{
    "info": {
        "nct_id": "NCT00006229",
        "official_title": "A Phase II/III Double Blind Randomized Trial of BMS-275291 vs. Placebo in Patients Receiving Paclitaxel/Carboplatin Chemotherapy for the Treatment of Advanced or Metastatic Non-small Cell Lung Cancer",
        "inclusion_criteria": "Healthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 120 Years",
        "exclusion_criteria": "",
        "miscellaneous_criteria": "DISEASE CHARACTERISTICS:\n\n* Histologically or cytologically confirmed stage IIIB or IV non-small cell lung cancer (NSCLC)\n\n  * Local or metastatic failure after surgery and/or radiotherapy allowed\n* Phase II only:\n\n  * At least one measurable lesion\n\n    * At least 20 mm by conventional techniques OR 10 mm by spiral CT scan\n* No known CNS metastases unless asymptomatic and at least 4 weeks since prior corticosteroid therapy\n\nPATIENT CHARACTERISTICS:\n\nAge:\n\n* 18 and over\n\nPerformance status:\n\n* ECOG 0-2\n\nLife expectancy:\n\n* At least 12 weeks\n\nHematopoietic:\n\n* Absolute granulocyte count at least 1,500/mm^3\n* Platelet count at least 100,000/mm^3\n\nHepatic:\n\n* Bilirubin no greater than 1.5 times upper limit of normal (ULN)\n* ALT no greater than 2 times ULN (5 times ULN for liver metastases)\n\nRenal:\n\n* Creatinine no greater than 1.5 times ULN\n\nCardiovascular:\n\n* No significant cardiac disease\n* No uncontrolled high blood pressure, unstable angina, congestive heart failure, second or third degree atrioventricular conduction defects, or ventricular arrhythmias requiring medication\n* No myocardial infarction within the past year\n\nOther:\n\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception\n* No prior allergic reaction to drugs containing Cremophor EL\n* No serious active infection or other underlying medical condition that would preclude study participation\n* No peripheral neuropathy\n* No condition (e.g., psychological, geographical) that would preclude study participation\n* No prior breast cancer or melanoma\n* No other prior malignancy within the past 5 years except carcinoma in situ, basal cell or squamous cell skin cancer, or other cancer that has been curatively treated surgically\n\nPRIOR CONCURRENT THERAPY:\n\nBiologic therapy:\n\n* No prior immunotherapy\n* No prior biological response modifiers\n* No other concurrent biologic therapy or immunotherapy\n\nChemotherapy:\n\n* No prior antineoplastic chemotherapy, including intrapleural chemotherapy\n\nEndocrine therapy:\n\n* See Disease Characteristics\n\nRadiotherapy:\n\n* See Disease Characteristics\n* No prior radiotherapy to study lesion (unless evidence of disease progression) or to 30% or greater of marrow bearing bones\n* At least 1 week since prior radiotherapy and recovered\n* No concurrent radiotherapy\n\nSurgery:\n\n* See Disease Characteristics\n* At least 2 weeks since prior major surgery\n* No concurrent surgery\n\nOther:\n\n* At least 2 weeks since prior investigational drugs\n* No other concurrent cytotoxic anticancer therapy\n* No other investigational drugs during and for 30 days after study"
    },
    "inclusion_lines": [
        {
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                "line": "Healthy volunteers allowed",
                "criterions": [
                    {
                        "exact_snippets": "Healthy volunteers allowed",
                        "criterion": "volunteer health status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Healthy volunteers allowed",
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                        }
                    }
                ]
            }
        },
        {
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                "line": "Must have minimum age of 18 Years",
                "criterions": [
                    {
                        "exact_snippets": "minimum age of 18 Years",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "minimum age of 18 Years",
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                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        },
        {
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                "line": "Must have maximum age of 120 Years",
                "criterions": [
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                        "exact_snippets": "maximum age of 120 Years",
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                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "maximum age of 120 Years",
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                            "expected_value": {
                                "operator": "<=",
                                "value": 120,
                                "unit": "Years"
                            }
                        }
                    }
                ]
            }
        }
    ],
    "exclusion_lines": [],
    "miscellaneous_lines": [
        {
            "identified_line": {
                "line": "DISEASE CHARACTERISTICS:",
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                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "DISEASE CHARACTERISTICS",
                        "criterion": "disease characteristics",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Local or metastatic failure after surgery and/or radiotherapy allowed",
                "criterions": [
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                        "exact_snippets": "Local or metastatic failure after surgery and/or radiotherapy allowed",
                        "criterion": "local or metastatic failure",
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                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Local or metastatic failure after surgery and/or radiotherapy allowed",
                        "criterion": "local or metastatic failure",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
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                "line": "* Phase II only:",
                "criterions": [
                    {
                        "exact_snippets": "Phase II only",
                        "criterion": "trial phase",
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                            "requirement_type": "specificity",
                            "expected_value": "Phase II"
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Phase II only",
                        "criterion": "trial phase",
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                    }
                ]
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        },
        {
            "identified_line": {
                "line": "* At least one measurable lesion",
                "criterions": [
                    {
                        "exact_snippets": "At least one measurable lesion",
                        "criterion": "measurable lesion",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least one measurable lesion",
                        "criterion": "measurable lesion",
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                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "N/A"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 20 mm by conventional techniques OR 10 mm by spiral CT scan",
                "criterions": [
                    {
                        "exact_snippets": "At least 20 mm by conventional techniques",
                        "criterion": "tumor size by conventional techniques",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "mm"
                            }
                        }
                    },
                    {
                        "exact_snippets": "10 mm by spiral CT scan",
                        "criterion": "tumor size by spiral CT scan",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 10,
                                "unit": "mm"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "or_criteria": [
                    {
                        "exact_snippets": "At least 20 mm by conventional techniques",
                        "criterion": "tumor size by conventional techniques",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 20,
                                "unit": "mm"
                            }
                        }
                    },
                    {
                        "exact_snippets": "10 mm by spiral CT scan",
                        "criterion": "tumor size by spiral CT scan",
                        "requirement": {
                            "requirement_type": "size",
                            "expected_value": {
                                "operator": ">=",
                                "value": 10,
                                "unit": "mm"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No known CNS metastases unless asymptomatic and at least 4 weeks since prior corticosteroid therapy",
                "criterions": [
                    {
                        "exact_snippets": "No known CNS metastases",
                        "criterion": "CNS metastases",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "unless asymptomatic",
                        "criterion": "CNS metastases",
                        "requirement": {
                            "requirement_type": "symptoms",
                            "expected_value": "asymptomatic"
                        }
                    },
                    {
                        "exact_snippets": "at least 4 weeks since prior corticosteroid therapy",
                        "criterion": "corticosteroid therapy",
                        "requirement": {
                            "requirement_type": "time since therapy",
                            "expected_value": {
                                "operator": ">=",
                                "value": 4,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "condition": {
                    "and_criteria": [
                        {
                            "exact_snippets": "unless asymptomatic",
                            "criterion": "CNS metastases",
                            "requirement": {
                                "requirement_type": "symptoms",
                                "expected_value": "asymptomatic"
                            }
                        },
                        {
                            "exact_snippets": "at least 4 weeks since prior corticosteroid therapy",
                            "criterion": "corticosteroid therapy",
                            "requirement": {
                                "requirement_type": "time since therapy",
                                "expected_value": {
                                    "operator": ">=",
                                    "value": 4,
                                    "unit": "weeks"
                                }
                            }
                        }
                    ]
                },
                "then_criteria": null,
                "else_criteria": {
                    "exact_snippets": "No known CNS metastases",
                    "criterion": "CNS metastases",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "Age:",
                "criterions": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Age:",
                        "criterion": "age",
                        "requirement": {
                            "requirement_type": "N/A",
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                        }
                    }
                ]
            }
        },
        {
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                    {
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                            "requirement_type": "range",
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                                        "operator": ">=",
                                        "value": 18,
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                                    }
                                ]
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                ]
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                                        "unit": "years"
                                    }
                                ]
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Performance status:",
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                    {
                        "exact_snippets": "Performance status:",
                        "criterion": "performance status",
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                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
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                        "exact_snippets": "Performance status:",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* ECOG 0-2",
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                    {
                        "exact_snippets": "ECOG 0-2",
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                            "requirement_type": "range",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "ECOG 0-2",
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                                        "operator": ">=",
                                        "value": 0,
                                        "unit": "N/A"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 2,
                                        "unit": "N/A"
                                    }
                                ]
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Life expectancy:",
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                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
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                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
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                    {
                        "exact_snippets": "Life expectancy",
                        "criterion": "life expectancy",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* At least 12 weeks",
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                    {
                        "exact_snippets": "At least 12 weeks",
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                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
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            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "At least 12 weeks",
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                            "requirement_type": "minimum duration",
                            "expected_value": {
                                "operator": ">=",
                                "value": 12,
                                "unit": "weeks"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Hematopoietic:",
                "criterions": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Hematopoietic:",
                        "criterion": "hematopoietic system",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Absolute granulocyte count at least 1,500/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Absolute granulocyte count at least 1,500/mm^3",
                        "criterion": "absolute granulocyte count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Absolute granulocyte count at least 1,500/mm^3",
                        "criterion": "absolute granulocyte count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1500,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Creatinine no greater than 1.5 times ULN",
                "criterions": [
                    {
                        "exact_snippets": "Creatinine no greater than 1.5 times ULN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Creatinine no greater than 1.5 times ULN",
                        "criterion": "creatinine level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            }
        },
        {
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                "line": "Cardiovascular:",
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                        "exact_snippets": "Cardiovascular:",
                        "criterion": "cardiovascular condition",
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                        }
                    }
                ]
            },
            "logical_structure": {
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                        "exact_snippets": "Cardiovascular:",
                        "criterion": "cardiovascular condition",
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                            "expected_value": true
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No significant cardiac disease",
                "criterions": [
                    {
                        "exact_snippets": "No significant cardiac disease",
                        "criterion": "cardiac disease",
                        "requirement": {
                            "requirement_type": "severity",
                            "expected_value": "not significant"
                        }
                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "No significant cardiac disease",
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                            "requirement_type": "severity",
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                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
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                "criterions": [
                    {
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                        "criterion": "high blood pressure",
                        "requirement": {
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                            "expected_value": false
                        }
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                    {
                        "exact_snippets": "unstable angina",
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                        }
                    },
                    {
                        "exact_snippets": "congestive heart failure",
                        "criterion": "congestive heart failure",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "second or third degree atrioventricular conduction defects",
                        "criterion": "atrioventricular conduction defects",
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                            "requirement_type": "degree",
                            "expected_value": [
                                "second",
                                "third"
                            ]
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                    },
                    {
                        "exact_snippets": "ventricular arrhythmias requiring medication",
                        "criterion": "ventricular arrhythmias",
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                            "requirement_type": "medication requirement",
                            "expected_value": true
                        }
                    }
                ]
            },
            "logical_structure": {
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                            {
                                "exact_snippets": "uncontrolled high blood pressure",
                                "criterion": "high blood pressure",
                                "requirement": {
                                    "requirement_type": "control",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "unstable angina",
                                "criterion": "angina",
                                "requirement": {
                                    "requirement_type": "stability",
                                    "expected_value": false
                                }
                            },
                            {
                                "exact_snippets": "congestive heart failure",
                                "criterion": "congestive heart failure",
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                                    "expected_value": false
                                }
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                            {
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                                "criterion": "atrioventricular conduction defects",
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                                        "second",
                                        "third"
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                                "criterion": "ventricular arrhythmias",
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                                    "requirement_type": "medication requirement",
                                    "expected_value": true
                                }
                            }
                        ]
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* No myocardial infarction within the past year",
                "criterions": [
                    {
                        "exact_snippets": "No myocardial infarction within the past year",
                        "criterion": "myocardial infarction",
                        "requirement": {
                            "requirement_type": "time since last occurrence",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "year"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No myocardial infarction within the past year",
                    "criterion": "myocardial infarction",
                    "requirement": {
                        "requirement_type": "time since last occurrence",
                        "expected_value": {
                            "operator": ">=",
                            "value": 1,
                            "unit": "year"
                        }
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "* Negative pregnancy test",
                "criterions": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
                        "requirement": {
                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Negative pregnancy test",
                        "criterion": "pregnancy test",
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                            "requirement_type": "result",
                            "expected_value": "negative"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Fertile patients must use effective contraception",
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                    {
                        "exact_snippets": "Fertile patients",
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                            "requirement_type": "prior occurrence",
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                    {
                        "exact_snippets": "No prior ... melanoma",
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                    {
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                            "requirement_type": "types",
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                                "carcinoma in situ",
                                "basal cell skin cancer",
                                "squamous cell skin cancer",
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            "identified_line": {
                "line": "PRIOR CONCURRENT THERAPY:",
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                    {
                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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                        "exact_snippets": "PRIOR CONCURRENT THERAPY",
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        {
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                        "exact_snippets": "No prior immunotherapy",
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                        "exact_snippets": "Chemotherapy",
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                        "exact_snippets": "No prior antineoplastic chemotherapy",
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        {
            "identified_line": {
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                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
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                            "requirement_type": "presence",
                            "expected_value": true
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            "logical_structure": {
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                        "exact_snippets": "Endocrine therapy",
                        "criterion": "endocrine therapy",
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        {
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        {
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                                "operator": ">=",
                                "value": 1,
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
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                    }
                ]
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            "logical_structure": {
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                            "requirement_type": "time elapsed",
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                                "operator": ">=",
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                ]
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        {
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
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                    }
                ]
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            "logical_structure": {
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                        "exact_snippets": "At least 2 weeks since prior investigational drugs",
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                            "requirement_type": "duration",
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                                "operator": ">=",
                                "value": 2,
                                "unit": "weeks"
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                ]
            }
        },
        {
            "identified_line": {
                "line": "* No other concurrent cytotoxic anticancer therapy",
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                    {
                        "exact_snippets": "No other concurrent cytotoxic anticancer therapy",
                        "criterion": "concurrent cytotoxic anticancer therapy",
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                            "requirement_type": "presence",
                            "expected_value": false
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                    }
                ]
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            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other concurrent cytotoxic anticancer therapy",
                    "criterion": "concurrent cytotoxic anticancer therapy",
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                        "expected_value": false
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                }
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            "identified_line": {
                "line": "* No other investigational drugs during and for 30 days after study",
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                    {
                        "exact_snippets": "No other investigational drugs during and for 30 days after study",
                        "criterion": "use of investigational drugs",
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                            "requirement_type": "presence",
                            "expected_value": false
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                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No other investigational drugs during and for 30 days after study",
                    "criterion": "use of investigational drugs",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": false
                    }
                }
            }
        },
        {
            "identified_line": {
                "line": "PATIENT CHARACTERISTICS:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "Other:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        },
        {
            "identified_line": {
                "line": "* Not pregnant or nursing",
                "criterions": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "exact_snippets": "Not pregnant",
                        "criterion": "pregnancy status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    },
                    {
                        "exact_snippets": "not ... nursing",
                        "criterion": "nursing status",
                        "requirement": {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "Other:",
                "criterions": []
            },
            "logical_structure": {
                "and_criteria": []
            }
        }
    ],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": [
        {
            "identified_line": {
                "line": "* Histologically or cytologically confirmed stage IIIB or IV non-small cell lung cancer (NSCLC)",
                "criterions": [
                    {
                        "exact_snippets": "Histologically or cytologically confirmed",
                        "criterion": "confirmation method",
                        "requirement": {
                            "requirement_type": "method",
                            "expected_value": [
                                "histologically",
                                "cytologically"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "stage IIIB or IV non-small cell lung cancer (NSCLC)",
                        "criterion": "cancer stage",
                        "requirement": {
                            "requirement_type": "stage",
                            "expected_value": [
                                "IIIB",
                                "IV"
                            ]
                        }
                    },
                    {
                        "exact_snippets": "non-small cell lung cancer (NSCLC)",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "non-small cell lung cancer (NSCLC)"
                        }
                    }
                ]
            },
            "logical_structure": {
                "and_criteria": [
                    {
                        "and_criteria": [
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "Histologically or cytologically confirmed",
                                        "criterion": "confirmation method",
                                        "requirement": {
                                            "requirement_type": "method",
                                            "expected_value": "histologically"
                                        }
                                    },
                                    {
                                        "exact_snippets": "Histologically or cytologically confirmed",
                                        "criterion": "confirmation method",
                                        "requirement": {
                                            "requirement_type": "method",
                                            "expected_value": "cytologically"
                                        }
                                    }
                                ]
                            },
                            {
                                "or_criteria": [
                                    {
                                        "exact_snippets": "stage IIIB or IV non-small cell lung cancer (NSCLC)",
                                        "criterion": "cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "IIIB"
                                        }
                                    },
                                    {
                                        "exact_snippets": "stage IIIB or IV non-small cell lung cancer (NSCLC)",
                                        "criterion": "cancer stage",
                                        "requirement": {
                                            "requirement_type": "stage",
                                            "expected_value": "IV"
                                        }
                                    }
                                ]
                            }
                        ]
                    },
                    {
                        "exact_snippets": "non-small cell lung cancer (NSCLC)",
                        "criterion": "cancer type",
                        "requirement": {
                            "requirement_type": "type",
                            "expected_value": "non-small cell lung cancer (NSCLC)"
                        }
                    }
                ]
            }
        },
        {
            "identified_line": {
                "line": "* Platelet count at least 100,000/mm^3",
                "criterions": [
                    {
                        "exact_snippets": "Platelet count at least 100,000/mm^3",
                        "criterion": "platelet count",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 100000,
                                "unit": "mm^3"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Hepatic:",
                "criterions": [
                    {
                        "exact_snippets": "Hepatic:",
                        "criterion": "hepatic function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* Bilirubin no greater than 1.5 times upper limit of normal (ULN)",
                "criterions": [
                    {
                        "exact_snippets": "Bilirubin no greater than 1.5 times upper limit of normal (ULN)",
                        "criterion": "bilirubin level",
                        "requirement": {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": "<=",
                                "value": 1.5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* ALT no greater than 2 times ULN (5 times ULN for liver metastases)",
                "criterions": [
                    {
                        "exact_snippets": "ALT no greater than 2 times ULN",
                        "criterion": "ALT",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 2,
                                "unit": "times ULN"
                            }
                        }
                    },
                    {
                        "exact_snippets": "ALT ... (5 times ULN for liver metastases)",
                        "criterion": "ALT with liver metastases",
                        "requirement": {
                            "requirement_type": "level",
                            "expected_value": {
                                "operator": "<=",
                                "value": 5,
                                "unit": "times ULN"
                            }
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "Renal:",
                "criterions": [
                    {
                        "exact_snippets": "Renal:",
                        "criterion": "renal function",
                        "requirement": {
                            "requirement_type": "N/A",
                            "expected_value": "N/A"
                        }
                    }
                ]
            },
            "logical_structure": {
                "exact_snippets": "failed",
                "criterion": "failed",
                "requirement": {
                    "requirement_type": "failed",
                    "expected_value": "failed"
                }
            }
        },
        {
            "identified_line": {
                "line": "* No prior biological response modifiers",
                "criterions": [
                    {
                        "exact_snippets": "No prior biological response modifiers",
                        "criterion": "prior biological response modifiers",
                        "requirement": {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    }
                ]
            },
            "logical_structure": {
                "not_criteria": {
                    "exact_snippets": "No prior biological response modifiers",
                    "criterion": "prior biological response modifiers",
                    "requirement": {
                        "requirement_type": "presence",
                        "expected_value": true
                    }
                }
            }
        }
    ]
}