{
    "info": {
        "nct_id": "NCT06798376",
        "official_title": "The Comparison of Different Cycles of PD-1 Blockades Combined with Chemotherapy As Neoadjuvant Therapy for Patients with Advanced Gastric Cancer",
        "inclusion_criteria": "* Non-bedridden patients aged 18-90 years;\n* Histologically confirmed gastric or gastroesophageal junction adenocarcinoma by biopsy;\n* Evaluated as resectable advanced gastric cancer via CT, MRI, or laparoscopic exploration;\n* No prior anti-tumor treatments such as chemotherapy, radiotherapy, or immunotherapy;\n* No history of other malignancies within the past 5 years;\n* Received at least one cycle of PD-1 inhibitor combined with chemotherapy preoperatively, with no restrictions on the specific PD-1 inhibitor or chemotherapeutic agents;\n* Underwent radical gastrectomy after neoadjuvant therapy;\n* No severe underlying diseases.\nHealthy volunteers allowed\nMust have minimum age of 18 Years\nMust have maximum age of 90 Years",
        "exclusion_criteria": "* Incomplete or inaccessible clinical and pathological data;\n* Postoperative pathology confirming non-gastric or non-gastroesophageal junction adenocarcinoma;\n* Distant metastases present prior to treatment;\n* Concurrent diagnosis of other malignancies.",
        "miscellaneous_criteria": ""
    },
    "inclusion_lines": [
        {
            "line": "* Non-bedridden patients aged 18-90 years;",
            "criterions": [
                {
                    "exact_snippets": "Non-bedridden patients",
                    "criterion": "bedridden status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "aged 18-90 years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "N/A",
                            "expected_value": {
                                "comparisons": [
                                    {
                                        "operator": ">=",
                                        "value": 18,
                                        "unit": "years"
                                    },
                                    {
                                        "operator": "<=",
                                        "value": 90,
                                        "unit": "years"
                                    }
                                ]
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Histologically confirmed gastric or gastroesophageal junction adenocarcinoma by biopsy;",
            "criterions": [
                {
                    "exact_snippets": "Histologically confirmed gastric or gastroesophageal junction adenocarcinoma by biopsy",
                    "criterion": "gastric or gastroesophageal junction adenocarcinoma",
                    "requirements": [
                        {
                            "requirement_type": "confirmation method",
                            "expected_value": "histologically confirmed by biopsy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Evaluated as resectable advanced gastric cancer via CT, MRI, or laparoscopic exploration;",
            "criterions": [
                {
                    "exact_snippets": "Evaluated as resectable advanced gastric cancer",
                    "criterion": "resectable advanced gastric cancer",
                    "requirements": [
                        {
                            "requirement_type": "evaluation",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "via CT, MRI, or laparoscopic exploration",
                    "criterion": "evaluation method",
                    "requirements": [
                        {
                            "requirement_type": "methods",
                            "expected_value": [
                                "CT",
                                "MRI",
                                "laparoscopic exploration"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No prior anti-tumor treatments such as chemotherapy, radiotherapy, or immunotherapy;",
            "criterions": [
                {
                    "exact_snippets": "No prior anti-tumor treatments such as chemotherapy",
                    "criterion": "prior chemotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No prior anti-tumor treatments such as ... radiotherapy",
                    "criterion": "prior radiotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                },
                {
                    "exact_snippets": "No prior anti-tumor treatments such as ... immunotherapy",
                    "criterion": "prior immunotherapy",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": false
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No history of other malignancies within the past 5 years;",
            "criterions": [
                {
                    "exact_snippets": "No history of other malignancies within the past 5 years",
                    "criterion": "history of other malignancies",
                    "requirements": [
                        {
                            "requirement_type": "time frame",
                            "expected_value": {
                                "operator": "<",
                                "value": 5,
                                "unit": "years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Received at least one cycle of PD-1 inhibitor combined with chemotherapy preoperatively, with no restrictions on the specific PD-1 inhibitor or chemotherapeutic agents;",
            "criterions": [
                {
                    "exact_snippets": "Received at least one cycle of PD-1 inhibitor combined with chemotherapy preoperatively",
                    "criterion": "PD-1 inhibitor and chemotherapy preoperative treatment",
                    "requirements": [
                        {
                            "requirement_type": "quantity",
                            "expected_value": {
                                "operator": ">=",
                                "value": 1,
                                "unit": "cycle"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Underwent radical gastrectomy after neoadjuvant therapy;",
            "criterions": [
                {
                    "exact_snippets": "Underwent radical gastrectomy",
                    "criterion": "radical gastrectomy",
                    "requirements": [
                        {
                            "requirement_type": "procedure",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "after neoadjuvant therapy",
                    "criterion": "neoadjuvant therapy",
                    "requirements": [
                        {
                            "requirement_type": "treatment history",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* No severe underlying diseases.",
            "criterions": [
                {
                    "exact_snippets": "No severe underlying diseases.",
                    "criterion": "underlying diseases",
                    "requirements": [
                        {
                            "requirement_type": "severity",
                            "expected_value": "not severe"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Healthy volunteers allowed",
            "criterions": [
                {
                    "exact_snippets": "Healthy volunteers allowed",
                    "criterion": "volunteer health status",
                    "requirements": [
                        {
                            "requirement_type": "status",
                            "expected_value": "healthy"
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have minimum age of 18 Years",
            "criterions": [
                {
                    "exact_snippets": "minimum age of 18 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "minimum",
                            "expected_value": {
                                "operator": ">=",
                                "value": 18,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        },
        {
            "line": "Must have maximum age of 90 Years",
            "criterions": [
                {
                    "exact_snippets": "maximum age of 90 Years",
                    "criterion": "age",
                    "requirements": [
                        {
                            "requirement_type": "maximum",
                            "expected_value": {
                                "operator": "<=",
                                "value": 90,
                                "unit": "Years"
                            }
                        }
                    ]
                }
            ]
        }
    ],
    "exclusion_lines": [
        {
            "line": "* Incomplete or inaccessible clinical and pathological data;",
            "criterions": [
                {
                    "exact_snippets": "Incomplete or inaccessible clinical and pathological data",
                    "criterion": "clinical data",
                    "requirements": [
                        {
                            "requirement_type": "accessibility",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "completeness",
                            "expected_value": true
                        }
                    ]
                },
                {
                    "exact_snippets": "Incomplete or inaccessible clinical and pathological data",
                    "criterion": "pathological data",
                    "requirements": [
                        {
                            "requirement_type": "accessibility",
                            "expected_value": true
                        },
                        {
                            "requirement_type": "completeness",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Postoperative pathology confirming non-gastric or non-gastroesophageal junction adenocarcinoma;",
            "criterions": [
                {
                    "exact_snippets": "Postoperative pathology confirming non-gastric or non-gastroesophageal junction adenocarcinoma",
                    "criterion": "adenocarcinoma type",
                    "requirements": [
                        {
                            "requirement_type": "confirmation",
                            "expected_value": [
                                "non-gastric",
                                "non-gastroesophageal junction"
                            ]
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Distant metastases present prior to treatment;",
            "criterions": [
                {
                    "exact_snippets": "Distant metastases present",
                    "criterion": "distant metastases",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        },
        {
            "line": "* Concurrent diagnosis of other malignancies.",
            "criterions": [
                {
                    "exact_snippets": "Concurrent diagnosis of other malignancies.",
                    "criterion": "other malignancies",
                    "requirements": [
                        {
                            "requirement_type": "presence",
                            "expected_value": true
                        }
                    ]
                }
            ]
        }
    ],
    "miscellaneous_lines": [],
    "failed_inclusion": [],
    "failed_exclusion": [],
    "failed_miscellaneous": []
}