
                            "criterion": "evidence of disease",
                            "requirement": {
                                "requirement_type": "documentation method",
                                "expected_value": "prior surgery"
                            }
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": {
                    "exact_snippets": "Measurable disease by anatomic-based radiological tests",
                    "criterion": "measurable disease",
                    "requirement": {
                        "requirement_type": "detection method",
                        "expected_value": "anatomic-based radiological tests"
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Planned resection of tumor to establish an autologous tumor cell line",
                "criterions": [
                    {
                        "exact_snippets": "Planned resection of tumor",
                        "criterion": "tumor resection",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "establish an autologous tumor cell line",
                        "criterion": "autologous tumor cell line establishment",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Planned resection of tumor",
                        "criterion": "tumor resection",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "establish an autologous tumor cell line",
                        "criterion": "autologous tumor cell line establishment",
                        "requirement": {
                            "requirement_type": "planned",
                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
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                "criterions": [
                    {
                        "exact_snippets": "No active CNS metastases such as brain metastases",
                        "criterion": "CNS metastases",
                        "requirement": {
                            "requirement_type": "presence",
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                        }
                    },
                    {
                        "exact_snippets": "spinal cord compression",
                        "criterion": "spinal cord compression",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "leptomeningeal disease",
                        "criterion": "leptomeningeal disease",
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                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
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                        "and_criteria": [
                            {
                                "exact_snippets": "No active CNS metastases such as brain metastases",
                                "criterion": "CNS metastases",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "spinal cord compression",
                                "criterion": "spinal cord compression",
                                "requirement": {
                                    "requirement_type": "presence",
                                    "expected_value": false
                                }
                            }
                        ]
                    },
                    {
                        "exact_snippets": "leptomeningeal disease",
                        "criterion": "leptomeningeal disease",
                        "requirement": {
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                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Prior brain metastases or spinal cord compression allowed provided there is radiographic evidence of lack of progression and no requirement for pharmacologic doses of corticosteroids",
                "criterions": [
                    {
                        "exact_snippets": "Prior brain metastases",
                        "criterion": "brain metastases",
                        "requirement": {
                            "requirement_type": "prior occurrence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "spinal cord compression",
                        "criterion": "spinal cord compression",
                        "requirement": {
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                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "radiographic evidence of lack of progression",
                        "criterion": "progression of brain metastases or spinal cord compression",
                        "requirement": {
                            "requirement_type": "progression",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "no requirement for pharmacologic doses of corticosteroids",
                        "criterion": "requirement for pharmacologic doses of corticosteroids",
                        "requirement": {
                            "requirement_type": "requirement",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "or_criteria": [
                            {
                                "and_criteria": [
                                    {
                                        "exact_snippets": "Prior brain metastases",
                                        "criterion": "brain metastases",
                                        "requirement": {
                                            "requirement_type": "prior occurrence",
                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "radiographic evidence of lack of progression",
                                        "criterion": "progression of brain metastases or spinal cord compression",
                                        "requirement": {
                                            "requirement_type": "progression",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "no requirement for pharmacologic doses of corticosteroids",
                                        "criterion": "requirement for pharmacologic doses of corticosteroids",
                                        "requirement": {
                                            "requirement_type": "requirement",
                                            "expected_value": false
                                        }
                                    }
                                ]
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                            {
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                                        "exact_snippets": "spinal cord compression",
                                        "criterion": "spinal cord compression",
                                        "requirement": {
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                                            "expected_value": true
                                        }
                                    },
                                    {
                                        "exact_snippets": "radiographic evidence of lack of progression",
                                        "criterion": "progression of brain metastases or spinal cord compression",
                                        "requirement": {
                                            "requirement_type": "progression",
                                            "expected_value": false
                                        }
                                    },
                                    {
                                        "exact_snippets": "no requirement for pharmacologic doses of corticosteroids",
                                        "criterion": "requirement for pharmacologic doses of corticosteroids",
                                        "requirement": {
                                            "requirement_type": "requirement",
                                            "expected_value": false
                                        }
                                    }
                                ]
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Age:",
                "criterions": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* 16 and over",
                "criterions": [
                    {
                        "exact_snippets": "16 and over",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 16,
                                        "unit": "years"
                                    }
                                ]
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                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
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                        "exact_snippets": "16 and over",
                        "criterion": "age",
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                            "requirement_type": "N/A",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 16,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status:",
                "criterions": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG 0-2",
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                    {
                        "exact_snippets": "ECOG 0-2",
                        "criterion": "ECOG performance status",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "ECOG 0-2",
                        "criterion": "ECOG performance status",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy:",
                "criterions": [
                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 4 months",
                "criterions": [
                    {
                        "exact_snippets": "At least 4 months",
                        "criterion": "time period",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "months"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 4 months",
                        "criterion": "time period",
                        "requirement": {
                            "requirement_type": "duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "months"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic:",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Hematocrit greater than 25%",
                "criterions": [
                    {
                        "exact_snippets": "Hematocrit greater than 25%",
                        "criterion": "hematocrit",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 25,
                                "unit": "%"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematocrit greater than 25%",
                        "criterion": "hematocrit",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": ">",
                                "value": 25,
                                "unit": "%"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count greater than 100,000/mm3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count greater than 100,000/mm3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "mm3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Platelet count greater than 100,000/mm3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">",
                                "value": 100000,
                                "unit": "mm3"
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                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* No ongoing transfusion requirements",
                "criterions": [
                    {
                        "exact_snippets": "No ongoing transfusion requirements",
                        "criterion": "transfusion requirements",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No ongoing transfusion requirements",
                    "criterion": "transfusion requirements",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No underlying cardiac disease associated with New York Heart Association class III or IV heart function",
                "criterions": [
                    {
                        "exact_snippets": "No underlying cardiac disease",
                        "criterion": "underlying cardiac disease",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "New York Heart Association class III or IV heart function",
                        "criterion": "New York Heart Association heart function class",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": [
                                "III",
                                "IV"
                            ]
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "not_criteria": {
                            "exact_snippets": "No underlying cardiac disease",
                            "criterion": "underlying cardiac disease",
                            "requirement": {
                                "requirement_type": "presence",
                                "expected_value": true
                            }
                        }
                    },
                    {
                        "not_criteria": {
                            "exact_snippets": "New York Heart Association class III or IV heart function",
                            "criterion": "New York Heart Association heart function class",
                            "requirement": {
                                "requirement_type": "severity",
                                "expected_value": [
                                    "III",
                                    "IV"
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No unstable angina related to atherosclerotic cardiovascular disease",
                "criterions": [
                    {
                        "exact_snippets": "unstable angina related to atherosclerotic cardiovascular disease",
                        "criterion": "unstable angina",
                        "requirement": {
                            "requirement_type": "relation",
                            "expected_value": "atherosclerotic cardiovascular disease"
                        }
                    },
                    {
                        "exact_snippets": "unstable angina related to atherosclerotic cardiovascular disease",
                        "criterion": "unstable angina",
                        "requirement": {
                            "requirement_type": "stability",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No other malignancy within the past 5 years except carcinoma in situ, basal cell or localized squamous cell skin cancer, or localized prostate cancer",
                "criterions": [
                    {
                        "exact_snippets": "No other malignancy within the past 5 years",
                        "criterion": "other malignancy",
                        "requirement": {
                            "requirement_type": "time since last occurrence",
                            "expected_value": {
                                "operator": "<",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    },
                    {
                        "exact_snippets": "except carcinoma in situ",
                        "criterion": "carcinoma in situ",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except ... basal cell ... skin cancer",
                        "criterion": "basal cell skin cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except ... localized squamous cell skin cancer",
                        "criterion": "localized squamous cell skin cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    },
                    {
                        "exact_snippets": "except ... localized prostate cancer",
                        "criterion": "localized prostate cancer",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No active infection",
                "criterions": [
                    {
                        "exact_snippets": "No active infection",
                        "criterion": "active infection",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No other active medical condition that could be eminently life threatening",
                "criterions": [
                    {
                        "exact_snippets": "No other active medical condition that could be eminently life threatening",
                        "criterion": "active medical condition",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not eminently life threatening"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent chemotherapy",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent chemotherapy",
                        "criterion": "concurrent chemotherapy",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent chemotherapy",
                    "criterion": "concurrent chemotherapy",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* No concurrent corticosteroids",
                "criterions": [
                    {
                        "exact_snippets": "No concurrent corticosteroids",
                        "criterion": "corticosteroid use",
                        "requirement": {
                            "requirement_type": "concurrent use",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No concurrent corticosteroids",
                    "criterion": "corticosteroid use",
                    "requirement": {
                        "requirement_type": "concurrent use",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}